All Outputs (44)

Indian Ornamental Tarantula (Poecilotheria regalis) Venom Affects Myoblast Function and Causes Skeletal Muscle Damage (2023)
Journal Article
Richards, N. J., Alqallaf, A., Mitchell, R. D., Parnell, A., Haidar, H. B., Almeida, J. R., Williams, J., Vijayakumar, P., Balogun, A., Matsakas, A., Trim, S. A., Patel, K., & Vaiyapuri, S. (2023). Indian Ornamental Tarantula (Poecilotheria regalis) Venom Affects Myoblast Function and Causes Skeletal Muscle Damage. Cells, 12(16), Article 2074. https://doi.org/10.3390/cells12162074

Envenomation by the Indian ornamental tarantula (Poecilotheria regalis) is medically relevant to humans, both in its native India and worldwide, where they are kept as pets. Muscle-related symptoms such as cramps and pain are commonly reported in hum... Read More about Indian Ornamental Tarantula (Poecilotheria regalis) Venom Affects Myoblast Function and Causes Skeletal Muscle Damage.

Studies on skeletal muscle stem cell biology of the apolipoprotein E deficient mice (2022)
Thesis
Barlow, J. J. Studies on skeletal muscle stem cell biology of the apolipoprotein E deficient mice. (Thesis). Hull York Medical School, the University of Hull and the University of York. https://hull-repository.worktribe.com/output/4224384

Skeletal muscle has tremendous adaptive and regenerative ability, this is achieved through a resource of stem cells which remain present in adults. These cells remain quiescent until activated by myogenic factors, at which point they proliferate and... Read More about Studies on skeletal muscle stem cell biology of the apolipoprotein E deficient mice.

Current Insights into Cellular Senescence and Myotoxicity Induced by Doxorubicin: The Role of Exercise and Growth Factors (2022)
Journal Article
Andreou, C., & Matsakas, A. (2022). Current Insights into Cellular Senescence and Myotoxicity Induced by Doxorubicin: The Role of Exercise and Growth Factors. International journal of sports medicine, 43(13), 1084-1096. https://doi.org/10.1055/a-1797-7622

Doxorubicin is an anti-neoplasmic drug that prevents DNA replication but induces senescence and cellular toxicity. Intensive research has focused on strategies to alleviate the doxorubicin-induced skeletal myotoxicity. The aim of the present review i... Read More about Current Insights into Cellular Senescence and Myotoxicity Induced by Doxorubicin: The Role of Exercise and Growth Factors.

Author Correction: Attenuation of autophagy impacts on muscle fibre development, starvation induced stress and fibre regeneration following acute injury (Scientific Reports, (2018), 8, 1, (9062), 10.1038/s41598-018-27429-7) (2021)
Journal Article
Paolini, A., Omairi, S., Mitchell, R., Vaughan, D., Matsakas, A., Vaiyapuri, S., Ricketts, T., Rubinsztein, D. C., & Patel, K. (2021). Author Correction: Attenuation of autophagy impacts on muscle fibre development, starvation induced stress and fibre regeneration following acute injury (Scientific Reports, (2018), 8, 1, (9062), 10.1038/s41598-018-27429-7). Scientific reports, 11(1), Article 24532. https://doi.org/10.1038/s41598-021-04140-8

The original version of this Article contained errors. In Figure 5, the distance that “leaky” images were taken from the damaged tissue was not consistent, and there was a partial overlap of the “leaky” and undamaged images for Figure 5D and 5J. In a... Read More about Author Correction: Attenuation of autophagy impacts on muscle fibre development, starvation induced stress and fibre regeneration following acute injury (Scientific Reports, (2018), 8, 1, (9062), 10.1038/s41598-018-27429-7).

Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting programs (2021)
Journal Article
Solagna, F., Tezze, C., Lindenmeyer, M. T., Lu, S., Wu, G., Liu, S., Zhao, Y., Mitchell, R., Meyer, C., Omairi, S., Kilic, T., Paolini, A., Ritvos, O., Pasternack, A., Matsakas, A., Kylies, D., zur Wiesch, J. S., Turner, J. E., Wanner, N., Nair, V., …Huber, T. B. (2021). Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting programs. Journal of Clinical Investigation, 131(11), Article e135821. https://doi.org/10.1172/JCI135821

Skeletal muscle wasting is commonly associated with chronic kidney disease (CKD), resulting in increased morbidity and mortality. However, the link between kidney and muscle function remains poorly understood. Here, we took a complementary interorgan... Read More about Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting programs.

