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All Outputs (904)

Abstract 224: Establishing de novo platform for whole genome sequencing of pancreatic cyst fluid for early detection and diagnosis of pancreatic cancer (2023)
Presentation / Conference Contribution
Adekeye, A., Haque, F., Ettelaie, C., Nikitenko, L., & Maraveyas, A. Abstract 224: Establishing de novo platform for whole genome sequencing of pancreatic cyst fluid for early detection and diagnosis of pancreatic cancer. Presented at AACR Annual Meeting 2023, Orlando, Florida

Background: Pancreatic cancer (PC) is a leading cause of cancer-related deaths globally. Accurate PC detection at early or premalignant stage, when surgery is effective, would increase survival rates and prevent unnecessary surgery or surveillance. A... Read More about Abstract 224: Establishing de novo platform for whole genome sequencing of pancreatic cyst fluid for early detection and diagnosis of pancreatic cancer.

Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells (2023)
Thesis
Haque, F. Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4371279

The premalignant pancreatic cellular genotype can remain stable for years before rapid malignant transformation, often associated with inflammation. Tissue factor (TF) is an inflammatory modulator regulated by factor VIIa (fVIIa) for its levels and a... Read More about Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells.

Provision and delivery of survivorship care for adult patients with haematological malignancies: A scoping review protocol (2023)
Journal Article
Baldwin, Z.-A., Busby, S., Allsup, D., Cohen, J., & Bamidele, O. (2023). Provision and delivery of survivorship care for adult patients with haematological malignancies: A scoping review protocol. PLoS ONE, 18(3), Article e0282458. https://doi.org/10.1371/journal.pone.0282458

Introduction Haematological malignancies are a heterogenous group of blood and lymphatic cancers. Survivorship care is a similarly diverse term concerning patients’ health and wellbeing from diagnosis to end of life. Survivorship care for patients wi... Read More about Provision and delivery of survivorship care for adult patients with haematological malignancies: A scoping review protocol.

The effect of platelet releasate on oocytes has a detrimental impact on early mammalian embryos (2023)
Thesis
Martin, F. The effect of platelet releasate on oocytes has a detrimental impact on early mammalian embryos. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4430667

Background: Blood-derived products are a growing area of therapeutic treatments for a diverse range of conditions, including hair loss, scarring, muscle injury, wounds, arthritis, and symptoms related to the menopause. Platelet-rich plasma (PRP) is o... Read More about The effect of platelet releasate on oocytes has a detrimental impact on early mammalian embryos.

The Skin Microbiome: Current Landscape and Future Opportunities (2023)
Journal Article
Smythe, P., & Wilkinson, H. N. (2023). The Skin Microbiome: Current Landscape and Future Opportunities. International Journal of Molecular Sciences, 24(4), Article 3950. https://doi.org/10.3390/ijms24043950

Our skin is the largest organ of the body, serving as an important barrier against the harsh extrinsic environment. Alongside preventing desiccation, chemical damage and hypothermia, this barrier protects the body from invading pathogens through a so... Read More about The Skin Microbiome: Current Landscape and Future Opportunities.

Detection of microplastics in human saphenous vein tissue using μFTIR: a pilot study (2023)
Journal Article
Rotchell, J. M., Jenner, L. C., Chapman, E., Bennett, R., Bolanle, I. O., Loubani, M., Sadofsky, L., & Palmer, T. (2023). Detection of microplastics in human saphenous vein tissue using μFTIR: a pilot study. PLoS ONE, 18(2), Article e0280594. https://doi.org/10.1371/journal.pone.0280594

Microplastics (MPs) are ubiquitous in the environment, in the human food chain, and have been recently detected in blood and lung tissues. To undertake a pilot analysis of MP contamination in human vein tissue samples with respect to their presence (... Read More about Detection of microplastics in human saphenous vein tissue using μFTIR: a pilot study.

