All Outputs (1116)

Technical Note: Parameters of Bloodstain Pattern Spatial Reconstruction in Manual vs. Computer-Aided Data Acquisition (2025)
Journal Article
Kowalske, Z., Snively, D. T., Oleiwi, A., & Williams, G. (2025). Technical Note: Parameters of Bloodstain Pattern Spatial Reconstruction in Manual vs. Computer-Aided Data Acquisition. Forensic Science International: Reports, 11, Article 100418. https://doi.org/10.1016/j.fsir.2025.100418

This study compares the accuracy and precision of manual and computer-aided methods in bloodstain pattern analysis using equine blood under controlled conditions. Manual measurements by experienced analysts were compared to those obtained with FARO Z... Read More about Technical Note: Parameters of Bloodstain Pattern Spatial Reconstruction in Manual vs. Computer-Aided Data Acquisition.

Environmental and financial cost of surgical-site infection by severity after lower limb vascular surgery (2025)
Journal Article
Lathan, R., Daysley, H., Ravindhran, B., Lim, A., Cutteridge, J., Sidapra, M., Long, J., Hitchman, L., Beltran-Alvarez, P., Carradice, D., Smith, G., & Chetter, I. (2025). Environmental and financial cost of surgical-site infection by severity after lower limb vascular surgery. BJS Open, 9(3), Article zraf015. https://doi.org/10.1093/bjsopen/zraf015

BACKGROUND: There is sparse evidence of the relationship between environmental and financial costs of surgical-site infection. Identifying areas of high-cost burden would enable key targets for clinical interventions to aid in achieving the UK nation... Read More about Environmental and financial cost of surgical-site infection by severity after lower limb vascular surgery.

Fixed Duration Ibrutinib‐Venetoclax, a Redefinition of the CLL Treatment Landscape (2025)
Journal Article
Molica, S., & Allsup, D. (2025). Fixed Duration Ibrutinib‐Venetoclax, a Redefinition of the CLL Treatment Landscape. Hematological Oncology, 43(3), Article e70088. https://doi.org/10.1002/hon.70088

The fixed-duration combination of ibrutinib and venetoclax (IV) has emerged as a highly effective therapeutic strategy for treating chronic lymphocytic leukemia (CLL), marking a significant shift in the treatment paradigm for this disease. Preclinica... Read More about Fixed Duration Ibrutinib‐Venetoclax, a Redefinition of the CLL Treatment Landscape.

Social context prevents heat hormetic effects against mutagens during fish development (2025)
Journal Article
Feugere, L., Silva De Freitas, C., Bates, A., Storey, K. B., Beltran-Alvarez, P., & Wollenberg Valero, K. C. (2025). Social context prevents heat hormetic effects against mutagens during fish development. FEBS Letters, https://doi.org/10.1002/1873-3468.70047

Since stress can be transmitted to congeners via social metabolites, it is paramount to understand how the social context of abiotic stress influences aquatic organisms' responses to global changes. Here, we integrated the transcriptomic and phenotyp... Read More about Social context prevents heat hormetic effects against mutagens during fish development.

Adult B-Cell Acute Lymphoblastic Leukaemia Antigens and Enriched Pathways Identify New Targets for Therapy (2025)
Journal Article
Mohamed, E., Goodman, S., Cooksey, L., Fletcher, D. M., Dean, O., Boncheva, V. B., Mills, K. I., Orchard, K. H., & Guinn, B.-A. (2025). Adult B-Cell Acute Lymphoblastic Leukaemia Antigens and Enriched Pathways Identify New Targets for Therapy. Onco, 5(2), Article 19. https://doi.org/10.3390/onco5020019

Background: Adult B-cell acute lymphoblastic leukaemia (aB-ALL) is charac-terised by abnormal differentiation and proliferation of lymphoid progenitors. Despite a significant improvement in relapse-free and overall survival for children with BALL , a... Read More about Adult B-Cell Acute Lymphoblastic Leukaemia Antigens and Enriched Pathways Identify New Targets for Therapy.

Exploring the use of Arginine Methylation Inhibitors Against Brain Tumours in an ex vivo Perfusion System (2025)
Thesis
Barry, A. (2025). Exploring the use of Arginine Methylation Inhibitors Against Brain Tumours in an ex vivo Perfusion System. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/5133792

Glioblastoma (GBM) is the most common primary malignancy in the central nervous system and the most devastating, with a median survival of 18 months from diagnosis. The development of models to research and understand GBM tumourigenesis and progressi... Read More about Exploring the use of Arginine Methylation Inhibitors Against Brain Tumours in an ex vivo Perfusion System.

The Role of Environmentally Relevant Concentrations of SSRIs in Human Wound Healing (2025)
Thesis
Rodriguez-Barucg, Q. (2025). The Role of Environmentally Relevant Concentrations of SSRIs in Human Wound Healing. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/5126336

This thesis investigates the role of environmentally relevant concentrations of fluoxetine, a commonly prescribed selective serotonin reuptake inhibitor (SSRI), in wound healing. While SSRIs are effective in treating psychiatric conditions, their inc... Read More about The Role of Environmentally Relevant Concentrations of SSRIs in Human Wound Healing.

