All Outputs (16)

Environmental fluoxetine promotes skin cell proliferation and wound healing (2024)
Journal Article
Rodriguez-Barucg, Q., Garcia, A. A., Garcia-Merino, B., Akinmola, T., Okotie-Eboh, T., Francis, T., Bringas, E., Ortiz, I., Wade, M., Dowle, A., Joyce, D. A., Hardman, M. J., Wilkinson, H. N., & Beltran-Alvarez, P. (2024). Environmental fluoxetine promotes skin cell proliferation and wound healing. Environmental pollution, 362, Article 124952. https://doi.org/10.1016/j.envpol.2024.124952

This study investigates the effects of environmentally-relevant concentrations of fluoxetine (FLX, commercial name: Prozac) on wound healing. Pollution of water systems with pharmaceutical and personal care products, including antidepressants such as... Read More about Environmental fluoxetine promotes skin cell proliferation and wound healing.

Investigation into the role of the epigenetic target CBX2 in Glioblastoma (2024)
Thesis
Beattie, H. Investigation into the role of the epigenetic target CBX2 in Glioblastoma. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4866108

Glioblastoma (GBM) has been identified as an extremely difficult tumour to treat owing to issues of heterogeneity, as well as the aggressive nature of the tumours’ growth. Despite current treatments using a combination of methods, treatment resistanc... Read More about Investigation into the role of the epigenetic target CBX2 in Glioblastoma.

Investigating the importance of CBX2’s structural motifs for its chromatin interactions and pro-oncogenic epigenetic regulatory function in triple negative breast cancer (2022)
Thesis
Dobrowinski, W. Investigating the importance of CBX2’s structural motifs for its chromatin interactions and pro-oncogenic epigenetic regulatory function in triple negative breast cancer. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4291232

Epigenetics is the study of the change in gene expression patterns that are not caused by direct alterations in the DNA nucleotide sequence but instead are as a result of the dynamic remodelling of the chromatin state. Regulation of the chromatin lan... Read More about Investigating the importance of CBX2’s structural motifs for its chromatin interactions and pro-oncogenic epigenetic regulatory function in triple negative breast cancer.

Investigating the role Of CBX2 to promote cell growth in triple negative breast cancer (2022)
Thesis
Bilton, L. Investigating the role Of CBX2 to promote cell growth in triple negative breast cancer. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4240594

Breast cancer is the uncontrolled proliferation of breast cells and is one of the most common cancers in the UK. It is a complex disease that can be divided into different subtypes based upon the presence or lack of hormone receptors, namely the oest... Read More about Investigating the role Of CBX2 to promote cell growth in triple negative breast cancer.

The Epigenetic Regulatory Protein CBX2 Promotes mTORC1 Signalling and Inhibits DREAM Complex Activity to Drive Breast Cancer Cell Growth (2022)
Journal Article
Bilton, L. J., Warren, C., Humphries, R. M., Kalsi, S., Waters, E., Francis, T., …Wade, M. A. (2022). The Epigenetic Regulatory Protein CBX2 Promotes mTORC1 Signalling and Inhibits DREAM Complex Activity to Drive Breast Cancer Cell Growth. Cancers, 14(14), Article 3491. https://doi.org/10.3390/cancers14143491

Chromobox 2 (CBX2) is a chromatin-binding component of polycomb repressive complex 1, which causes gene silencing. CBX2 expression is elevated in triple-negative breast cancer (TNBC), for which there are few therapeutic options. Here, we aimed to inv... Read More about The Epigenetic Regulatory Protein CBX2 Promotes mTORC1 Signalling and Inhibits DREAM Complex Activity to Drive Breast Cancer Cell Growth.

Isolation and characterisation of graves’ disease-specific extracellular vesicles from tissue maintained on a bespoke microfluidic device (2021)
Journal Article
Foster, H., Wade, M., England, J., Greenman, J., & Green, V. (2021). Isolation and characterisation of graves’ disease-specific extracellular vesicles from tissue maintained on a bespoke microfluidic device. Organs-on-a-Chip, 3, Article 100011. https://doi.org/10.1016/j.ooc.2021.100011

Abstract
This report demonstrates the ability of a microfluidic device to maintain human Graves' disease tissue enabling the isolation and characterisation of Graves' disease specific exosomes. Graves' disease (n = 7) and non-Graves’ disease (Hashim... Read More about Isolation and characterisation of graves’ disease-specific extracellular vesicles from tissue maintained on a bespoke microfluidic device.

