Association between APOE genotype, neuropathology and dementia in the older population of England and Wales

Nicoll, J. A.R.; Savva, G. M.; Stewart, J.; Matthews, F. E.; Brayne, C.; Ince, P.

doi:10.1111/j.1365-2990.2010.01130.x

Are autism spectrum conditions more prevalent in an information-technology region? A school-based study of three regions in the Netherlands (2012)
Journal Article
Roelfsema, M. T., Hoekstra, R. A., Allison, C., Wheelwright, S., Brayne, C., Matthews, F. E., & Baron-Cohen, S. (2012). Are autism spectrum conditions more prevalent in an information-technology region? A school-based study of three regions in the Netherlands. Journal of Autism and Developmental Disorders, 42(5), 734-739. https://doi.org/10.1007/s10803-011-1302-1

We tested for differences in the prevalence of autism spectrum conditions (ASC) in school-aged children in three geographical regions in the Netherlands. Schools were asked to provide the number of children enrolled, the number having a clinical diag... Read More about Are autism spectrum conditions more prevalent in an information-technology region? A school-based study of three regions in the Netherlands.

Multiple biological pathways link cognitive lifestyle to protection from dementia (2012)
Journal Article
Valenzuela, M. J., Matthews, F. E., Brayne, C., Ince, P., Halliday, G., Kril, J. J., Dalton, M. A., Richardson, K., Forster, G., & Sachdev, P. S. (2012). Multiple biological pathways link cognitive lifestyle to protection from dementia. Biological Psychiatry, 71(9), 783-791. https://doi.org/10.1016/j.biopsych.2011.07.036

Background: An active cognitive lifestyle is linked to diminished dementia risk, but the underlying mechanisms are poorly understood. Potential mechanisms include disease modification, neuroprotection, and compensation. Prospective, population-based... Read More about Multiple biological pathways link cognitive lifestyle to protection from dementia.

Population heterogeneity in trajectories of midlife blood pressure (2012)
Journal Article
Wills, A. K., Lawlor, D. A., Muniz-Terrera, G., Matthews, F., Cooper, R., Ghosh, A. K., Kuh, D., & Hardy, R. (2012). Population heterogeneity in trajectories of midlife blood pressure. Epidemiology, 23(2), 203-211. https://doi.org/10.1097/EDE.0b013e3182456567

Background: We investigated whether there are subgroups with different underlying (latent) trajectories of midlife systolic blood pressure (BP), diastolic BP, and pulse pressure in a UK cohort. Methods: Data are from 1840 men and 1819 women with BP m... Read More about Population heterogeneity in trajectories of midlife blood pressure.

Delirium is a strong risk factor for dementia in the oldest-old: A population-based cohort study (2012)
Journal Article
Davis, D. H., Muniz Terrera, G., Keage, H., Rahkonen, T., Oinas, M., Matthews, F. E., Cunningham, C., Polvikoski, T., Sulkava, R., MacLullich, A. M., & Brayne, C. (2012). Delirium is a strong risk factor for dementia in the oldest-old: A population-based cohort study. Brain, 135(9), 2809-2816. https://doi.org/10.1093/brain/aws190

Recent studies suggest that delirium is associated with risk of dementia and also acceleration of decline in existing dementia. However, previous studies may have been confounded by incomplete ascertainment of cognitive status at baseline. Herein, we... Read More about Delirium is a strong risk factor for dementia in the oldest-old: A population-based cohort study.

The neuropathology of vascular disease in the medical research council cognitive function and ageing study (MRC CFAS) (2012)
Journal Article
Richardson, K., Stephan, B. C., Ince, P. G., Brayne, C., Matthews, F. E., & Esiri, M. M. (2012). The neuropathology of vascular disease in the medical research council cognitive function and ageing study (MRC CFAS). Current Alzheimer Research, 9(6), 687-696. https://doi.org/10.2174/156720512801322654

Background: Vascular disease is associated with increased risk of dementia. Vascular health worsens with age. We investigated the relationship between self-reported vascular disease and brain pathology. Methods: Brain donations to the population-base... Read More about The neuropathology of vascular disease in the medical research council cognitive function and ageing study (MRC CFAS).

