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All Outputs (18)

The influence of musculoskeletal forces on the growth of the prenatal cortex in the ilium: a finite element study (2020)
Journal Article
Watson, P. J., Fagan, M. J., & Dobson, C. A. (in press). The influence of musculoskeletal forces on the growth of the prenatal cortex in the ilium: a finite element study. Computer methods in biomechanics and biomedical engineering, https://doi.org/10.1080/10255842.2020.1777546

Remodelling and adaptation of bone within the pelvis is believed to be influenced by the mechanical strains generated during locomotion. Variation in the cortical bone thickness observed in the prenatal ilium has been linked to the musculoskeletal lo... Read More about The influence of musculoskeletal forces on the growth of the prenatal cortex in the ilium: a finite element study.

The potential role of variations in juvenile hip geometry on the development of Legg-Calvé-Perthes disease: a biomechanical investigation (2018)
Journal Article
Pinheiro, M. D. S., Dobson, C., Clarke, N. M., & Fagan, M. (2018). The potential role of variations in juvenile hip geometry on the development of Legg-Calvé-Perthes disease: a biomechanical investigation. Computer methods in biomechanics and biomedical engineering, 21(2), 194-200. https://doi.org/10.1080/10255842.2018.1437151

© 2018 Informa UK Limited, trading as Taylor & Francis Group Legg-Calvé-Perthes disease (LCP) is one of the most poorly understood diseases in paediatric orthopaedics. One common trait of LCP is the marked morphological difference between healthy a... Read More about The potential role of variations in juvenile hip geometry on the development of Legg-Calvé-Perthes disease: a biomechanical investigation.

New insights into the biomechanics of Legg-Calvé-Perthes’ disease: The role of epiphyseal skeletal immaturity in vascular obstruction (2018)
Journal Article
Pinheiro, M., Dobson, C. A., Perry, D., & Fagan, M. J. (2018). New insights into the biomechanics of Legg-Calvé-Perthes’ disease: The role of epiphyseal skeletal immaturity in vascular obstruction. Bone & joint research, 7(2), 148-156. https://doi.org/10.1302/2046-3758.72.bjr-2017-0191.r1

Objectives
Legg–Calvé–Perthes’ disease (LCP) is an idiopathic osteonecrosis of the femoral head that is most common in children between four and eight years old. The factors that lead to the onset of LCP are still unclear; however, it is believed th... Read More about New insights into the biomechanics of Legg-Calvé-Perthes’ disease: The role of epiphyseal skeletal immaturity in vascular obstruction.

The effect of boundary constraints on finite element modelling of the human pelvis (2017)
Journal Article
Watson, P., Dostanpor, A., Fagan, M. J., & Dobson, C. A. (2017). The effect of boundary constraints on finite element modelling of the human pelvis. Medical engineering & physics, 43, 48-57. https://doi.org/10.1016/j.medengphy.2017.02.001

The use of finite element analysis (FEA) to investigate the biomechanics of anatomical systems critically relies on the specification of physiologically representative boundary conditions. The biomechanics of the pelvis has been the specific focus of... Read More about The effect of boundary constraints on finite element modelling of the human pelvis.

Skeletal immaturity, rostral sparing, and disparate hip morphologies as biomechanical causes for Legg-Calvé-Perthes’ disease (2016)
Journal Article
Berthaume, M. A., Perry, D. C., Dobson, C. A., Witzel, U., Clarke, N. M., & Fagan, M. J. (2016). Skeletal immaturity, rostral sparing, and disparate hip morphologies as biomechanical causes for Legg-Calvé-Perthes’ disease. Clinical Anatomy, 29(6), 759-772. https://doi.org/10.1002/ca.22690

Legg-Calvé-Perthes' (Perthes') disease is a developmental disease of the hip joint that may result in numerous short and long term problems. The etiology of the disease remains largely unknown, but the mechanism is believed to be vascular and/or biom... Read More about Skeletal immaturity, rostral sparing, and disparate hip morphologies as biomechanical causes for Legg-Calvé-Perthes’ disease.

Sensitivity to model geometry in finite element analyses of reconstructed skeletal structures: Experience with a juvenile pelvis (2014)
Journal Article
Watson, P. J., Fagan, M. J., & Dobson, C. A. (2015). Sensitivity to model geometry in finite element analyses of reconstructed skeletal structures: Experience with a juvenile pelvis. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 229(1), 9-19. https://doi.org/10.1177/0954411914564476

Biomechanical analysis of juvenile pelvic growth can be used in the evaluation of medical devices and investigation of hip joint disorders. This requires access to scan data of healthy juveniles, which are not always freely available. This article an... Read More about Sensitivity to model geometry in finite element analyses of reconstructed skeletal structures: Experience with a juvenile pelvis.

Validation of a morphometric reconstruction technique applied to a juvenile pelvis (2010)
Journal Article
Watson, P., O'Higgins, P., Fagan, M. J., & Dobson, C. A. (2011). Validation of a morphometric reconstruction technique applied to a juvenile pelvis. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 225(1), 48-57. https://doi.org/10.1243/09544119jeim810

Three-dimensional reconstructions of bone geometry from microCT (computed tomography) data are frequently used in biomechanical and finite element analyses. Digitization of bone models is usually a simple process for specimens with a complete geometr... Read More about Validation of a morphometric reconstruction technique applied to a juvenile pelvis.

