All Outputs (328)

The association between social stress and global cognitive function in a population-based study: The European Prospective Investigation into Cancer (EPIC)-Norfolk study (2013)
Journal Article
Leng, Y., Wainwright, N. W., Hayat, S., Stephan, B. C., Matthews, F. E., Luben, R., …Brayne, C. (2013). The association between social stress and global cognitive function in a population-based study: The European Prospective Investigation into Cancer (EPIC)-Norfolk study. Psychological Medicine, 43(3), 655-666. https://doi.org/10.1017/S0033291712001316

Background Stress is thought to exert both positive and negative effects on cognition, but the precise cognitive effects of social stress and individuals' response to stress remain unclear. We aimed to investigate the association between different me... Read More about The association between social stress and global cognitive function in a population-based study: The European Prospective Investigation into Cancer (EPIC)-Norfolk study.

A semi-Markov model for stroke with piecewise-constant hazards in the presence of left, Right and intervalcensoring (2013)
Journal Article
Kapetanakis, V., Matthews, F. E., & Van Den Hout, A. (2013). A semi-Markov model for stroke with piecewise-constant hazards in the presence of left, Right and intervalcensoring. Statistics in Medicine, 32(4), 697-713. https://doi.org/10.1002/sim.5534

This paper presents a parametric method of fitting semi-Markov models with piecewise-constant hazards in the presence of left, right and interval censoring. We investigate transition intensities in a three-state illness-death model with no recovery.... Read More about A semi-Markov model for stroke with piecewise-constant hazards in the presence of left, Right and intervalcensoring.

A commentary on studies presenting projections of the future prevalence of dementia (2013)
Journal Article
Norton, S., Matthews, F. E., & Brayne, C. (2013). A commentary on studies presenting projections of the future prevalence of dementia. BMC public health, 13(1), https://doi.org/10.1186/1471-2458-13-1

Background: Population ageing over the first half of this century is likely to lead to dramatic increases in the prevalence of dementia. This will affect all regions of the world, but particularly developing regions. Dementia projections have been us... Read More about A commentary on studies presenting projections of the future prevalence of dementia.

Cognitive decline and dementia risk in older adults with psychotic symptoms: A prospective cohort study (2013)
Journal Article
Köhler, S., Allardyce, J., Verhey, F. R., McKeith, I. G., Matthews, F., Brayne, C., & Savva, G. M. (2013). Cognitive decline and dementia risk in older adults with psychotic symptoms: A prospective cohort study. American Journal of Geriatric Psychiatry, 21(2), 119-128. https://doi.org/10.1016/j.jagp.2012.10.010

Objectives: To study the temporal association between psychotic symptoms with cognitive decline and incident dementia. Design: Population-based prospective cohort study. Setting: General population in England and Wales. Participants: A subsample of 2... Read More about Cognitive decline and dementia risk in older adults with psychotic symptoms: A prospective cohort study.

A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: Results of the cognitive function and ageing study i and II (2013)
Journal Article
Matthews, F. E., Arthur, A., Barnes, L. E., Bond, J., Jagger, C., Robinson, L., & Brayne, C. (2013). A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: Results of the cognitive function and ageing study i and II. Lancet, 382(9902), 1405-1412. https://doi.org/10.1016/S0140-6736%2813%2961570-6

Background: The prevalence of dementia is of interest worldwide. Contemporary estimates are needed to plan for future care provision, but much evidence is decades old. We aimed to investigate whether the prevalence of dementia had changed in the past... Read More about A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: Results of the cognitive function and ageing study i and II.

Service provision for autism in mainland China: A service providers' perspective (2013)
Journal Article
Sun, X., Allison, C., Auyeung, B., Matthews, F. E., Murray, S., Baron-Cohen, S., & Brayne, C. (2013). Service provision for autism in mainland China: A service providers' perspective. Research in Developmental Disabilities, 34(1), 440-451. https://doi.org/10.1016/j.ridd.2012.08.010

Qualitative semi-structured interviews were conducted with service providers regarding the current healthcare provision and education services for children with Autism Spectrum Conditions (ASC) and their families in mainland China. 10 service provide... Read More about Service provision for autism in mainland China: A service providers' perspective.

Change point models for cognitive tests using semi-parametric maximum likelihood (2013)
Journal Article
Van Den Hout, A., Muniz-Terrera, G., & Matthews, F. E. (2013). Change point models for cognitive tests using semi-parametric maximum likelihood. Computational Statistics and Data Analysis, 57(1), 684-698. https://doi.org/10.1016/j.csda.2012.07.024

Random-effects change point models are formulated for longitudinal data obtained from cognitive tests. The conditional distribution of the response variable in a change point model is often assumed to be normal even if the response variable is discre... Read More about Change point models for cognitive tests using semi-parametric maximum likelihood.

