All Outputs (61)

Comparison of assays measuring extracellular vesicle tissue factor in plasma samples: communication from the ISTH SSC Subcommittee on Vascular Biology (2024)
Journal Article
Bonifay, A., Mackman, N., Hisada, Y., Sachetto, A. T. A., Hau, C., Gray, E., Hogwood, J., Aharon, A., Badimon, L., Barile, L., Baudar, J., Beckmann, L., Benedikter, B., Bolis, S., Bouriche, T., Brambilla, M., Burrello, J., Camera, M., Campello, E., Ettelaie, C., …Lacroix, R. (2024). Comparison of assays measuring extracellular vesicle tissue factor in plasma samples: communication from the ISTH SSC Subcommittee on Vascular Biology. Journal of Thrombosis and Haemostasis, https://doi.org/10.1016/j.jtha.2024.05.037

Background: Scientific and clinical interest in extracellular vesicles (EVs) is growing. EVs that expose tissue factor (TF) bind factor VII/VIIa and can trigger coagulation. Highly procoagulant TF-exposing EVs are detectable in the circulation in var... Read More about Comparison of assays measuring extracellular vesicle tissue factor in plasma samples: communication from the ISTH SSC Subcommittee on Vascular Biology.

Endothelial-derived microvesicles promote pro-migratory cross-talk with smooth muscle cells by a mechanism requiring tissue factor and PAR2 activation (2024)
Journal Article
Featherby, S., & Ettelaie, C. (2024). Endothelial-derived microvesicles promote pro-migratory cross-talk with smooth muscle cells by a mechanism requiring tissue factor and PAR2 activation. Frontiers in Cardiovascular Medicine, 11, Article 1365008. https://doi.org/10.3389/fcvm.2024.1365008

Introduction: Microvesicles (MV) released by endothelial cells (EC) following injury or inflammation contain tissue factor (TF) and mediate communication with the underlying smooth muscle cells (SMC). Ser253-phosphorylated TF co-localizes with filami... Read More about Endothelial-derived microvesicles promote pro-migratory cross-talk with smooth muscle cells by a mechanism requiring tissue factor and PAR2 activation.

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches (2024)
Journal Article
Welsh, J. A., Goberdhan, D. C., O'Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., …Witwer, K. W. (2024). Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. Journal of Extracellular Vesicles, 13(2), Article e12404. https://doi.org/10.1002/jev2.12404

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated bro... Read More about Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches.

Regulation of tissue factor activity by interaction with the first PDZ domain of MAGI1 (2024)
Journal Article
Mohammad, M. A., Featherby, S., & Ettelaie, C. (2024). Regulation of tissue factor activity by interaction with the first PDZ domain of MAGI1. Thrombosis journal, 22(1), Article 12. https://doi.org/10.1186/s12959-023-00580-6

Background: Tissue factor (TF) activity is stringently regulated through processes termed encryption. Post-translational modification of TF and its interactions with various protein and lipid moieties allows for a multi-step de-encryption of TF and p... Read More about Regulation of tissue factor activity by interaction with the first PDZ domain of MAGI1.

Abstract 224: Establishing de novo platform for whole genome sequencing of pancreatic cyst fluid for early detection and diagnosis of pancreatic cancer (2023)
Presentation / Conference Contribution
Adekeye, A., Haque, F., Ettelaie, C., Nikitenko, L., & Maraveyas, A. (2023). Abstract 224: Establishing de novo platform for whole genome sequencing of pancreatic cyst fluid for early detection and diagnosis of pancreatic cancer. Cancer Research, 83(7_Supplement), 224-224. https://doi.org/10.1158/1538-7445.am2023-224

Background: Pancreatic cancer (PC) is a leading cause of cancer-related deaths globally. Accurate PC detection at early or premalignant stage, when surgery is effective, would increase survival rates and prevent unnecessary surgery or surveillance. A... Read More about Abstract 224: Establishing de novo platform for whole genome sequencing of pancreatic cyst fluid for early detection and diagnosis of pancreatic cancer.

Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells (2023)
Thesis
Haque, F. Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4371279

The premalignant pancreatic cellular genotype can remain stable for years before rapid malignant transformation, often associated with inflammation. Tissue factor (TF) is an inflammatory modulator regulated by factor VIIa (fVIIa) for its levels and a... Read More about Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells.

Tumour-Associated Tissue Factor (TF)-mRNA Is A Precursor for Rapid TF-Microvesicle Release and A Potential Predictive Marker for the Risk of Pulmonary Embolism (PE) in Gastrointestinal Cancer Patients (2022)
Journal Article
Ettelaie, C., Benelhaj, N., Featherby, S., Haque, F., Johnson, M., Cooke, J., & Maraveyas, A. (2022). Tumour-Associated Tissue Factor (TF)-mRNA Is A Precursor for Rapid TF-Microvesicle Release and A Potential Predictive Marker for the Risk of Pulmonary Embolism (PE) in Gastrointestinal Cancer Patients. Journal of Biotechnology and Biomedicine, 5(2), 78-93. https://doi.org/10.26502/jbb.2642-280050

Predicting which cancer patients are at risk of thrombosis remains a key challenge to effective thromboprophylaxis. This study was based on the hypothesis that the rapid release of TF-containing MV occurs in cancer cells that possess high levels of T... Read More about Tumour-Associated Tissue Factor (TF)-mRNA Is A Precursor for Rapid TF-Microvesicle Release and A Potential Predictive Marker for the Risk of Pulmonary Embolism (PE) in Gastrointestinal Cancer Patients.

