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The Effects of the iPlayClean Education Programme on Doping Attitudes and Susceptibility to use Banned Substances among High-Level Adolescent Athletes from the UK: A Cluster-Randomised Control Trial (2020)
Journal Article
Huang, C. (in press). The Effects of the iPlayClean Education Programme on Doping Attitudes and Susceptibility to use Banned Substances among High-Level Adolescent Athletes from the UK: A Cluster-Randomised Control Trial. International Journal of Drug Policy,

Background: This study examined the effects of the iPlayClean anti-doping intervention on attitudes towards doping and susceptibility, and whether delivery mode affected the results. Methods: A total of 1,081 high-level UK athletes (14-18 years old... Read More about The Effects of the iPlayClean Education Programme on Doping Attitudes and Susceptibility to use Banned Substances among High-Level Adolescent Athletes from the UK: A Cluster-Randomised Control Trial.

The Effects of the iPlayClean Education Programme on Doping Attitudes and Susceptibility to use Banned Substances among High-Level Adolescent Athletes from the UK: A Cluster-Randomised Control Trial (2020)
Journal Article
Nicholls, A., Morley, D., Thompson, M. A., Huang, C., Abt, G., Rothwell, M., …Ntoumanis, N. (in press). The Effects of the iPlayClean Education Programme on Doping Attitudes and Susceptibility to use Banned Substances among High-Level Adolescent Athletes from the UK: A Cluster-Randomised Control Trial. International Journal of Drug Policy,

Background: This study examined the effects of the iPlayClean anti-doping intervention on attitudes towards doping and susceptibility, and whether delivery mode affected the results. Methods: A total of 1,081 high-level UK athletes (14-18 years old... Read More about The Effects of the iPlayClean Education Programme on Doping Attitudes and Susceptibility to use Banned Substances among High-Level Adolescent Athletes from the UK: A Cluster-Randomised Control Trial.

A randomised Phase II trial of carboplatin and gemcitabine ± vandetanib in first-line treatment of patients with advanced urothelial cell cancer not suitable to receive cisplatin: TOUCAN Phase II trial final (2020)
Journal Article
Jones, R., Crabb, S., Chester, J., Elliott, T., Huddart, R., Birtle, A., …Griffiths, G. (in press). A randomised Phase II trial of carboplatin and gemcitabine ± vandetanib in first-line treatment of patients with advanced urothelial cell cancer not suitable to receive cisplatin: TOUCAN Phase II trial final. BJU international, https://doi.org/10.1111/bju.15096

Objectives To assess the efficacy and tolerability of the dual epidermal growth factor receptor/vascular endothelial growth factor receptor inhibitor, vandetanib, in combination with carboplatin and gemcitabine in the first‐line treatment of patient... Read More about A randomised Phase II trial of carboplatin and gemcitabine ± vandetanib in first-line treatment of patients with advanced urothelial cell cancer not suitable to receive cisplatin: TOUCAN Phase II trial final.

high INtensity Interval Training In pATiEnts with intermittent claudication (INITIATE): protocol for a multi-centre, proof-of-concept, prospective interventional study (2020)
Journal Article
S, P., AE, H., S, I., G, M., C, H., M, T., …I. C, C. (in press). high INtensity Interval Training In pATiEnts with intermittent claudication (INITIATE): protocol for a multi-centre, proof-of-concept, prospective interventional study. BMJ open,

Introduction: The first-line recommended treatment for patients with intermittent claudication (IC), is a supervised exercise programme (SEP), which includes a minimum of 2 hours exercise per week over a 12-week period. However, provision, uptake, an... Read More about high INtensity Interval Training In pATiEnts with intermittent claudication (INITIATE): protocol for a multi-centre, proof-of-concept, prospective interventional study.