Neuropathological correlates of falling in the CC75C population-based ample of the older old (2012)
Journal Article
Richardson, K., Hunter, S., Dening, T., Xuereb, J. H., Matthews, F. E., Brayne, C., Fleming, J., Huppert, F., Hills, R., Mukaetova-Ladinska, E., O'Sullivan, A., & Paykel, E. (2012). Neuropathological correlates of falling in the CC75C population-based ample of the older old. Current Alzheimer Research, 9(6), 697-708. https://doi.org/10.2174/156720512801322636

Background: Previous imaging studies have suggested links between brain pathologies and factors that are associated with falls such as gait, balance and daily function. Possible neuropathological correlates of older people's falls have been suggested... Read More about Neuropathological correlates of falling in the CC75C population-based ample of the older old.

Alzheimer and vascular neuropathological changes associated with different cognitive states in a non-demented sample (2012)
Journal Article
Stephan, B. C., Matthews, F. E., Ma, B., Muniz, G., Hunter, S., Davis, D., McKeith, I. G., Foster, G., Ince, P. G., & Brayne, C. (2012). Alzheimer and vascular neuropathological changes associated with different cognitive states in a non-demented sample. Journal of Alzheimer's Disease, 29(2), 309-318. https://doi.org/10.3233/JAD-2011-110518

The state between aging with no cognitive impairment and dementia has become a major focus for intervention. The neuropathological and neurobiological correlates of this intermediate state are therefore of considerable interest, particularly from pop... Read More about Alzheimer and vascular neuropathological changes associated with different cognitive states in a non-demented sample.

Impact of less common and "disregarded" neurodegenerative pathologies on dementia burden in a population-based cohort (2012)
Journal Article
Keage, H. A., Ince, P. G., Matthews, F. E., Wharton, S. B., McKeith, I. G., & Brayne, C. (2012). Impact of less common and "disregarded" neurodegenerative pathologies on dementia burden in a population-based cohort. Journal of Alzheimer's Disease, 28(2), 485-493. https://doi.org/10.3233/JAD-2011-111268

Epidemiological studies investigating the pathological bases of late onset dementia focus on classical markers such as plaques and tangles. The significance of pathologies characteristically associated with rare dementia syndromes such as Pick bodies... Read More about Impact of less common and "disregarded" neurodegenerative pathologies on dementia burden in a population-based cohort.

Active cognitive lifestyle associates with cognitive recovery and a reduced risk of cognitive decline (2012)
Journal Article
Marioni, R. E., Van Den Hout, A., Valenzuela, M. J., Brayne, C., & Matthews, F. E. (2012). Active cognitive lifestyle associates with cognitive recovery and a reduced risk of cognitive decline. Journal of Alzheimer's Disease, 28(1), 223-230. https://doi.org/10.3233/JAD-2011-110377

Education and lifestyle factors linked with complex mental activity are thought to affect the progression of cognitive decline. Collectively, these factors can be combined to create a cognitive reserve or cognitive lifestyle score. This study tested... Read More about Active cognitive lifestyle associates with cognitive recovery and a reduced risk of cognitive decline.

Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology: A study in the MRC-CFAS population neuropathology cohort (2011)
Journal Article
Viggars, A. P., Wharton, S. B., Simpson, J. E., Matthews, F. E., Brayne, C., Savva, G. M., Garwood, C., Drew, D., Shaw, P. J., & Ince, P. G. (2011). Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology: A study in the MRC-CFAS population neuropathology cohort. Neuroscience letters, 505(1), 25-30. https://doi.org/10.1016/j.neulet.2011.09.049

Impairment of the blood brain barrier (BBB) in human brain ageing and its relationship to Alzheimer-type pathology remains poorly defined. We have investigated the BBB in temporal cortex of brain donations from a population-representative sample of 9... Read More about Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology: A study in the MRC-CFAS population neuropathology cohort.

