All Outputs (4)

A sample-to-answer COVID-19 diagnostic device based on immiscible filtration and CRISPR-Cas12a-assisted detection (2022)
Journal Article
Ngamsom, B., Iles, A., Kamita, M., Kimani, R., Wakaba, P., Rodriguez-Mateos, P., Mungai, M., Dyer, C. E., Walter, C., Gitaka, J., & Pamme, N. (2022). A sample-to-answer COVID-19 diagnostic device based on immiscible filtration and CRISPR-Cas12a-assisted detection. Talanta Open, 6, Article 100166. https://doi.org/10.1016/j.talo.2022.100166

In response to the ongoing coronavirus disease 2019 (COVID-19) pandemic and disparities of vaccination coverage in low-and middle-income countries, it is vital to adopt a widespread testing and screening programme, combined with contact tracing, to m... Read More about A sample-to-answer COVID-19 diagnostic device based on immiscible filtration and CRISPR-Cas12a-assisted detection.

Spheroid-on-chip microfluidic technology for the evaluation of the impact of continuous flow on metastatic potential in cancer models in vitro (2021)
Journal Article
Collins, T., Pyne, E., Christensen, M., Iles, A., Pamme, N., & Pires, I. M. (2021). Spheroid-on-chip microfluidic technology for the evaluation of the impact of continuous flow on metastatic potential in cancer models in vitro. Biomicrofluidics, 15(4), Article 044103. https://doi.org/10.1063/5.0061373

The majority of cancer deaths are linked to tumor spread, or metastasis, but 3D in vitro metastasis models relevant to the tumor microenvironment (including interstitial fluid flow) remain an area of unmet need. Microfluidics allows us to introduce c... Read More about Spheroid-on-chip microfluidic technology for the evaluation of the impact of continuous flow on metastatic potential in cancer models in vitro.

Host-pathogen adhesion as the basis of innovative diagnostics for emerging pathogens (2021)
Journal Article
van Belkum, A., Almeida, C., Bardiaux, B., Barrass, S. V., Butcher, S. J., Çaykara, T., Chowdhury, S., Datar, R., Eastwood, I., Goldman, A., Goyal, M., Happonen, L., Izadi-Pruneyre, N., Jacobsen, T., Johnson, P. H., Kempf, V. A. J., Kiessling, A., Bueno, J. L., Malik, A., Malmström, J., …Linke, D. (2021). Host-pathogen adhesion as the basis of innovative diagnostics for emerging pathogens. Diagnostics, 11(7), Article 1259. https://doi.org/10.3390/diagnostics11071259

Infectious diseases are an existential health threat, potentiated by emerging and re-emerging viruses and increasing bacterial antibiotic resistance. Targeted treatment of infectious diseases requires precision diagnostics, especially in cases where... Read More about Host-pathogen adhesion as the basis of innovative diagnostics for emerging pathogens.

A lab-on-a-chip platform for integrated extraction and detection of SARS-CoV-2 RNA in resource-limited settings (2021)
Journal Article
Rodriguez-Mateos, P., Ngamsom, B., Walter, C., Dyer, C. E., Gitaka, J., Iles, A., & Pamme, N. (2021). A lab-on-a-chip platform for integrated extraction and detection of SARS-CoV-2 RNA in resource-limited settings. Analytica Chimica Acta, 1177, Article 338758. https://doi.org/10.1016/j.aca.2021.338758

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the unprecedented global pandemic of coronavirus disease-2019 (COVID-19). Efforts are needed to develop rapid and accurate diagnostic tools for extensive testing, allowing for ef... Read More about A lab-on-a-chip platform for integrated extraction and detection of SARS-CoV-2 RNA in resource-limited settings.