All Outputs (28)

The influence of oxidised low density lipoproteins on platelet activation (2013)
Thesis
Wraith, K. S. The influence of oxidised low density lipoproteins on platelet activation. (Thesis). Hull York Medical School, the University of Hull and the University of York. https://hull-repository.worktribe.com/output/4214678

The oxidation of low density lipoproteins (LDL) may contribute to platelet hyperactivity and thrombotic events in cardiovascular diseases. Although these pathological particles are known to stimulate platelet activation, the exact signalling mechanis... Read More about The influence of oxidised low density lipoproteins on platelet activation.

Regulation of blood platelet function by nitric oxide (2013)
Thesis
Wake, J. D. Regulation of blood platelet function by nitric oxide. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4214507

Upon vascular injury, platelets instantly adhere to the exposed extracellular matrix resulting in platelet activation and aggregation to form a haemostatic plug. This self-amplifying mechanism requires a tight control to prevent uncontrolled platelet... Read More about Regulation of blood platelet function by nitric oxide.

Adiponectin : a novel circulating anti-thrombotic factor in humans? (2011)
Thesis
Yousaf, T. A. Adiponectin : a novel circulating anti-thrombotic factor in humans?. (Thesis). Hull York Medical School, the University of Hull and the University of York. https://hull-repository.worktribe.com/output/4212180

Adiponectin is an adipocyte-derived pro-inflammatory adipokine that regulates metabolic homeostasis, although it has been reported to modulate platelet function and thrombosis. In this study the effects of globular adiponectin (gAd), a novel platelet... Read More about Adiponectin : a novel circulating anti-thrombotic factor in humans?.

Thrombospondin-1 induces platelet activation through CD36-dependent inhibition of the cAMP/protein kinase A signaling cascade (2010)
Journal Article
Roberts, W., Magwenzi, S., Aburima, A., & Naseem, K. (2010). Thrombospondin-1 induces platelet activation through CD36-dependent inhibition of the cAMP/protein kinase A signaling cascade. Blood, 116(20), 4297-4306. https://doi.org/10.1182/blood-2010-01-265561

Cyclic adenosine monophosphate (cAMP)-dependent signaling modulates platelet function at sites of vascular injury. Here we show that thrombospondin-1 (TSP-1) prevents cAMP/protein kinase A (PKA) signaling through a CD36-dependent mechanism. Prostagla... Read More about Thrombospondin-1 induces platelet activation through CD36-dependent inhibition of the cAMP/protein kinase A signaling cascade.

Regulation of blood platelet function by the AGC family of protein kinases (2010)
Thesis
Aburima, A. A. Regulation of blood platelet function by the AGC family of protein kinases. (Thesis). Hull York Medical School, the University of Hull and the University of York. https://hull-repository.worktribe.com/output/4212803

Upon vascular injury, platelets aggregate at the site of blood vessel injury to form a hemostatic plug maintaining the physiological integrity of the vascular system. Platelets respond to a variety of extracellular stimuli to undergo a rapid aggregat... Read More about Regulation of blood platelet function by the AGC family of protein kinases.

Nitric oxide inhibits von Willebrand factor-mediated platelet adhesion and spreading through regulation of integrin α IIbβ 3 and myosin light chain (2009)
Journal Article
Roberts, W., Michno, A., Aburima, A., & Naseem, K. M. (2009). Nitric oxide inhibits von Willebrand factor-mediated platelet adhesion and spreading through regulation of integrin α IIbβ 3 and myosin light chain. Journal of thrombosis and haemostasis : JTH, 7(12), 2106-2115. https://doi.org/10.1111/j.1538-7836.2009.03619.x

Background: von Willebrand factor (VWF)-mediated platelet adhesion and spreading at sites of vascular injury is a critical step in hemostasis. This process requires two individual receptors: glycoprotein Ib (GPIb)-V-IX and integrin αIIbβ3. However, l... Read More about Nitric oxide inhibits von Willebrand factor-mediated platelet adhesion and spreading through regulation of integrin α IIbβ 3 and myosin light chain.

Globular adiponectin increases cGMP formation in blood platelets independently of nitric oxide (2008)
Journal Article
Riba, R., Patel, B., Aburima, A., & Naseem, K. M. (2008). Globular adiponectin increases cGMP formation in blood platelets independently of nitric oxide. Journal of thrombosis and haemostasis : JTH, 6(12), 2121-2131. https://doi.org/10.1111/j.1538-7836.2008.03179.x

Background: Platelet-derived nitric oxide (NO) has been shown to play conflicting roles in platelet function, although it is accepted that NO mediates its actions through soluble guanylyl cyclase (sGC). This confusion concerning the roles of platelet... Read More about Globular adiponectin increases cGMP formation in blood platelets independently of nitric oxide.

Globular adiponectin induces platelet activation through the collagen receptor GPVI-Fc receptor γ chain complex (2008)
Journal Article
Riba, R., Hughes, C. E., Graham, A., Watson, S. P., & Naseem, K. M. (2008). Globular adiponectin induces platelet activation through the collagen receptor GPVI-Fc receptor γ chain complex. Journal of thrombosis and haemostasis : JTH, 6(6), 1012-1020. https://doi.org/10.1111/j.1538-7836.2008.02982.x

Background: The adipocyte-derived cytokine, adiponectin (Ad), exerts potent vascular effects, although the direct effects of Ad on blood platelets are unclear. Objective: The influence of globular Ad (gAd) on blood platelet function was investigated.... Read More about Globular adiponectin induces platelet activation through the collagen receptor GPVI-Fc receptor γ chain complex.