Dr Mark Wade
| Biography | I am a Senior Lecturer in Molecular Genetics in the Hull York Medical School Centre for Biomedicine (Hull) l where I lead the Cancer Epigenetics Team. I was awarded my Ph.D. in 2012 having worked in the lab of Professor James Allan at Newcastle University studying the molecular genetics of radiation-induced breast cancer. Prior to my current role I was a post-doctoral research associate in the lab of Dr Luke Gaughan from 2012-2017 studying the role of histone demethylase (HDMs) enzymes in breast cancer. In particular the function of the HDMs KDM4B and KDM3A and their role in estrogen receptor signalling. My current research continues to investigate the role of epigenetic regulatory enzymes in cancer development and progression, particularly in breast cancer and glioblastoma, in an aim to identify novel therapeutic targets. My current interests lie in 'epi-reader' proteins which recognise and interpret histone modifications in order to control gene expression. |
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| Research Interests | My research interests are mainly focused on epigenetic mechanisms in cancer, in particular breast and prostate cancer and glioblastoma. I am interested in enzymes which regulate the chemical modification of histones to control chromatin structure and gene expression, and their potential as therapeutic targets to treat cancer. I also have interests in the molecular genetics of radiation-induced cancer and the development of ex vivo microfluidic platforms as novel therapeutic target validation tools. |
| Teaching and Learning | On the Biomedical Sciences undergraduate programme I am module coordinator for the Level 6 Human Genetics module and teach on the Level 4 Principles of Genetics module and Level 5 Molecular Genetics and Proteomics module. I also supervise undergraduate students for their Independent Research Projects at Level 6 and MSc by Thesis postrgraduate students and teach on the Level 4 and 5 skills modules. |
| Scopus Author ID | 57212596068 |
| PhD Supervision Availability | Yes |
| PhD Topics | There are current opportunities for self-funded PhD students in the area of epigenetic regulation in breast cancer and glioblastoma. |