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All Outputs (18)

Calcium dysregulation in relation to Alzheimer-type pathology in the ageing brain (2013)
Journal Article
Garwood, C., Faizullabhoy, A., Wharton, S. B., Ince, P. G., Heath, P. R., Shaw, P. J., …Simpson, J. E. (2013). Calcium dysregulation in relation to Alzheimer-type pathology in the ageing brain. Neuropathology and Applied Neurobiology, 39(7), 788-799. https://doi.org/10.1111/nan.12033

Aims: Calcium dyshomeostasis is implicated in the pathogenesis of several neurodegenerative disorders including Alzheimer's disease. However, much of the previous research has focused on changes in neuronal calcium signalling. In a recent microarray... Read More about Calcium dysregulation in relation to Alzheimer-type pathology in the ageing brain.

Service provision for autism in mainland China: Preliminary mapping of service pathways (2013)
Journal Article
Sun, X., Allison, C., Auyeung, B., Matthews, F. E., Baron-Cohen, S., & Brayne, C. (2013). Service provision for autism in mainland China: Preliminary mapping of service pathways. Social science & medicine, 98, 87-94. https://doi.org/10.1016/j.socscimed.2013.08.016

Few data on healthcare services for individuals with Autism Spectrum Conditions (ASC) are available from mainland China. This article is based on findings from 69 semi-structured interviews with parents of children with ASC in three intervention cent... Read More about Service provision for autism in mainland China: Preliminary mapping of service pathways.

COSMIC (Cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups (2013)
Journal Article
Sachdev, P. S., Lipnicki, D. M., Kochan, N. A., Crawford, J. D., Rockwood, K., Xiao, S., …Santabárbara, J. (2013). COSMIC (Cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups. BMC Neurology, 13, https://doi.org/10.1186/1471-2377-13-165

Background: A large number of longitudinal studies of population-based ageing cohorts are in progress internationally, but the insights from these studies into the risk and protective factors for cognitive ageing and conditions like mild cognitive im... Read More about COSMIC (Cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups.

The Mandarin Chinese version of the childhood autism spectrum test (CAST): Test-retest reliability (2013)
Journal Article
Sun, X., Allison, C., Auyeung, B., Matthews, F. E., Baron-Cohen, S., & Brayne, C. (2013). The Mandarin Chinese version of the childhood autism spectrum test (CAST): Test-retest reliability. Research in Developmental Disabilities, 34(10), 3267-3275. https://doi.org/10.1016/j.ridd.2013.05.042

This study aimed to investigate the test-retest reliability of a Mandarin Chinese version of the Childhood Autism Spectrum Test (CAST), in a Chinese population. Parents in a school based study on the prevalence of ASC in mainland China were asked to... Read More about The Mandarin Chinese version of the childhood autism spectrum test (CAST): Test-retest reliability.

Predicting risk of 2-year incident dementia using the camcog total and subscale scores (2013)
Journal Article
Restaino, M., Matthews, F. E., Minett, T., Albanese, E., Brayne, C., & Stephan, B. C. M. (2013). Predicting risk of 2-year incident dementia using the camcog total and subscale scores. Age and ageing, 42(5), 649-653. https://doi.org/10.1093/ageing/aft082

Background: being able to identify individuals at high risk of dementia is important for diagnostics and intervention. Currently, there is no standard approach to assessing cognitive function in older aged individuals to best predict incident dementi... Read More about Predicting risk of 2-year incident dementia using the camcog total and subscale scores.

Investigating terminal decline: Results from a UK population-based study of aging (2013)
Journal Article
Muniz-Terrera, G., van den Hout, A., Piccinin, A. M., Matthews, F. E., & Hofer, S. M. (2013). Investigating terminal decline: Results from a UK population-based study of aging. Psychology and Aging, 28(2), 377-385. https://doi.org/10.1037/a0031000

The terminal decline hypothesis states that in the proximity of death, an individual's decline in cognitive abilities accelerates. We aimed at estimating the onset of faster rate of decline in global cognition using Mini Mental State Examination (MMS... Read More about Investigating terminal decline: Results from a UK population-based study of aging.

