All Outputs (107)

ROMANA 3: a phase 3 safety extension study of anamorelin in advanced non-small-cell lung cancer (NSCLC) patients with cachexia (2017)
Journal Article
Currow, D., Temel, J. S., Abernethy, A., Milanowski, J., Friend, J., & Fearon, K. C. (2017). ROMANA 3: a phase 3 safety extension study of anamorelin in advanced non-small-cell lung cancer (NSCLC) patients with cachexia. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO, 28(8), 1949-1956. https://doi.org/10.1093/annonc/mdx192

© The Author 2017. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. Background: Cancer anorexia-cachexia is a debilitating condition frequently observed in NSCLC patients, characterized... Read More about ROMANA 3: a phase 3 safety extension study of anamorelin in advanced non-small-cell lung cancer (NSCLC) patients with cachexia.

A pragmatic, phase III, multisite, double-blind, placebo-controlled, parallel-arm, dose increment randomised trial of regular, low-dose extended-release morphine for chronic breathlessness: Breathlessness, Exertion And Morphine Sulfate (BEAMS) study protocol (2017)
Journal Article
Currow, D., Watts, G. J., Johnson, M., McDonald, C. F., Miners, J. O., Somogyi, A. A., Denehy, L., McCaffrey, N., Eckert, D. J., McCloud, P., Louw, S., Lam, L., Greene, A., Fazekas, B., Clark, K. C., Fong, K., Agar, M. R., Joshi, R., Kilbreath, S., Ferreira, D., & Ekström, M. (2017). A pragmatic, phase III, multisite, double-blind, placebo-controlled, parallel-arm, dose increment randomised trial of regular, low-dose extended-release morphine for chronic breathlessness: Breathlessness, Exertion And Morphine Sulfate (BEAMS) study protocol. BMJ open, 7(7), 1-18. https://doi.org/10.1136/bmjopen-2017-018100

© Article author(s). Introduction Chronic breathlessness is highly prevalent and distressing to patients and families. No medication is registered for its symptomatic reduction. The strongest evidence is for regular, low-dose, extended-release (ER) o... Read More about A pragmatic, phase III, multisite, double-blind, placebo-controlled, parallel-arm, dose increment randomised trial of regular, low-dose extended-release morphine for chronic breathlessness: Breathlessness, Exertion And Morphine Sulfate (BEAMS) study protocol.

The complex relationship between household income of family caregivers, access to palliative care services and place of death: A national household population survey (2017)
Journal Article
Chen, H., Currow, D. C., Dunn, L., Johnson, M. J., Macleod, U., & Allgar, V. (2018). The complex relationship between household income of family caregivers, access to palliative care services and place of death: A national household population survey. Palliative medicine, 32(2), 357-365. https://doi.org/10.1177/0269216317711825

Background: Previous work shows that more affluent patients with cancer are more likely to die at home, whereas those dying from non-cancer conditions are more likely to die in hospital. Family caregivers are an important factor in determining place... Read More about The complex relationship between household income of family caregivers, access to palliative care services and place of death: A national household population survey.

Effect of opioids and benzodiazepines on clinical outcomes in patients receiving palliative care: an exploratory analysis (2017)
Journal Article
Boland, J. W., Allgar, V., Boland, E. G., Oviasu, O., Agar, M., Currow, D. C., & Johnson, M. J. (2017). Effect of opioids and benzodiazepines on clinical outcomes in patients receiving palliative care: an exploratory analysis. Journal of palliative medicine, 20(11), 1274-1279. https://doi.org/10.1089/jpm.2017.0129

Background: Medications for symptom management in palliative care have associated, but poorly understood, harms. Drug-related harms have important clinical implications, may impact on patients’ compliance and contribute to symptoms. Objective: To exp... Read More about Effect of opioids and benzodiazepines on clinical outcomes in patients receiving palliative care: an exploratory analysis.

Quality of missing data reporting and handling in palliative care trials demonstrates that further development of the CONSORT statement is required : a systematic review (2017)
Journal Article
Hussain, J. A., Johnson, M. J., Currow, D. C., White, I. R., Currow, D., Hussain, J., Johnson, M., Bland, M., Langan, D., & White, I. (2017). Quality of missing data reporting and handling in palliative care trials demonstrates that further development of the CONSORT statement is required : a systematic review. Journal of clinical epidemiology, 88, 81-91. https://doi.org/10.1016/j.jclinepi.2017.05.009

Objectives Assess (i) the quality of reporting and handling of missing data (MD) in palliative care trials, (ii) whether there are differences in the reporting of criteria specified by the Consolidated Standards of Reporting Trials (CONSORT) 2010 sta... Read More about Quality of missing data reporting and handling in palliative care trials demonstrates that further development of the CONSORT statement is required : a systematic review.