Multi-dimensional experimental and computational exploration of metabolism pinpoints complex probiotic interactions (2023)
Journal Article
Zampieri, G., Efthimiou, G., & Angione, C. (2023). Multi-dimensional experimental and computational exploration of metabolism pinpoints complex probiotic interactions. Metabolic Engineering, 76, 120-132. https://doi.org/10.1016/j.ymben.2023.01.008

Multi-strain probiotics are widely regarded as effective products for improving gut microbiota stability and host health, providing advantages over single-strain probiotics. However, in general, it is unclear to what extent different strains would co... Read More about Multi-dimensional experimental and computational exploration of metabolism pinpoints complex probiotic interactions.

Accuracy and utility of blood and urine biomarkers for the noninvasive diagnosis of endometriosis: a systematic literature review and meta-analysis (2022)
Journal Article
Dolińska, W., Draper, H., Othman, L., Thompson, C., Girvan, S., Cunningham, K., Allen, J., Rigby, A., Phillips, K., & Guinn, B. A. (2023). Accuracy and utility of blood and urine biomarkers for the noninvasive diagnosis of endometriosis: a systematic literature review and meta-analysis. F&S Reviews, 4(2), 116-130. https://doi.org/10.1016/j.xfnr.2022.12.001

Objective: Endometriosis is a chronic, incurable condition associated with debilitating pain and subfertility affecting over 190 million women worldwide, which has no reliable noninvasive diagnostic tool. We aimed to determine the state-of-the-art in... Read More about Accuracy and utility of blood and urine biomarkers for the noninvasive diagnosis of endometriosis: a systematic literature review and meta-analysis.

Machine learning-based predictions of gamma passing rates for virtual specific-plan verification based on modulation maps, monitor unit profiles, and composite dose images (2022)
Journal Article
Quintero, P., Benoit, D., Cheng, Y., Moore, C., & Beavis, A. (2022). Machine learning-based predictions of gamma passing rates for virtual specific-plan verification based on modulation maps, monitor unit profiles, and composite dose images. Physics in Medicine and Biology, 67(24), Article 245001. https://doi.org/10.1088/1361-6560/aca38a

Machine learning (ML) methods have been implemented in radiotherapy to aid virtual specific-plan verification protocols, predicting gamma passing rates (GPR) based on calculated modulation complexity metrics because of their direct relation to dose d... Read More about Machine learning-based predictions of gamma passing rates for virtual specific-plan verification based on modulation maps, monitor unit profiles, and composite dose images.

Investigating the importance of CBX2’s structural motifs for its chromatin interactions and pro-oncogenic epigenetic regulatory function in triple negative breast cancer (2022)
Thesis
Dobrowinski, W. Investigating the importance of CBX2’s structural motifs for its chromatin interactions and pro-oncogenic epigenetic regulatory function in triple negative breast cancer. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4291232

Epigenetics is the study of the change in gene expression patterns that are not caused by direct alterations in the DNA nucleotide sequence but instead are as a result of the dynamic remodelling of the chromatin state. Regulation of the chromatin lan... Read More about Investigating the importance of CBX2’s structural motifs for its chromatin interactions and pro-oncogenic epigenetic regulatory function in triple negative breast cancer.

The language of abiotic stress in aquatic animals : molecular characterisation of stress metabolite-mediated stress communication (2022)
Thesis
Feugère, L. The language of abiotic stress in aquatic animals : molecular characterisation of stress metabolite-mediated stress communication. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4311814

It is well established that aquatic animals inform their neighbours of predation risk through chemical cues. In this thesis, I tested the hypothesis that stress propagation is a widespread mechanism also activated by abiotic stressors – such as those... Read More about The language of abiotic stress in aquatic animals : molecular characterisation of stress metabolite-mediated stress communication.

Investigating the role Of CBX2 to promote cell growth in triple negative breast cancer (2022)
Thesis
Bilton, L. Investigating the role Of CBX2 to promote cell growth in triple negative breast cancer. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4240594

Breast cancer is the uncontrolled proliferation of breast cells and is one of the most common cancers in the UK. It is a complex disease that can be divided into different subtypes based upon the presence or lack of hormone receptors, namely the oest... Read More about Investigating the role Of CBX2 to promote cell growth in triple negative breast cancer.

