Does radiation-induced c-MYC amplification initiate breast oncogenesis?

Wade, Mark A.; May, Felicity E.B.; Onel, Ken; Allan, James M.

Abstract

© 2016 Taylor and Francis Group, LLC. The MYC (v-myc avian myelocytomatosis viral oncogene homolog; c-MYC) locus on chromosome 8q is susceptible to high-level amplification following exposure of human breast cells to ionizing radiation, and c-MYC amplification is a common feature of both radiogenic adenocarcinoma and radiogenic angiosarcoma of the breast. Taken together, these observations suggest common breast-specific susceptibility factors that predispose cells to amplification of this critical proto-oncogene and the development of radiogenic cancer in multiple tissue types of this radiosensitive organ.

Citation

Wade, M. A., May, F. E., Onel, K., & Allan, J. M. (2016). Does radiation-induced c-MYC amplification initiate breast oncogenesis?. Molecular and Cellular Oncology, 3(1), Article e1010950. https://doi.org/10.1080/23723556.2015.1010950

• Journal Article Type: Article
• Acceptance Date: Jan 17, 2015
• Online Publication Date: Feb 3, 2015
• Publication Date: Jan 2, 2016
• Deposit Date: May 3, 2022
• Journal: Molecular and Cellular Oncology
• Electronic ISSN: 2372-3556
• Publisher: Taylor and Francis
• Peer Reviewed: Peer Reviewed
• Volume: 3
• Issue: 1
• Article Number: e1010950
• DOI: https://doi.org/10.1080/23723556.2015.1010950
• Keywords: Radiosensitive; Amplification; Oncogene; MYC; Adenocarcinoma
• Public URL: https://hull-repository.worktribe.com/output/3635810