Masticatory loading and bone adaptation in the supraorbital torus of developing macaques (2008)
Journal Article
Kupczik, K., Dobson, C. A., Crompton, R. H., Phillips, R., Oxnard, C. E., Fagan, M. J., & O'Higgins, P. (2009). Masticatory loading and bone adaptation in the supraorbital torus of developing macaques. American journal of physical anthropology, 139(2), 193-203. https://doi.org/10.1002/ajpa.20972

Research on the evolution and adaptive significance of primate craniofacial morphologies has focused on adult, fully developed individuals. Here, we investigate the possible relationship between the local stress environment arising from masticatory l... Read More about Masticatory loading and bone adaptation in the supraorbital torus of developing macaques.

Assessing mechanical function of the zygomatic region in macaques: validation and sensitivity testing of finite element models (2006)
Journal Article
Kupczik, K., Dobson, C. A., Fagan, M. J., Crompton, R. H., Oxnard, C. E., & O'Higgins, P. (2007). Assessing mechanical function of the zygomatic region in macaques: validation and sensitivity testing of finite element models. Journal of anatomy, 210(1), 41-53. https://doi.org/10.1111/j.1469-7580.2006.00662.x

Crucial to the interpretation of the results of any finite element analysis of a skeletal system is a test of the validity of the results and an assessment of the sensitivity of the model parameters. We have therefore developed finite element models... Read More about Assessing mechanical function of the zygomatic region in macaques: validation and sensitivity testing of finite element models.

Three dimensional stereolithography models of cancellous bone structures from μCT data: Testing and validation of finite element results (2006)
Journal Article
Dobson, C. A., Sisias, G., Phillips, R., Langton, C. M., & Fagan, M. J. (2006). Three dimensional stereolithography models of cancellous bone structures from μCT data: Testing and validation of finite element results. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 220(3), 481-484. https://doi.org/10.1243/09544119H00405

Stereolithography (STL) models of complex cancellous bone structures have been produced from three-dimensional micro-computed tomography data sets of human cancellous bone histological samples from four skeletal sites. The STL models have been mechan... Read More about Three dimensional stereolithography models of cancellous bone structures from μCT data: Testing and validation of finite element results.

Algorithms for accurate rapid prototyping replication of cancellous bone voxel maps (2002)
Journal Article
Sisias, G., Phillips, R., Dobson, C., Fagan, M., & Langton, C. (2002). Algorithms for accurate rapid prototyping replication of cancellous bone voxel maps. Rapid Prototyping Journal, 8(1), 6-24. https://doi.org/10.1108/13552540210413266

A set of algorithms has been developed and evaluated for 3D and 21/2D rapid prototyping replication of 3D reconstructions of cancellous bone samples. The algorithms replicate a voxel map without any loss of fidelity, so as to increase the validity of... Read More about Algorithms for accurate rapid prototyping replication of cancellous bone voxel maps.

Smoothing of pixelated finite element models of cancellous bone structures and the effect on the predicted structural properties of the bone (2002)
Journal Article
Dobson, C. A., Sisias, G., Phillips, R., Langton, C. M., & Fagan, M. J. (2002). Smoothing of pixelated finite element models of cancellous bone structures and the effect on the predicted structural properties of the bone. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 216(2), 145-149. https://doi.org/10.1243/0954411021536360

Many areas of biomedical engineering involve the modelling of biological systems, often using data from medical scanning techniques such as computed microtomography (μCT), and the prediction of the mechanical properties of these systems via finite el... Read More about Smoothing of pixelated finite element models of cancellous bone structures and the effect on the predicted structural properties of the bone.

Stochastically simulated assessment of anabolic treatment following varying degrees of cancellous bone resorption (2000)
Journal Article
Langton, C., Haire, T., Ganney, P., Dobson, C., Fagan, M., Sisias, G., & Phillips, R. (2000). Stochastically simulated assessment of anabolic treatment following varying degrees of cancellous bone resorption. Bone, 27(1), 111-118. https://doi.org/10.1016/s8756-3282%2800%2900290-8

The aim of this study was to investigate the recovery in cancellous bone stiffness resulting from anabolic treatment following varying degrees of resorption, using a stochastic simulation applied to a simplistic structure consisting of five vertical... Read More about Stochastically simulated assessment of anabolic treatment following varying degrees of cancellous bone resorption.

Stereo visualization of 3D trabecular bone structures produced by bone remodelling simulation
Presentation / Conference Contribution
Phillips, R., Grunchec, J. A., Ward, J. W., Fagan, M. J., Dobson, C. A., Langton, C. M., & Sisias, G. Stereo visualization of 3D trabecular bone structures produced by bone remodelling simulation

Adult human bone is constantly being renewed by a process known as remodelling. For cancellous bone this renewal process occurs at the interface between bone and marrow where bone is depleted by osteoclasts and rebuilt by osteoblasts. This remodellin... Read More about Stereo visualization of 3D trabecular bone structures produced by bone remodelling simulation.