Skip to main content

Research Repository

Advanced Search

All Outputs (31)

Unmet needs and future directions of treatment options for chronic cough (2025)
Journal Article
Zhang, M., & Morice, A. (2025). Unmet needs and future directions of treatment options for chronic cough. Expert Review of Respiratory Medicine, https://doi.org/10.1080/17476348.2025.2499663

Introduction: Chronic cough is a persistent condition that significantly affects patients’ quality of life and poses diagnostic and therapeutic challenges. Traditional anatomical diagnostic approaches often fail to address the underlying mechanisms,... Read More about Unmet needs and future directions of treatment options for chronic cough.

Cough Reflex Hypersensitivity as a Key Treatable Trait (2024)
Journal Article
Song, W. J., Manian, D. V., Kim, Y., Zhang, M., & Morice, A. H. (in press). Cough Reflex Hypersensitivity as a Key Treatable Trait. The journal of allergy and clinical immunology. In practice, https://doi.org/10.1016/j.jaip.2024.10.046

Cough reflex hypersensitivity is emerging as a key treatable trait in chronic cough and other cough-associated respiratory conditions. This review examines the neurological basis of cough, highlighting the complex interplay between peripheral and cen... Read More about Cough Reflex Hypersensitivity as a Key Treatable Trait.

Current and emerging opioids for the treatment of chronic cough: a mini review (2024)
Journal Article
Zhang, M., & Morice, A. H. (online). Current and emerging opioids for the treatment of chronic cough: a mini review. Expert Opinion on Pharmacotherapy, https://doi.org/10.1080/14656566.2024.2418983

Introduction: Chronic cough has increasingly been recognized as a distinct clinical entity that affects a significant portion of the global population. Despite advancements in understanding its pathophysiology, treatment options remain limited. Opioi... Read More about Current and emerging opioids for the treatment of chronic cough: a mini review.

Decoding the impact of the placebo response in clinical trials for chronic cough (2024)
Journal Article
Zhang, M., Zhang, B., & Morice, A. H. (2024). Decoding the impact of the placebo response in clinical trials for chronic cough. ERJ Open Research, 10(5), Article 00335-2024. https://doi.org/10.1183/23120541.00335-2024

Chronic cough is a prevalent and challenging condition, with limited treatment options available. The interpretation of clinical trial results for antitussive drugs is complicated by the presence of the placebo response, which can confound outcomes a... Read More about Decoding the impact of the placebo response in clinical trials for chronic cough.

Role of alveolar nitric oxide in gastroesophageal reflux-associated cough: prospective observational study (2024)
Journal Article
Zhang, L., Zhang, M., Aierken, A., Dong, R., & Chen, Q. (2024). Role of alveolar nitric oxide in gastroesophageal reflux-associated cough: prospective observational study. Therapeutic Advances in Respiratory Disease, 18, https://doi.org/10.1177/17534666241231117

Background: Fractional exhaled nitric oxide (FeNO) measured at multiple exhalation flow rates can be used as a biomarker to differentiate central and peripheral airway inflammation. However, the role of alveolar nitric oxide (CaNO) indicating periphe... Read More about Role of alveolar nitric oxide in gastroesophageal reflux-associated cough: prospective observational study.

Unravelling vagal hypersensitivity in chronic cough: A distinct disease (2023)
Journal Article
Zhang, M., & Morice, A. H. (2024). Unravelling vagal hypersensitivity in chronic cough: A distinct disease. The Journal of physiology, 602(22), 6039-6046. https://doi.org/10.1113/JP284641

Chronic cough (CC) is a common but poorly understood disease that has a negative impact on quality of life. For years, clinicians have been trying to find the underlying diagnosis and using existing disease models to describe the patients’ illness. T... Read More about Unravelling vagal hypersensitivity in chronic cough: A distinct disease.