Towards an expert consensus to delineate a clinical syndrome of chronic breathlessness (2017)
Journal Article
Johnson, M. J., Yorke, J., Hansen-Flaschen, J., Lansing, R., Ekström, M., Similowski, T., & Currow, D. (2017). Towards an expert consensus to delineate a clinical syndrome of chronic breathlessness. European respiratory journal, 49(5), Article 1602277. https://doi.org/10.1183/13993003.02277-2016

Copyright ©ERS 2017. Breathlessness that persists despite treatment for the underlying conditions is debilitating. Identifying this discrete entity as a clinical syndrome should raise awareness amongst patients, clinicians, service providers, researc... Read More about Towards an expert consensus to delineate a clinical syndrome of chronic breathlessness.

Chronic breathlessness associated with poorer physical and mental health-related quality of life (SF-12) across all adult age groups (2017)
Journal Article
Currow, D. C., Johnson, M. J., Dal Grande, E., Ekström, M., Ferreira, D., & McCaffrey, N. (2017). Chronic breathlessness associated with poorer physical and mental health-related quality of life (SF-12) across all adult age groups. Thorax, 72(12), 1151-1153. https://doi.org/10.1136/thoraxjnl-2016-209908

© 2017 Published by the BMJ Publishing Group Limited. Little is known about the impact of chronic breathlessness (modified Medical Research Council (mMRC) score ≥2 for most days, at least three of the last six months) on health-related quality of lif... Read More about Chronic breathlessness associated with poorer physical and mental health-related quality of life (SF-12) across all adult age groups.

Non-opioid medications for the relief of chronic breathlessness: current evidence (2017)
Journal Article
Barbetta, C., Currow, D. C., & Johnson, M. J. (2017). Non-opioid medications for the relief of chronic breathlessness: current evidence. Expert Review of Respiratory Medicine, 11(4), 333-341. https://doi.org/10.1080/17476348.2017.1305896

Introduction: To evaluate systematically randomised clinical trials investigating non-opioid medications for the management and treatment of chronic breathlessness. Areas covered: The evidence for the role of benzodiazepines, anxiolytics, selective s... Read More about Non-opioid medications for the relief of chronic breathlessness: current evidence.

Efficacy of oral risperidone, haloperidol, or placebo for symptoms of delirium among patients in palliative care: A randomized clinical trial (2017)
Journal Article
Agar, M. R., Lawlor, P. G., Quinn, S., Draper, B., Caplan, G. A., Rowett, D., Sanderson, C., Hardy, J., Le, B., Eckermann, S., McCaffrey, N., Devilee, L., Fazekas, B., Hill, M., & Currow, D. C. (2017). Efficacy of oral risperidone, haloperidol, or placebo for symptoms of delirium among patients in palliative care: A randomized clinical trial. JAMA Internal Medicine, 177(1), 34-42. https://doi.org/10.1001/jamainternmed.2016.7491

IMPORTANCE Antipsychotics are widely used for distressing symptoms of delirium, but efficacy has not been established in placebo-controlled trials in palliative care. OBJECTIVE To determine efficacy of risperidone or haloperidol relative to placebo i... Read More about Efficacy of oral risperidone, haloperidol, or placebo for symptoms of delirium among patients in palliative care: A randomized clinical trial.

Oxygen for breathlessness in patients with chronic obstructive pulmonary disease who do not qualify for home oxygen therapy (2016)
Journal Article
Ekström, M., Ahmadi, Z., Bornefalk-Hermansson, A., Abernethy, A., & Currow, D. (2016). Oxygen for breathlessness in patients with chronic obstructive pulmonary disease who do not qualify for home oxygen therapy. The Cochrane database of systematic reviews, 2016(11), https://doi.org/10.1002/14651858.CD006429.pub3

© 2016 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. Background: Breathlessness is a cardinal symptom of chronic obstructive pulmonary disease (COPD). Long-term oxygen therapy (LTOT) is given to improve survival time in people wi... Read More about Oxygen for breathlessness in patients with chronic obstructive pulmonary disease who do not qualify for home oxygen therapy.

