All Outputs (722)

Thermal stress induces a positive phenotypic and molecular feedback loop in zebrafish embryos (2021)
Journal Article
Feugere, L., Wollenberg Valero, K. C., Scott, V., Rodriguez-Barucg, Q., & Beltran-Alvarez, P. (2021). Thermal stress induces a positive phenotypic and molecular feedback loop in zebrafish embryos. Journal of Thermal Biology, 102, Article 103114. https://doi.org/10.1016/j.jtherbio.2021.103114

Aquatic organisms must cope with both rising and rapidly changing temperatures. These thermal changes can affect numerous traits, from molecular to ecological scales. Biotic stressors are already known to induce the release of chemical cues which tri... Read More about Thermal stress induces a positive phenotypic and molecular feedback loop in zebrafish embryos.

A kit-based aluminium-[18F]fluoride approach to radiolabelled microbubbles (2021)
Journal Article
Teh, J., Costa-Braga, M., Allott, L., Barnes, C., Hernandez-Gil, J., Tang, M., …Long, N. J. (2021). A kit-based aluminium-[18F]fluoride approach to radiolabelled microbubbles. Chemical communications : Chem comm / the Royal Society of Chemistry, https://doi.org/10.1039/d1cc04790f

The production of 18F-labelled microbubbles (MBs) via the aluminium-[18F]fluoride ([18F]AlF) radiolabelling method and facile inverse-electron-demand Diels-Alder (IEDDA) ‘click’ chemistry is reported. An [18F]AlF-NODA-labelled tetrazine was synthesis... Read More about A kit-based aluminium-[18F]fluoride approach to radiolabelled microbubbles.

Survivin’ acute myeloid leukaemia—a personalised target for inv(16) patients (2021)
Journal Article
Greiner, J., Brown, E., Bullinger, L., Hills, R. K., Morris, V., Döhner, H., …Guinn, B. A. (2021). Survivin’ acute myeloid leukaemia—a personalised target for inv(16) patients. International Journal of Molecular Sciences, 22(19), Article 10482. https://doi.org/10.3390/ijms221910482

Abstract: Despite recent advances in therapies including immunotherapy, patients with acute myeloid leukaemia (AML) still experience relatively poor survival rates. The Inhibition of Apoptosis (IAP) family member, survivin, also known by its gene and... Read More about Survivin’ acute myeloid leukaemia—a personalised target for inv(16) patients.

Interactome and evolutionary conservation of dictyostelid small GTPases and their direct regulators (2021)
Journal Article
Forbes, G., Schilde, C., Lawal, H., Kin, K., Du, Q., Chen, Z., …Schaap, P. (in press). Interactome and evolutionary conservation of dictyostelid small GTPases and their direct regulators. Small GTPases, https://doi.org/10.1080/21541248.2021.1984829

The GTP binding proteins known as small GTPases make up one of the largest groups of regulatory proteins and control almost all functions of living cells. Their activity is under respectively positive and negative regulation by guanine nucleotide exc... Read More about Interactome and evolutionary conservation of dictyostelid small GTPases and their direct regulators.

Enhanced clearing of Candida biofilms on a 3D urothelial cell in vitro model using lysozyme-functionalized fluconazole-loaded shellac nanoparticles (2021)
Journal Article
Wang, A., Weldrick, P. J., Madden, L. A., & Paunov, V. N. (2021). Enhanced clearing of Candida biofilms on a 3D urothelial cell in vitro model using lysozyme-functionalized fluconazole-loaded shellac nanoparticles. Biomaterials science / Royal Society of Chemistry, 9(20), 6927-6939. https://doi.org/10.1039/d1bm01035b

Candida urinary tract biofilms are increasingly witnessed in nosocomial infections due to reduced immunity of patients and the hospital ecosystem. The indwelling devices utilized to support patients with urethral diseases that connect the unsterilize... Read More about Enhanced clearing of Candida biofilms on a 3D urothelial cell in vitro model using lysozyme-functionalized fluconazole-loaded shellac nanoparticles.