New Insights Into Refractory Chronic Cough and Unexplained Chronic Cough: A 6-Year Ambispective Cohort Study (2023)
Journal Article
Zhang, M., Morice, A. H., Si, F., Zhang, L., Chen, Q., Wang, S., Zhu, Y., Xu, X., Yu, L., & Qiu, Z. (2023). New Insights Into Refractory Chronic Cough and Unexplained Chronic Cough: A 6-Year Ambispective Cohort Study. Allergy Asthma and Immunology Research, 15(6), 795-811. https://doi.org/10.4168/aair.2023.15.6.795

Purpose: Only limited studies have depicted the unique features and management of refractory chronic cough (RCC) and unexplained chronic cough (UCC). These led to the initiation of this study, which reported the demographic characteristics, manifesta... Read More about New Insights Into Refractory Chronic Cough and Unexplained Chronic Cough: A 6-Year Ambispective Cohort Study.

Subcutaneous octreotide as a therapeutic option for refractory chronic cough: subjective response pattern and adverse effects from a retrospective single-centre case series (2023)
Journal Article
Brindle, K., Zhang, M., Carter, N., & Morice, A. H. (2023). Subcutaneous octreotide as a therapeutic option for refractory chronic cough: subjective response pattern and adverse effects from a retrospective single-centre case series. ERJ Open Research, 9(3), Article 00100-2023. https://doi.org/10.1183/23120541.00100-2023

Pathogenesis and management of gastroesophageal reflux disease-associated cough: a narrative review (2023)
Journal Article
Zhang, L., Aierken, A., Zhang, M., & Qiu, Z. (2023). Pathogenesis and management of gastroesophageal reflux disease-associated cough: a narrative review. Journal of thoracic disease, 15(4), 2314-2323. https://doi.org/10.21037/jtd-22-1757

Background and Objective: Gastroesophageal reflux disease (GERD)-associated cough is defined as a special GERD with a predominant cough symptom and is a common cause of chronic cough. This review summarizes our current understanding on the pathogenes... Read More about Pathogenesis and management of gastroesophageal reflux disease-associated cough: a narrative review.

Improved diagnostic yield of symptom association probability involving only cough for gastroesophageal reflux-induced chronic cough (2023)
Journal Article
Zhang, L., Zhang, M., Chen, Q., Sun, H., Bian, X., Xu, X., Yu, L., & Qiu, Z. (2023). Improved diagnostic yield of symptom association probability involving only cough for gastroesophageal reflux-induced chronic cough. Journal of thoracic disease, 15(4), 2277-2287. https://doi.org/10.21037/jtd-22-1016

Background: Use of symptom association probability (SAP) is recommended for identifying gastroesophageal reflux-induced chronic cough (GERC). This study aimed to compare the diagnostic yield of SAPs involving only cough (C-SAP) or total symptoms (T-S... Read More about Improved diagnostic yield of symptom association probability involving only cough for gastroesophageal reflux-induced chronic cough.

Mean Nocturnal Baseline Impedance (MNBI) Provides Evidence for Standardized Management Algorithms of Nonacid Gastroesophageal Reflux-Induced Chronic Cough (2023)
Journal Article
Zhu, Y., Zhang, T., Wang, S., Li, W., Shi, W., Bai, X., Sha, B., Zhang, M., Wen, S., Shi, C., Xu, X., & Yu, L. (2023). Mean Nocturnal Baseline Impedance (MNBI) Provides Evidence for Standardized Management Algorithms of Nonacid Gastroesophageal Reflux-Induced Chronic Cough. International Journal of Clinical Practice, 2023, Article 7992062. https://doi.org/10.1155/2023/7992062

Background. The clinical management of nonacid gastroesophageal reflux-induced chronic cough (GERC) is challenging, and patient response to standard antireflux therapy (omeprazole 20 mg twice daily plus mosapride 10 mg thrice daily) is suboptimal. Th... Read More about Mean Nocturnal Baseline Impedance (MNBI) Provides Evidence for Standardized Management Algorithms of Nonacid Gastroesophageal Reflux-Induced Chronic Cough.