Active Cognitive Lifestyle Is Associated with Positive Cognitive Health Transitions and Compression of Morbidity from Age Sixty-Five (2012)
Journal Article
Marioni, R. E., Valenzuela, M. J., van den Hout, A., Brayne, C., & Matthews, F. E. (2012). Active Cognitive Lifestyle Is Associated with Positive Cognitive Health Transitions and Compression of Morbidity from Age Sixty-Five. PLoS ONE, 7(12), https://doi.org/10.1371/journal.pone.0050940

Background: Three factors commonly used as measures of cognitive lifestyle are education, occupation, and social engagement. This study determined the relative importance of each variable to long term cognitive health in those with and without severe... Read More about Active Cognitive Lifestyle Is Associated with Positive Cognitive Health Transitions and Compression of Morbidity from Age Sixty-Five.

The neuropathological profile of mild cognitive impairment (MCI): A systematic review (2012)
Journal Article
Stephan, B. C., Hunter, S., Harris, D., Llewellyn, D. J., Siervo, M., Matthews, F. E., & Brayne, C. (2012). The neuropathological profile of mild cognitive impairment (MCI): A systematic review. Molecular Psychiatry, 17(11), 1056-1076. https://doi.org/10.1038/mp.2011.147

Whether mild cognitive impairment (MCI) has a distinct neuropathological profile that reflects an intermediate state between no cognitive impairment and dementia is not clear. Identifying which biological events occur at the earliest stage of progres... Read More about The neuropathological profile of mild cognitive impairment (MCI): A systematic review.

Mesial temporal astrocyte tau pathology in the MRC-CFAS ageing brain cohort (2012)
Journal Article
Lace, G., Ince, P. G., Brayne, C., Savva, G. M., Matthews, F. E., De Silva, R., …Wharton, S. B. (2012). Mesial temporal astrocyte tau pathology in the MRC-CFAS ageing brain cohort. Dementia and Geriatric Cognitive Disorders, 34(1), 15-24. https://doi.org/10.1159/000341581

Background: Glial tau pathology is seen in certain tauopathies and in ageing. We determined its frequency in ageing mesial temporal lobe and its relationship to other tau pathologies in the MRC-CFAS population-representative neuropathology cohort. Me... Read More about Mesial temporal astrocyte tau pathology in the MRC-CFAS ageing brain cohort.

Examining the influence of gender, education, social class and birth cohort on MMSE tracking over time: A population-based prospective cohort study (2012)
Journal Article
Matthews, F., Marioni, R., & Brayne, C. (2012). Examining the influence of gender, education, social class and birth cohort on MMSE tracking over time: A population-based prospective cohort study. BMC Geriatrics, 12, https://doi.org/10.1186/1471-2318-12-45

Background: Whilst many studies have analysed predictors of longitudinal cognitive decline, few have described their impact on population distributions of cognition by age cohort. The aim of this paper was to examine whether gender, education, social... Read More about Examining the influence of gender, education, social class and birth cohort on MMSE tracking over time: A population-based prospective cohort study.

What sleep characteristics predict cognitive decline in the elderly? (2012)
Journal Article
Keage, H. A. D., Banks, S., Yang, K. L., Morgan, K., Brayne, C., & Matthews, F. E. (2012). What sleep characteristics predict cognitive decline in the elderly?. Sleep medicine, 13(7), 886-892. https://doi.org/10.1016/j.sleep.2012.02.003

Background: Sleep is critical for optimal cognitive function, but as we age both cognitive impairment and sleep problems increase. Longitudinal, population-based studies can be used to investigate temporal relationships between sleep and cognition. M... Read More about What sleep characteristics predict cognitive decline in the elderly?.

Neuropathological profile of mild cognitive impairment from a population perspective (2012)
Journal Article
Stephan, B. C., Matthews, F. E., Hunter, S., Savva, G. M., Bond, J., McKeith, I. G., …Brayne, C. (2012). Neuropathological profile of mild cognitive impairment from a population perspective. Alzheimer Disease and Associated Disorders, 26(3), 205-212. https://doi.org/10.1097/WAD.0b013e31822fc24d

Whether the neuropathological profile of mild cognitive impairment (MCI) reflects an intermediate state between normal aging and dementia is not clear. Identifying which phenomena initiate disease and which occur secondary to the neuropathological pr... Read More about Neuropathological profile of mild cognitive impairment from a population perspective.