Microarray analysis of the astrocyte transcriptome in the aging brain: Relationship to Alzheimer's pathology and APOE genotype (2011)
Journal Article
Simpson, J. E., Ince, P. G., Shaw, P. J., Heath, P. R., Raman, R., Garwood, C. J., Gelsthorpe, C., Baxter, L., Forster, G., Matthews, F. E., Brayne, C., & Wharton, S. B. (2011). Microarray analysis of the astrocyte transcriptome in the aging brain: Relationship to Alzheimer's pathology and APOE genotype. Neurobiology of Aging, 32(10), 1795-1807. https://doi.org/10.1016/j.neurobiolaging.2011.04.013

Astrocytes contribute to a variety of functions in the brain, including homeostasis, synapse formation, plasticity, and metabolism. Astrocyte dysfunction may disrupt their normal role, including neuronal support, thereby contributing to neurodegenera... Read More about Microarray analysis of the astrocyte transcriptome in the aging brain: Relationship to Alzheimer's pathology and APOE genotype.

The reliability of assigning individuals to cognitive states using the Mini Mental-State Examination: A population-based prospective cohort study (2011)
Journal Article
Marioni, R. E., Chatfield, M., Brayne, C., & Matthews, F. E. (2011). The reliability of assigning individuals to cognitive states using the Mini Mental-State Examination: A population-based prospective cohort study. BMC Medical Research Methodology, 11, https://doi.org/10.1186/1471-2288-11-127

Background: Previous investigations of test re-test reliability of the Mini-Mental State Examination (MMSE) have used correlations and statistics such as Cronbach's to assess consistency. In practice, the MMSE is usually used to group individuals int... Read More about The reliability of assigning individuals to cognitive states using the Mini Mental-State Examination: A population-based prospective cohort study.

Full-scale scores of the Mini Mental State Examination can be generated from an abbreviated version (2011)
Journal Article
Matthews, F. E., Stephan, B. C., Khaw, K. T., Hayat, S., Luben, R., Bhaniani, A., Moore, S., & Brayne, C. (2011). Full-scale scores of the Mini Mental State Examination can be generated from an abbreviated version. Journal of clinical epidemiology, 64(9), 1005-1013. https://doi.org/10.1016/j.jclinepi.2010.11.014

Objective: To determine whether the full Mini Mental State Examination (MMSE) scale range can be derived from an abbreviated 11-item version that was designed for testing general cognitive function in a cohort where only a small proportion were expec... Read More about Full-scale scores of the Mini Mental State Examination can be generated from an abbreviated version.

Anticholinergic medication use and cognitive impairment in the older population: The medical research council cognitive function and ageing study (2011)
Journal Article
Fox, C., Richardson, K., Maidment, I. D., Savva, G. M., Matthews, F. E., Smithard, D., Coulton, S., Katona, C., Boustani, M. A., & Brayne, C. (2011). Anticholinergic medication use and cognitive impairment in the older population: The medical research council cognitive function and ageing study. Journal of the American Geriatrics Society, 59(8), 1477-1483. https://doi.org/10.1111/j.1532-5415.2011.03491.x

Objectives: To determine whether the use of medications with possible and definite anticholinergic activity increases the risk of cognitive impairment and mortality in older people and whether risk is cumulative. Design: A 2-year longitudinal study o... Read More about Anticholinergic medication use and cognitive impairment in the older population: The medical research council cognitive function and ageing study.

Variation over time in the association between polypharmacy and mortality in the older population (2011)
Journal Article
Richardson, K., Ananou, A., Lafortune, L., Brayne, C., & Matthews, F. E. (2011). Variation over time in the association between polypharmacy and mortality in the older population. Drugs and Aging, 28(7), 547-560. https://doi.org/10.2165/11592000-000000000-00000

Background: In the older population, multimorbidity is common and best practice may invite the prescription of multiple medications. Objective: To examine the association between polypharmacy, defined as the concurrent use of five or more prescriptio... Read More about Variation over time in the association between polypharmacy and mortality in the older population.

