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Interatrial shunt devices for heart failure with normal ejection fraction: a technology update (2017)
Journal Article
Cuthbert, J. J., Pellicori, P., & Clark, A. L. (2017). Interatrial shunt devices for heart failure with normal ejection fraction: a technology update. Medical Devices: Evidence and Research, 10, 123-132. https://doi.org/10.2147/mder.s113105

Heart failure with normal ejection fraction (HeFNEF) accounts for ~50% of heart failure admissions. Its pathophysiology and diagnostic criteria are yet to be defined clearly which may hinder the search for effective treatments. The clinical hallmark... Read More about Interatrial shunt devices for heart failure with normal ejection fraction: a technology update.

Influence of case definition on incidence and outcome of acute coronary syndromes (2016)
Journal Article
Torabi, A., Cleland, J. G. F., Sherwi, N., Atkin, P., Panahi, H., Kilpatrick, E., Thackray, S., Hoye, A., Alamgir, F., Goode, K., Clark, A. L., & Rigby, A. (2016). Influence of case definition on incidence and outcome of acute coronary syndromes. Open heart, 3(2), e000487. https://doi.org/10.1136/openhrt-2016-000487

© 2016, BMJ Publishing Group. All rights reserved. Objective: Acute coronary syndromes (ACS) are common, but their incidence and outcome might depend greatly on how data are collected. We compared case ascertainment rates for ACS and myocardial infar... Read More about Influence of case definition on incidence and outcome of acute coronary syndromes.

Xanthine oxidase inhibition for the treatment of cardiovascular disease: an updated systematic review and meta-analysis (2016)
Journal Article
Zhang, J., Dierckx, R., Mohee, K., Clark, A. L., & Cleland, J. G. (2017). Xanthine oxidase inhibition for the treatment of cardiovascular disease: an updated systematic review and meta-analysis. ESC Heart Failure, 4(1), 40-45. https://doi.org/10.1002/ehf2.12112

Background Previous studies have shown that xanthine oxidase inhibitors (XOI) might improve outcome for patients with cardiovascular disease. However, more evidence is required. Methods and results We published a meta-analysis of trials conducted bef... Read More about Xanthine oxidase inhibition for the treatment of cardiovascular disease: an updated systematic review and meta-analysis.

Prevalence and outcomes of anemia and hematinic deficiencies in patients with chronic heart failure (2016)
Journal Article
Cleland, J. G., Zhang, J., Pellicori, P., Dicken, B., Dierckx, R., Shoaib, A., Wong, K., Rigby, A., Goode, K., & Clark, A. L. (2016). Prevalence and outcomes of anemia and hematinic deficiencies in patients with chronic heart failure. JAMA Cardiology, 1(5), 539-547. https://doi.org/10.1001/jamacardio.2016.1161

Copyright © 2016 American Medical Association. All rights reserved. Importance: Detailed information on the prevalence, associations, and consequences of anemia and iron deficiency in epidemiologically representative outpatients with chronic heart fa... Read More about Prevalence and outcomes of anemia and hematinic deficiencies in patients with chronic heart failure.

Is the diagnostic coding position of acute heart failure related to mortality? A report from the Euro Heart Failure Survey-1 (2016)
Journal Article
Shoaib, A., Farag, M., Nasir, M., John, J., Gupta, S., Pellicori, P., Antony, R., Perveen, R., Rigby, A., Goode, K. M., Yassin, A., Clark, A. L., & Cleland, J. G. (2016). Is the diagnostic coding position of acute heart failure related to mortality? A report from the Euro Heart Failure Survey-1. European journal of heart failure, 18(5), 556-563. https://doi.org/10.1002/ejhf.505

© 2016 The Authors. European Journal of Heart Failure. Aims Most studies on acute heart failure (HF) exploring the relationship between admissions to hospital for HF and subsequent outcomes have focused only on HF coded as the primary diagnosis, but... Read More about Is the diagnostic coding position of acute heart failure related to mortality? A report from the Euro Heart Failure Survey-1.

Exploring quality of life in patients with and without heart failure (2015)
Journal Article
Zhang, J., Hobkirk, J., Carroll, S., Pellicori, P., Clark, A. L., & Cleland, J. G. (2016). Exploring quality of life in patients with and without heart failure. International journal of cardiology, 202, 676-684. https://doi.org/10.1016/j.ijcard.2015.09.076

Aims The EuroHeart Failure Survey Questionnaire (EHFSQ-1) has 39 questions on symptoms and quality of life (QoL); many items are related. We sought to identify underlying clusters amongst EHFSQ-1 questions, construct an overall “QoL score” and invest... Read More about Exploring quality of life in patients with and without heart failure.

