All Outputs (109)

COVID-19: guidance on palliative care from a European Respiratory Society international task force (2020)
Journal Article
Janssen, D. J., Maddocks, M., Janssen, D. J. A., Ekström, M., Currow, D. C., Johnson, M. J., Maddocks, M., Simonds, A. K., Tonia, T., & Marsaa, K. (2020). COVID-19: guidance on palliative care from a European Respiratory Society international task force. European respiratory journal, 56(3), 2002583. https://doi.org/10.1183/13993003.02583-2020

Copyright ©ERS 2020. BACKGROUND: Many people are dying from coronavirus disease 2019 (COVID-19), but consensus guidance on palliative care in COVID-19 is lacking. This new life-threatening disease has put healthcare systems under pressure, with the i... Read More about COVID-19: guidance on palliative care from a European Respiratory Society international task force.

Letter in Response to Grobler AC, Lee K. Intention-To-Treat Analyses for Randomized Controlled Trials in Hospice/Palliative Care Enhanced by Principled Methods to Handle Missing Data (2020)
Journal Article
Huang, C., Kochovska, S., & Currow, D. C. (2020). Letter in Response to Grobler AC, Lee K. Intention-To-Treat Analyses for Randomized Controlled Trials in Hospice/Palliative Care Enhanced by Principled Methods to Handle Missing Data. Journal of pain and symptom management, 60(4), e30-e31. https://doi.org/10.1016/j.jpainsymman.2020.07.004

Opioids for breathlessness: a narrative review (2020)
Journal Article
Currow, D. C., Johnson, M. J., Pollack, A., Ferreira, D. H., Kochovska, S., Ekström, M., & Harrison, C. (2020). Opioids for breathlessness: a narrative review. BMJ Supportive & Palliative Care, 10(3), 287-295. https://doi.org/10.1136/bmjspcare-2020-002314

ABSTRACT
Chronic breathlessness is a disabling and distressing condition for which there is a growing evidence base for a range of interventions. Non-pharmacological interventions are the mainstay of management and should be optimised prior to use... Read More about Opioids for breathlessness: a narrative review.

Development of a core outcome set to use in the research and assessment of malignant bowel obstruction: protocol for the RAMBO study (2020)
Journal Article
Baddeley, E., Bravington, A., Johnson, M., Currow, D., Murtagh, F. E., Boland, E., Obita, G., Nelson, A., Seddon, K., Oliver, A., Noble, S., & Boland, J. (2020). Development of a core outcome set to use in the research and assessment of malignant bowel obstruction: protocol for the RAMBO study. BMJ open, 10(6), Article 039154. https://doi.org/10.1136/bmjopen-2020-039154

INTRODUCTION: Studies regarding the management of malignant bowel obstruction (MBO) report conflicting findings. This is partly due to different outcome measures being used to evaluate severity of MBO and the response to treatments. Furthermore, curr... Read More about Development of a core outcome set to use in the research and assessment of malignant bowel obstruction: protocol for the RAMBO study.

Patients’ and caregivers’ experiences of driving with chronic breathlessness before and after regular low-dose sustained-release morphine: A qualitative study (2020)
Journal Article
Ferreira, D. H., Boland, J. W., Kochovska, S., Honson, A., Phillips, J. L., & Currow, D. C. (2020). Patients’ and caregivers’ experiences of driving with chronic breathlessness before and after regular low-dose sustained-release morphine: A qualitative study. Palliative medicine, 34(8), 1078-1087. https://doi.org/10.1177/0269216320929549

Background:
Chronic breathlessness is a disabling syndrome that profoundly impacts patients’ and caregivers’ lives. Driving is important for most people, including those with advanced disease. Regular, low-dose, sustained-release morphine safely red... Read More about Patients’ and caregivers’ experiences of driving with chronic breathlessness before and after regular low-dose sustained-release morphine: A qualitative study.

