All Outputs (3)

Identification of the Antigens Recognised by Colorectal Cancer Patients Using Sera from Patients Who Exhibit a Crohn’s-like Lymphoid Reaction (2022)
Journal Article
Boncheva, V. B., Linnebacher, M., Kdimati, S., Draper, H., Orchard, L., Mills, K. I., …Guinn, B. A. (2022). Identification of the Antigens Recognised by Colorectal Cancer Patients Using Sera from Patients Who Exhibit a Crohn’s-like Lymphoid Reaction. Biomolecules, 12(8), 1058. https://doi.org/10.3390/biom12081058

A Crohn’s-like lymphoid reaction (CLR) is observed in about 15% of colorectal cancer (CRC) patients and is associated with favourable outcomes. To identify the immune targets recognised by CRC CLR patient sera, we immunoscreened a testes cDNA library... Read More about Identification of the Antigens Recognised by Colorectal Cancer Patients Using Sera from Patients Who Exhibit a Crohn’s-like Lymphoid Reaction.

Oral tolerance to cancer can be abrogated by T regulatory cell inhibition (2014)
Journal Article
Whelan, M. C., Casey, G., Larkin, J. O., Guinn, B. A., O'Sullivan, G. C., & Tangney, M. (2014). Oral tolerance to cancer can be abrogated by T regulatory cell inhibition. PLoS ONE, 9(5), Article e97602. https://doi.org/10.1371/journal.pone.0097602

Oral administration of tumour cells induces an immune hypo-responsiveness known as oral tolerance. We have previously shown that oral tolerance to a cancer is tumour antigen specific, non-cross-reactive and confers a tumour growth advantage. We inves... Read More about Oral tolerance to cancer can be abrogated by T regulatory cell inhibition.

New targets for the immunotherapy of colon cancer - Does reactive disease hold the answer (2013)
Journal Article
Boncheva, V., Bonney, S. A., Brooks, S. E., Tangney, M., O'Sullivan, G., Mirnezami, A., & Guinn, B. A. (2013). New targets for the immunotherapy of colon cancer - Does reactive disease hold the answer. Cancer Gene Therapy, 20(3), 157-168. https://doi.org/10.1038/cgt.2013.5

Colorectal cancer (CRC) is one of the most commonly diagnosed cancers in both men and women, posing a serious demographic and economic burden worldwide. In the United Kingdom, CRC affects 1 in every 20 people and it is often detected once well establ... Read More about New targets for the immunotherapy of colon cancer - Does reactive disease hold the answer.