Occurrence of medical co-morbidity in mild cognitive impairment: Implications for generalisation of MCI research (2011)
Journal Article
Stephan, B. C., Brayne, C., Savva, G. M., & Matthews, F. E. (2011). Occurrence of medical co-morbidity in mild cognitive impairment: Implications for generalisation of MCI research. Age and ageing, 40(4), 501-507. https://doi.org/10.1093/ageing/afr057

Background: diagnosis of mild cognitive impairment (MCI) typically excludes individuals with medical co-morbidity. Interest in MCI screening raises the questions of what are the best criteria to identify a representative sample and what factors are a... Read More about Occurrence of medical co-morbidity in mild cognitive impairment: Implications for generalisation of MCI research.

Life course trajectories of systolic blood pressure using longitudinal data from eight UK cohorts (2011)
Journal Article
Wills, A. K., Lawlor, D. A., Matthews, F. E., Sayer, A. A., Bakra, E., Ben-Shlomo, Y., Benzeval, M., Brunner, E., Cooper, R., Kivimaki, M., Kuh, D., Muniz-Terrera, G., & Hardy, R. (2011). Life course trajectories of systolic blood pressure using longitudinal data from eight UK cohorts. PLoS Medicine, 8(6), https://doi.org/10.1371/journal.pmed.1000440

Background: Much of our understanding of the age-related progression of systolic blood pressure (SBP) comes from cross-sectional data, which do not directly capture within-individual change. We estimated life course trajectories of SBP using longitud... Read More about Life course trajectories of systolic blood pressure using longitudinal data from eight UK cohorts.

Are terminal decline and its potential indicators detectable in population studies of the oldest old? (2011)
Journal Article
Muniz-Terrera, G., Matthews, F. E., Stephan, B., & Brayne, C. (2011). Are terminal decline and its potential indicators detectable in population studies of the oldest old?. International journal of geriatric psychiatry, 26(6), 584-592. https://doi.org/10.1002/gps.2566

Objectives To explore whether it is possible to detect decline in global scores of cognitive function in the proximity of death whilst simultaneously investigating potential risk profiles. Methods Using the Mini Mental State Examination in a populati... Read More about Are terminal decline and its potential indicators detectable in population studies of the oldest old?.

Cognitive lifestyle and long-term risk of dementia and survival after diagnosis in a multicenter population-based cohort (2011)
Journal Article
Valenzuela, M., Brayne, C., Sachdev, P., Wilcock, G., & Matthews, F. (2011). Cognitive lifestyle and long-term risk of dementia and survival after diagnosis in a multicenter population-based cohort. American Journal of Epidemiology, 173(9), 1004-1012. https://doi.org/10.1093/aje/kwq476

An active cognitive lifestyle has been linked to dementia incidence and survival, but the separate and combined effects of its subcomponents are not clear. Data were derived from the Medical Research Council Cognitive Function and Ageing Study, a pop... Read More about Cognitive lifestyle and long-term risk of dementia and survival after diagnosis in a multicenter population-based cohort.

Association between APOE genotype, neuropathology and dementia in the older population of England and Wales (2011)
Journal Article
Nicoll, J. A., Savva, G. M., Stewart, J., Matthews, F. E., Brayne, C., & Ince, P. (2011). Association between APOE genotype, neuropathology and dementia in the older population of England and Wales. Neuropathology and Applied Neurobiology, 37(3), 285-294. https://doi.org/10.1111/j.1365-2990.2010.01130.x

Aims: Apolipoprotein E (APOE) genotype is the major genetic risk factor for sporadic Alzheimer's disease (AD) but it is unclear how this is mediated. Most studies of APOE genotype have used case-control design to compare groups differing by two varia... Read More about Association between APOE genotype, neuropathology and dementia in the older population of England and Wales.

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