Antitussive efficacy of the current treatment protocol for refractory chronic cough: our real-world experience in a retrospective cohort study (2023)
Journal Article
Zhang, M., Morice, A. H., Si, F., Zhang, L., Chen, Q., Wang, S., Zhu, Y., Xu, X., Yu, L., & Qiu, Z. (2023). Antitussive efficacy of the current treatment protocol for refractory chronic cough: our real-world experience in a retrospective cohort study. Therapeutic Advances in Respiratory Disease, 17, https://doi.org/10.1177/17534666231167716

BACKGROUND: The management of refractory chronic cough (RCC) is a great challenge. Neuromodulators have long been used for RCC with imperfect efficacy. OBJECTIVES: We summarized the outcomes of the current treatments used at our specialist cough clin... Read More about Antitussive efficacy of the current treatment protocol for refractory chronic cough: our real-world experience in a retrospective cohort study.

Chronic cough—the limitation and advances in assessment techniques (2022)
Journal Article
Zhang, M., Sykes, D. L., Brindle, K., Sadofsky, L. R., & Morice, A. H. (2022). Chronic cough—the limitation and advances in assessment techniques. Journal of thoracic disease, 14(12), 5097-5119. https://doi.org/10.21037/jtd-22-874

Accurate and consistent assessments of cough are essential to advance the understanding of the mechanisms of cough and individualised the management of patients. Considerable progress has been made in this work. Here we reviewed the currently availab... Read More about Chronic cough—the limitation and advances in assessment techniques.

ATP, an attractive target for the treatment of refractory chronic cough (2022)
Journal Article
Zhang, M., Sykes, D. L., Sadofsky, L. R., & Morice, A. H. (2022). ATP, an attractive target for the treatment of refractory chronic cough. Purinergic Signalling, 18, 289-305. https://doi.org/10.1007/s11302-022-09877-z

Chronic cough is the most common complaint in respiratory clinics. Most of them have identifiable causes and some may respond to common disease-modifying therapies. However, there are many patients whose cough lacks effective aetiologically targeted... Read More about ATP, an attractive target for the treatment of refractory chronic cough.

Tracheobronchial-esophageal reflex initiates esophageal hypersensitivity and aggravates cough hyperreactivity in guinea pigs with esophageal acid infusion (2022)
Journal Article
Chen, Q., Dong, R., Zhang, L., Zhang, M., Xu, X., Yu, L., & Qiu, Z. (2022). Tracheobronchial-esophageal reflex initiates esophageal hypersensitivity and aggravates cough hyperreactivity in guinea pigs with esophageal acid infusion. Respiratory Physiology and Neurobiology, 301, Article 103890. https://doi.org/10.1016/j.resp.2022.103890

Esophageal-tracheobronchial reflex is considered the main mechanism underlying cough due to gastroesophageal reflux, and is associated with esophageal hypersensitivity. We hypothesized that tracheobronchial-esophageal reflex may also exist, and may b... Read More about Tracheobronchial-esophageal reflex initiates esophageal hypersensitivity and aggravates cough hyperreactivity in guinea pigs with esophageal acid infusion.

Treatment of chronic cough: P2X3 receptor antagonists and beyond (2022)
Journal Article
Sykes, D. L., Zhang, M., & Morice, A. H. (2022). Treatment of chronic cough: P2X3 receptor antagonists and beyond. Pharmacology and Therapeutics, 237, Article 108166. https://doi.org/10.1016/j.pharmthera.2022.108166

For years chronic cough (CC) has presented an enormous physical, psychological, and social burden on those who experience it, with no approved pharmacological therapies to assuage their symptoms. With our improved understanding of the pathophysiologi... Read More about Treatment of chronic cough: P2X3 receptor antagonists and beyond.