Simulated heat waves affect cell fate and fitness in the social amoeba Dictyostelium discoideum (2025)
Journal Article
Rivero Crespo, F., Wollenberg-Valero, K., & Banu, S. (2025). Simulated heat waves affect cell fate and fitness in the social amoeba Dictyostelium discoideum. Microbial Ecology, 88, Article 21. https://doi.org/10.1007/s00248-025-02519-y

The effects of heatwaves at organism and population levels have been widely investigated; however, little is known about how they affect the development of cell populations and the fitness of the resulting organism. Disruptions caused by heatwaves ar... Read More about Simulated heat waves affect cell fate and fitness in the social amoeba Dictyostelium discoideum.

O-GlcNAcylation and Phosphorylation Crosstalk in Vascular Smooth Muscle Cells: Cellular and Therapeutic Significance in Cardiac and Vascular Pathologies (2025)
Journal Article
Bolanle, I. O., & Palmer, T. M. (2025). O-GlcNAcylation and Phosphorylation Crosstalk in Vascular Smooth Muscle Cells: Cellular and Therapeutic Significance in Cardiac and Vascular Pathologies. International Journal of Molecular Sciences, 26(7), Article 3303. https://doi.org/10.3390/ijms26073303

More than 400 different types of post-translational modifications (PTMs), including O-GlcNAcylation and phosphorylation, combine to co-ordinate almost all aspects of protein function. Often, these PTMs overlap and the specific relationship between O-... Read More about O-GlcNAcylation and Phosphorylation Crosstalk in Vascular Smooth Muscle Cells: Cellular and Therapeutic Significance in Cardiac and Vascular Pathologies.

Oxygen Concentration Plays a Critical Role in Fibrinogen-Mediated Platelet Activation via Inactivation of αIIbβ3 and Modulation of Fibrinogen (2025)
Journal Article
Leonard, S. V. L., Booth, Z., Naylor-Adamson, L., Bibby, L., Wraith, K. S., Pula, G., Arman, M., & Calaminus, S. D. J. (2025). Oxygen Concentration Plays a Critical Role in Fibrinogen-Mediated Platelet Activation via Inactivation of αIIbβ3 and Modulation of Fibrinogen. Biomolecules, 15(4), Article 501. https://doi.org/10.3390/biom15040501

In the vascular system, pathological conditions that cause hypoxia are associated with increased platelet activity and thrombosis. Using a platelet spreading assay, we show that severe hypoxia (i.e., 1%), venous (i.e., 5%), and, surprisingly, arteria... Read More about Oxygen Concentration Plays a Critical Role in Fibrinogen-Mediated Platelet Activation via Inactivation of αIIbβ3 and Modulation of Fibrinogen.

Ibrutinib enhances the bias of T cell responses towards staphylococcal superantigens sustaining inflammation in chronic lymphocytic leukaemia (2025)
Journal Article
Tantoush, F., Allsup, D., Naylor-Adamson, L., Voncken, F., & Caserta, S. (2025). Ibrutinib enhances the bias of T cell responses towards staphylococcal superantigens sustaining inflammation in chronic lymphocytic leukaemia. Frontiers in immunology, 16, Article 1531059. https://doi.org/10.3389/fimmu.2025.1531059

Chronic lymphocytic leukaemia (CLL) is an uncurable haematological malignancy and is associated with significant infection morbidity. Bruton’s tyrosine-kinase inhibitors (e.g., ibrutinib) have improved disease outcomes, but severe infections and poor... Read More about Ibrutinib enhances the bias of T cell responses towards staphylococcal superantigens sustaining inflammation in chronic lymphocytic leukaemia.

Hemoglobin in the brain frontal lobe tissue of patients with Alzheimer's disease is susceptible to reactive nitrogen species-mediated oxidative damage (2025)
Journal Article
Smallwood, M. J., Alghayth, M. A., Knight, A. R., Tveen-Jensen, K., Pitt, A. R., Spickett, C. M., Llewellyn, D., Pula, G., Wearn, A., Vanhatalo, A., Jones, A. M., Francis, P., Coulthard, E., Kehoe, P. G., & Winyard, P. G. (2025). Hemoglobin in the brain frontal lobe tissue of patients with Alzheimer's disease is susceptible to reactive nitrogen species-mediated oxidative damage. Redox Biology, 82, Article 103612. https://doi.org/10.1016/j.redox.2025.103612

Brain inflammation in Alzheimer's disease (AD) involves reactive nitrogen species (RNS) generation. Protein contents of 3-nitrotyrosine, a product of RNS generation, were assessed in frontal lobe brain homogenates from patients with AD, patients with... Read More about Hemoglobin in the brain frontal lobe tissue of patients with Alzheimer's disease is susceptible to reactive nitrogen species-mediated oxidative damage.