Are autism spectrum conditions more prevalent in an information-technology region? A school-based study of three regions in the Netherlands (2012)
Journal Article
Roelfsema, M. T., Hoekstra, R. A., Allison, C., Wheelwright, S., Brayne, C., Matthews, F. E., & Baron-Cohen, S. (2012). Are autism spectrum conditions more prevalent in an information-technology region? A school-based study of three regions in the Netherlands. Journal of Autism and Developmental Disorders, 42(5), 734-739. https://doi.org/10.1007/s10803-011-1302-1

We tested for differences in the prevalence of autism spectrum conditions (ASC) in school-aged children in three geographical regions in the Netherlands. Schools were asked to provide the number of children enrolled, the number having a clinical diag... Read More about Are autism spectrum conditions more prevalent in an information-technology region? A school-based study of three regions in the Netherlands.

Multiple biological pathways link cognitive lifestyle to protection from dementia (2012)
Journal Article
Valenzuela, M. J., Matthews, F. E., Brayne, C., Ince, P., Halliday, G., Kril, J. J., …Sachdev, P. S. (2012). Multiple biological pathways link cognitive lifestyle to protection from dementia. Biological Psychiatry, 71(9), 783-791. https://doi.org/10.1016/j.biopsych.2011.07.036

Background: An active cognitive lifestyle is linked to diminished dementia risk, but the underlying mechanisms are poorly understood. Potential mechanisms include disease modification, neuroprotection, and compensation. Prospective, population-based... Read More about Multiple biological pathways link cognitive lifestyle to protection from dementia.

Population heterogeneity in trajectories of midlife blood pressure (2012)
Journal Article
Wills, A. K., Lawlor, D. A., Muniz-Terrera, G., Matthews, F., Cooper, R., Ghosh, A. K., …Hardy, R. (2012). Population heterogeneity in trajectories of midlife blood pressure. Epidemiology, 23(2), 203-211. https://doi.org/10.1097/EDE.0b013e3182456567

Background: We investigated whether there are subgroups with different underlying (latent) trajectories of midlife systolic blood pressure (BP), diastolic BP, and pulse pressure in a UK cohort. Methods: Data are from 1840 men and 1819 women with BP m... Read More about Population heterogeneity in trajectories of midlife blood pressure.

Delirium is a strong risk factor for dementia in the oldest-old: A population-based cohort study (2012)
Journal Article
Davis, D. H., Muniz Terrera, G., Keage, H., Rahkonen, T., Oinas, M., Matthews, F. E., …Brayne, C. (2012). Delirium is a strong risk factor for dementia in the oldest-old: A population-based cohort study. Brain, 135(9), 2809-2816. https://doi.org/10.1093/brain/aws190

Recent studies suggest that delirium is associated with risk of dementia and also acceleration of decline in existing dementia. However, previous studies may have been confounded by incomplete ascertainment of cognitive status at baseline. Herein, we... Read More about Delirium is a strong risk factor for dementia in the oldest-old: A population-based cohort study.

The neuropathology of vascular disease in the medical research council cognitive function and ageing study (MRC CFAS) (2012)
Journal Article
Richardson, K., Stephan, B. C., Ince, P. G., Brayne, C., Matthews, F. E., & Esiri, M. M. (2012). The neuropathology of vascular disease in the medical research council cognitive function and ageing study (MRC CFAS). Current Alzheimer Research, 9(6), 687-696. https://doi.org/10.2174/156720512801322654

Background: Vascular disease is associated with increased risk of dementia. Vascular health worsens with age. We investigated the relationship between self-reported vascular disease and brain pathology. Methods: Brain donations to the population-base... Read More about The neuropathology of vascular disease in the medical research council cognitive function and ageing study (MRC CFAS).

Neuropathological correlates of falling in the CC75C population-based ample of the older old (2012)
Journal Article
Richardson, K., Hunter, S., Dening, T., Xuereb, J. H., Matthews, F. E., Brayne, C., …Paykel, E. (2012). Neuropathological correlates of falling in the CC75C population-based ample of the older old. Current Alzheimer Research, 9(6), 697-708. https://doi.org/10.2174/156720512801322636

Background: Previous imaging studies have suggested links between brain pathologies and factors that are associated with falls such as gait, balance and daily function. Possible neuropathological correlates of older people's falls have been suggested... Read More about Neuropathological correlates of falling in the CC75C population-based ample of the older old.

Alzheimer and vascular neuropathological changes associated with different cognitive states in a non-demented sample (2012)
Journal Article
Stephan, B. C., Matthews, F. E., Ma, B., Muniz, G., Hunter, S., Davis, D., …Brayne, C. (2012). Alzheimer and vascular neuropathological changes associated with different cognitive states in a non-demented sample. Journal of Alzheimer's Disease, 29(2), 309-318. https://doi.org/10.3233/JAD-2011-110518

The state between aging with no cognitive impairment and dementia has become a major focus for intervention. The neuropathological and neurobiological correlates of this intermediate state are therefore of considerable interest, particularly from pop... Read More about Alzheimer and vascular neuropathological changes associated with different cognitive states in a non-demented sample.