Chronic Lymphocytic Leukemia Care and Beyond: Navigating the Needs of Long-Term Survivors

Molica, Stefano; Allsup, David

Abstract

Chronic lymphocytic leukemia (CLL) treatment has evolved from traditional chemotherapy to targeted therapies, such as Bruton tyrosine kinase (BTK) and BCL-2 inhibitors with significant improvements in survival rates and a transformation of CLL into a manageable, chronic condition. However, long-term survivors face an increased risk of infections, cardiovascular complications, and secondary malignancies. This shift in care necessitates the development of holistic survivorship models that incorporate disease treatment with the proactive management of frailty, comorbidities, and psychosocial well-being. Comprehensive geriatric assessments (GAs) are essential in older patients to guide treatment decisions and identify frail multimorbid individuals. The development of CLL survivorship-focused care models, which integrate patient-reported outcomes and frailty metrics, are crucial for the enhancement of both survival and quality of life (QoL).

Citation

Molica, S., & Allsup, D. (2025). Chronic Lymphocytic Leukemia Care and Beyond: Navigating the Needs of Long-Term Survivors. Cancers, 17(1), Article 119. https://doi.org/10.3390/cancers17010119

• Journal Article Type: Review
• Acceptance Date: Dec 31, 2024
• Online Publication Date: Jan 2, 2025
• Publication Date: Jan 1, 2025
• Deposit Date: Jan 3, 2025
• Publicly Available Date: Jan 6, 2025
• Journal: Cancers
• Electronic ISSN: 2072-6694
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 17
• Issue: 1
• Article Number: 119
• DOI: https://doi.org/10.3390/cancers17010119
• Keywords: CLL; Disease care; Beyond treatment; Long survivors; Long-term monitoring
• Public URL: https://hull-repository.worktribe.com/output/5001346