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Intraluminal thrombus has a selective influence on matrix metalloproteinases and their inhibitors (tissue inhibitors of matrix metalloproteinases) in the wall of abdominal aortic aneurysms

Abdul Rahman, M.N.A.; Mazari, F.A.K.; Khan, Junaid A.; Madden, L.; McCollum, P.T.; Shahin, Y.; Chetter, I.C.; Greenman, J.; Fagan, M.J.; Smith, G.

Authors

M.N.A. Abdul Rahman

F.A.K. Mazari

Junaid A. Khan

P.T. McCollum

Y. Shahin

I.C. Chetter I.Chetter@hull.ac.uk

G. Smith George.Smith@hull.ac.uk



Abstract

BACKGROUND The influence of intraluminal thrombus (ILT) on the proteolytic environment within the wall of an abdominal aortic aneurysm (AAA) is unknown. This is the first study to examine the correlation between ILT thickness and the levels of matrix metalloproteinases (MMPs) and their natural inhibitors (tissue inhibitors of matrix metalloproteinases [TIMPs]) within the adjacent AAA wall. METHODS Thirty-five patients undergoing elective repair of AAAs were studied. A single full-thickness infrarenal aortic sample was obtained uniformly from the arteriotomy site from each patient. All samples were snap frozen and analyzed for total and active MMP 2, 8, and 9 and TIMP 1 and 2. Thrombus thickness at the specimen site was measured on the preoperative contrast computed tomographic angiograms. RESULTS There was a statistically significant correlation between ILT thickness, concentration of TIMP 1, and active concentration of MMP 9. MMP 2 (active and total) and TIMP 2 demonstrated a positive correlation with ILT thickness, although not statistically significant. CONCLUSION In this novel study, we found a significant positive correlation of ILT thickness with active MMP 9 and TIMP 1 concentration in the adjacent AAA wall, and this may have implications for AAA expansion and eventual rupture.

Journal Article Type Article
Publication Date 2012-04
Journal Annals of vascular surgery
Print ISSN 0890-5096
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 26
Issue 3
Pages 322-329
APA6 Citation Abdul Rahman, M., Mazari, F., Khan, J. A., Madden, L., McCollum, P., Shahin, Y., …Smith, G. (2012). Intraluminal thrombus has a selective influence on matrix metalloproteinases and their inhibitors (tissue inhibitors of matrix metalloproteinases) in the wall of abdominal aortic aneurysms. Annals of vascular surgery, 26(3), 322-329. https://doi.org/10.1016/j.avsg.2011.08.015
DOI https://doi.org/10.1016/j.avsg.2011.08.015
Keywords Surgery; Cardiology and Cardiovascular Medicine; General Medicine
PMID 22305865
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