Investigating the impact of interstitial fluid flow on cancer biology (2022)
Thesis
Pyne, E. S. Investigating the impact of interstitial fluid flow on cancer biology. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4251436

Despite major advances in our understanding of cancer progression mechanisms, cancer remains a leading cause of death in the UK and globally. Solid tumours are complex, and heterogeneous, existing in a dynamic microenvironment subjected to a variety... Read More about Investigating the impact of interstitial fluid flow on cancer biology.

Airborne transmission of biological agents within the indoor built environment: a multidisciplinary review (2022)
Journal Article
Argyropoulos, C. D., Skoulou, V., Efthimiou, G., & Michopoulos, A. K. (2022). Airborne transmission of biological agents within the indoor built environment: a multidisciplinary review. Air Quality, Atmosphere and Health, https://doi.org/10.1007/s11869-022-01286-w

The nature and airborne dispersion of the underestimated biological agents, monitoring, analysis and transmission among the human occupants into building environment is a major challenge of today. Those agents play a crucial role in ensuring comforta... Read More about Airborne transmission of biological agents within the indoor built environment: a multidisciplinary review.

Microplastics in the surgical environment (2022)
Journal Article
Field, D. T., Green, J. L., Bennett, R., Jenner, L. C., Sadofsky, L., Chapman, E., Loubani, M., & Rotchell, J. M. (2022). Microplastics in the surgical environment. Environment International, 170, Article 107630. https://doi.org/10.1016/j.envint.2022.107630

Atmospheric microplastics (MPs) have been consistently detected within indoor and outdoor air samples. Locations with high human activity are reported to have high MP levels. The aim was to quantify and characterise the MPs present within the surgica... Read More about Microplastics in the surgical environment.

Age-Associated Changes in Voltage-Gated Sodium Channels Within the Right Atrium Predispose the Elderly to Atrial Fibrillation (2022)
Thesis
Isaac, E. S. Age-Associated Changes in Voltage-Gated Sodium Channels Within the Right Atrium Predispose the Elderly to Atrial Fibrillation. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4508137

Atrial Fibrillation (AF) is the most common cardiac arrhythmia worldwide with sufferers of the condition facing significant morbidity and mortality. Ageing alone is identified as the most significant risk factor for developing the arrhythmia. As such... Read More about Age-Associated Changes in Voltage-Gated Sodium Channels Within the Right Atrium Predispose the Elderly to Atrial Fibrillation.

Identification and prioritization of tumour-associated antigens for immunotherapeutic and diagnostic capacity in epithelial ovarian cancer: a systematic literature review (2022)
Journal Article
Wiseman, L., Cinti, N., & Guinn, B. A. (2022). Identification and prioritization of tumour-associated antigens for immunotherapeutic and diagnostic capacity in epithelial ovarian cancer: a systematic literature review. Carcinogenesis, 43(11), 1015-1029. https://doi.org/10.1093/carcin/bgac084

Epithelial ovarian cancer (EOC) is a prevalent carcinoma in the female population associated with poor prognostic outcomes, in part due to the late stage of the disease at diagnosis. Aiming to identify tumour-associated antigens (TAAs) with the poten... Read More about Identification and prioritization of tumour-associated antigens for immunotherapeutic and diagnostic capacity in epithelial ovarian cancer: a systematic literature review.

Should aspirin be replaced with ADP blockers or anti-GPVI to manage thrombosis? (2022)
Journal Article
Khan, H., Ghulam, T., Ahmed, N., Babar, M. R., Calaminus, S. D., & Yusuf, M. Z. (2022). Should aspirin be replaced with ADP blockers or anti-GPVI to manage thrombosis?. Vascular Biology, https://doi.org/10.1530/vb-22-0010

Platelets have a pivotal role in maintaining cardiovascular homeostasis. They are kept docile by endothelial derived mediators. Aberration in haemostatic balance predisposes an individual to an elevated risk of a pro-thrombotic environment. Anti-plat... Read More about Should aspirin be replaced with ADP blockers or anti-GPVI to manage thrombosis?.