The relation between repeated 6-minute walk test performance and outcome in patients with chronic heart failure

Ingle, L.; Cleland, J. G.; Clark, A. L.

Abstract

Objective: To assess the prognostic implications of the 6-minute walk test (6-MWT) distance measured twice, one year apart, in a large sample of patients with chronic heart failure (CHF) followed for an extended period ( > . 8. years from baseline). Material and methods: Patients undertook a 6-MWT at baseline and at one year, and were followed up for 8. years from baseline. Results: Six hundred patients (median [inter-quartile range, IQR]) (age 78 [72-84] years; 75% males; body mass index 27 [25-31] kg·m -2 ; left ventricular ejection fraction 34 [26-38] %) were included. At baseline, median 6-MWT distance was 232 (60-386) m. There was no significant change in 6-MWT distance at one year (change -12m; P=0.533). During a median follow-up of 8.0years in survivors, 396patients had died (66%). Four variables were independent predictors of all-cause mortality in a multivariable Cox model (adjusted for body mass index, age, QRS duration, left ventricular ejection fraction); increasing NT pro-BNP, decreasing 6-MWT distance at 1year, decreasing haemoglobin, and increasing urea. Conclusions: Distance walked during the 6-MWT is an independent predictor of all-cause mortality in patients with CHF. In survivors, the 6-MWT distance is stable at 1 year. The 6-MWT distance at 1 year carries similar prognostic information. © 2014 Elsevier Masson SAS.

• Journal Article Type: Article
• Publication Date: 2014-06
• Journal: Annals of physical and rehabilitation medicine
• Print ISSN: 1877-0657
• Electronic ISSN: 1877-0665
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 57
• Issue: 4
• Pages: 244-253
• APA6 Citation: Ingle, L., Cleland, J. G., & Clark, A. L. (2014). The relation between repeated 6-minute walk test performance and outcome in patients with chronic heart failure. Annals of physical and rehabilitation medicine, 57(4), 244-253. https://doi.org/10.1016/j.rehab.2014.03.004
• DOI: https://doi.org/10.1016/j.rehab.2014.03.004
• Keywords: Repeat testing, 6-minute walk test, Risk, Chronic heart failure
• Publisher URL: http://www.sciencedirect.com/science/article/pii/S1877065714000475
• Copyright Statement: © 2014. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
• Additional Information: This article is maintained by: Elsevier; Article Title: The relation between repeated 6-minute walk test performance and outcome in patients with chronic heart failure; Journal Title: Annals of Physical and Rehabilitation Medicine; CrossRef DOI link to publisher maintained version: http://dx.doi.org/10.1016/j.rehab.2014.03.004; Content Type: article; Copyright: Copyright © 2014 Elsevier Masson SAS. All rights reserved.