All Outputs (294)

The longitudinal associations between ambient air pollution exposure and dementia in the UK: results from the cognitive function and ageing study II and Wales (2024)
Journal Article
Wu, Y. T., Kitwiroon, N., Beevers, S., Barratt, B., Brayne, C., Cerin, E., …Matthews, F. (2024). The longitudinal associations between ambient air pollution exposure and dementia in the UK: results from the cognitive function and ageing study II and Wales. BMC public health, 24(1), Article 1233. https://doi.org/10.1186/s12889-024-18723-3

Background: Air pollution has been recognised as a potential risk factor for dementia. Yet recent epidemiological research shows mixed evidence. The aim of this study is to investigate the longitudinal associations between ambient air pollution expos... Read More about The longitudinal associations between ambient air pollution exposure and dementia in the UK: results from the cognitive function and ageing study II and Wales.

Associations between multimorbidity and neuropathology in dementia: Consideration of functional cognitive disorders, psychiatric illness and dementia mimics (2024)
Journal Article
Hamilton, C. A., Matthews, F. E., Attems, J., Donaghy, P. C., Erskine, D., Taylor, J. P., & Thomas, A. J. (2024). Associations between multimorbidity and neuropathology in dementia: Consideration of functional cognitive disorders, psychiatric illness and dementia mimics. British Journal of Psychiatry, 224(6), 237-244. https://doi.org/10.1192/bjp.2024.25

Background Multimorbidity, the presence of two or more health conditions, has been identified as a possible risk factor for clinical dementia. It is unclear whether this is due to worsening brain health and underlying neuropathology, or other factors... Read More about Associations between multimorbidity and neuropathology in dementia: Consideration of functional cognitive disorders, psychiatric illness and dementia mimics.

The Microglial Transcriptome of Age-Associated Deep Subcortical White Matter Lesions Suggests a Neuroprotective Response to Blood–Brain Barrier Dysfunction (2024)
Journal Article
Almansouri, T., Waller, R., Wharton, S. B., Heath, P. R., Matthews, F. E., Brayne, C., …Simpson, J. E. (2024). The Microglial Transcriptome of Age-Associated Deep Subcortical White Matter Lesions Suggests a Neuroprotective Response to Blood–Brain Barrier Dysfunction. International Journal of Molecular Sciences, 25(8), Article 4445. https://doi.org/10.3390/ijms25084445

Age-associated deep-subcortical white matter lesions (DSCLs) are an independent risk factor for dementia, displaying high levels of CD68+ microglia. This study aimed to characterize the transcriptomic profile of microglia in DSCLs and surrounding rad... Read More about The Microglial Transcriptome of Age-Associated Deep Subcortical White Matter Lesions Suggests a Neuroprotective Response to Blood–Brain Barrier Dysfunction.

Health conditions in spousal caregivers of people with dementia and their relationships with stress, caregiving experiences, and social networks: longitudinal findings from the IDEAL programme (2024)
Journal Article
Sabatini, S., Martyr, A., Hunt, A., Gamble, L. D., Matthews, F. E., Thom, J. M., …Clare, L. (2024). Health conditions in spousal caregivers of people with dementia and their relationships with stress, caregiving experiences, and social networks: longitudinal findings from the IDEAL programme. BMC Geriatrics, 24(1), Article 171. https://doi.org/10.1186/s12877-024-04707-w

Objectives: Longitudinal evidence documenting health conditions in spousal caregivers of people with dementia and whether these influence caregivers’ outcomes is scarce. This study explores type and number of health conditions over two years in careg... Read More about Health conditions in spousal caregivers of people with dementia and their relationships with stress, caregiving experiences, and social networks: longitudinal findings from the IDEAL programme.

Comorbid health conditions and their impact on social isolation, loneliness, quality of life, and well-being in people with dementia: longitudinal findings from the IDEAL programme (2024)
Journal Article
Sabatini, S., Martyr, A., Hunt, A., Gamble, L. D., Matthews, F. E., Thom, J. M., …Clare, L. (2024). Comorbid health conditions and their impact on social isolation, loneliness, quality of life, and well-being in people with dementia: longitudinal findings from the IDEAL programme. BMC Geriatrics, 24(1), Article 23. https://doi.org/10.1186/s12877-023-04601-x

Background: Most people with dementia have multiple health conditions. This study explores (1) number and type of health condition(s) in people with dementia overall and in relation to age, sex, dementia type, and cognition; (2) change in number of h... Read More about Comorbid health conditions and their impact on social isolation, loneliness, quality of life, and well-being in people with dementia: longitudinal findings from the IDEAL programme.