Minimal clinically important differences in average, best, worst and current intensity and unpleasantness of chronic breathlessness (2020)
Journal Article
Ekström, M., Johnson, M. J., Huang, C., & Currow, D. C. (2020). Minimal clinically important differences in average, best, worst and current intensity and unpleasantness of chronic breathlessness. European respiratory journal, 55(5), https://doi.org/10.1183/13993003.02202-2019

Background: Chronic breathlessness has devastating consequences. The minimal clinically important difference (MCID) for current intensity has been estimated as 9mm on a 100mm visual analogue scale (VAS). We aimed to determine MCIDs for commonly used... Read More about Minimal clinically important differences in average, best, worst and current intensity and unpleasantness of chronic breathlessness.

Intention-to-treat analyses for randomised controlled trials in hospice/palliative care: the case for analyses to be of people exposed to the intervention. (2019)
Journal Article
Currow, D. C., Higginson, I. J., Portenoy, R. K., Hussain, J. A., Kochovska, S., Huang, C., …Currow, D. C. (2019). Intention-to-treat analyses for randomised controlled trials in hospice/palliative care: the case for analyses to be of people exposed to the intervention. Journal of pain and symptom management, https://doi.org/10.1016/j.jpainsymman.2019.10.026

Introduction Minimising bias in randomised controlled trials (RCTs) includes intention-to-treat (ITT) analyses. Hospice/palliative care RCTs are constrained by high attrition unpredictable when consenting, including withdrawals between randomisati... Read More about Intention-to-treat analyses for randomised controlled trials in hospice/palliative care: the case for analyses to be of people exposed to the intervention..

Low agreement between mMRC rated by patients and clinicians ─ implications for practice (2019)
Journal Article
Ekström, M., Chang, S., Johnson, M. J., Fazekas, B., Kochovska, S., Huang, C., & Currow, D. C. (in press). Low agreement between mMRC rated by patients and clinicians ─ implications for practice. The European respiratory journal, 1901517. https://doi.org/10.1183/13993003.01517-2019

Chronic breathlessness [1] causes immense suffering in cardiorespiratory diseases. The functional impact of activity-related breathlessness, measured on the modified Medical Research (mMRC) scale [2], is highly prognostic, informs disease evaluation... Read More about Low agreement between mMRC rated by patients and clinicians ─ implications for practice.

Presurgery conditioning interventions (prehabilitation) in adults undergoing lower limb surgery for peripheral arterial disease (2019)
Journal Article
Smith, G. E., Palmer, J., Pymer, S., Smith, G. E., Harwood, A. E., Ingle, L., …Chetter, I. C. (2019). Presurgery conditioning interventions (prehabilitation) in adults undergoing lower limb surgery for peripheral arterial disease. The Cochrane database of systematic reviews, 2019(9), https://doi.org/10.1002/14651858.cd013407

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effectiveness of prehabilitation (preoperative exercise, either alone or in combination with nutritional or psychological interventions or both)... Read More about Presurgery conditioning interventions (prehabilitation) in adults undergoing lower limb surgery for peripheral arterial disease.

Validity and effectiveness of paediatric early warning systems and track and trigger tools for identifying and reducing clinical deterioration in hospitalised children: a systematic review (2019)
Journal Article
Trubey, R., Huang, C., Lugg-Widger, F. V., Hood, K., Allen, D., Edwards, D., …Powell, C. (2019). Validity and effectiveness of paediatric early warning systems and track and trigger tools for identifying and reducing clinical deterioration in hospitalised children: a systematic review. BMJ open, 9(5), https://doi.org/10.1136/bmjopen-2018-022105

Objective To assess (1) how well validated existing paediatric track and trigger tools (PTTT) are for predicting adverse outcomes in hospitalised children, and (2) how effective broader paediatric early warning systems are at reducing adverse outcome... Read More about Validity and effectiveness of paediatric early warning systems and track and trigger tools for identifying and reducing clinical deterioration in hospitalised children: a systematic review.

