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All Outputs (222)

The FINISH-3 trial: A phase 3, international, randomized, single-blind, controlled trial of topical fibrocaps in intraoperative surgical hemostasis (2014)
Journal Article
Bochicchio, G. V., Gupta, N., Porte, R. J., Renkens, K. L., Pattyn, P., Topal, B., …Frohna, P. A. (2015). The FINISH-3 trial: A phase 3, international, randomized, single-blind, controlled trial of topical fibrocaps in intraoperative surgical hemostasis. Journal of The American College of Surgeons, 220(1), 70-81. https://doi.org/10.1016/j.jamcollsurg.2014.09.019

Background This Phase 3, international, randomized, single-blind, controlled trial (FINISH-3) compared the efficacy and safety of Fibrocaps, a ready-to-use, dry-powder fibrin sealant containing human plasma-derived thrombin and fibrinogen, vs gelatin... Read More about The FINISH-3 trial: A phase 3, international, randomized, single-blind, controlled trial of topical fibrocaps in intraoperative surgical hemostasis.

Cost-effectiveness of ultrasound-guided foam sclerotherapy, endovenous laser ablation or surgery as treatment for primary varicose veins from the randomized CLASS trial: Cost-effectiveness of primary varicose vein treatments (2014)
Journal Article
Tassie, E., Scotland, G., Brittenden, J., Cotton, S. C., Elders, A., Campbell, M. K., …on behalf of the CLASS study team, . (2014). Cost-effectiveness of ultrasound-guided foam sclerotherapy, endovenous laser ablation or surgery as treatment for primary varicose veins from the randomized CLASS trial: Cost-effectiveness of primary varicose vein treatments. British journal of surgery, 101(12), 1532-1540. https://doi.org/10.1002/bjs.9595

© 2014 Crown copyright. Background: The treatment of patients with varicose veins constitutes a considerable workload and financial burden to the National Health Service. This study aimed to assess the cost-effectiveness of ultrasound-guided foam scl... Read More about Cost-effectiveness of ultrasound-guided foam sclerotherapy, endovenous laser ablation or surgery as treatment for primary varicose veins from the randomized CLASS trial: Cost-effectiveness of primary varicose vein treatments.

A randomized trial comparing treatments for varicose veins. (2014)
Journal Article
Brittenden, J., Cotton, S. C., Elders, A., Ramsay, C. R., Norrie, J., Burr, J., …Campbell, M. K. (2014). A randomized trial comparing treatments for varicose veins. New England Journal of Medicine, 371, 1218-1227. https://doi.org/10.1056/NEJMoa1400781

BACKGROUND Ultrasound-guided foam sclerotherapy and endovenous laser ablation are widely used alternatives to surgery for the treatment of varicose veins, but their comparative effectiveness and safety remain uncertain. METHODS In a randomized t... Read More about A randomized trial comparing treatments for varicose veins..

A comparison of the effectiveness of treating those with and without the complications of superficial venous insufficiency (2014)
Journal Article
Carradice, D., Wallace, T., Gohil, R., & Chetter, I. (2014). A comparison of the effectiveness of treating those with and without the complications of superficial venous insufficiency. Annals of Surgery, 260(2), 396-401. https://doi.org/10.1097/sla.0000000000000541

Objective: To test the hypothesis that patients with soft tissue changes related to superficial venous insufficiency (SVI) have greater benefits from treatment than those with only symptomatic varicose veins. Background: A commonly held view is that... Read More about A comparison of the effectiveness of treating those with and without the complications of superficial venous insufficiency.

Clinical outcomes and quality of life 5 years after a randomized trial of concomitant or sequential phlebectomy following endovenous laser ablation for varicose veins (2014)
Journal Article
El-Sheikha, J., Nandhra, S., Carradice, D., Wallace, T., Samuel, N., Smith, G., & Chetter, I. C. (2014). Clinical outcomes and quality of life 5 years after a randomized trial of concomitant or sequential phlebectomy following endovenous laser ablation for varicose veins. British journal of surgery, 101(9), 1093-1097. https://doi.org/10.1002/bjs.9565

BackgroundEndovenous laser ablation (EVLA) is a popular treatment for superficial venous insufficiency. Debate continues regarding the optimal management of symptomatic varicose tributaries following ablation of the main saphenous trunk. This randomi... Read More about Clinical outcomes and quality of life 5 years after a randomized trial of concomitant or sequential phlebectomy following endovenous laser ablation for varicose veins.

