Dr Barbara Guinn
Reader in Biomedical Sciences
|Biography||I am a Reader in Biomedical Sciences at the University of Hull. I have a BSc Genetics from University of Aberyswyth (1991) and a PhD from the University of Wales College of Medicine Cardiff (1995). I then worked at the University of Toronto as a postdoctoral fellow and started my own research group at King's College London in 1999.
I am interested in identifying antigens as targets for immunotherapy (where the immune system is stimulated to kill diseased cells) but we have also realised that disease-specific proteins can provide insights into the biology of disease and biomarkers for disease stage and survival.
Currently we are looking for antigenic targets for the targeted therapy of adult B-cell acute lymphocytic leukaemia, colon and ovarian cancer, as well as endometriosis and incidental lung nodules. We have shown that antigens can act as biomarkers for disease (diagnosis, survival and subtype) as well as providing new insights into the biology underlying these difficult to treat diseases.
|Research Interests||My research interests focus around antigen identification reflecting my own background in genetics, immunology and cancer research. We use a range of techniques to identify and characterise antigens including SEREX, proto-arrays, cDNA expression arrays, qPCR and pMHC arrays.
I am particularly interested in identifying new biomarkers for difficult to diagnose diseases such as endometriosis, ovarian cancer and lung nodules that develop into cancer. These are often difficult to treat diseases because of their late diagnosis.
|Teaching and Learning||Undergraduate - BSc Programmes
- Human Genetics
- Professional and Research Skills for Biomedical Sciences
- Final Year Independent Projects
- Molecular and Cell Biology
Postgraduate - MSc Programmes
- Research Project and Dissertation