Does the International Narcotics Control Board (INCB) sufficiently prioritise enablement of access to therapeutic opioids? A systematic critical analysis of six INCB annual reports, 1968-2018 (2020)
Journal Article
Clark, J. D., Johnson, M., Fabowale, B., Farrelly, M., & Currow, D. (in press). Does the International Narcotics Control Board (INCB) sufficiently prioritise enablement of access to therapeutic opioids? A systematic critical analysis of six INCB annual reports, 1968-2018. Journal of Global Health Reports, 4, Article e2020042

Background
The International Narcotics Control Board (INCB) has overseen international drug control since 1968 with the dual remit of restricting illicit production and use of controlled substances, whilst enabling access for clinical purposes. Two... Read More about Does the International Narcotics Control Board (INCB) sufficiently prioritise enablement of access to therapeutic opioids? A systematic critical analysis of six INCB annual reports, 1968-2018.

Quality of life changes with duration of chronic breathlessness: a random sample of community-dwelling people. (2020)
Journal Article
Currow, D. C., Chang, S., Grande, E. D., Ferreira, D. H., Kochovska, S., Kinchin PhD, I., Johnson, M. J., & Ekstrom, M. (2020). Quality of life changes with duration of chronic breathlessness: a random sample of community-dwelling people. Journal of pain and symptom management, https://doi.org/10.1016/j.jpainsymman.2020.05.015

Introduction
Chronic breathlessness is associated with poorer quality of life. This population study aimed to define dimensions of quality of life (QoL), and duration and dominant causes of breathlessness that most diminished QoL.

Methods
This... Read More about Quality of life changes with duration of chronic breathlessness: a random sample of community-dwelling people..

Breathlessness and opioid prescribing in COPD in general practice: a cross-sectional, observational study (2020)
Journal Article
Currow, D. C., Johnson, M. J., Pollack, A., Ferreira, D. H., Kochovska, S., Ekström, M., & Harrison, C. (2020). Breathlessness and opioid prescribing in COPD in general practice: a cross-sectional, observational study. ERJ Open Research, 6(2), Article 00299-2019. https://doi.org/10.1183/23120541.00299-2019

Chronic breathlessness is a disabling syndrome, prevalent in people with advanced chronic obstructive pulmonary disease (COPD). Regular, low-dose, oral sustained-release morphine is approved in Australia to reduce symptomatic chronic breathlessness.... Read More about Breathlessness and opioid prescribing in COPD in general practice: a cross-sectional, observational study.

A Dyadic Growth Modeling Approach for Examining Associations Between Weight Gain and Lung Function Decline (2020)
Journal Article
Cornelius, T., Schwartz, J. E., Balte, P., Bhatt, S. P., Cassano, P. A., Currow, D., Jacobs, D. R., Johnson, M., Kalhan, R., Kronmal, R., Loehr, L., O’Connor, G. T., Smith, B., White, W. B., Yende, S., & Oelsner, E. C. (2020). A Dyadic Growth Modeling Approach for Examining Associations Between Weight Gain and Lung Function Decline. American Journal of Epidemiology, 189(10), 1173-1184. https://doi.org/10.1093/aje/kwaa059

The relationship between body weight and lung function is complex. Using a dyadic multilevel linear modeling approach, treating body mass index (BMI; weight (kg)/height (m)2) and lung function as paired, within-person outcomes, we tested the hypothes... Read More about A Dyadic Growth Modeling Approach for Examining Associations Between Weight Gain and Lung Function Decline.

Managing the supportive care needs of those affected by COVID-19 (2020)
Journal Article
Bajwah, S., Wilcock, A., Towers, R., Costantini, M., Bausewein, C., Johnson, M. J., Simon, S. T., Bendstrup, E., Prentice, W., Johnson, M. J., Currow, D. C., Kreuter, M., Wells, A. U., Birring, S. S., Edmonds, P., & Higginson, I. J. (2020). Managing the supportive care needs of those affected by COVID-19. European respiratory journal, 55(4), Article 2000815. https://doi.org/10.1183/13993003.00815-2020