Comparison of the procoagulant activity between extracellular vesicles obtained from cellular monolayers and spheroids (2025)
Journal Article
Rondon, A. M., Featherby, S., Gomes, T., Laghmani, E. H., Ettelaie, C., & Versteeg, H. H. (in press). Comparison of the procoagulant activity between extracellular vesicles obtained from cellular monolayers and spheroids. Journal of Thrombosis and Thrombolysis, https://doi.org/10.1007/s11239-025-03076-4

Tissue factor (TF) is the main activator of blood coagulation and is associated with thrombosis and tumor progression. It can be released into the blood circulation incorporated within cancer cell-derived extracellular vesicles (EVs). In this study,... Read More about Comparison of the procoagulant activity between extracellular vesicles obtained from cellular monolayers and spheroids.

Investigating the impact of environmental contaminants on periconceptual environment and early reproductive events (2025)
Thesis
Papachristofi, V. (2025). Investigating the impact of environmental contaminants on periconceptual environment and early reproductive events. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/5038856

The modern environment in which we live is replete with chemicals that have accumulated to levels that have been proposed to impact various aspects of physiology. The impact of a selection of these environmental contaminants on the physiology of earl... Read More about Investigating the impact of environmental contaminants on periconceptual environment and early reproductive events.

The Creation of 3D Thyroid Models to Investigate the Effects of Sorafenib on Thyroid Tumour Tissue (2025)
Thesis
Golebiewski, P. (2025). The Creation of 3D Thyroid Models to Investigate the Effects of Sorafenib on Thyroid Tumour Tissue. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/5087881

Thyroid cancer (TC) is the most common endocrine malignancy globally. While surgery and radioactive iodine (RAI) therapy generally yield favourable outcomes, prognosis worsens in RAI-refractory or resistant cases, highlighting the need for alternativ... Read More about The Creation of 3D Thyroid Models to Investigate the Effects of Sorafenib on Thyroid Tumour Tissue.

Identification of the Interacting Domains Between Tissue Factor and β1-Integrin and the Signalling Properties of the Two Fibronectin-like Domains of Tissue Factor (2025)
Journal Article
Featherby, S. J., Faulkner, E. C., Maraveyas, A., & Ettelaie, C. (2025). Identification of the Interacting Domains Between Tissue Factor and β1-Integrin and the Signalling Properties of the Two Fibronectin-like Domains of Tissue Factor. Cancers, 17(4), Article 644. https://doi.org/10.3390/cancers17040644

Background: Interactions between tissue factor (TF) and β1-integrin induce cell signals, but the molecular mechanisms are not completely understood. The extracellular domain of TF and EGF4-βTD domains of β1-integrin were hypothesised to be the most l... Read More about Identification of the Interacting Domains Between Tissue Factor and β1-Integrin and the Signalling Properties of the Two Fibronectin-like Domains of Tissue Factor.

The impact of impact: an invitation to philosophise (2025)
Journal Article
Brauer, R., Björn, I., Burgess, G., Dymitrow, M., Greenman, J., Grzelak-Kostulska, E., Pöllänen, P., & Williams, T. (in press). The impact of impact: an invitation to philosophise. Minerva, https://doi.org/10.1007/s11024-024-09558-8

This position paper argues for the introduction of a philosophy of research impact, as an invitation to think deeply about the implications of the impact agenda. It delves into the transformative influence of prioritising the end-product of the resea... Read More about The impact of impact: an invitation to philosophise.

Development of Multimodal Imaging Agents for Thrombosis (2025)
Thesis
Gil, H. (2025). Development of Multimodal Imaging Agents for Thrombosis. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/5088352

Quantum dots (QDs) are colloidal nanoparticles with unique optical and electronic characteristics attributed to quantum confinement effects, making them ideal for fluorescence imaging of biological systems. This thesis investigates the synthesis and... Read More about Development of Multimodal Imaging Agents for Thrombosis.

Chronic Lymphocytic Leukemia Care and Beyond: Navigating the Needs of Long-Term Survivors (2025)
Journal Article
Molica, S., & Allsup, D. (2025). Chronic Lymphocytic Leukemia Care and Beyond: Navigating the Needs of Long-Term Survivors. Cancers, 17(1), Article 119. https://doi.org/10.3390/cancers17010119

Chronic lymphocytic leukemia (CLL) treatment has evolved from traditional chemotherapy to targeted therapies, such as Bruton tyrosine kinase (BTK) and BCL-2 inhibitors with significant improvements in survival rates and a transformation of CLL into a... Read More about Chronic Lymphocytic Leukemia Care and Beyond: Navigating the Needs of Long-Term Survivors.

Hyperactivity and Pro-inflammatory Functions of Platelets in Diabetes (2025)
Journal Article
Pula, G., & Greaves, J. (2025). Hyperactivity and Pro-inflammatory Functions of Platelets in Diabetes. Frontiers in Bioscience-Landmark, 30(1), Article 26190. https://doi.org/10.31083/FBL26190

Cardiovascular complications claim the lives of up to 70% of patients with diabetes mellitus (DM). The mechanisms increasing cardiovascular risk in DM remain to be fully understood and successfully addressed. Nonetheless, there is increasing evidence... Read More about Hyperactivity and Pro-inflammatory Functions of Platelets in Diabetes.