The presence of behavioural and psychological symptoms and progression to dementia in the cognitively impaired older population (2013)
Journal Article
Van Der Linde, R. M., Stephan, B. C., Matthews, F. E., Brayne, C., & Savva, G. M. (2013). The presence of behavioural and psychological symptoms and progression to dementia in the cognitively impaired older population. International journal of geriatric psychiatry, 28(7), 700-709. https://doi.org/10.1002/gps.3873

Objective Behavioural and psychological symptoms (BPS) are common in the older population and may be an indication of early dementia. We explored the predictive effect of the presence of BPS on the 2-year progression to dementia in a cognitively impa... Read More about The presence of behavioural and psychological symptoms and progression to dementia in the cognitively impaired older population.

Prevalence Studies of Dementia in Mainland China, Hong Kong and Taiwan: A Systematic Review and Meta-Analysis (2013)
Journal Article
Wu, Y. T., Lee, H. Y., Norton, S., Chen, C., Chen, H., He, C., …Brayne, C. (2013). Prevalence Studies of Dementia in Mainland China, Hong Kong and Taiwan: A Systematic Review and Meta-Analysis. PLoS ONE, 8(6), https://doi.org/10.1371/journal.pone.0066252

Background:Many studies have considered the prevalence of dementia in mainland China, Hong Kong and Taiwan. However, area level estimates have not been produced. This study examines area differences across mainland China, Hong Kong and Taiwan adjusti... Read More about Prevalence Studies of Dementia in Mainland China, Hong Kong and Taiwan: A Systematic Review and Meta-Analysis.

Prevalence of autism in mainland China, Hong Kong and Taiwan: A systematic review and meta-analysis (2013)
Journal Article
Sun, X., Allison, C., Matthews, F. E., Sharp, S. J., Auyeung, B., Baron-Cohen, S., & Brayne, C. (2013). Prevalence of autism in mainland China, Hong Kong and Taiwan: A systematic review and meta-analysis. Molecular Autism, 4(1), https://doi.org/10.1186/2040-2392-4-7

Background: The prevalence of autism spectrum conditions (ASC) is 1% in developed countries, but little data are available from mainland China, Hong Kong and Taiwan. This study synthesizes evidence relating to the prevalence of ASC in these areas and... Read More about Prevalence of autism in mainland China, Hong Kong and Taiwan: A systematic review and meta-analysis.

What is available for case identification in autism research in mainland China? (2013)
Journal Article
Sun, X., Allison, C., Auyeung, B., Matthews, F. E., Baron-Cohen, S., & Brayne, C. (2013). What is available for case identification in autism research in mainland China?. Research in Autism Spectrum Disorders, 7(5), 579-590. https://doi.org/10.1016/j.rasd.2012.11.003

Little is known about research on Autism Spectrum Conditions (ASC) in mainland China. The few available studies in mainland China have shown the screening and diagnostic instruments for ASC used in mainland China were different from the West. Literat... Read More about What is available for case identification in autism research in mainland China?.

The association between social stress and global cognitive function in a population-based study: The European Prospective Investigation into Cancer (EPIC)-Norfolk study (2013)
Journal Article
Leng, Y., Wainwright, N. W., Hayat, S., Stephan, B. C., Matthews, F. E., Luben, R., …Brayne, C. (2013). The association between social stress and global cognitive function in a population-based study: The European Prospective Investigation into Cancer (EPIC)-Norfolk study. Psychological Medicine, 43(3), 655-666. https://doi.org/10.1017/S0033291712001316

Background Stress is thought to exert both positive and negative effects on cognition, but the precise cognitive effects of social stress and individuals' response to stress remain unclear. We aimed to investigate the association between different me... Read More about The association between social stress and global cognitive function in a population-based study: The European Prospective Investigation into Cancer (EPIC)-Norfolk study.