Living well with dementia: An exploratory matched analysis of minority ethnic and white people with dementia and carers participating in the IDEAL programme (2024)
Journal Article
Victor, C. R., Gamble, L. D., Pentecost, C., Quinn, C., Charlwood, C., Matthews, F. E., & Clare, L. (2024). Living well with dementia: An exploratory matched analysis of minority ethnic and white people with dementia and carers participating in the IDEAL programme. International journal of geriatric psychiatry, 39(1), Article e6048. https://doi.org/10.1002/gps.6048

Objectives: The increasing heterogeneity of the population of older people is reflected in an increasing number of people with dementia and carers drawn from minority ethnic groups. Data from the IDEAL study are used to compare indices of ‘living wel... Read More about Living well with dementia: An exploratory matched analysis of minority ethnic and white people with dementia and carers participating in the IDEAL programme.

Dyadic perspectives on loneliness and social isolation among people with dementia and spousal carers: findings from the IDEAL programme (2023)
Journal Article
Rippon, I., Victor, C. R., Martyr, A., Matthews, F. E., Quinn, C., Rusted, J. M., …Clare, L. (in press). Dyadic perspectives on loneliness and social isolation among people with dementia and spousal carers: findings from the IDEAL programme. Aging and Mental Health, 1-9. https://doi.org/10.1080/13607863.2023.2286618

Objectives: This study aims to investigate the impact of self and partner experiences of loneliness and social isolation on life satisfaction in people with dementia and their spousal carers. Methods: We used data from 1042 dementia caregiving dyads... Read More about Dyadic perspectives on loneliness and social isolation among people with dementia and spousal carers: findings from the IDEAL programme.

Study protocol for development and validation of a single tool to assess risks of stroke, diabetes mellitus, myocardial infarction and dementia: DemNCD-Risk (2023)
Journal Article
Kootar, S., Huque, M. H., Kiely, K. M., Anderson, C. S., Jorm, L., Kivipelto, M., …Anstey, K. J. (2023). Study protocol for development and validation of a single tool to assess risks of stroke, diabetes mellitus, myocardial infarction and dementia: DemNCD-Risk. BMJ open, 13(9), Article e076860. https://doi.org/10.1136/bmjopen-2023-076860

Introduction Current efforts to reduce dementia focus on prevention and risk reduction by targeting modifiable risk factors. As dementia and cardiometabolic non-communicable diseases (NCDs) share risk factors, a single risk-estimating tool for dement... Read More about Study protocol for development and validation of a single tool to assess risks of stroke, diabetes mellitus, myocardial infarction and dementia: DemNCD-Risk.

Trajectories of cognitive and perceived functional decline in people with dementia: Findings from the IDEAL programme (2023)
Journal Article
Martyr, A., Ravi, M., Gamble, L. D., Morris, R. G., Rusted, J. M., Pentecost, C., …Clare, L. (2024). Trajectories of cognitive and perceived functional decline in people with dementia: Findings from the IDEAL programme. Alzheimer's & dementia, 20(1), 410-420. https://doi.org/10.1002/alz.13448

INTRODUCTION: Impaired cognition and instrumental activities of daily living (iADL) are key diagnostic features of dementia; however, few studies have compared trajectories of cognition and iADL. METHODS: Participants from the IDEAL study comprised 1... Read More about Trajectories of cognitive and perceived functional decline in people with dementia: Findings from the IDEAL programme.

Predicting cognitive decline using neuropsychiatric symptoms in prodromal Lewy body dementia: A longitudinal study (2023)
Journal Article
Wright, L. M., Donaghy, P. C., Burn, D. J., Taylor, J. P., O'Brien, J. T., Yarnall, A. J., …Lawson, R. A. (2023). Predicting cognitive decline using neuropsychiatric symptoms in prodromal Lewy body dementia: A longitudinal study. Parkinsonism and Related Disorders, 113, Article 105762. https://doi.org/10.1016/j.parkreldis.2023.105762

Introduction: Neuropsychiatric symptoms (NPS) in Lewy body dementias (LBD) occur frequently and early in disease progression. Such symptoms are associated with worse quality of life, caregiver burden and functional limitations. Limited evidence exist... Read More about Predicting cognitive decline using neuropsychiatric symptoms in prodromal Lewy body dementia: A longitudinal study.