Randomised, double-blind, multicentre, mixed-methods, dose-escalation feasibility trial of mirtazapine for better treatment of severe breathlessness in advanced lung disease (BETTER-B feasibility) (2020)
Journal Article
Higginson, I., Wilcock, A., Johnson, M. J., Bajwah, S., Lovell, N., Yi, D., Hart, S., Crosby, V., Poad, H., Currow, D., Best, E., & Brown, S. (2020). Randomised, double-blind, multicentre, mixed-methods, dose-escalation feasibility trial of mirtazapine for better treatment of severe breathlessness in advanced lung disease (BETTER-B feasibility). Thorax, 75(2), 176-179. https://doi.org/10.1136/thoraxjnl-2019-213879

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. New treatments are required for severe breathlessness in advanced disease. We conducted a randomised feasibility trial of mirtazapine over 28 days in adults with... Read More about Randomised, double-blind, multicentre, mixed-methods, dose-escalation feasibility trial of mirtazapine for better treatment of severe breathlessness in advanced lung disease (BETTER-B feasibility).

Low agreement between mMRC rated by patients and clinicians: Implications for practice (2019)
Journal Article
Ekstrom, M., Chang, S., Johnson, M. J., Fazekas, B., Kochovska, S., Huang, C., & Currow, D. C. (2019). Low agreement between mMRC rated by patients and clinicians: Implications for practice. European respiratory journal, 54(6), Article 1901517. https://doi.org/10.1183/13993003.01517-2019

Intention-to-treat analyses for randomised controlled trials in hospice/palliative care: the case for analyses to be of people exposed to the intervention. (2019)
Journal Article
Kochovska, S., Huang, C., Johnson, M. J., Agar, M. R., Fallon, M. T., Kaasa, S., Hussain, J. A., Portenoy, R. K., Higginson, I. J., & Currow, D. C. (2020). Intention-to-treat analyses for randomised controlled trials in hospice/palliative care: the case for analyses to be of people exposed to the intervention. Journal of pain and symptom management, 59(3), 637-645. https://doi.org/10.1016/j.jpainsymman.2019.10.026

© 2019 American Academy of Hospice and Palliative Medicine Context: Minimizing bias in randomized controlled trials (RCTs) includes intention-to-treat analyses. Hospice/palliative care RCTs are constrained by high attrition unpredictable when consent... Read More about Intention-to-treat analyses for randomised controlled trials in hospice/palliative care: the case for analyses to be of people exposed to the intervention..

Breathlessness, anxiety, depression and function - the BAD-F study: a cross-sectional, population prevalence study in adults. (2019)
Journal Article
Kinchin, I., Currow, D. C., Chang, S., Reddel, H. K., Kochovska, S., Ferreira, D., Johnson, M., & Ekström, M. (2020). Breathlessness, anxiety, depression and function - the BAD-F study: a cross-sectional, population prevalence study in adults. Journal of pain and symptom management, 59(2), 197-205.e2. https://doi.org/10.1016/j.jpainsymman.2019.09.021

© 2019 American Academy of Hospice and Palliative Medicine Context: Breathlessness is associated with depression, but its relationship to anxiety or impaired function is less clear. Objectives: This study evaluated associations between chronic breath... Read More about Breathlessness, anxiety, depression and function - the BAD-F study: a cross-sectional, population prevalence study in adults..

Mental wellbeing in bereaved carers: A Health Survey for England population study (2019)
Journal Article
Hodiamont, F., Allgar, V., Currow, D. C., & Johnson, M. J. (in press). Mental wellbeing in bereaved carers: A Health Survey for England population study. BMJ Supportive & Palliative Care, https://doi.org/10.1136/bmjspcare-2019-001957

Objectives: The experience of caregiving may affect carers' well-being into bereavement. We explored associations between mental well-being and previous experience of bereavement of, and caring for, someone close at the end-of-life. Methods: An end-o... Read More about Mental wellbeing in bereaved carers: A Health Survey for England population study.