A muscle growth-promoting treatment based on the attenuation of activin/myostatin signalling results in long-term testicular abnormalities (2021)
Journal Article
Vaughan, D., Mitchell, R., Kretz, O., Chambers, D., Lalowski, M., Amthor, H., Ritvos, O., Pasternack, A., Matsakas, A., Vaiyapuri, S., Huber, T. B., Denecke, B., Mukherjee, A., Widera, D., & Patel, K. (2021). A muscle growth-promoting treatment based on the attenuation of activin/myostatin signalling results in long-term testicular abnormalities. Disease Models and Mechanisms, 14(2), Article dmm047555. https://doi.org/10.1242/dmm.047555

© 2021. Published by The Company of Biologists Ltd. Activin/myostatin signalling acts to induce skeletal muscle atrophy in adult mammals by inhibiting protein synthesis as well as promoting protein and organelle turnover. Numerous strategies have bee... Read More about A muscle growth-promoting treatment based on the attenuation of activin/myostatin signalling results in long-term testicular abnormalities.

Platelet releasate normalises the compromised muscle regeneration in a mouse model of hyperlipidaemia (2021)
Journal Article
Barlow, J., Sfyri, P. P., Mitchell, R., Verpoorten, S., Scully, D., Andreou, C., Papadopoulos, P., Patel, K., & Matsakas, A. (2021). Platelet releasate normalises the compromised muscle regeneration in a mouse model of hyperlipidaemia. Experimental Physiology, 106(3), 700-713. https://doi.org/10.1113/ep088937

Muscle satellite cells are important stem cells for skeletal muscle regeneration and repair after injury. ApoE‐deficient mice, an established mouse model of hyperlipidaemia and atherosclerosis, show evidence of oxidative stress‐induced lesions and fa... Read More about Platelet releasate normalises the compromised muscle regeneration in a mouse model of hyperlipidaemia.

Evaluating trastuzumab in the treatment of HER2 positive breast cancer (2020)
Journal Article
Jaques, R., Xu, S., & Matsakas, A. (2020). Evaluating trastuzumab in the treatment of HER2 positive breast cancer. Histology and Histopathology, 35(10), 1059-1075. https://doi.org/10.14670/HH-18-221

© 2020, Histology and Histopathology. All rights reserved. The transmembrane oncoprotein HER2 is encoded by ERBB2 gene and overexpressed in around 20% of invasive breast cancers. It can be specifically targeted by Trastuzumab (Herceptin®), a humanise... Read More about Evaluating trastuzumab in the treatment of HER2 positive breast cancer.

Diminution in sperm quantity and quality in mouse models of Duchenne Muscular Dystrophy induced by a myostatin-based muscle growth-promoting intervention (2020)
Journal Article
Vaughan, D., Kretz, O., Alqallaf, A., Mitchell, R., von der Heide, J., Vaiyapuri, S., Matsakas, A., Pasternack, A., Collins-Hooper, H., Ritvos, O., Ballesteros, R., Huber, T. B., Amthor, H., Mukherjee, A., & Patel, K. (in press). Diminution in sperm quantity and quality in mouse models of Duchenne Muscular Dystrophy induced by a myostatin-based muscle growth-promoting intervention. European Journal of Translational Myology, 30(2), 276-285. https://doi.org/10.4081/ejtm.0.8904

Duchenne Muscular Dystrophy is a devastating disease caused by the absence of a functional rod-shaped cytoplasmic protein called dystrophin. Several avenues are being developed aimed to restore dystrophin expression in boys affected by this X-linked... Read More about Diminution in sperm quantity and quality in mouse models of Duchenne Muscular Dystrophy induced by a myostatin-based muscle growth-promoting intervention.

