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The relation between repeated 6-minute walk test performance and outcome in patients with chronic heart failure

Cleland, J. G.; Clark, A. L.; Ingle, L.; Cleland, John


A. L. Clark

J. G. Cleland


Objective: To assess the prognostic implications of the 6-minute walk test (6-MWT) distance measured twice, one year apart, in a large sample of patients with chronic heart failure (CHF) followed for an extended period ( > . 8. years from baseline). Material and methods: Patients undertook a 6-MWT at baseline and at one year, and were followed up for 8. years from baseline. Results: Six hundred patients (median [inter-quartile range, IQR]) (age 78 [72-84] years; 75% males; body mass index 27 [25-31] kg·m -2 ; left ventricular ejection fraction 34 [26-38] %) were included. At baseline, median 6-MWT distance was 232 (60-386) m. There was no significant change in 6-MWT distance at one year (change -12m; P=0.533). During a median follow-up of 8.0years in survivors, 396patients had died (66%). Four variables were independent predictors of all-cause mortality in a multivariable Cox model (adjusted for body mass index, age, QRS duration, left ventricular ejection fraction); increasing NT pro-BNP, decreasing 6-MWT distance at 1year, decreasing haemoglobin, and increasing urea. Conclusions: Distance walked during the 6-MWT is an independent predictor of all-cause mortality in patients with CHF. In survivors, the 6-MWT distance is stable at 1 year. The 6-MWT distance at 1 year carries similar prognostic information. © 2014 Elsevier Masson SAS.

Journal Article Type Article
Publication Date 2014-06
Journal Annals of physical and rehabilitation medicine
Print ISSN 1877-0657
Electronic ISSN 1877-0665
Publisher Elsevier Masson
Peer Reviewed Peer Reviewed
Volume 57
Issue 4
Pages 244-253
Keywords Repeat testing, 6-minute walk test, Risk, Chronic heart failure
Publisher URL
Copyright Statement © 2014. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Additional Information This article is maintained by: Elsevier; Article Title: The relation between repeated 6-minute walk test performance and outcome in patients with chronic heart failure; Journal Title: Annals of Physical and Rehabilitation Medicine; CrossRef DOI link to publisher maintained version:; Content Type: article; Copyright: Copyright © 2014 Elsevier Masson SAS. All rights reserved.


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