A Dyadic Growth Modeling Approach for Examining Associations Between Weight Gain and Lung Function Decline

Cornelius, Talea; Schwartz, Joseph E.; Balte, Pallavi; Bhatt, Surya P.; Cassano, Patricia A.; Currow, David; Jacobs, David R.; Johnson, Miriam; Kalhan, Ravi; Kronmal, Richard; Loehr, Laura; O’Connor, George T.; Smith, Benjamin; White, Wendy B.; Yende, Sachin; Oelsner, Elizabeth C.

Abstract

The relationship between body weight and lung function is complex. Using a dyadic multilevel linear modeling approach, treating body mass index (BMI; weight (kg)/height (m)2) and lung function as paired, within-person outcomes, we tested the hypothesis that persons with more rapid increase in BMI exhibit more rapid decline in lung function, as measured by forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and their ratio (FEV1:FVC). Models included random intercepts and slopes and adjusted for sociodemographic and smoking-related factors. A sample of 9,115 adults with paired measurements of BMI and lung function taken at ≥3 visits were selected from a pooled set of 5 US population-based cohort studies (1983-2018; mean age at baseline = 46 years; median follow-up, 19 years). At age 46 years, average annual rates of change in BMI, FEV1, FVC, and FEV1:FVC ratio were 0.22 kg/m2/year, -25.50 mL/year, -21.99 mL/year, and-0.24%/year, respectively. Persons with steeper BMI increases had faster declines in FEV1 (r=-0.16) and FVC (r=-0.26) and slower declines in FEV1:FVC ratio (r=0.11) (all Pvalues

Citation

Cornelius, T., Schwartz, J. E., Balte, P., Bhatt, S. P., Cassano, P. A., Currow, D., Jacobs, D. R., Johnson, M., Kalhan, R., Kronmal, R., Loehr, L., O’Connor, G. T., Smith, B., White, W. B., Yende, S., & Oelsner, E. C. (2020). A Dyadic Growth Modeling Approach for Examining Associations Between Weight Gain and Lung Function Decline. American Journal of Epidemiology, 189(10), 1173-1184. https://doi.org/10.1093/aje/kwaa059

• Journal Article Type: Article
• Acceptance Date: Apr 10, 2020
• Online Publication Date: Apr 14, 2020
• Publication Date: Oct 1, 2020
• Deposit Date: Apr 1, 2020
• Publicly Available Date: Apr 15, 2021
• Journal: American journal of epidemiology
• Print ISSN: 0002-9262
• Electronic ISSN: 1476-6256
• Publisher: Oxford University Press (OUP)
• Peer Reviewed: Peer Reviewed
• Volume: 189
• Issue: 10
• Article Number: kwaa059
• Pages: 1173-1184
• DOI: https://doi.org/10.1093/aje/kwaa059
• Keywords: (3-8): BMI; Cohort studies; COPD; Dyadic models; Longitudinal; Lung function; Obesity; Spirometry
• Public URL: https://hull-repository.worktribe.com/output/3486571
• Publisher URL: https://academic.oup.com/aje/advance-article-abstract/doi/10.1093/aje/kwaa059/5819837?redirectedFrom=fulltext