All Outputs (13)

Dyadic perspectives on loneliness and social isolation among people with dementia and spousal carers: findings from the IDEAL programme (2023)
Journal Article
Rippon, I., Victor, C. R., Martyr, A., Matthews, F. E., Quinn, C., Rusted, J. M., …Clare, L. (in press). Dyadic perspectives on loneliness and social isolation among people with dementia and spousal carers: findings from the IDEAL programme. Aging and Mental Health, 1-9. https://doi.org/10.1080/13607863.2023.2286618

Objectives: This study aims to investigate the impact of self and partner experiences of loneliness and social isolation on life satisfaction in people with dementia and their spousal carers. Methods: We used data from 1042 dementia caregiving dyads... Read More about Dyadic perspectives on loneliness and social isolation among people with dementia and spousal carers: findings from the IDEAL programme.

Study protocol for development and validation of a single tool to assess risks of stroke, diabetes mellitus, myocardial infarction and dementia: DemNCD-Risk (2023)
Journal Article
Kootar, S., Huque, M. H., Kiely, K. M., Anderson, C. S., Jorm, L., Kivipelto, M., …Anstey, K. J. (2023). Study protocol for development and validation of a single tool to assess risks of stroke, diabetes mellitus, myocardial infarction and dementia: DemNCD-Risk. BMJ open, 13(9), Article e076860. https://doi.org/10.1136/bmjopen-2023-076860

Introduction Current efforts to reduce dementia focus on prevention and risk reduction by targeting modifiable risk factors. As dementia and cardiometabolic non-communicable diseases (NCDs) share risk factors, a single risk-estimating tool for dement... Read More about Study protocol for development and validation of a single tool to assess risks of stroke, diabetes mellitus, myocardial infarction and dementia: DemNCD-Risk.

Trajectories of cognitive and perceived functional decline in people with dementia: Findings from the IDEAL programme (2023)
Journal Article
Martyr, A., Ravi, M., Gamble, L. D., Morris, R. G., Rusted, J. M., Pentecost, C., …Clare, L. (2024). Trajectories of cognitive and perceived functional decline in people with dementia: Findings from the IDEAL programme. Alzheimer's & dementia, 20(1), 410-420. https://doi.org/10.1002/alz.13448

INTRODUCTION: Impaired cognition and instrumental activities of daily living (iADL) are key diagnostic features of dementia; however, few studies have compared trajectories of cognition and iADL. METHODS: Participants from the IDEAL study comprised 1... Read More about Trajectories of cognitive and perceived functional decline in people with dementia: Findings from the IDEAL programme.

Insights into the pathological basis of dementia from population-based neuropathology studies (2023)
Journal Article
Wharton, S. B., Simpson, J. E., Ince, P. G., Richardson, C. D., Merrick, R., Matthews, F. E., & Brayne, C. (2023). Insights into the pathological basis of dementia from population-based neuropathology studies. Neuropathology and Applied Neurobiology, 49(4), Article e12923. https://doi.org/10.1111/nan.12923

The epidemiological neuropathology perspective of population and community-based studies allows unbiased assessment of the prevalence of various pathologies and their relationships to late-life dementia. In addition, this approach provides complement... Read More about Insights into the pathological basis of dementia from population-based neuropathology studies.

Predicting cognitive decline using neuropsychiatric symptoms in prodromal Lewy body dementia: A longitudinal study (2023)
Journal Article
Wright, L. M., Donaghy, P. C., Burn, D. J., Taylor, J. P., O'Brien, J. T., Yarnall, A. J., …Lawson, R. A. (2023). Predicting cognitive decline using neuropsychiatric symptoms in prodromal Lewy body dementia: A longitudinal study. Parkinsonism and Related Disorders, 113, Article 105762. https://doi.org/10.1016/j.parkreldis.2023.105762

Introduction: Neuropsychiatric symptoms (NPS) in Lewy body dementias (LBD) occur frequently and early in disease progression. Such symptoms are associated with worse quality of life, caregiver burden and functional limitations. Limited evidence exist... Read More about Predicting cognitive decline using neuropsychiatric symptoms in prodromal Lewy body dementia: A longitudinal study.

Time trends in neuropathology give clues to dementia risk reduction (2023)
Journal Article
Merrick, R., & Matthews, F. E. (2023). Time trends in neuropathology give clues to dementia risk reduction. Nature Reviews Neurology, 19(7), 389-390. https://doi.org/10.1038/s41582-023-00812-3

A new study sheds light on the declining incidence of dementia by examining trends in neuropathology over time in autopsy results from two large US cohorts. Although the prevalence of neurodegenerative pathologies remained similar, a reduction in the... Read More about Time trends in neuropathology give clues to dementia risk reduction.

Poorer White Matter Microstructure Predicts Slower and More Variable Reaction Time Performance: Evidence for a Neural Noise Hypothesis in a Large Lifespan Cohort (2023)
Journal Article
McCormick, E. M., Kievit, R. A., Tyler, L. K., Brayne, C., Bullmore, E. T., Calder, A. C., …Knights, E. (2023). Poorer White Matter Microstructure Predicts Slower and More Variable Reaction Time Performance: Evidence for a Neural Noise Hypothesis in a Large Lifespan Cohort. Journal of Neuroscience, 43(19), 3557-3566. https://doi.org/10.1523/JNEUROSCI.1042-22.2023

Most prior research has focused on characterizing averages in cognition, brain characteristics, or behavior, and attempting to predict differences in these averages among individuals. However, this overwhelming focus on mean levels may leave us with... Read More about Poorer White Matter Microstructure Predicts Slower and More Variable Reaction Time Performance: Evidence for a Neural Noise Hypothesis in a Large Lifespan Cohort.