The relationship between red blood cell distribution width and metabolic syndrome in elderly Chinese: a cross-sectional study (2019)
Journal Article
Yan, Z., Fan, Y., Meng, Z., Huang, C., Liu, M., Zhang, Q., …Jia, Q. (2019). The relationship between red blood cell distribution width and metabolic syndrome in elderly Chinese: a cross-sectional study. Lipids in Health and Disease, 18, https://doi.org/10.1186/s12944-019-0978-7

Objective Metabolic syndrome (MS) is a group of risk factors which includes hypertension, hyperglycemia, abnormal cholesterol levels, and obesity. Red blood cell distribution width (RDW) is a parameter that reflects the heterogeneity of erythrocyte... Read More about The relationship between red blood cell distribution width and metabolic syndrome in elderly Chinese: a cross-sectional study.

Association between platelet distribution width with serum uric acid in Chinese population (2019)
Journal Article
Liu, X., Wang, H., Huang, C., Meng, Z., Zhang, W., Li, Y., …Fan, Y. (2019). Association between platelet distribution width with serum uric acid in Chinese population. BioFactors, 45(3), 326-334. https://doi.org/10.1002/biof.1491

Platelet distribution width (PDW) is a simple and inexpensive parameter, which could predict activation of coagulation efficiently. And it has been confirmed to have a significant role in many diseases. We aimed to explore the association between PDW... Read More about Association between platelet distribution width with serum uric acid in Chinese population.

Agreement between breathlessness severity and unpleasantness in people with chronic breathlessness: A longitudinal clinical study (2019)
Journal Article
Ekström, M., Williams, M., Johnson, M. J., Huang, C., & Currow, D. C. (2019). Agreement between breathlessness severity and unpleasantness in people with chronic breathlessness: A longitudinal clinical study. Journal of pain and symptom management, 57(4), 715-723.e5. https://doi.org/10.1016/j.jpainsymman.2019.01.001

Context Chronic breathlessness is a cardinal symptom in cardiopulmonary disease where both overall intensity or severity (S) and unpleasantness (U) are commonly quantified. Objective We aimed to evaluate agreement between breathlessness severity... Read More about Agreement between breathlessness severity and unpleasantness in people with chronic breathlessness: A longitudinal clinical study.

Cardiovascular and musculoskeletal response to supervised exercise in patients with intermittent claudication (2018)
Journal Article
Harwood, A. E., Totty, J. P., Pymer, S., Huang, C., Hitchman, L., Carradice, D., …Chetter, I. C. (2019). Cardiovascular and musculoskeletal response to supervised exercise in patients with intermittent claudication. Journal of vascular surgery, 69(6), 1899-1908.e1. https://doi.org/10.1016/j.jvs.2018.10.065

Objective Intermittent claudication occurs in 20 % of the population over 70 and treatment includes a supervised exercise programme (SEP). Whilst there is evidence demonstrating walking improvements following a SEP there is conflicting data on the ph... Read More about Cardiovascular and musculoskeletal response to supervised exercise in patients with intermittent claudication.

A validation and calibration process for self-reported tobacco use with participants’ cotinine levels: an example from the Building Blocks trial (2018)
Journal Article
Huang, C., Roberts, Z., Cannings-John, R., Sanders, J., Pickett, K., Montgomery, A., & Robling, M. (in press). A validation and calibration process for self-reported tobacco use with participants’ cotinine levels: an example from the Building Blocks trial. Nicotine and Tobacco Research, doi:10.1093/ntr/nty232

Introduction: Reducing smoking in pregnancy was a primary outcome in our Building Blocks trial of the Family Nurse Partnership[1]. We calibrated maternal reports of smoking using cotinine values derived from urine samples to assess tobacco use [2]. T... Read More about A validation and calibration process for self-reported tobacco use with participants’ cotinine levels: an example from the Building Blocks trial.