Synthesis and analysis of small molecules to restrain the function of tissue factor within tumour cells (2021)
Journal Article
Adeniran, O. I., Mohammad, M. A., Featherby, S., Maraveyas, A., Boa, A. N., & Ettelaie, C. (2021). Synthesis and analysis of small molecules to restrain the function of tissue factor within tumour cells. Frontiers in Bioscience-Landmark, 26(10), 752-764. https://doi.org/10.52586/4985

Introduction: The restriction of prolyl-protein cis/trans isomerase 1 (Pin1) activity has been shown to prevent the release of tissue factor (TF) leading to the accumulation of the latter protein within the cell. This study tested the ability of nove... Read More about Synthesis and analysis of small molecules to restrain the function of tissue factor within tumour cells.

De-palmitoylation of tissue factor regulates its activity, phosphorylation and cellular functions (2021)
Journal Article
Ettelaie, C., Featherby, S., Rondon, A. M. R., Greenman, J., Versteeg, H. H., & Maraveyas, A. (2021). De-palmitoylation of tissue factor regulates its activity, phosphorylation and cellular functions. Cancers, 13(15), Article 3837. https://doi.org/10.3390/cancers13153837

In this study, the role of de-palmitoylation of tissue factor (TF) in the decryption of its activity was explored. TF-tGFP constructs were prepared by mutagenesis-substitution at Cys245 to prevent or mimic palmitolyation. Additionally, to reduce TF d... Read More about De-palmitoylation of tissue factor regulates its activity, phosphorylation and cellular functions.

Factor VIIa regulates the level of cell-surface tissue factor through separate but cooperative mechanisms (2021)
Journal Article
Madkhali, Y., Rondon, A. M., Featherby, S., Maraveyas, A., Greenman, J., & Ettelaie, C. (2021). Factor VIIa regulates the level of cell-surface tissue factor through separate but cooperative mechanisms. Cancers, 13(15), Article 3718. https://doi.org/10.3390/cancers13153718

Procoagulant activity of tissue factor (TF) in response to injury or inflammation is accompanied with cellular signals which determine the fate of cells. However, to prevent excessive signalling, TF is rapidly dissipated through release into microves... Read More about Factor VIIa regulates the level of cell-surface tissue factor through separate but cooperative mechanisms.

Investigation of the effects of anticoagulants on tissue factor mediated cellular processes (2021)
Thesis
Featherby, S. (2021). Investigation of the effects of anticoagulants on tissue factor mediated cellular processes. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4223521

Thrombotic complications are common in cancer patients and are amongst the leading causes of morbidity and mortality. Recently, it was reported that treatment of cancer patients with the low molecular weight heparin (LMWH) family of anticoagulants ca... Read More about Investigation of the effects of anticoagulants on tissue factor mediated cellular processes.

Activation of PAR2 by tissue factor induces the release of the PTEN from MAGI proteins and regulates PTEN and Akt activities (2020)
Journal Article
Mohammad, M. A., Greenman, J., Maraveyas, A., & Ettelaie, C. (2020). Activation of PAR2 by tissue factor induces the release of the PTEN from MAGI proteins and regulates PTEN and Akt activities. Scientific reports, 10(1), Article 20908. https://doi.org/10.1038/s41598-020-77963-6

Tissue factor (TF) signalling has been associated with alterations in Akt activity influencing cellular survival and proliferation. TF is also shown to induce signalling through activation of the protease activated receptor (PAR)2. Seven cell lines w... Read More about Activation of PAR2 by tissue factor induces the release of the PTEN from MAGI proteins and regulates PTEN and Akt activities.

An investigation of the regulatory mechanisms of cellular homeostasis and haemostasis initiated by tissue factor (2020)
Thesis
Mohammad, M. A. (2020). An investigation of the regulatory mechanisms of cellular homeostasis and haemostasis initiated by tissue factor. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4222998

The signalling arising from tissue factor (TF) has been associated with cellular homeostasis as well as haemostasis and, is particularly pertinent in carcinogenesis and cancer progression. The formation of the TF-FVIIa complex is known to activate pr... Read More about An investigation of the regulatory mechanisms of cellular homeostasis and haemostasis initiated by tissue factor.