Electrical stimulation vs. standard care for chronic ulcer healing: a systematic review and meta-analysis of randomised controlled trials (2014)
Journal Article
Barnes, R., Shahin, Y., Gohil, R., & Chetter, I. (2014). Electrical stimulation vs. standard care for chronic ulcer healing: a systematic review and meta-analysis of randomised controlled trials. European Journal of Clinical Investigation, 44(4), 429-440. https://doi.org/10.1111/eci.12244

Background We conducted a systematic review to investigate the effect of electrical stimulation on ulcer healing compared to usual treatment and/or sham stimulation. This systematic review also aimed to investigate the effect of different types of... Read More about Electrical stimulation vs. standard care for chronic ulcer healing: a systematic review and meta-analysis of randomised controlled trials.

Randomized clinical trial of selective versus routine preoperative duplex ultrasound imaging before arteriovenous fistula surgery: Duplex imaging before arteriovenous fistula surgery (2014)
Journal Article
Barnes, R., Chetter, I. C., & Smith, G. E. (2014). Randomized clinical trial of selective versus routine preoperative duplex ultrasound imaging before arteriovenous fistula surgery: Duplex imaging before arteriovenous fistula surgery. British journal of surgery, 101(5), 469-474. https://doi.org/10.1002/bjs.9435

BackgroundAnatomical suitability for arteriovenous fistula (AVF) formation was formerly determined by clinical examination alone. There are potential benefits from imaging to assess anatomical suitability. Existing studies examined the role of routin... Read More about Randomized clinical trial of selective versus routine preoperative duplex ultrasound imaging before arteriovenous fistula surgery: Duplex imaging before arteriovenous fistula surgery.

Effect of supervised exercise on physical function and balance in patients with intermittent claudication (2014)
Journal Article
Mockford, K. A., Gohil, R. A., Mazari, F., Khan, J. A., Vanicek, N., Coughlin, P. A., & Chetter, I. C. (2014). Effect of supervised exercise on physical function and balance in patients with intermittent claudication. British journal of surgery, 101(4), 356-362. https://doi.org/10.1002/bjs.9402

Background The aim of the study was to identify whether a standard supervised exercise programme (SEP) for patients with intermittent claudication improved specific measures of functional performance including balance. Methods A prospective observati... Read More about Effect of supervised exercise on physical function and balance in patients with intermittent claudication.

Fear of falling in claudicants and its relationship to physical ability, balance, and quality of Life (2014)
Journal Article
Lane, R. A., Mazari, F., Mockford, K. A., Vanicek, N., Chetter, I. C., & Coughlin, P. A. (2014). Fear of falling in claudicants and its relationship to physical ability, balance, and quality of Life. Vascular and endovascular surgery, 48(4), 297-304. https://doi.org/10.1177/1538574413519711

Objectives: Intermittent claudication is associated with poor physical function, quality of life (QoL), and balance impairment. Fear of falling (FoF) is a recognized contributing factor to poor physical ability. Any link between claudication and FoF... Read More about Fear of falling in claudicants and its relationship to physical ability, balance, and quality of Life.

The Impact of Previous Surgery and Revisions on Outcome after Major Lower Limb Amputation (2013)
Journal Article
Souroullas, P., Barnes, R., Lane, R. A., & Chetter, I. (2014). The Impact of Previous Surgery and Revisions on Outcome after Major Lower Limb Amputation. Annals of vascular surgery, 28(5), 1166-1171. https://doi.org/10.1016/j.avsg.2013.10.017

IntroductionMorbidity and mortality after lower limb amputation (LLA) remain disappointingly high. This study aimed to assess the impact of previous ipsilateral vascular intervention on outcomes after major LLA.MethodsProspective data were collected... Read More about The Impact of Previous Surgery and Revisions on Outcome after Major Lower Limb Amputation.

Supervised exercise program improves aerobic fitness in patients awaiting abdominal aortic aneurysm repair (2013)
Journal Article
Barakat, H. M., Shahin, Y., Barnes, R., Gohil, R., Souroullas, P., Khan, J., …Chetter, I. C. (2014). Supervised exercise program improves aerobic fitness in patients awaiting abdominal aortic aneurysm repair. Annals of vascular surgery, 28(1), 74-79. https://doi.org/10.1016/j.avsg.2013.09.001

Background Aerobic fitness is an important predictor of postoperative outcome in major surgery. In this study, we assess the effects of a period of preoperative exercise on aerobic fitness as measured by cardiopulmonary exercise testing (CPET) in pa... Read More about Supervised exercise program improves aerobic fitness in patients awaiting abdominal aortic aneurysm repair.