Identification of soluble tissue‑derived biomarkers from human thyroid tissue explants maintained on a microfluidic device (2021)
Journal Article
Riley, A., Jones, H., England, J., Kuvshinov, D., Green, V., & Greenman, J. (2021). Identification of soluble tissue‑derived biomarkers from human thyroid tissue explants maintained on a microfluidic device. Oncology Letters, 22(5), Article 780. https://doi.org/10.3892/ol.2021.13041

Although a large cohort of potential biomarkers for thyroid cancer aggressiveness have been tested in various formats in recent years, to the best of our knowledge, thyro‑ globulin and calcitonin remain the only two established biomarkers associated... Read More about Identification of soluble tissue‑derived biomarkers from human thyroid tissue explants maintained on a microfluidic device.

Predicting personalised optimal arc parameter using knowledge-based planning model for inoperable locally advanced lung cancer patients to reduce organ at risk doses (2021)
Journal Article
Tambe, N. S., Pires, I. M., Moore, C., Wieczorek, A., Upadhyay, S., & Beavis, A. W. (2021). Predicting personalised optimal arc parameter using knowledge-based planning model for inoperable locally advanced lung cancer patients to reduce organ at risk doses. Biomedical Physics and Engineering Express, 7(6), Article 065016. https://doi.org/10.1088/2057-1976/ac2635

Objectives. Volumetric modulated arc therapy (VMAT) allows for reduction of organs at risk (OAR) volumes receiving higher doses, but increases OAR volumes receiving lower radiation doses and can subsequently increasing associated toxicity. Therefore,... Read More about Predicting personalised optimal arc parameter using knowledge-based planning model for inoperable locally advanced lung cancer patients to reduce organ at risk doses.

Amino acids and the early mammalian embryo: Origin, fate, function and life‐long legacy (2021)
Journal Article
Leese, H. J., McKeegan, P., & Sturmey, R. G. (2021). Amino acids and the early mammalian embryo: Origin, fate, function and life‐long legacy. International Journal of Environmental Research and Public Health, 18(18), Article 9874. https://doi.org/10.3390/ijerph18189874

Amino acids are now recognised as having multiple cellular functions in addition to their traditional role as constituents of proteins. This is well-illustrated in the early mammalian embryo where amino acids are now known to be involved in intermedi... Read More about Amino acids and the early mammalian embryo: Origin, fate, function and life‐long legacy.

Validation of in-house knowledge-based planning model for predicting change in target coverage during VMAT radiotherapy to in-operable advanced-stage NSCLC patients (2021)
Journal Article
Tambe, N. S., Pires, I. M., Moore, C., Wieczorek, A., Upadhyay, S., & Beavis, A. W. (2021). Validation of in-house knowledge-based planning model for predicting change in target coverage during VMAT radiotherapy to in-operable advanced-stage NSCLC patients. Biomedical Physics and Engineering Express, 7(6), https://doi.org/10.1088/2057-1976/ac1f94

Objectives. anatomical changes are inevitable during the course of radiotherapy treatments and, if significant, can severely alter expected dose distributions and affect treatment outcome. Adaptive radiotherapy (ART) is employed to maintain the plann... Read More about Validation of in-house knowledge-based planning model for predicting change in target coverage during VMAT radiotherapy to in-operable advanced-stage NSCLC patients.

In-Depth Profiling of T-Cell Responsiveness to Commonly Recognized CMV Antigens in Older People Reveals Important Sex Differences (2021)
Journal Article
Reus, B., Caserta, S., Larsen, M., Morrow, G., Bano, A., Hallensleben, M., …Kern, F. (2021). In-Depth Profiling of T-Cell Responsiveness to Commonly Recognized CMV Antigens in Older People Reveals Important Sex Differences. Frontiers in immunology, 12, Article 707830. https://doi.org/10.3389/fimmu.2021.707830

The impact of biological sex on T-cell immunity to Cytomegalovirus (CMV) has not been investigated in detail with only one published study comparing CMV-specific T-cell responses in men and women. Many studies, however, have shown an association betw... Read More about In-Depth Profiling of T-Cell Responsiveness to Commonly Recognized CMV Antigens in Older People Reveals Important Sex Differences.