Poorer White Matter Microstructure Predicts Slower and More Variable Reaction Time Performance: Evidence for a Neural Noise Hypothesis in a Large Lifespan Cohort (2023)
Journal Article
McCormick, E. M., Kievit, R. A., Tyler, L. K., Brayne, C., Bullmore, E. T., Calder, A. C., …Knights, E. (2023). Poorer White Matter Microstructure Predicts Slower and More Variable Reaction Time Performance: Evidence for a Neural Noise Hypothesis in a Large Lifespan Cohort. Journal of Neuroscience, 43(19), 3557-3566. https://doi.org/10.1523/JNEUROSCI.1042-22.2023

Most prior research has focused on characterizing averages in cognition, brain characteristics, or behavior, and attempting to predict differences in these averages among individuals. However, this overwhelming focus on mean levels may leave us with... Read More about Poorer White Matter Microstructure Predicts Slower and More Variable Reaction Time Performance: Evidence for a Neural Noise Hypothesis in a Large Lifespan Cohort.

Are there socioeconomic inequalities in polypharmacy among older people? A systematic review and meta-analysis (2023)
Journal Article
Iqbal, A., Richardson, C., Iqbal, Z., O’Keefe, H., Hanratty, B., Matthews, F. E., & Todd, A. (2023). Are there socioeconomic inequalities in polypharmacy among older people? A systematic review and meta-analysis. BMC Geriatrics, 23(1), Article 149. https://doi.org/10.1186/s12877-023-03835-z

Background: Socioeconomic status (SES) may influence prescribing, concordance and adherence to medication regimens. This review set out to investigate the association between polypharmacy and an individual’s socioeconomic status. Methods: A systemati... Read More about Are there socioeconomic inequalities in polypharmacy among older people? A systematic review and meta-analysis.

Assessment of Alzheimer-related pathologies of dementia using machine learning feature selection (2023)
Journal Article
Rajab, M. D., Jammeh, E., Taketa, T., Brayne, C., Matthews, F. E., Su, L., …Wang, D. (2023). Assessment of Alzheimer-related pathologies of dementia using machine learning feature selection. Alzheimer's Research and Therapy, 15(1), Article 47. https://doi.org/10.1186/s13195-023-01195-9

Although a variety of brain lesions may contribute to the pathological assessment of dementia, the relationship of these lesions to dementia, how they interact and how to quantify them remains uncertain. Systematically assessing neuropathological mea... Read More about Assessment of Alzheimer-related pathologies of dementia using machine learning feature selection.

The prevalence, correlation, and co-occurrence of neuropathology in old age: harmonisation of 12 measures across six community-based autopsy studies of dementia (2023)
Journal Article
Nichols, E., Merrick, R., Hay, S. I., Himali, D., Himali, J. J., Hunter, S., …Vos, T. (2023). The prevalence, correlation, and co-occurrence of neuropathology in old age: harmonisation of 12 measures across six community-based autopsy studies of dementia. The Lancet Healthy Longevity, 4(3), e115-e125. https://doi.org/10.1016/S2666-7568%2823%2900019-3

Background: Population-based autopsy studies provide valuable insights into the causes of dementia but are limited by sample size and restriction to specific populations. Harmonisation across studies increases statistical power and allows meaningful... Read More about The prevalence, correlation, and co-occurrence of neuropathology in old age: harmonisation of 12 measures across six community-based autopsy studies of dementia.

Household wealth, neighbourhood deprivation and frailty amongst middle-aged and older adults in England: a longitudinal analysis over 15 years (2002-2017) (2023)
Journal Article
Maharani, A., Sinclair, D. R., Chandola, T., Bower, P., Clegg, A., Hanratty, B., …Matthews, F. E. (2023). Household wealth, neighbourhood deprivation and frailty amongst middle-aged and older adults in England: a longitudinal analysis over 15 years (2002-2017). Age and ageing, 52(3), Article afad034. https://doi.org/10.1093/ageing/afad034

Background: frailty is a condition of reduced function and health due to ageing processes and is associated with a higher risk of falls, hospitalisation, disability and mortality. Objective: to determine the relationship between household wealth and... Read More about Household wealth, neighbourhood deprivation and frailty amongst middle-aged and older adults in England: a longitudinal analysis over 15 years (2002-2017).