Are there socioeconomic inequalities in polypharmacy among older people? A systematic review and meta-analysis (2023)
Journal Article
Iqbal, A., Richardson, C., Iqbal, Z., O’Keefe, H., Hanratty, B., Matthews, F. E., & Todd, A. (2023). Are there socioeconomic inequalities in polypharmacy among older people? A systematic review and meta-analysis. BMC Geriatrics, 23(1), Article 149. https://doi.org/10.1186/s12877-023-03835-z

Background: Socioeconomic status (SES) may influence prescribing, concordance and adherence to medication regimens. This review set out to investigate the association between polypharmacy and an individual’s socioeconomic status. Methods: A systemati... Read More about Are there socioeconomic inequalities in polypharmacy among older people? A systematic review and meta-analysis.

Assessment of Alzheimer-related pathologies of dementia using machine learning feature selection (2023)
Journal Article
Rajab, M. D., Jammeh, E., Taketa, T., Brayne, C., Matthews, F. E., Su, L., …Wang, D. (2023). Assessment of Alzheimer-related pathologies of dementia using machine learning feature selection. Alzheimer's Research and Therapy, 15(1), Article 47. https://doi.org/10.1186/s13195-023-01195-9

Although a variety of brain lesions may contribute to the pathological assessment of dementia, the relationship of these lesions to dementia, how they interact and how to quantify them remains uncertain. Systematically assessing neuropathological mea... Read More about Assessment of Alzheimer-related pathologies of dementia using machine learning feature selection.

Household wealth, neighbourhood deprivation and frailty amongst middle-aged and older adults in England: a longitudinal analysis over 15 years (2002-2017) (2023)
Journal Article
Maharani, A., Sinclair, D. R., Chandola, T., Bower, P., Clegg, A., Hanratty, B., …Matthews, F. E. (2023). Household wealth, neighbourhood deprivation and frailty amongst middle-aged and older adults in England: a longitudinal analysis over 15 years (2002-2017). Age and ageing, 52(3), Article afad034. https://doi.org/10.1093/ageing/afad034

Background: frailty is a condition of reduced function and health due to ageing processes and is associated with a higher risk of falls, hospitalisation, disability and mortality. Objective: to determine the relationship between household wealth and... Read More about Household wealth, neighbourhood deprivation and frailty amongst middle-aged and older adults in England: a longitudinal analysis over 15 years (2002-2017).

The prevalence, correlation, and co-occurrence of neuropathology in old age: harmonisation of 12 measures across six community-based autopsy studies of dementia (2023)
Journal Article
Nichols, E., Merrick, R., Hay, S. I., Himali, D., Himali, J. J., Hunter, S., …Vos, T. (2023). The prevalence, correlation, and co-occurrence of neuropathology in old age: harmonisation of 12 measures across six community-based autopsy studies of dementia. The Lancet Healthy Longevity, 4(3), e115-e125. https://doi.org/10.1016/S2666-7568%2823%2900019-3

Background: Population-based autopsy studies provide valuable insights into the causes of dementia but are limited by sample size and restriction to specific populations. Harmonisation across studies increases statistical power and allows meaningful... Read More about The prevalence, correlation, and co-occurrence of neuropathology in old age: harmonisation of 12 measures across six community-based autopsy studies of dementia.

Distinct components of cardiovascular health are linked with age-related differences in cognitive abilities (2023)
Journal Article
King, D. L., Henson, R. N., Kievit, R., Wolpe, N., Brayne, C., Tyler, L. K., …Tsvetanov, K. A. (2023). Distinct components of cardiovascular health are linked with age-related differences in cognitive abilities. Scientific reports, 13(1), Article 978. https://doi.org/10.1038/s41598-022-27252-1

Cardiovascular ageing contributes to cognitive impairment. However, the unique and synergistic contributions of multiple cardiovascular factors to cognitive function remain unclear because they are often condensed into a single composite score or exa... Read More about Distinct components of cardiovascular health are linked with age-related differences in cognitive abilities.

Could Country-Level Factors Explain Sex Differences in Dementia Incidence and Prevalence? A Systematic Review and Meta-Analysis (2023)
Journal Article
Huque, H., Eramudugolla, R., Chidiac, B., Ee, N., Ehrenfeld, L., Matthews, F. E., …Anstey, K. J. (2023). Could Country-Level Factors Explain Sex Differences in Dementia Incidence and Prevalence? A Systematic Review and Meta-Analysis. Journal of Alzheimer's Disease, 91(4), 1231-1241. https://doi.org/10.3233/JAD-220724

Background: Despite rising interest in sex differences in dementia, it is unclear whether sex differences in dementia incidence and prevalence are apparent globally. Objective: We examine sex differences in incidence and prevalence of Any dementia, A... Read More about Could Country-Level Factors Explain Sex Differences in Dementia Incidence and Prevalence? A Systematic Review and Meta-Analysis.