Computerized dynamic posturography for postural control assessment in patients with intermittent claudication. (2013)
Journal Article
Vanicek, N., King, S. A., Gohil, R., Chetter, I. C., & Coughlin, P. A. (2013). Computerized dynamic posturography for postural control assessment in patients with intermittent claudication. Journal of Visualized Experiments, Article e51077. https://doi.org/10.3791/51077

Computerized dynamic posturography with the EquiTest is an objective technique for measuring postural strategies under challenging static and dynamic conditions. As part of a diagnostic assessment, the early detection of postural deficits is importan... Read More about Computerized dynamic posturography for postural control assessment in patients with intermittent claudication..

Meta-analysis of angiotensin converting enzyme inhibitors effect on walking ability and ankle brachial pressure index in patients with intermittent claudication (2013)
Journal Article
Shahin, Y., Barnes, R., Barakat, H., & Chetter, I. C. (2013). Meta-analysis of angiotensin converting enzyme inhibitors effect on walking ability and ankle brachial pressure index in patients with intermittent claudication. Atherosclerosis, 231(2), 283-290. https://doi.org/10.1016/j.atherosclerosis.2013.09.037

Objective The aim of this meta-analysis was to investigate the effect of angiotensin converting enzyme (ACE) inhibitors on maximum walking distance (MWD), pain-free walking distance (PFWD) and ankle brachial pressure index (ABPI) in patients with in... Read More about Meta-analysis of angiotensin converting enzyme inhibitors effect on walking ability and ankle brachial pressure index in patients with intermittent claudication.

Outcomes after open repair of ruptured abdominal aortic aneurysms in octogenarians: a 20-year, single-center experience (2013)
Journal Article
Barakat, H. M., Shahin, Y., Barnes, R., Chetter, I., & McCollum, P. (2014). Outcomes after open repair of ruptured abdominal aortic aneurysms in octogenarians: a 20-year, single-center experience. Annals of vascular surgery, 28(1), 80-86. https://doi.org/10.1016/j.avsg.2013.07.006

Background The purpose of this study was to evaluate morbidity, mortality, and survival in octogenarians undergoing open repair of ruptured abdominal aortic aneurysms (RAAAs) in comparison to younger patients.MethodsThis investigation was a retrospe... Read More about Outcomes after open repair of ruptured abdominal aortic aneurysms in octogenarians: a 20-year, single-center experience.

Status update and interim results from the Asymptomatic Carotid Surgery Trial-2 (ACST-2) (2013)
Journal Article
ACST-2 Collaborative Group, . (2013). Status update and interim results from the Asymptomatic Carotid Surgery Trial-2 (ACST-2). European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 46(5), 510-518. https://doi.org/10.1016/j.ejvs.2013.07.020

ObjectivesACST-2 is currently the largest trial ever conducted to compare carotid artery stenting (CAS) with carotid endarterectomy (CEA) in patients with severe asymptomatic carotid stenosis requiring revascularization.ResultsA total of 986 patients... Read More about Status update and interim results from the Asymptomatic Carotid Surgery Trial-2 (ACST-2).

Percutaneous transluminal angioplasty results in improved physical function but not balance in patients with intermittent claudication (2013)
Journal Article
Gohil, R. A., Mockford, K. A., Mazari, F. A., Khan, J. A., Van Vanicek, N., Chetter, I. C., & Coughlin, P. A. (2013). Percutaneous transluminal angioplasty results in improved physical function but not balance in patients with intermittent claudication. Journal of vascular surgery, 58(6), 1533-1539. https://doi.org/10.1016/j.jvs.2013.05.106

Objective The aim of this study was to identify whether revascularization by percutaneous transluminal angioplasty (PTA) for patients with intermittent claudication improved measures of functional performance including balance. Methods A prospective... Read More about Percutaneous transluminal angioplasty results in improved physical function but not balance in patients with intermittent claudication.

Economic analysis of a randomized trial of percutaneous angioplasty, supervised exercise or combined treatment for intermittent claudication due to femoropopliteal arterial disease (2013)
Journal Article
Mazari, F. A. K., Khan, J. A., Carradice, D., Samuel, N., Gohil, R., McCollum, P. T., & Chetter, I. C. (2013). Economic analysis of a randomized trial of percutaneous angioplasty, supervised exercise or combined treatment for intermittent claudication due to femoropopliteal arterial disease. British journal of surgery, 100(9), 1172-1179. https://doi.org/10.1002/bjs.9200

BackgroundThe aim was to compare costs and utilities of percutaneous transluminal angioplasty (PTA), a supervised exercise programme (SEP) and combined treatment (PTA + SEP) in patients with intermittent claudication (IC) to establish the most cost-e... Read More about Economic analysis of a randomized trial of percutaneous angioplasty, supervised exercise or combined treatment for intermittent claudication due to femoropopliteal arterial disease.