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Cranial sutures work collectively to distribute strain throughout the reptile skull (2013)
Journal Article
Curtis, N., Fagan, M. J., Evans, S. E., Jones, M. E. H., & O'Higgins, P. (2013). Cranial sutures work collectively to distribute strain throughout the reptile skull. Journal of the Royal Society interface / the Royal Society, 10(86), 1-9. https://doi.org/10.1098/rsif.2013.0442

The skull is composed of many bones that come together at sutures. These sutures are important sites of growth, and as growth ceases some become fused while others remain patent. Their mechanical behaviour and how they interact with changing form and... Read More about Cranial sutures work collectively to distribute strain throughout the reptile skull.

The Head and Neck Anatomy of Sea Turtles (Cryptodira: Chelonioidea) and Skull Shape in Testudines (2012)
Journal Article
Jones, M. E., Werneburg, I., Curtis, N., Penrose, R., O'Higgins, P., Fagan, M. J., & Evans, S. E. (2012). The Head and Neck Anatomy of Sea Turtles (Cryptodira: Chelonioidea) and Skull Shape in Testudines. PLoS ONE, 7(11), Article e47852. https://doi.org/10.1371/journal.pone.0047852

Background: Sea turtles (Chelonoidea) are a charismatic group of marine reptiles that occupy a range of important ecological roles. However, the diversity and evolution of their feeding anatomy remain incompletely known. Methodology/Principal Finding... Read More about The Head and Neck Anatomy of Sea Turtles (Cryptodira: Chelonioidea) and Skull Shape in Testudines.

The effect of osteocyte apoptosis on signalling in the osteocyte and bone lining cell network: A computer simulation (2012)
Journal Article
Jahani, M., Genever, P. G., Patton, R. J., Ahwal, F., & Fagan, M. J. (2012). The effect of osteocyte apoptosis on signalling in the osteocyte and bone lining cell network: A computer simulation. Journal of biomechanics, 45(16), 2876-2883. https://doi.org/10.1016/j.jbiomech.2012.08.005

Osteocytes play a critical role in the regulation of bone remodelling by translating strain due to mechanical loading into biochemical signals transmitted through the interconnecting lacuno-canalicular network to bone lining cells (BLCs) on the bone... Read More about The effect of osteocyte apoptosis on signalling in the osteocyte and bone lining cell network: A computer simulation.

Comparing the distribution of strains with the distribution of bone tissue in a human mandible: a finite element study (2012)
Journal Article
Gröning, F., Fagan, M., & O'Higgins, P. (2013). Comparing the distribution of strains with the distribution of bone tissue in a human mandible: a finite element study. Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, 296(1), 9-18. https://doi.org/10.1002/ar.22597

Comparative anatomy and experimental studies suggest that the mass and distribution of tissue within a bone is adapted to the strains the bone experiences during function. Finite element analysis is a powerful tool that can be used to investigate thi... Read More about Comparing the distribution of strains with the distribution of bone tissue in a human mandible: a finite element study.

Masticatory loadings and cranial deformation in Macaca fascicularis: a finite element analysis sensitivity study (2012)
Journal Article
Fitton, L. C., Shi, J. F., Fagan, M. J., & O'Higgins, P. (2012). Masticatory loadings and cranial deformation in Macaca fascicularis: a finite element analysis sensitivity study. Journal of anatomy, 221(1), 55-68. https://doi.org/10.1111/j.1469-7580.2012.01516.x

Biomechanical analyses are commonly conducted to investigate how craniofacial form relates to function, particularly in relation to dietary adaptations. However, in the absence of corresponding muscle activation patterns, incomplete muscle data recor... Read More about Masticatory loadings and cranial deformation in Macaca fascicularis: a finite element analysis sensitivity study.

Developing a musculoskeletal model of the primate skull: Predicting muscle activations, bite force, and joint reaction forces using multibody dynamics analysis and advanced optimisation methods (2012)
Journal Article
Shi, J., Curtis, N., Fitton, L. C., O'Higgins, P., & Fagan, M. J. (2012). Developing a musculoskeletal model of the primate skull: Predicting muscle activations, bite force, and joint reaction forces using multibody dynamics analysis and advanced optimisation methods. Journal of Theoretical Biology, 310, 21-30. https://doi.org/10.1016/j.jtbi.2012.06.006

An accurate, dynamic, functional model of the skull that can be used to predict muscle forces, bite forces, and joint reaction forces would have many uses across a broad range of disciplines. One major issue however with musculoskeletal analyses is t... Read More about Developing a musculoskeletal model of the primate skull: Predicting muscle activations, bite force, and joint reaction forces using multibody dynamics analysis and advanced optimisation methods.