Palliative care for people living with heart failure: European Association for Palliative Care Task Force expert position statement (2019)
Journal Article
Sobanski, P. Z., Alt-Epping, B., Currow, D. C., Goodlin, S. J., Grodzicki, T., Hogg, K., Janssen, D. J. A., Johnson, M. J., Krajnik, M., Leget, C., Martínez-Sellés, M., Moroni, M., Mueller, P. S., Ryder, M., Simon, S. T., Stowe, E., & Larkin, P. J. (2020). Palliative care for people living with heart failure: European Association for Palliative Care Task Force expert position statement. Cardiovascular research, 116(1), 12-27. https://doi.org/10.1093/cvr/cvz200

© 2019 Published on behalf of the European Society of Cardiology. All rights reserved. Contrary to common perception, modern palliative care (PC) is applicable to all people with an incurable disease, not only cancer. PC is appropriate at every stage... Read More about Palliative care for people living with heart failure: European Association for Palliative Care Task Force expert position statement.

Oral modified release morphine for breathlessness in chronic heart failure: a randomized placebo-controlled trial (2019)
Journal Article
Johnson, M. J., Cockayne, S., Currow, D. C., Bell, K., Hicks, K., Fairhurst, C., Gabe, R., Torgerson, D., Jefferson, L., Oxberry, S., Ghosh, J., Hogg, K., Murphy, J., Allgar, V., Cleland, J., & Clark, A. (2019). Oral modified release morphine for breathlessness in chronic heart failure: a randomized placebo-controlled trial. ESC Heart Failure, 6(6), 1149-1160. https://doi.org/10.1002/ehf2.12498

© 2019 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology. Aims: Morphine is shown to relieve chronic breathlessness in chronic obstructive pulmonary disease. There are no definitive da... Read More about Oral modified release morphine for breathlessness in chronic heart failure: a randomized placebo-controlled trial.

Clustering of 27,525,663 death records from the United States based on health conditions associated with death: an example of big health data exploration (2019)
Journal Article
Janssen, D. J., Rechberger, S., Wouters, E. F., Schols, J. M., Johnson, M. J., Currow, D. C., Curtis, J. R., & Spruit, M. A. (2019). Clustering of 27,525,663 death records from the United States based on health conditions associated with death: an example of big health data exploration. Journal of Clinical Medicine, 8(7), Article 922. https://doi.org/10.3390/jcm8070922

Background: Insight into health conditions associated with death can inform healthcare policy. We aimed to cluster 27,525,663 deceased people based on the health conditions associated with death to study the associations between the health condition... Read More about Clustering of 27,525,663 death records from the United States based on health conditions associated with death: an example of big health data exploration.

Timely recognition of palliative care needs of patients with advanced chronic heart failure: a pilot study of a Dutch translation of the Needs Assessment Tool: Progressive Disease – Heart Failure (NAT:PD-HF) (2019)
Journal Article
Janssen, D. J., Boyne, J., Currow, D. C., Schols, J. M., Johnson, M. J., & La Rocca, H. P. (2019). Timely recognition of palliative care needs of patients with advanced chronic heart failure: a pilot study of a Dutch translation of the Needs Assessment Tool: Progressive Disease – Heart Failure (NAT:PD-HF). European journal of cardiovascular nursing : journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology, 18(5), 375-388. https://doi.org/10.1177/1474515119831510

© The European Society of Cardiology 2019. Background: The Needs Assessment Tool: Progressive Disease – Heart Failure (NAT:PD-HF) was developed to identify and triage palliative care needs in patients with chronic heart failure. A Dutch version is cu... Read More about Timely recognition of palliative care needs of patients with advanced chronic heart failure: a pilot study of a Dutch translation of the Needs Assessment Tool: Progressive Disease – Heart Failure (NAT:PD-HF).

Battery operated fan and chronic breathlessness: Does it help? (2019)
Journal Article
Barnes-Harris, M., Swan, F., Allgar, V., Booth, S., Currow, D., Hart, S., Phillips, J., & Johnson, M. J. (in press). Battery operated fan and chronic breathlessness: Does it help?. BMJ supportive & palliative care, https://doi.org/10.1136/bmjspcare-2018-001749

Objectives: To examine whether use of a hand-held fan (â € fan') improves breathlessness and increases physical activity. Methods: A secondary exploratory analysis using pooled data from the fan arms of two feasibility randomised controlled trials in... Read More about Battery operated fan and chronic breathlessness: Does it help?.