Development of a human model for the study of effects of hypoxia, exercise, and sildenafil on cardiac and vascular function in chronic heart failure (2015)
Journal Article
Damy, T., Hobkirk, J., Walters, M., Ciobanu, A., Rigby, A. S., Kallvikbacka-Bennett, A., Guellich, A., Dubois-Rande, J.-L., Hittinger, L., Clark, A. L., & Cleland, J. G. F. (2015). Development of a human model for the study of effects of hypoxia, exercise, and sildenafil on cardiac and vascular function in chronic heart failure. Journal of Cardiovascular Pharmacology, 66(3), 229-238. https://doi.org/10.1097/fjc.0000000000000262

Background: Pulmonary hypertension is associated with poor outcome in patients with chronic heart failure (CHF) and may be a therapeutic target. Our aims were to develop a noninvasive model for studying pulmonary vasoreactivity in CHF and characteriz... Read More about Development of a human model for the study of effects of hypoxia, exercise, and sildenafil on cardiac and vascular function in chronic heart failure.

Does home oxygen therapy (HOT) in addition to standard care reduce disease severity and improve symptoms in people with chronic heart failure? A randomised trial of home oxygen therapy for patients with chronic heart failure (2015)
Journal Article
Clark, A. L., Johnson, M., Fairhurst, C., Torgerson, D., Cockayne, S., Rodgers, S., Griffin, S., Allgar, V., Jones, L., Nabb, S., Harvey, I., Squire, I., Murphy, J., & Greenstone, M. (2015). Does home oxygen therapy (HOT) in addition to standard care reduce disease severity and improve symptoms in people with chronic heart failure? A randomised trial of home oxygen therapy for patients with chronic heart failure. Health Technology Assessment, 19(75), 1-120. https://doi.org/10.3310/hta19750

Background: Home oxygen therapy (HOT) is commonly used for patients with severe chronic heart failure
(CHF) who have intractable breathlessness. There is no trial evidence to support its use.

Objectives: To detect whether or not there was a quality-... Read More about Does home oxygen therapy (HOT) in addition to standard care reduce disease severity and improve symptoms in people with chronic heart failure? A randomised trial of home oxygen therapy for patients with chronic heart failure.

Prognostic significance of ultrasound-assessed jugular vein distensibility in heart failure (2015)
Journal Article
Pellicori, P., Kallvikbacka-Bennett, A., Dierckx, R., Zhang, J., Putzu, P., Cuthbert, J., Boyalla, V., Shoaib, A., Clark, A. L., & Cleland, J. G. (2015). Prognostic significance of ultrasound-assessed jugular vein distensibility in heart failure. Heart, 101(14), 1149-1158. https://doi.org/10.1136/heartjnl-2015-307558

Aims: Jugular venous distension is a classical sign of heart failure (HF) but it can be difficult to assess clinically. Methods and results: Outpatients with HF and control subjects were assessed. Internal jugular vein diameter ( JVD) was measured us... Read More about Prognostic significance of ultrasound-assessed jugular vein distensibility in heart failure.

The obesity paradox in type 2 diabetes mellitus: Relationship of body mass index to prognosis a cohort study (2015)
Journal Article
Costanzo, P., Cleland, J. G., Pellicori, P., Clark, A. L., Hepburn, D., Kilpatrick, E. S., …Atkin, S. L. (2015). The obesity paradox in type 2 diabetes mellitus: Relationship of body mass index to prognosis a cohort study. Annals of Internal Medicine, 162(9), 610-618. https://doi.org/10.7326/M14-1551

Background: Whether obesity is associated with a better prognosis in patients with type 2 diabetes mellitus is controversial. Objective: To investigate the association between body weight and prognosis in a large cohort of patients with type 2 diabet... Read More about The obesity paradox in type 2 diabetes mellitus: Relationship of body mass index to prognosis a cohort study.

Prescribing patterns to optimize heart rate. Analysis of 1,000 consecutive outpatient appointments toasingle heart failure clinic over a 6-month period. (2015)
Journal Article
Dierckx, R., Cleland, J. G., Parsons, S., Putzu, P., Pellicori, P., Dicken, B., Boyalla, V., & Clark, A. L. (2015). Prescribing patterns to optimize heart rate. Analysis of 1,000 consecutive outpatient appointments toasingle heart failure clinic over a 6-month period. JACC: Heart Failure, 3(3), 224-230. https://doi.org/10.1016/j.jchf.2014.11.003

Objectives: This study sought to characterize patients attending a community heart failure (HF) clinic and identified those who were eligible for optimization of beta-blockers (BB) or ivabradine. Background: Among patients with HF due to left ventric... Read More about Prescribing patterns to optimize heart rate. Analysis of 1,000 consecutive outpatient appointments toasingle heart failure clinic over a 6-month period..

