Maria C. Whelan
Oral tolerance to cancer can be abrogated by T regulatory cell inhibition
Whelan, Maria C.; Casey, Garrett; Larkin, John O.; Guinn, Barbara Ann; O'Sullivan, Gerald C.; Tangney, Mark
Authors
Garrett Casey
John O. Larkin
Dr Barbara Guinn B.Guinn@hull.ac.uk
Reader in Biomedical Sciences
Gerald C. O'Sullivan
Mark Tangney
Abstract
Oral administration of tumour cells induces an immune hypo-responsiveness known as oral tolerance. We have previously shown that oral tolerance to a cancer is tumour antigen specific, non-cross-reactive and confers a tumour growth advantage. We investigated the utilisation of regulatory T cell (Treg) depletion on oral tolerance to a cancer and its ability to control tumour growth. Balb/C mice were gavage fed homogenised tumour tissue - JBS fibrosarcoma (to induce oral tolerance to a cancer), or PBS as control. Growth of subcutaneous JBS tumours were measured; splenic tissue excised and flow cytometry used to quantify and compare systemic Tregs and T effector (Teff) cell populations. Prior to and/or following tumour feeding, mice were intraperitoneally administered anti-CD25, to inactivate systemic Tregs, or given isotype antibody as a control. Mice which were orally tolerised prior to subcutaneous tumour induction, displayed significantly higher systemic Treg levels (14% vs 6%) and faster tumour growth rates than controls (p
Citation
Whelan, M. C., Casey, G., Larkin, J. O., Guinn, B. A., O'Sullivan, G. C., & Tangney, M. (2014). Oral tolerance to cancer can be abrogated by T regulatory cell inhibition. PLoS ONE, 9(5), Article e97602. https://doi.org/10.1371/journal.pone.0097602
Journal Article Type | Article |
---|---|
Acceptance Date | Apr 22, 2014 |
Online Publication Date | May 15, 2014 |
Publication Date | May 15, 2014 |
Deposit Date | Apr 9, 2019 |
Publicly Available Date | Apr 10, 2019 |
Journal | PLoS ONE |
Print ISSN | 1932-6203 |
Publisher | Public Library of Science |
Peer Reviewed | Peer Reviewed |
Volume | 9 |
Issue | 5 |
Article Number | e97602 |
DOI | https://doi.org/10.1371/journal.pone.0097602 |
Public URL | https://hull-repository.worktribe.com/output/1567103 |
Publisher URL | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0097602 |
Contract Date | Apr 10, 2019 |
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Copyright Statement
Copyright: 2014 Whelan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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