Shearing Mechanics and the Influence of a Flexible Symphysis During Oral Food Processing in Sphenodon (Lepidosauria: Rhynchocephalia) (2012)
Journal Article
Jones, M. E. H., Evans, S. E., Curtis, N., O'Higgins, P., & Fagan, M. J. (2012). Shearing Mechanics and the Influence of a Flexible Symphysis During Oral Food Processing in Sphenodon (Lepidosauria: Rhynchocephalia). Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, 295(7), 1075-1091. https://doi.org/10.1002/ar.22487

Intraluminal thrombus has a selective influence on matrix metalloproteinases and their inhibitors (tissue inhibitors of matrix metalloproteinases) in the wall of abdominal aortic aneurysms (2012)
Journal Article
Abdul Rahman, M., Mazari, F., Khan, J. A., Madden, L., McCollum, P., Shahin, Y., Chetter, I., Greenman, J., Fagan, M., & Smith, G. (2012). Intraluminal thrombus has a selective influence on matrix metalloproteinases and their inhibitors (tissue inhibitors of matrix metalloproteinases) in the wall of abdominal aortic aneurysms. Annals of vascular surgery, 26(3), 322-329. https://doi.org/10.1016/j.avsg.2011.08.015

BACKGROUND The influence of intraluminal thrombus (ILT) on the proteolytic environment within the wall of an abdominal aortic aneurysm (AAA) is unknown. This is the first study to examine the correlation between ILT thickness and the levels of matrix... Read More about Intraluminal thrombus has a selective influence on matrix metalloproteinases and their inhibitors (tissue inhibitors of matrix metalloproteinases) in the wall of abdominal aortic aneurysms.

Functional evolution of the feeding system in rodents (2012)
Journal Article
Cox, P. G., Rayfield, E. J., Fagan, M. J., Herrel, A., Pataky, T. C., & Jeffery, N. (2012). Functional evolution of the feeding system in rodents. PLoS ONE, 7(4), e36299. https://doi.org/10.1371/journal.pone.0036299

The masticatory musculature of rodents has evolved to enable both gnawing at the incisors and chewing at the molars. In particular, the masseter muscle is highly specialised, having extended anteriorly to originate from the rostrum. All living rodent... Read More about Functional evolution of the feeding system in rodents.

Modeling the human mandible under masticatory loads: which input variables are important? (2012)
Journal Article
Gröning, F., Fagan, M., & O'higgins, P. (2012). Modeling the human mandible under masticatory loads: which input variables are important?. Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, 295(5), 853-863. https://doi.org/10.1002/ar.22455

Finite element analyses (FEA) that have simulated masticatory loadings of the human mandible differ significantly with regard to their basic input variables such as material properties, constraints, and applied forces. With sensitivity analyses it is... Read More about Modeling the human mandible under masticatory loads: which input variables are important?.

Improving the validation of finite element models with quantitative full-field strain comparisons (2012)
Journal Article
Gröning, F., Bright, J. A., Fagan, M. J., & O'Higgins, P. (2012). Improving the validation of finite element models with quantitative full-field strain comparisons. Journal of biomechanics, 45(8), 1498-1506. https://doi.org/10.1016/j.jbiomech.2012.02.009

The techniques used to validate finite element (FE) models against experimental results have changed little during the last decades, even though the traditional approach of using single point measurements from strain gauges has major limitations: the... Read More about Improving the validation of finite element models with quantitative full-field strain comparisons.

Comment on "The effects of modelling simplifications on craniofacial finite element models: the alveoli (tooth sockets) and periodontal ligaments" (volume 44, issue 10, pages 1831-1838) (2012)
Journal Article
Gröning, F., & Fagan, M. (2012). Comment on "The effects of modelling simplifications on craniofacial finite element models: the alveoli (tooth sockets) and periodontal ligaments" (volume 44, issue 10, pages 1831-1838). Journal of biomechanics, 45(9), 1749-1750. https://doi.org/10.1016/j.jbiomech.2011.10.042

Small-vocabulary speech recognition using a silent speech interface based on magnetic sensing (2012)
Journal Article
Hofe, R., Ell, S. R., Fagan, M. J., Gilbert, J., Green, P. D., Moore, R. K., & Rybchenko, S. (2013). Small-vocabulary speech recognition using a silent speech interface based on magnetic sensing. Speech communication, 55(1), 22-32. https://doi.org/10.1016/j.specom.2012.02.001

This paper reports on word recognition experiments using a silent speech interface based on magnetic sensing of articulator movements. A magnetic field was generated by permanent magnet pellets fixed to relevant speech articulators. Magnetic field se... Read More about Small-vocabulary speech recognition using a silent speech interface based on magnetic sensing.