A prospective, mixed-methods, before and after study to identify the evidence base for the core components of an effective Paediatric Early Warning System and the development of an implementation package containing those core recommendations for use in th (2018)
Journal Article
Thomas-Jones, E., Lloyd, A., Roland, D., Sefton, G., Tume, L., Hood, K., …Powell, C. (2018). A prospective, mixed-methods, before and after study to identify the evidence base for the core components of an effective Paediatric Early Warning System and the development of an implementation package containing those core recommendations for use in the UK: Paediatric early warning system – utilisation and mortality avoidance– the PUMA study protocol. BMC Pediatrics, 18, https://doi.org/10.1186/s12887-018-1210-z

Background In hospital, staff need to routinely monitor patients to identify those who are seriously ill, so that they receive timely treatment to improve their condition. A Paediatric Early Warning System is a multi-faceted socio-technical system t... Read More about A prospective, mixed-methods, before and after study to identify the evidence base for the core components of an effective Paediatric Early Warning System and the development of an implementation package containing those core recommendations for use in th.

Determinants of physiological uptake of 18F-fluorodeoxyglucose in palatine tonsils (2018)
Journal Article
Birkin, E., Moore, K. S., Huang, C., Christopher, M., Rees, J. I., Jayaprakasam, V., & Fielding, P. A. (2018). Determinants of physiological uptake of 18F-fluorodeoxyglucose in palatine tonsils. Medicine, 97(24), https://doi.org/10.1097/md.0000000000011040

To determine the extent of physiological variation of uptake of 18F-flurodeoxyglucose (FDG) within palatine tonsils. To define normal limits for side-to-side variation and characterize factors affecting tonsillar uptake of FDG. Over a period of 16... Read More about Determinants of physiological uptake of 18F-fluorodeoxyglucose in palatine tonsils.

The effectiveness of an intervention to reduce alcohol-related violence in premises licensed for the sale and on-site consumption of alcohol: a randomized controlled trial: All-Wales licensed premises intervention (2017)
Journal Article
Moore, S. C., Alam, M. F., Heikkinen, M., Hood, K., Huang, C., Moore, L., …Williams, A. (2017). The effectiveness of an intervention to reduce alcohol-related violence in premises licensed for the sale and on-site consumption of alcohol: a randomized controlled trial: All-Wales licensed premises intervention. Addiction, 112(11), 1898-1906. https://doi.org/10.1111/add.13878

Background and Aims Premises licensed for the sale and consumption of alcohol can contribute to levels of assault‐related injury through poor operational practices that, if addressed, could reduce violence. We tested the real‐world effectiveness of... Read More about The effectiveness of an intervention to reduce alcohol-related violence in premises licensed for the sale and on-site consumption of alcohol: a randomized controlled trial: All-Wales licensed premises intervention.

Ignorability for general longitudinal data (2017)
Journal Article
Farewell, D. M., Huang, C., & Didelez, V. (2017). Ignorability for general longitudinal data. Biometrika, 104(2), 317-326. https://doi.org/10.1093/biomet/asx020

Likelihood factors that can be disregarded for inference are termed ignorable. We demonstrate that close ties exist between ignorability and identification of causal effects by covariate adjustment. A graphical condition, stability, plays a role anal... Read More about Ignorability for general longitudinal data.

Oral and topical antibiotics for clinically infected eczema in children: A pragmatic randomized controlled trial in ambulatory care (2017)
Journal Article
Francis, N. A., Ridd, M. J., Thomas-Jones, E., Butler, C. C., Hood, K., Shepherd, V., …Sullivan, F. (2017). Oral and topical antibiotics for clinically infected eczema in children: A pragmatic randomized controlled trial in ambulatory care. Annals of Family Medicine, 15(2), 124-130. https://doi.org/10.1370/afm.2038

PURPOSE Eczema may flare because of bacterial infection, but evidence supporting antibiotic treatment is of low quality. We aimed to determine the effect of oral and topical antibiotics in addition to topical emollient and corticosteroids in children... Read More about Oral and topical antibiotics for clinically infected eczema in children: A pragmatic randomized controlled trial in ambulatory care.


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