Distinct components of cardiovascular health are linked with age-related differences in cognitive abilities (2023)
Journal Article
King, D. L., Henson, R. N., Kievit, R., Wolpe, N., Brayne, C., Tyler, L. K., …Tsvetanov, K. A. (2023). Distinct components of cardiovascular health are linked with age-related differences in cognitive abilities. Scientific reports, 13(1), Article 978. https://doi.org/10.1038/s41598-022-27252-1

Cardiovascular ageing contributes to cognitive impairment. However, the unique and synergistic contributions of multiple cardiovascular factors to cognitive function remain unclear because they are often condensed into a single composite score or exa... Read More about Distinct components of cardiovascular health are linked with age-related differences in cognitive abilities.

Are profiles of social, cultural, and economic capital related to living well with dementia? Longitudinal findings from the IDEAL programme (2022)
Journal Article
Sabatini, S., Martyr, A., Gamble, L. D., Jones, I. R., Collins, R., Matthews, F. E., …Clare, L. (2023). Are profiles of social, cultural, and economic capital related to living well with dementia? Longitudinal findings from the IDEAL programme. Social science & medicine, 317, Article 115603. https://doi.org/10.1016/j.socscimed.2022.115603

Rationale: Research exploring social, cultural, and economic capital among people with dementia is scarce. Objective: We describe levels of social, cultural, and economic capital in people with dementia at baseline and levels of social and cultural c... Read More about Are profiles of social, cultural, and economic capital related to living well with dementia? Longitudinal findings from the IDEAL programme.

Autism incidence and spatial analysis in more than 7 million pupils in English schools: a retrospective, longitudinal, school registry study (2022)
Journal Article
Roman-Urrestarazu, A., Yang, J. C., van Kessel, R., Warrier, V., Dumas, G., Jongsma, H., …Brayne, C. (2022). Autism incidence and spatial analysis in more than 7 million pupils in English schools: a retrospective, longitudinal, school registry study. The Lancet Child & Adolescent Health, 6(12), 857-868. https://doi.org/10.1016/S2352-4642%2822%2900247-4

Background: Understanding how certain factors affect autism incidence can help to identify inequities in diagnostic access. We aimed to investigate the incidence of autism in England as a function of geography and sociodemographics, examining spatial... Read More about Autism incidence and spatial analysis in more than 7 million pupils in English schools: a retrospective, longitudinal, school registry study.

Impact of COVID-19 policies on perceptions of loneliness in people aged 75 years and over in the cognitive function and aging study (CFAS II) (2022)
Journal Article
Richardson, C. D., Roscoe, H., Green, E., Brooks, R., Barnes, L., Matthews, F. E., & Brayne, C. (2023). Impact of COVID-19 policies on perceptions of loneliness in people aged 75 years and over in the cognitive function and aging study (CFAS II). Journal of the American Geriatrics Society, 71(2), 463-473. https://doi.org/10.1111/jgs.18099

Background: The COVID-19 pandemic and associated social distancing measures have profoundly impacted society and social contact patterns, with older people disproportionately affected. Concerns have been raised about a resulting pandemic of lonelines... Read More about Impact of COVID-19 policies on perceptions of loneliness in people aged 75 years and over in the cognitive function and aging study (CFAS II).

Blood pressure lowering and prevention of dementia: an individual patient data meta-analysis (2022)
Journal Article
Peters, R., Xu, Y., Fitzgerald, O., Aung, H. L., Beckett, N., Bulpitt, C., …Anderson, C. S. (2022). Blood pressure lowering and prevention of dementia: an individual patient data meta-analysis. European Heart Journal, 43(48), 4980-4990. https://doi.org/10.1093/eurheartj/ehac584

Aims Observational studies indicate U-shaped associations of blood pressure (BP) and incident dementia in older age, but randomized controlled trials of BP-lowering treatment show mixed results on this outcome in hypertensive patients. A pooled indiv... Read More about Blood pressure lowering and prevention of dementia: an individual patient data meta-analysis.