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Does radiation-induced c-MYC amplification initiate breast oncogenesis?

Wade, Mark A.; May, Felicity E.B.; Onel, Ken; Allan, James M.

Authors

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Dr Mark Wade M.Wade@hull.ac.uk
Senior Lecturer in Molecular Genetics

Felicity E.B. May

Ken Onel

James M. Allan



Abstract

© 2016 Taylor and Francis Group, LLC. The MYC (v-myc avian myelocytomatosis viral oncogene homolog; c-MYC) locus on chromosome 8q is susceptible to high-level amplification following exposure of human breast cells to ionizing radiation, and c-MYC amplification is a common feature of both radiogenic adenocarcinoma and radiogenic angiosarcoma of the breast. Taken together, these observations suggest common breast-specific susceptibility factors that predispose cells to amplification of this critical proto-oncogene and the development of radiogenic cancer in multiple tissue types of this radiosensitive organ.

Citation

Wade, M. A., May, F. E., Onel, K., & Allan, J. M. (2016). Does radiation-induced c-MYC amplification initiate breast oncogenesis?. Molecular and Cellular Oncology, 3(1), Article e1010950. https://doi.org/10.1080/23723556.2015.1010950

Journal Article Type Article
Acceptance Date Jan 17, 2015
Online Publication Date Feb 3, 2015
Publication Date Jan 2, 2016
Deposit Date May 3, 2022
Journal Molecular and Cellular Oncology
Electronic ISSN 2372-3556
Publisher Taylor and Francis
Peer Reviewed Peer Reviewed
Volume 3
Issue 1
Article Number e1010950
DOI https://doi.org/10.1080/23723556.2015.1010950
Keywords Radiosensitive; Amplification; Oncogene; MYC; Adenocarcinoma
Public URL https://hull-repository.worktribe.com/output/3635810