The histone demethylase enzymes KDM3A and KDM4B co-operatively regulate chromatin transactions of the estrogen receptor in breast cancer (2019)
Journal Article
Jones, D., Wilson, L., Thomas, H., Gaughan, L., & Wade, M. A. (2019). The histone demethylase enzymes KDM3A and KDM4B co-operatively regulate chromatin transactions of the estrogen receptor in breast cancer. Cancers, 11(8), Article 1122. https://doi.org/10.3390/cancers11081122

Many estrogen receptor (ER)-positive breast cancers develop resistance to endocrine therapy but retain canonical receptor signalling in the presence of selective ER antagonists. Numerous co-regulatory proteins, including enzymes that modulate the chr... Read More about The histone demethylase enzymes KDM3A and KDM4B co-operatively regulate chromatin transactions of the estrogen receptor in breast cancer.

The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart (2019)
Journal Article
Onwuli, D. O., Samuel, S., Sfyri, P., Welham, K., Goddard, M., Abu-Omar, Y., Loubani, M., Rivero, F., Matsakas, A., Benoit, D. M., Wade, M., Greenman, J., & Beltran-Alvarez, P. (2019). The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart. International journal of cardiology, 282, 76-80. https://doi.org/10.1016/j.ijcard.2019.01.102

Background
The inhibitory subunit of cardiac troponin (cTnI) is a gold standard cardiac biomarker and also an essential protein in cardiomyocyte excitation-contraction coupling. The interactions of cTnI with other proteins are fine-tuned by post-tra... Read More about The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart.

Common cancer-associated imbalances in the DNA damage response confer sensitivity to single agent ATR inhibition (2015)
Journal Article
Middleton, F. K., Patterson, M. J., Elstob, C. J., Fordham, S., Herriott, A., Wade, M. A., McCormick, A., Edmondson, R., May, F. E., Allan, J. M., Pollard, J. R., & Curtin, N. J. (2015). Common cancer-associated imbalances in the DNA damage response confer sensitivity to single agent ATR inhibition. Oncotarget, 6(32), 32396-32409. https://doi.org/10.18632/oncotarget.6136

ATR is an attractive target in cancer therapy because it signals replication stress and DNA lesions for repair and to S/G2 checkpoints. Cancer-specific defects in the DNA damage response (DDR) may render cancer cells vulnerable to ATR inhibition alon... Read More about Common cancer-associated imbalances in the DNA damage response confer sensitivity to single agent ATR inhibition.

FOXA1 regulates androgen receptor variant activity in models of castrate-resistant prostate cancer (2015)
Journal Article
Jones, D., Wade, M., Nakjang, S., Chaytor, L., Grey, J., Robson, C. N., & Gaughan, L. (2015). FOXA1 regulates androgen receptor variant activity in models of castrate-resistant prostate cancer. Oncotarget, 6(30), 29782-29794. https://doi.org/10.18632/oncotarget.4927

Retention of androgen receptor (AR) signalling in castrate-resistant prostate cancer (CRPC) highlights the requirement for the development of more effective AR targeting therapies. A key mechanism of resistance to anti-androgens is through expression... Read More about FOXA1 regulates androgen receptor variant activity in models of castrate-resistant prostate cancer.

Development and exploitation of a novel mutant androgen receptor modelling strategy to identify new targets for advanced prostate cancer therapy (2015)
Journal Article
O’Neill, D., Jones, D., Wade, M., Grey, J., Nakjang, S., Guo, W., Cork, D., Davies, B. R., Wedge, S. R., Robson, C. N., & Gaughan, L. (2015). Development and exploitation of a novel mutant androgen receptor modelling strategy to identify new targets for advanced prostate cancer therapy. Oncotarget, 6(28), 26029-26040. https://doi.org/10.18632/oncotarget.4347

The persistence of androgen receptor (AR) signalling in castrate-resistant prostate cancer (CRPC) highlights the unmet clinical need for the development of more effective AR targeting therapies. A key mechanism of therapy-resistance is by selection o... Read More about Development and exploitation of a novel mutant androgen receptor modelling strategy to identify new targets for advanced prostate cancer therapy.

