M.N.A. Abdul Rahman
Intraluminal thrombus has a selective influence on matrix metalloproteinases and their inhibitors (tissue inhibitors of matrix metalloproteinases) in the wall of abdominal aortic aneurysms
Abdul Rahman, M.N.A.; Mazari, F.A.K.; Khan, Junaid A.; Madden, L.; McCollum, P.T.; Shahin, Y.; Chetter, I.C.; Greenman, J.; Fagan, M.J.; Smith, G.
Authors
F.A.K. Mazari
Junaid A. Khan
Dr Leigh Madden L.A.Madden@hull.ac.uk
Post-Doctoral Research Assistant
P.T. McCollum
Y. Shahin
Professor Ian Chetter I.Chetter@hull.ac.uk
Professor of Vascular Surgery
Professor John Greenman J.Greenman@hull.ac.uk
Professor of Tumour Immunology
M.J. Fagan
Mr George Smith George.Smith@hull.ac.uk
Senior Lecturer
Abstract
BACKGROUND The influence of intraluminal thrombus (ILT) on the proteolytic environment within the wall of an abdominal aortic aneurysm (AAA) is unknown. This is the first study to examine the correlation between ILT thickness and the levels of matrix metalloproteinases (MMPs) and their natural inhibitors (tissue inhibitors of matrix metalloproteinases [TIMPs]) within the adjacent AAA wall. METHODS Thirty-five patients undergoing elective repair of AAAs were studied. A single full-thickness infrarenal aortic sample was obtained uniformly from the arteriotomy site from each patient. All samples were snap frozen and analyzed for total and active MMP 2, 8, and 9 and TIMP 1 and 2. Thrombus thickness at the specimen site was measured on the preoperative contrast computed tomographic angiograms. RESULTS There was a statistically significant correlation between ILT thickness, concentration of TIMP 1, and active concentration of MMP 9. MMP 2 (active and total) and TIMP 2 demonstrated a positive correlation with ILT thickness, although not statistically significant. CONCLUSION In this novel study, we found a significant positive correlation of ILT thickness with active MMP 9 and TIMP 1 concentration in the adjacent AAA wall, and this may have implications for AAA expansion and eventual rupture.
Citation
Abdul Rahman, M., Mazari, F., Khan, J. A., Madden, L., McCollum, P., Shahin, Y., Chetter, I., Greenman, J., Fagan, M., & Smith, G. (2012). Intraluminal thrombus has a selective influence on matrix metalloproteinases and their inhibitors (tissue inhibitors of matrix metalloproteinases) in the wall of abdominal aortic aneurysms. Annals of vascular surgery, 26(3), 322-329. https://doi.org/10.1016/j.avsg.2011.08.015
Journal Article Type | Article |
---|---|
Acceptance Date | Apr 30, 2012 |
Publication Date | 2012-04 |
Journal | Annals of vascular surgery |
Print ISSN | 0890-5096 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 26 |
Issue | 3 |
Pages | 322-329 |
DOI | https://doi.org/10.1016/j.avsg.2011.08.015 |
Keywords | Surgery; Cardiology and Cardiovascular Medicine; General Medicine |
Public URL | https://hull-repository.worktribe.com/output/417589 |
PMID | 22305865 |
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