An investigation into the regulation of cellular homeostasis through modulation of cell-surface tissue factor (2020)
Thesis
Madkhali, Y. A. An investigation into the regulation of cellular homeostasis through modulation of cell-surface tissue factor. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4836545

In recent years it has become evident that cell-derived microvesicles (MV) influence the recipient cells through inducing signalling mechanisms which lead to cell proliferation or apoptosis. In addition, the excessive release of procoagulant MV durin... Read More about An investigation into the regulation of cellular homeostasis through modulation of cell-surface tissue factor.

Evaluation of small molecule inhibitors of Pin1 for their effects on tissue factor within tumour cells (2019)
Thesis
Adeniran, O. I. (2019). Evaluation of small molecule inhibitors of Pin1 for their effects on tissue factor within tumour cells. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4222358

Most standard anticancer drugs are non-selective in their cytotoxicity towards cancerous versus normal cells. Therefore, there is a need for the development of selective and targeted anticancer agents. Previous studies have reported upregulation of t... Read More about Evaluation of small molecule inhibitors of Pin1 for their effects on tissue factor within tumour cells.

Accumulation of tissue factor in endothelial cells promotes cellular apoptosis through over-activation of Src1 and involves β1-integrin signalling (2019)
Journal Article
Ethaeb, A. M., Mohammad, M. A., Madkhali, Y., Maraveyas, A., Featherby, S., Greenman, J., & Ettelaie, C. (2020). Accumulation of tissue factor in endothelial cells promotes cellular apoptosis through over-activation of Src1 and involves β1-integrin signalling. Apoptosis, 25(1-2), 29-41. https://doi.org/10.1007/s10495-019-01576-2

Accumulation of tissue factor (TF) within cells leads to cellular apoptosis mediated through p38 and p53 pathways. In this study, the involvement of Src1 in the induction of TF-mediated cell apoptosis, and the mechanisms of Src1 activation were inves... Read More about Accumulation of tissue factor in endothelial cells promotes cellular apoptosis through over-activation of Src1 and involves β1-integrin signalling.

Apixaban suppresses the release of TF-positive microvesicles and restrains cancer cell proliferation through directly inhibiting TF-fVIIa activity (2019)
Journal Article
Featherby, S., Madkhali, Y., Maraveyas, A., & Ettelaie, C. (2019). Apixaban suppresses the release of TF-positive microvesicles and restrains cancer cell proliferation through directly inhibiting TF-fVIIa activity. Thrombosis and haemostasis, 119(9), 1419-1432. https://doi.org/10.1055/s-0039-1692682

The activation of protease-activated receptor (PAR)-2 by factor Xa (fXa) promotes the release of tissue factor-positive microvesicles (TF + MV), and contributes to proliferation in cancer cells. This study examined the ability of direct oral anticoag... Read More about Apixaban suppresses the release of TF-positive microvesicles and restrains cancer cell proliferation through directly inhibiting TF-fVIIa activity.

A study of clinicopathological characteristics, symptoms and patients experiences related to outcomes in people with cancer and I-PE (2019)
Thesis
Benelhaj, N. E. (2019). A study of clinicopathological characteristics, symptoms and patients experiences related to outcomes in people with cancer and I-PE. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4222310

Background: The clinical course of incidental pulmonary embolism in cancer population represents an area of controversy. It presents a growing challenge for clinicians because of a lack of prospective data.

Aim: This research aims to investigate t... Read More about A study of clinicopathological characteristics, symptoms and patients experiences related to outcomes in people with cancer and I-PE.

The Ratio of Factor VIIa:Tissue Factor Content within Microvesicles Determines the Differential Influence on Endothelial Cells (2019)
Journal Article
Madkhali, Y., Featherby, S., Collier, M., Maraveyas, A., Greenman, J., & Ettelaie, C. (2019). The Ratio of Factor VIIa:Tissue Factor Content within Microvesicles Determines the Differential Influence on Endothelial Cells. TH Open, 03(02), e132-e145. https://doi.org/10.1055/s-0039-1688934

Tissue factor (TF)-positive microvesicles from various sources can promote cellular proliferation or alternatively induce apoptosis, but the determining factors are unknown. In this study the hypothesis that the ratio of fVIIa:TF within microvesicles... Read More about The Ratio of Factor VIIa:Tissue Factor Content within Microvesicles Determines the Differential Influence on Endothelial Cells.

Low molecular weight heparin and direct oral anticoagulants influence tumour formation, growth, invasion and vascularisation by separate mechanisms (2019)
Journal Article
Featherby, S., Xiao, Y. P., Ettelaie, C., Nikitenko, L. L., Greenman, J., & Maraveyas, A. (2019). Low molecular weight heparin and direct oral anticoagulants influence tumour formation, growth, invasion and vascularisation by separate mechanisms. Scientific reports, 9(1), Article 6272. https://doi.org/10.1038/s41598-019-42738-1

The bidirectional association between coagulation and cancer has been established. However, anticoagulant therapies have been reported to have beneficial outcomes by influencing the vascularisation of the tumours. In this study the influence of a set... Read More about Low molecular weight heparin and direct oral anticoagulants influence tumour formation, growth, invasion and vascularisation by separate mechanisms.