Inhibition of arginine methylation impairs platelet function (2021)
Journal Article
Marsden, A. J., Riley, D. R. J., Barry, A., Khalil, J. S., Guinn, B. A., Kemp, N. T., …Beltran-Alvarez, P. (in press). Inhibition of arginine methylation impairs platelet function. ACS Pharmacology & Translational Science, https://doi.org/10.1021/acsptsci.1c00135

Protein arginine methyltransferases (PRMTs) catalyze the transfer of methyl groups to arginine residues in proteins. PRMT inhibitors are novel, promising drugs against cancer that are currently in clinical trials, which include oral administration of... Read More about Inhibition of arginine methylation impairs platelet function.

Spheroid-on-chip microfluidic technology for the evaluation of the impact of continuous flow on metastatic potential in cancer models in vitro (2021)
Journal Article
Collins, T., Pyne, E., Christensen, M., Iles, A., Pamme, N., & Pires, I. M. (2021). Spheroid-on-chip microfluidic technology for the evaluation of the impact of continuous flow on metastatic potential in cancer models in vitro. Biomicrofluidics, 15(4), Article 044103. https://doi.org/10.1063/5.0061373

The majority of cancer deaths are linked to tumor spread, or metastasis, but 3D in vitro metastasis models relevant to the tumor microenvironment (including interstitial fluid flow) remain an area of unmet need. Microfluidics allows us to introduce c... Read More about Spheroid-on-chip microfluidic technology for the evaluation of the impact of continuous flow on metastatic potential in cancer models in vitro.

De-palmitoylation of tissue factor regulates its activity, phosphorylation and cellular functions (2021)
Journal Article
Ettelaie, C., Featherby, S., Rondon, A. M. R., Greenman, J., Versteeg, H. H., & Maraveyas, A. (2021). De-palmitoylation of tissue factor regulates its activity, phosphorylation and cellular functions. Cancers, 13(15), Article 3837. https://doi.org/10.3390/cancers13153837

In this study, the role of de-palmitoylation of tissue factor (TF) in the decryption of its activity was explored. TF-tGFP constructs were prepared by mutagenesis-substitution at Cys245 to prevent or mimic palmitolyation. Additionally, to reduce TF d... Read More about De-palmitoylation of tissue factor regulates its activity, phosphorylation and cellular functions.

Factor VIIa regulates the level of cell-surface tissue factor through separate but cooperative mechanisms (2021)
Journal Article
Madkhali, Y., Rondon, A. M., Featherby, S., Maraveyas, A., Greenman, J., & Ettelaie, C. (2021). Factor VIIa regulates the level of cell-surface tissue factor through separate but cooperative mechanisms. Cancers, 13(15), Article 3718. https://doi.org/10.3390/cancers13153718

Procoagulant activity of tissue factor (TF) in response to injury or inflammation is accompanied with cellular signals which determine the fate of cells. However, to prevent excessive signalling, TF is rapidly dissipated through release into microves... Read More about Factor VIIa regulates the level of cell-surface tissue factor through separate but cooperative mechanisms.

The significance of HOXB7 and IL17RB serum levels in prognosis of hormonally dependent breast cancer: A pilot study (2021)
Journal Article
Todorović-Raković, N., Milovanović, J., Greenman, J., & Radulovic, M. (2021). The significance of HOXB7 and IL17RB serum levels in prognosis of hormonally dependent breast cancer: A pilot study. Advances in Medical Sciences, 66(2), 359-365. https://doi.org/10.1016/j.advms.2021.07.007

Purpose: Improved prognostication of a patient's outcome could allow for personalized treatment decisions in breast cancer. Homeobox B7 (HOXB7) and interleukin 17 receptor B (IL17RB) are proteins reportedly involved in the development of hormonal the... Read More about The significance of HOXB7 and IL17RB serum levels in prognosis of hormonally dependent breast cancer: A pilot study.