A novel mathematical model of bone remodelling cycles for trabecular bone at the cellular level (2012)
Journal Article
Ji, B., Genever, P. G., Patton, R. J., Putra, D., & Fagan, M. J. (2012). A novel mathematical model of bone remodelling cycles for trabecular bone at the cellular level. Biomechanics and Modeling in Mechanobiology, 11(7), 973-982. https://doi.org/10.1007/s10237-011-0366-3

After an initial phase of growth and development, bone undergoes a continuous cycle of repair, renewal and optimisation by a process called remodelling. This paper describes a novel mathematical model of the trabecular bone remodelling cycle. It is e... Read More about A novel mathematical model of bone remodelling cycles for trabecular bone at the cellular level.

Speech synthesis parameter generation for the assistive silent speech interface MVOCA (2011)
Journal Article
Hofe, R., Ell, S. R., Fagan, M. J., Gilbert, J. M., Green, P. D., Moore, R. K., & Rybchenko, S. I. (2011). Speech synthesis parameter generation for the assistive silent speech interface MVOCA. Proceedings of the Annual Conference of the International Speech Communication Association, INTERSPEECH, 3009 - 3012

In previous publications, a silent speech interface based on permanent-magnetic articulography (PMA) has been introduced and evaluated using standard automatic speech recognition techniques. However, word recognition is a task that is computationally... Read More about Speech synthesis parameter generation for the assistive silent speech interface MVOCA.

The head and neck muscles associated with feeding in sphenodon (Reptilia: Lepidosauria: Rhynchocephalia) (2011)
Journal Article
Curtis, N., Jones, M. E., Junfen, S., O'Higgins, P., Evans, S. E., & Fagan, M. (2011). The head and neck muscles associated with feeding in sphenodon (Reptilia: Lepidosauria: Rhynchocephalia). Palaeontologia electronica, 12(2), 0 - 0. https://doi.org/10.1371/journal.pone.0029804

Feeding in Sphenodon, the tuatara of New Zealand, is of interest for several reasons. First, the modern animal is threatened by extinction, and some populations are in competition for food with Pacific rats. Second, Sphenodon demonstrates a feeding a... Read More about The head and neck muscles associated with feeding in sphenodon (Reptilia: Lepidosauria: Rhynchocephalia).

Functional relationship between skull form and feeding mechanics in Sphenodon, and implications for diapsid skull development (2011)
Journal Article
Curtis, N., Jones, M. E. H., Shi, J., O'Higgins, P., Evans, S. E., & Fagan, M. J. (2011). Functional relationship between skull form and feeding mechanics in Sphenodon, and implications for diapsid skull development. PLoS ONE, 6(12), Article ARTN e29804. https://doi.org/10.1371/journal.pone.0029804

The vertebrate skull evolved to protect the brain and sense organs, but with the appearance of jaws and associated forces there was a remarkable structural diversification. This suggests that the evolution of skull form may be linked to these forces,... Read More about Functional relationship between skull form and feeding mechanics in Sphenodon, and implications for diapsid skull development.

The earliest evidence for anatomically modern humans in northwestern Europe (2011)
Journal Article
Higham, T., Compton, T., Stringer, C., Jacobi, R., Shapiro, B., Trinkaus, E., Chandler, B., Gröning, F., Collins, C., Hillson, S., O’Higgins, P., FitzGerald, C., & Fagan, M. (2011). The earliest evidence for anatomically modern humans in northwestern Europe. Nature, 479(7374), 521-524. https://doi.org/10.1038/nature10484

The earliest anatomically modern humans in Europe are thought to have appeared around 43,000-42,000 calendar years before present (43-42 kyr cal BP), by association with Aurignacian sites and lithic assemblages assumed to have been made by modern hum... Read More about The earliest evidence for anatomically modern humans in northwestern Europe.

Finite element modelling of squirrel, guinea pig and rat skulls: using geometric morphometrics to assess sensitivity. (2011)
Journal Article
Cox, P. G., Fagan, M. J., Rayfield, E. J., & Jeffery, N. (2011). Finite element modelling of squirrel, guinea pig and rat skulls: using geometric morphometrics to assess sensitivity. Journal of anatomy, 219(6), 696-709. https://doi.org/10.1111/j.1469-7580.2011.01436.x

Rodents are defined by a uniquely specialized dentition and a highly complex arrangement of jaw-closing muscles. Finite element analysis (FEA) is an ideal technique to investigate the biomechanical implications of these specializations, but it is ess... Read More about Finite element modelling of squirrel, guinea pig and rat skulls: using geometric morphometrics to assess sensitivity..