The relation between repeated 6-minute walk test performance and outcome in patients with chronic heart failure (2014)
Journal Article
Ingle, L., Cleland, J. G., & Clark, A. L. (2014). The relation between repeated 6-minute walk test performance and outcome in patients with chronic heart failure. Annals of physical and rehabilitation medicine, 57(4), 244-253. https://doi.org/10.1016/j.rehab.2014.03.004

Objective: To assess the prognostic implications of the 6-minute walk test (6-MWT) distance measured twice, one year apart, in a large sample of patients with chronic heart failure (CHF) followed for an extended period ( > . 8. years from baseline).... Read More about The relation between repeated 6-minute walk test performance and outcome in patients with chronic heart failure.

The long-term prognostic significance of 6-minute walk test distance in patients with chronic heart failure (2014)
Journal Article
Ingle, L., Cleland, J. G., & Clark, A. L. (2014). The long-term prognostic significance of 6-minute walk test distance in patients with chronic heart failure. Biomed research international, 2014, 1-7. https://doi.org/10.1155/2014/505969

Background. The 6-minute walk test (6-MWT) is used to assess patients with chronic heart failure (CHF). The prognostic significance of the 6-MWT distance during long-term followup ( > 5 years) is unclear. Methods. 1,667 patients (median [inter-quarti... Read More about The long-term prognostic significance of 6-minute walk test distance in patients with chronic heart failure.

Development of a composite model derived from cardiopulmonary exercise tests to predict mortality risk in patients with mild-to-moderate heart failure (2014)
Journal Article
Ingle, L., Rigby, A. S., Sloan, R., Carroll, S., Goode, K. M., Cleland, J. G., & Clark, A. L. (2014). Development of a composite model derived from cardiopulmonary exercise tests to predict mortality risk in patients with mild-to-moderate heart failure. Heart, 100(10), 781-786. https://doi.org/10.1136/heartjnl-2013-304614

Objective: Cardiopulmonary exercise testing (CPET) is used to predict outcome in patients with mild-to-moderate heart failure (HF). Single CPET-derived variables are often used, but we wanted to see if a composite score achieved better predictive pow... Read More about Development of a composite model derived from cardiopulmonary exercise tests to predict mortality risk in patients with mild-to-moderate heart failure.

Disowned recollections: Denying true experiences undermines belief in occurrence but not judgments of remembering (2013)
Journal Article
Mazzoni, G., Clark, A., & Nash, R. A. (2014). Disowned recollections: Denying true experiences undermines belief in occurrence but not judgments of remembering. Acta Psychologica, 145(1), 139-146. https://doi.org/10.1016/j.actpsy.2013.11.007

Recent research findings have illustrated that false memories induced in the laboratory can be dissociated from the beliefs that the events had in fact occurred. In this study we assessed whether this dissociability is a quality peculiar to false mem... Read More about Disowned recollections: Denying true experiences undermines belief in occurrence but not judgments of remembering.

Effects of reducing inspired oxygen concentration for one hour in patients with chronic heart failure: implications for air travel (2013)
Journal Article
Hobkirk, J. P., Damy, T., Walters, M., Bennett, A., Smith, S. J., Ingle, L., Clark, A. L., & Cleland, J. G. (2013). Effects of reducing inspired oxygen concentration for one hour in patients with chronic heart failure: implications for air travel. European journal of heart failure, 15(5), 505-510. https://doi.org/10.1093/eurjhf/hft003

AimsThe objective of this study was to establish the acute effects of hypoxia on clinical, spirometric, haemodynamic, and echocardiographic variables. Reducing inspired oxygen to 15%, as experienced during commercial air travel, decreases arterial ox... Read More about Effects of reducing inspired oxygen concentration for one hour in patients with chronic heart failure: implications for air travel.

Abnormalities of the ventilatory equivalent for carbon dioxide in patients with chronic heart failure (2012)
Journal Article
Ingle, L., Sloan, R., Carroll, S., Goode, K., Cleland, J. G., & Clark, A. L. (2012). Abnormalities of the ventilatory equivalent for carbon dioxide in patients with chronic heart failure. Pulmonary Medicine, 2012, 589164. https://doi.org/10.1155/2012/589164

Introduction. The relation between minute ventilation (VE) and carbon dioxide production (VCO(2)) can be characterised by the instantaneous ratio of ventilation to carbon dioxide production, the ventilatory equivalent for CO(2) (VEqCO(2)). We hypothe... Read More about Abnormalities of the ventilatory equivalent for carbon dioxide in patients with chronic heart failure.

Minimally clinically important difference in chronic breathlessness: every little helps (2012)
Journal Article
Oxberry, S. G., Bland, J. M., Clark, A. L., Cleland, J. G., & Johnson, M. (2012). Minimally clinically important difference in chronic breathlessness: every little helps. American Heart Journal, 164(2), 229-235. https://doi.org/10.1016/j.ahj.2012.05.003

ObjectivesThe aim of the study was to determine the minimally clinically important difference (MCID) for breathlessness due to chronic heart failure (CHF). BackgroundThe measurement of breathlessness is difficult because it is subjective and multifac... Read More about Minimally clinically important difference in chronic breathlessness: every little helps.