Novel Non-Congeneric Derivatives of the Choline Kinase Alpha Inhibitor ICL-CCIC-0019 (2021)
Journal Article
Wang, N., Brickute, D., Braga, M., Barnes, C., Lu, H., Allott, L., & Aboagye, E. O. (2021). Novel Non-Congeneric Derivatives of the Choline Kinase Alpha Inhibitor ICL-CCIC-0019. Pharmaceutics, 13(7), Article 1078. https://doi.org/10.3390/pharmaceutics13071078

Choline kinase alpha (CHKA) is a promising target for the development of cancer therapeutics. We have previously reported ICL-CCIC-0019, a potent CHKA inhibitor with high cellular activity but with some unfavorable pharmacological properties. In this... Read More about Novel Non-Congeneric Derivatives of the Choline Kinase Alpha Inhibitor ICL-CCIC-0019.

A Novel HAGE/WT1-ImmunoBody® Vaccine Combination Enhances Anti-Tumour Responses When Compared to Either Vaccine Alone (2021)
Journal Article
Almshayakhchi, R., Nagarajan, D., Vadakekolathu, J., Guinn, B. A., Reeder, S., Brentville, V., …McArdle, S. (2021). A Novel HAGE/WT1-ImmunoBody® Vaccine Combination Enhances Anti-Tumour Responses When Compared to Either Vaccine Alone. Frontiers in Oncology, 11, Article 636977. https://doi.org/10.3389/fonc.2021.636977

Many cancers, including myeloid leukaemia express the cancer testis antigen (CTA) DDX43 (HAGE) and/or the oncogene Wilms’ tumour (WT1). Here we demonstrate that HAGE/WT1-ImmunoBody® vaccines derived T-cells can kill ex-vivo human CML cell lines expre... Read More about A Novel HAGE/WT1-ImmunoBody® Vaccine Combination Enhances Anti-Tumour Responses When Compared to Either Vaccine Alone.

Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease (2021)
Journal Article
Boyett, M. R., Yanni, J., Tellez, J., Bucchi, A., Mesirca, P., Cai, X., …D'Souza, A. (in press). Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease. Progress in Biophysics and Molecular Biology, https://doi.org/10.1016/j.pbiomolbio.2021.06.008

The funny current, If, was first recorded in the heart 40 or more years ago by Dario DiFrancesco and others. Since then, we have learnt that If plays an important role in pacemaking in the sinus node, the innate pacemaker of the heart, and more recen... Read More about Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease.

Love is in the hair: arginine methylation of human hair proteins as novel cardiovascular biomarkers (2021)
Journal Article
Marsden, A. J., Riley, D. R., Birkett, S., Rodriguez-Barucg, Q., Guinn, B. A., Carroll, S., …Beltran-Alvarez, P. (in press). Love is in the hair: arginine methylation of human hair proteins as novel cardiovascular biomarkers. Amino acids, https://doi.org/10.1007/s00726-021-03024-5

Cardiovascular disease is the major cause of death worldwide. Extensive cardiovascular biomarkers are available using blood tests but very few, if any, investigations have described non-invasive tests for cardiovascular biomarkers based on readily av... Read More about Love is in the hair: arginine methylation of human hair proteins as novel cardiovascular biomarkers.

A novel HAGE/WT-1 ImmunoBody® vaccine combination enhances anti-tumour responses when compared to either vaccine alone. (2021)
Journal Article
Almshayakhchi, R., Nagarajan, D., Vadakekolathu, J., Guinn, B.-A., Reeder, S., Brentville, V., …McArdle, S. (in press). A novel HAGE/WT-1 ImmunoBody® vaccine combination enhances anti-tumour responses when compared to either vaccine alone. Frontiers in Oncology, 11, Article 636977. https://doi.org/10.3389/fonc.2021.636977

Many cancers, including myeloid leukaemia express the cancer testis antigen (CTA) DDX43 (HAGE) and/or the oncogene Wilms' tumour (WT1). Here we demonstrate that HAGE/WT1-ImmunoBody® vaccines derived T-cells can kill ex-vivo human CML cell lines expre... Read More about A novel HAGE/WT-1 ImmunoBody® vaccine combination enhances anti-tumour responses when compared to either vaccine alone..