A semi-Markov model for stroke with piecewise-constant hazards in the presence of left, Right and intervalcensoring (2013)
Journal Article
Kapetanakis, V., Matthews, F. E., & Van Den Hout, A. (2013). A semi-Markov model for stroke with piecewise-constant hazards in the presence of left, Right and intervalcensoring. Statistics in Medicine, 32(4), 697-713. https://doi.org/10.1002/sim.5534

This paper presents a parametric method of fitting semi-Markov models with piecewise-constant hazards in the presence of left, right and interval censoring. We investigate transition intensities in a three-state illness-death model with no recovery.... Read More about A semi-Markov model for stroke with piecewise-constant hazards in the presence of left, Right and intervalcensoring.

A commentary on studies presenting projections of the future prevalence of dementia (2013)
Journal Article
Norton, S., Matthews, F. E., & Brayne, C. (2013). A commentary on studies presenting projections of the future prevalence of dementia. BMC public health, 13(1), https://doi.org/10.1186/1471-2458-13-1

Background: Population ageing over the first half of this century is likely to lead to dramatic increases in the prevalence of dementia. This will affect all regions of the world, but particularly developing regions. Dementia projections have been us... Read More about A commentary on studies presenting projections of the future prevalence of dementia.

Cognitive decline and dementia risk in older adults with psychotic symptoms: A prospective cohort study (2013)
Journal Article
Köhler, S., Allardyce, J., Verhey, F. R., McKeith, I. G., Matthews, F., Brayne, C., & Savva, G. M. (2013). Cognitive decline and dementia risk in older adults with psychotic symptoms: A prospective cohort study. American Journal of Geriatric Psychiatry, 21(2), 119-128. https://doi.org/10.1016/j.jagp.2012.10.010

Objectives: To study the temporal association between psychotic symptoms with cognitive decline and incident dementia. Design: Population-based prospective cohort study. Setting: General population in England and Wales. Participants: A subsample of 2... Read More about Cognitive decline and dementia risk in older adults with psychotic symptoms: A prospective cohort study.

A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: Results of the cognitive function and ageing study i and II (2013)
Journal Article
Matthews, F. E., Arthur, A., Barnes, L. E., Bond, J., Jagger, C., Robinson, L., & Brayne, C. (2013). A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: Results of the cognitive function and ageing study i and II. Lancet, 382(9902), 1405-1412. https://doi.org/10.1016/S0140-6736%2813%2961570-6

Background: The prevalence of dementia is of interest worldwide. Contemporary estimates are needed to plan for future care provision, but much evidence is decades old. We aimed to investigate whether the prevalence of dementia had changed in the past... Read More about A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: Results of the cognitive function and ageing study i and II.

Service provision for autism in mainland China: A service providers' perspective (2013)
Journal Article
Sun, X., Allison, C., Auyeung, B., Matthews, F. E., Murray, S., Baron-Cohen, S., & Brayne, C. (2013). Service provision for autism in mainland China: A service providers' perspective. Research in Developmental Disabilities, 34(1), 440-451. https://doi.org/10.1016/j.ridd.2012.08.010

Qualitative semi-structured interviews were conducted with service providers regarding the current healthcare provision and education services for children with Autism Spectrum Conditions (ASC) and their families in mainland China. 10 service provide... Read More about Service provision for autism in mainland China: A service providers' perspective.

Change point models for cognitive tests using semi-parametric maximum likelihood (2013)
Journal Article
Van Den Hout, A., Muniz-Terrera, G., & Matthews, F. E. (2013). Change point models for cognitive tests using semi-parametric maximum likelihood. Computational Statistics and Data Analysis, 57(1), 684-698. https://doi.org/10.1016/j.csda.2012.07.024

Random-effects change point models are formulated for longitudinal data obtained from cognitive tests. The conditional distribution of the response variable in a change point model is often assumed to be normal even if the response variable is discre... Read More about Change point models for cognitive tests using semi-parametric maximum likelihood.