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Effect of creatine supplementation on the airways of youth elite soccer players (2019)
Journal Article
Simpson, A. J., Horne, S., Sharp, P., Sharps, R., & Kippelen, P. (2019). Effect of creatine supplementation on the airways of youth elite soccer players. Medicine and Science in Sports and Exercise, 51(8), 1582–1590. https://doi.org/10.1249/MSS.0000000000001979

Introduction. Owing to its well-established ergogenic potential, creatine is a highly popular food supplement in sports. As an oral supplement, creatine is considered safe and ethical. However, no data exist on the safety of creatine on lung function... Read More

Effect of spirometry on intra-thoracic pressures (2018)
Journal Article
Tiller, N. B., & Simpson, A. J. (2018). Effect of spirometry on intra-thoracic pressures. BMC research notes, 11(1), doi:10.1186/s13104-018-3217-9. ISSN 1756-0500

Objective Due to the high intra-thoracic pressures associated with forced vital capacity manoeuvres, spirometry is contraindicated for vulnerable patients. However, the typical pressure response to spirometry has not been reported. Eight healthy, re... Read More

Assessing machine learning algorithms for self-management of asthma (2017)
Conference Proceeding
Kocsis, O., Arvanitis, G., Lalos, A., Moustakas, K., Sont, J. K., Honkoop, P. J., …Simpson, A. (2017). Assessing machine learning algorithms for self-management of asthma. In 2017 E-Health and Bioengineering Conference (EHB), 571-574. https://doi.org/10.1109/EHB.2017.7995488

© 2017 IEEE. Control and monitoring of asthma progress is highly important for patient's quality of life and healthcare management. Emerging tools for self-management of various chronic diseases have the potential to support personalized patient guid... Read More

Exercise-induced dehydration alters pulmonary function but does not modify airway responsiveness to dry air in athletes with mild asthma (2017)
Journal Article
Simpson, A. J., Romer, L. M., & Kippelen, P. (2017). Exercise-induced dehydration alters pulmonary function but does not modify airway responsiveness to dry air in athletes with mild asthma. Journal of Applied Physiology, 122(5), (1329-1335). doi:10.1152/japplphysiol.01114.2016. ISSN 8750-7587

Local airway water loss is the main physiological trigger for exercise-induced bronchoconstriction (EIB). Our aim was to investigate the effects of whole body water loss on airway responsiveness and pulmonary function in athletes with mild asthma and... Read More

Perspectives of patients and healthcare professionals on mHealth for asthma self-management (2017)
Journal Article
Simpson, A. J., Honkoop, P. J., Kennington, E., Snoeck-Stroband, J., Smith, I., East, J., …Fowler, S. (2017). Perspectives of patients and healthcare professionals on mHealth for asthma self-management. The European respiratory journal, 49(5), https://doi.org/10.1183/13993003.01966-2016

Copyright ©ERS 2017. Mobile healthcare (mHealth) has the potential to revolutionise the self-management of long-term medical conditions such as asthma. A user-centred design is integral if mHealth is to be embraced by patients and healthcare professi... Read More

MyAirCoach: The use of home-monitoring and mHealth systems to predict deterioration in asthma control and the occurrence of asthma exacerbations; Study protocol of an observational study (2017)
Journal Article
Honkoop, P. J., Simpson, A., Bonini, M., Snoeck-Stroband, J. B., Meah, S., Chung, K. F., …Sont, J. K. (2017). MyAirCoach: The use of home-monitoring and mHealth systems to predict deterioration in asthma control and the occurrence of asthma exacerbations; Study protocol of an observational study. BMJ open, 7(1), https://doi.org/10.1136/bmjopen-2016-013935

© Published by the BMJ Publishing Group Limited. Introduction Asthma is a variable lung condition whereby patients experience periods of controlled and uncontrolled asthma symptoms. Patients who experience prolonged periods of uncontrolled asthma hav... Read More

A standard, single dose of inhaled terbutaline attenuates hyperpnea-induced bronchoconstriction and mast cell activation in athletes (2016)
Journal Article
Simpson, A. J., Bood, J. R., Anderson, S. D., Romer, L. M., Dahlén, B., Dahlén, S. E., & Kippelen, P. (2016). A standard, single dose of inhaled terbutaline attenuates hyperpnea-induced bronchoconstriction and mast cell activation in athletes. Journal of Applied Physiology, 120(9), 1011-1017. https://doi.org/10.1152/japplphysiol.00700.2015

Release of bronchoactive mediators from mast cells during exercise hyperpnea is a key factor in the pathophysiology of exercise-induced bronchoconstriction (EIB). Our aim was to investigate the effect of a standard, single dose of an inhaled β 2 -adr... Read More

Self-reported symptoms after induced and inhibited bronchoconstriction in athletes (2015)
Journal Article
Simpson, A. J., Romer, L. M., & Kippelen, P. (2015). Self-reported symptoms after induced and inhibited bronchoconstriction in athletes. Medicine and Science in Sports and Exercise, 47(10), 2005-2013. doi:10.1249/mss.0000000000000646

Purpose: A change in the perception of respiratory symptoms after treatment with inhaled beta2 agonists is often used to aid diagnosis of exercise-induced bronchoconstriction (EIB). Our aim was to test the association between subjective ratings of r... Read More

Effect of terbutaline on hyperpnoea-induced bronchoconstriction and urinary club cell protein 16 in athletes (2013)
Journal Article
Simpson, A. J., Simpson, A. J., Tufvesson, E., Tufvesson, E., Anderson, S. D., Anderson, S. D., …Kippelen, P. (2013). Effect of terbutaline on hyperpnoea-induced bronchoconstriction and urinary club cell protein 16 in athletes. Journal of Applied Physiology, 115(10), 1450-1456. https://doi.org/10.1152/japplphysiol.00716.2013

Repeated injury of the airway epithelium caused by hyperpnoea of poorly conditioned air has been proposed as a key factor in the pathogenesis of exercise-induced bronchoconstriction (EIB) in athletes. In animals, the short-acting β2-agonist terbutali... Read More