Somatostatin analogues compared to placebo and other pharmacological agents in the management of symptoms of inoperable malignant bowel obstruction: a systematic review (2016)
Journal Article
Obita, G. P., Boland, E. G., Currow, D. C., Johnson, M. J., & Boland, J. W. (2016). Somatostatin analogues compared to placebo and other pharmacological agents in the management of symptoms of inoperable malignant bowel obstruction: a systematic review. Journal of pain and symptom management, 52(6), 901-919. https://doi.org/10.1016/j.jpainsymman.2016.05.032

Context Somatostatin analogues are commonly used to relieve symptoms in malignant bowel obstruction (MBO) but are more expensive than other antisecretory agents. Objectives To evaluate the evidence of effectiveness of somatostatin analogues compared... Read More about Somatostatin analogues compared to placebo and other pharmacological agents in the management of symptoms of inoperable malignant bowel obstruction: a systematic review.

Missing data in randomized controlled trials testing palliative interventions pose a significant risk of bias and loss of power: a systematic review and meta-analyses (2016)
Journal Article
Hussain, J. A., White, I. R., Langan, D., Johnson, M. J., Currow, D. C., Torgerson, D. J., & Bland, M. (2016). Missing data in randomized controlled trials testing palliative interventions pose a significant risk of bias and loss of power: a systematic review and meta-analyses. Journal of clinical epidemiology, 74, 57-65. https://doi.org/10.1016/j.jclinepi.2015.12.003

Objectives To assess the risk posed by missing data (MD) to the power and validity of trials evaluating palliative interventions. Study Design and Setting A systematic review of MD in published randomized controlled trials (RCTs) of palliative interv... Read More about Missing data in randomized controlled trials testing palliative interventions pose a significant risk of bias and loss of power: a systematic review and meta-analyses.

Content and quality of websites supporting self-management of chronic breathlessness in advanced illness: a systematic review (2016)
Journal Article
Luckett, T., Disler, R., Hosie, A., Johnson, M., Davidson, P., Currow, D., Sumah, A., & Phillips, J. (2016). Content and quality of websites supporting self-management of chronic breathlessness in advanced illness: a systematic review. NPJ Primary Care Respiratory Medicine, 26(1), Article ARTN 16025. https://doi.org/10.1038/npjpcrm.2016.25

Chronic breathlessness is a common, burdensome and distressing symptom in many advanced chronic illnesses. Self-management strategies are essential to optimise treatment, daily functioning and emotional coping. People with chronic illness commonly se... Read More about Content and quality of websites supporting self-management of chronic breathlessness in advanced illness: a systematic review.

Anamorelin in patients with non-small-cell lung cancer and cachexia (ROMANA 1 and ROMANA 2): results from two randomised, double-blind, phase 3 trials (2016)
Journal Article
Temel, J. S., Abernethy, A. P., Currow, D. C., Friend, J., Duus, E. M., Yan, Y., & Fearon, K. C. (2016). Anamorelin in patients with non-small-cell lung cancer and cachexia (ROMANA 1 and ROMANA 2): results from two randomised, double-blind, phase 3 trials. The lancet oncology, 17(4), 519-531. https://doi.org/10.1016/S1470-2045%2815%2900558-6

© 2016 Elsevier Ltd Background Patients with advanced cancer frequently experience anorexia and cachexia, which are associated with reduced food intake, altered body composition, and decreased functionality. We assessed anamorelin, a novel ghrelin-re... Read More about Anamorelin in patients with non-small-cell lung cancer and cachexia (ROMANA 1 and ROMANA 2): results from two randomised, double-blind, phase 3 trials.

A mixed-methods, randomized controlled, feasibility trial to inform the design of a phase 3 trial to test the effect of the hand-held fan on physical activity and carer anxiety in patients with refractory breathlessness (2016)
Journal Article
Johnson, M. J., Booth, S., Currow, D. C., Lam, L. T., & Phillips, J. L. (2016). A mixed-methods, randomized controlled, feasibility trial to inform the design of a phase 3 trial to test the effect of the hand-held fan on physical activity and carer anxiety in patients with refractory breathlessness. Journal of pain and symptom management, 51(5), 807-815. https://doi.org/10.1016/j.jpainsymman.2015.11.026

Context The handheld fan is an inexpensive and safe way to provide facial airflow, which may reduce the sensation of chronic refractory breathlessness, a frequently encountered symptom. Objectives To test the feasibility of developing an adequately p... Read More about A mixed-methods, randomized controlled, feasibility trial to inform the design of a phase 3 trial to test the effect of the hand-held fan on physical activity and carer anxiety in patients with refractory breathlessness.