Quantitative Redox Biology of Exercise (2020)
Journal Article
Nikolaidis, M. G., Margaritelis, N. V., & Matsakas, A. (2020). Quantitative Redox Biology of Exercise. International journal of sports medicine, 41(10), 633-645. https://doi.org/10.1055/a-1157-9043

© Georg Thieme Verlag KG Stuttgart · New York. Biology is rich in claims that reactive oxygen and nitrogen species are involved in every biological process and disease. However, many quantitative aspects of redox biology remain elusive. The important... Read More about Quantitative Redox Biology of Exercise.

Inhibition of Activin/Myostatin signalling induces skeletal muscle hypertrophy but impairs mouse testicular development (2020)
Journal Article
Vaughan, D., Ritvos, O., Mitchell, R., Kretz, O., Lalowski, M., Amthor, H., Chambers, D., Matsakas, A., Pasternack, A., Collins-Hooper, H., Ballesteros, R., Huber, T. B., Denecke, B., Widera, D., Mukherjee, A., & Patel, K. (2020). Inhibition of Activin/Myostatin signalling induces skeletal muscle hypertrophy but impairs mouse testicular development. European Journal of Translational Myology, 30(1), 62-78. https://doi.org/10.4081/ejtm.2019.8737

© 2020 PAGEPress Publications. All rights reserved. Numerous approaches are being developed to promote post-natal muscle growth based on attenuating Myostatin/Activin signalling for clinical uses such as the treatment neuromuscular diseases, cancer c... Read More about Inhibition of Activin/Myostatin signalling induces skeletal muscle hypertrophy but impairs mouse testicular development.

Inhibition of Activin/Myostatin signalling impairs mouse testis Inhibition of Activin/Myostatin signalling induces skeletal muscle hypertrophy but impairs mouse testicular development (2020)
Journal Article
Vaughan, D., Ritvos, O., Mitchell, R., Kretz, O., Lalowski, M., Amthor, H., Chambers, D., Matsakas, A., Pasternack, A., Collins-Hooper, H., Ballesteros, R., Denecke, B., Widera, D., Mukherjee, A., Patel, K., & Huber, T. B. (online). Inhibition of Activin/Myostatin signalling impairs mouse testis Inhibition of Activin/Myostatin signalling induces skeletal muscle hypertrophy but impairs mouse testicular development. Œconomia, 30(1), 1-17

Numerous approaches are being developed to promote post-natal muscle growth based on attenuating Myostatin/Activin signalling for clinical uses such as the treatment neuromuscular diseases, cancer cachexia and sarcopenia. However there have been conc... Read More about Inhibition of Activin/Myostatin signalling impairs mouse testis Inhibition of Activin/Myostatin signalling induces skeletal muscle hypertrophy but impairs mouse testicular development.

The impact on high-fat diet on skeletal muscle stem cell recruitment in CD36 deficient mice (2019)
Thesis
Verpoorten, S. The impact on high-fat diet on skeletal muscle stem cell recruitment in CD36 deficient mice. (Thesis). Hull York Medical School, the University of Hull and the University of York. https://hull-repository.worktribe.com/output/4222387

The prevalence of obesity is a major risk factor for cardiovascular and metabolic diseases including impaired skeletal muscle regeneration. Given the importance of skeletal muscle function in the context of obesity, it is paramount to understand the... Read More about The impact on high-fat diet on skeletal muscle stem cell recruitment in CD36 deficient mice.

Optimising platelet secretomes to deliver robust tissue-specific regeneration (2019)
Journal Article
Scully, D., Sfyri, P., Wilkinson, H. N., Acebes‐Huerta, A., Verpoorten, S., Muñoz‐Turrillas, M. C., Parnell, A., Patel, K., Hardman, M. J., Gutiérrez, L., & Matsakas, A. (2020). Optimising platelet secretomes to deliver robust tissue-specific regeneration. Journal of tissue engineering and regenerative medicine, 14(1), 82-98. https://doi.org/10.1002/term.2965

Promoting cell proliferation is the cornerstone of most tissue regeneration therapies. As platelet-based applications promote cell division and can be customised for tissue-specific efficacy, this makes them strong candidates for developing novel reg... Read More about Optimising platelet secretomes to deliver robust tissue-specific regeneration.