Does radiation-induced c-MYC amplification initiate breast oncogenesis? (2015)
Journal Article
Wade, M. A., May, F. E., Onel, K., & Allan, J. M. (2016). Does radiation-induced c-MYC amplification initiate breast oncogenesis?. Molecular and Cellular Oncology, 3(1), Article e1010950. https://doi.org/10.1080/23723556.2015.1010950

© 2016 Taylor and Francis Group, LLC. The MYC (v-myc avian myelocytomatosis viral oncogene homolog; c-MYC) locus on chromosome 8q is susceptible to high-level amplification following exposure of human breast cells to ionizing radiation, and c-MYC amp... Read More about Does radiation-induced c-MYC amplification initiate breast oncogenesis?.

c-MYC is a radiosensitive locus in human breast cells (2014)
Journal Article
Wade, M. A., Sunter, N. J., Fordham, S. E., Long, A., Masic, D., Russell, L. J., Harrison, C. J., Rand, V., Elstob, C., Bown, N., Rowe, D., Lowe, C., Cuthbert, G., Bennett, S., Crosier, S., Bacon, C. M., Onel, K., Scott, K., Scott, D., Travis, L. B., …Allan, J. M. (2015). c-MYC is a radiosensitive locus in human breast cells. Oncogene, 34(38), 4985-4994. https://doi.org/10.1038/onc.2014.427

Ionising radiation is a potent human carcinogen. Epidemiological studies have shown that adolescent and young women are at increased risk of developing breast cancer following exposure to ionising radiation compared with older women, and that risk is... Read More about c-MYC is a radiosensitive locus in human breast cells.

The histone demethylase enzyme KDM3A is a key estrogen receptor regulator in breast cancer (2014)
Journal Article
Wade, M. A., Jones, D., Wilson, L., Stockley, J., Coffey, K., Robson, C. N., & Gaughan, L. (2015). The histone demethylase enzyme KDM3A is a key estrogen receptor regulator in breast cancer. Nucleic Acids Research, 43(1), 196-207. https://doi.org/10.1093/nar/gku1298

Endocrine therapy has successfully been used to treat estrogen receptor (ER)-positive breast cancer, but this invariably fails with cancers becoming refractory to treatment. Emerging evidence has suggested that fluctuations in ER co-regulatory protei... Read More about The histone demethylase enzyme KDM3A is a key estrogen receptor regulator in breast cancer.

KDM4B is a master regulator of the estrogen receptor signalling cascade (2013)
Journal Article
Gaughan, L., Stockley, J., Coffey, K., O’Neill, D., Jones, D. L., Wade, M., Wright, J., Moore, M., Tse, S., Rogerson, L., & Robson, C. N. (2013). KDM4B is a master regulator of the estrogen receptor signalling cascade. Nucleic Acids Research, 41(14), 6892-6904. https://doi.org/10.1093/nar/gkt469

The importance of the estrogen receptor (ER) in breast cancer (BCa) development makes it a prominent target for therapy. Current treatments, however, have limited effectiveness, and hence the definition of new therapeutic targets is vital. The ER is... Read More about KDM4B is a master regulator of the estrogen receptor signalling cascade.

Post-transcriptional exon shuffling events in humans can be evolutionarily conserved and abundant (2011)
Journal Article
Al-Balool, H. H., Weber, D., Liu, Y., Wade, M., Guleria, K., Nam, P. L. P., Clayton, J., Rowe, W., Coxhead, J., Irving, J., Elliott, D. J., Hall, A. G., Santibanez-Koref, M., & Jackson, M. S. (2011). Post-transcriptional exon shuffling events in humans can be evolutionarily conserved and abundant. Genome research, 21(11), 1788-1799. https://doi.org/10.1101/gr.116442.110

In silico analyses have established that transcripts from some genes can be processed into RNAs with rearranged exon order relative to genomic structure (post-transcriptional exon shuffling, or PTES). Although known to contribute to transcriptome div... Read More about Post-transcriptional exon shuffling events in humans can be evolutionarily conserved and abundant.