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Validation of in-house knowledge-based planning model for predicting change in target coverage during VMAT radiotherapy to in-operable advanced-stage NSCLC patients

Tambe, Nilesh S.; Pires, Isabel M.; Moore, Craig; Wieczorek, Andrzej; Upadhyay, Sunil; Beavis, Andrew W.


Nilesh S. Tambe

Isabel M. Pires

Craig Moore

Andrzej Wieczorek

Sunil Upadhyay


Objectives. anatomical changes are inevitable during the course of radiotherapy treatments and, if significant, can severely alter expected dose distributions and affect treatment outcome. Adaptive radiotherapy (ART) is employed to maintain the planned distribution and minimise detriment to predicted treatment outcome. Typically, patients who may benefit from adaptive planning are identified via a re-planning process, i.e., re-simulation, re-contouring, re-planning and treatment plan quality assurance (QA). This time-intensive process significantly increases workload, can introduce delays and increases unnecessary stress to those patients who will not actually gain benefit. We consider it crucial to develop efficient models to predict changes to target coverage and trigger ART, without the need for re-planning. Methods. knowledge-based planning (KBP) models were developed using data for 20 patients' (400 fractions) to predict changes in PTV V95 coverage (ΔV95PTV). Initially, this change in coverage was calculated on the synthetic computerised tomography (sCT) images produced using the Velocity adaptive radiotherapy software. Models were developed using patient (cell death bio-marker) and treatment fraction (PTV characteristic) specific parameters to predict (ΔV95PTV) and verified using five patients (100 fractions) data. Results. three models were developed using combinations of patient and fraction specific terms. The prediction accuracy of the model developed using biomarker (PD-L1 expression) and the difference in 'planning' and 'fraction' PTV centre of the mass (characterised by mean square difference, MSD) had the higher prediction accuracy, predicting the (ΔV95PTV) within ± 1.0% for 77% of the total fractions; with 59% for the model developed using, PTV size, PD-L1 and MSD and 48% PTV size and MSD respectively. Conclusion. the KBP models can predict (ΔV95PTV) very effectively and efficiently for advanced-stage NSCLC patients treated using volumetric modulated arc therapy and to identify patients who may benefit from adaption for a specific fraction.


Tambe, N. S., Pires, I. M., Moore, C., Wieczorek, A., Upadhyay, S., & Beavis, A. W. (2021). Validation of in-house knowledge-based planning model for predicting change in target coverage during VMAT radiotherapy to in-operable advanced-stage NSCLC patients. Biomedical Physics and Engineering Express, 7(6),

Journal Article Type Article
Acceptance Date Aug 19, 2021
Online Publication Date Aug 20, 2021
Publication Date Nov 1, 2021
Deposit Date Aug 27, 2021
Publicly Available Date Aug 21, 2022
Journal Biomedical Physics and Engineering Express
Print ISSN 2057-1976
Electronic ISSN 2057-1976
Publisher IOP Publishing
Peer Reviewed Peer Reviewed
Volume 7
Issue 6
Keywords General Nursing
Public URL


Article (615 Kb)

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