Loss of CD36 protects against diet-induced obesity but results in impaired muscle stem cell function, delayed muscle regeneration and hepatic steatosis (2019)
Journal Article
Verpoorten, S., Sfyri, P., Scully, D., Mitchell, R., Tzimou, A., Mougios, V., Patel, K., & Matsakas, A. (2020). Loss of CD36 protects against diet-induced obesity but results in impaired muscle stem cell function, delayed muscle regeneration and hepatic steatosis. Acta Physiologica, 228(3), https://doi.org/10.1111/apha.13395

Aim: The prevalence of obesity is a major risk factor for cardiovascular and metabolic diseases including impaired skeletal muscle regeneration. Since skeletal muscle regenerative capacity is regulated by satellite cells, we aimed to investigate whet... Read More about Loss of CD36 protects against diet-induced obesity but results in impaired muscle stem cell function, delayed muscle regeneration and hepatic steatosis.

The role of platelets in skeletal muscle regeneration (2019)
Thesis
Scully, D. The role of platelets in skeletal muscle regeneration. (Thesis). Hull York Medical School, the University of Hull and the University of York. https://hull-repository.worktribe.com/output/4222188

Overview: Biomaterials such as autologous platelet-based applications have gained intense research interest. However, the mechanisms driving platelet‐mediated skeletal myogenesis remain to be established. Therefore, the aim of this thesis was to opti... Read More about The role of platelets in skeletal muscle regeneration.

The effect of high-fat diet on the morphological properties of the forelimb musculature in hypertrophic myostatin null mice (2019)
Journal Article
Elashry, M. I., Eldaey, A., Glenske, K., Matsakas, A., Wenisch, S., Arnhold, S., & Patel, K. (2019). The effect of high-fat diet on the morphological properties of the forelimb musculature in hypertrophic myostatin null mice. Journal of anatomy, 235(4), 825-835. https://doi.org/10.1111/joa.13025

Obesity is a worldwide nutritional disorder affecting body performance, including skeletal muscle. Inhibition of myostatin not only increases the muscle mass but also it reduces body fat accumulation. We examined the effect of high-fat diet on the ph... Read More about The effect of high-fat diet on the morphological properties of the forelimb musculature in hypertrophic myostatin null mice.

Current Insights into the Potential Misuse of Platelet-based Applications for Doping in Sports (2019)
Journal Article
Scully, D., & Matsakas, A. (2019). Current Insights into the Potential Misuse of Platelet-based Applications for Doping in Sports. International journal of sports medicine, 40(7), 427-433. https://doi.org/10.1055/a-0884-0734

Platelet-based applications are currently used for the delivery of growth factors and other biomolecules as autologous biomaterials in regenerative medicine and cosmetic therapies. Many studies have revealed that platelet-based applications such as p... Read More about Current Insights into the Potential Misuse of Platelet-based Applications for Doping in Sports.

Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling (2019)
Journal Article
Alyodawi, K., Vermeij, W., Omairi, S., Kretz, O., Hopkinson, M., Solagna, F., Joch, B., Brandt, R., Barnhoorn, S., Van Vliet, N., Ridwan, Y., Essers, J., Mitchell, R., Morash, T., Pasternack, A., Ritvos, O., Matsakas, A., Collins-Hooper, H., Huber, T., Hoeijmakers, J., & Patel, K. (2019). Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling. Journal of Cachexia, Sarcopenia and Muscle, 10(3), 662-686. https://doi.org/10.1002/jcsm.12404

© 2019 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders Background: One of the principles underpinning our understanding of ageing is t... Read More about Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling.

Regulation of the dystrophin-associated glycoprotein complex composition by the metabolic properties of muscle fibres (2019)
Journal Article
Omairi, S., Hau, K. L., Collins-Hooper, H., Scott, C., Vaiyapuri, S., Torelli, S., Montanaro, F., Matsakas, A., & Patel, K. (2019). Regulation of the dystrophin-associated glycoprotein complex composition by the metabolic properties of muscle fibres. Scientific reports, 9(1), Article 2770. https://doi.org/10.1038/s41598-019-39532-4

The dystrophin-glycoprotein complex (DGC) links the muscle cytoskeleton to the extracellular matrix and is responsible for force transduction and protects the muscle fibres from contraction induced damage. Mutations in components of the DGC are respo... Read More about Regulation of the dystrophin-associated glycoprotein complex composition by the metabolic properties of muscle fibres.