The adaptation, face, and content validation of a needs assessment tool: progressive disease for people with interstitial lung disease (2016)
Journal Article
Boland, J. W., Reigada, C., Yorke, J., Hart, S. P., Bajwah, S., Ross, J., Wells, A., Papadopoulos, A., Currow, D. C., Grande, G., Macleod, U., & Johnson, M. J. (2016). The adaptation, face, and content validation of a needs assessment tool: progressive disease for people with interstitial lung disease. Journal of palliative medicine, 19(5), 549-555. https://doi.org/10.1089/jpm.2015.0355

Background: Irrreversible interstitial lung disease (ILD) is associated with high morbidity and mortality. Palliative care needs of patients and caregivers are not routinely assessed; there is no tool to identify needs and triage support in clinical... Read More about The adaptation, face, and content validation of a needs assessment tool: progressive disease for people with interstitial lung disease.

Family caregivers who would be unwilling to provide care at the end of life again: findings from the Health Survey for England population survey (2016)
Journal Article
Johnson, M. J., Allgar, V., Macleod, U., Jones, A., Oliver, S., & Currow, D. (2016). Family caregivers who would be unwilling to provide care at the end of life again: findings from the Health Survey for England population survey. PLoS ONE, 11(1), e0146960. https://doi.org/10.1371/journal.pone.0146960

Background Family caregivers provide significant care at the end of life. We aimed to describe caregiver characteristics, and of those unwilling to repeat this role under the same circumstances. Methods Observational study of adults in private househ... Read More about Family caregivers who would be unwilling to provide care at the end of life again: findings from the Health Survey for England population survey.

Breathlessness in the elderly during the last year of life sufficient to restrict activity (2016)
Journal Article
Johnson, M. J., Bland, J. M., Gahbauer, E. A., Ekström, M., Sinnarajah, A., Gill, T. M., & Currow, D. (2016). Breathlessness in the elderly during the last year of life sufficient to restrict activity. Journal of the American Geriatrics Society, 64(1), 73-80. https://doi.org/10.1111/jgs.13865

OBJECTIVES: Breathlessness is prevalent in older people. Symptom control at the end of life is important. This study investigated relationships between age, clinical characteristics and breathlessness sufficient to have people spend at least one half... Read More about Breathlessness in the elderly during the last year of life sufficient to restrict activity.

Effects of low dose morphine on perceived sleep quality in patients with refractory breathlessness : a hypothesis generating study (2015)
Journal Article
Martins, R. T., Currow, D., Abernethy, A. P., Johnson, M. J., Toson, B., & Eckert, D. J. (2016). Effects of low dose morphine on perceived sleep quality in patients with refractory breathlessness : a hypothesis generating study. Respirology : official journal of the Asian Pacific Society of Respirology, 21(2), 386-391. https://doi.org/10.1111/resp.12681

© 2015 Asian Pacific Society of Respirology. Background and objective The management of chronic refractory breathlessness is one of the indications for regular low-dose (≤30 mg/24 h) oral sustained release morphine. Morphine may disrupt sleep in some... Read More about Effects of low dose morphine on perceived sleep quality in patients with refractory breathlessness : a hypothesis generating study.

Blinded patient preference for morphine compared to placebo in the setting of chronic refractory breathlessness – an exploratory study (2015)
Journal Article
Ferreira, D. H., Silva, J. P., Quinn, S., Abernethy, A. P., Johnson, M. J., Oxberry, S. G., & Currow, D. C. (2016). Blinded patient preference for morphine compared to placebo in the setting of chronic refractory breathlessness – an exploratory study. Journal of pain and symptom management, 51(2), 247-254. https://doi.org/10.1016/j.jpainsymman.2015.10.005

Context Patients’ preference for morphine therapy has received little attention in the setting of chronic refractory breathlessness. However, this is one important factor in considering longer term therapy. Objectives The aim of this secondary analys... Read More about Blinded patient preference for morphine compared to placebo in the setting of chronic refractory breathlessness – an exploratory study.