Machine learning-based predictions of gamma passing rates for virtual specific-plan verification based on modulation maps, monitor unit profiles, and composite dose images

Quintero, Paulo; Benoit, David; Cheng, Yongqiang; Moore, Craig; Beavis, Andrew

Abstract

Machine learning (ML) methods have been implemented in radiotherapy to aid virtual specific-plan verification protocols, predicting gamma passing rates (GPR) based on calculated modulation complexity metrics because of their direct relation to dose deliverability. Nevertheless, these metrics might not comprehensively represent the modulation complexity, and automatically extracted features from alternative predictors associated with modulation complexity are needed. For this reason, three convolutional neural networks (CNN) based models were trained to predict GPR values (regression and classification), using respectively three predictors: (1) the modulation maps (MM) from the multi-leaf collimator, (2) the relative monitor units per control point profile (MUcp), and (3) the composite dose image (CDI) used for portal dosimetry, from 1024 anonymized prostate plans. The models’ performance was assessed for classification and regression by the area under the receiver operator characteristic curve (AUC_ROC) and Spearman’s correlation coefficient (r). Finally, four hybrid models were designed using all possible combinations of the three predictors. The prediction performance for the CNN-models using single predictors (MM, MUcp, and CDI) were AUC_ROC = 0.84 ± 0.03, 0.77 ± 0.07, 0.75 ± 0.04, and r = 0.6, 0.5, 0.7. Contrastingly, the hybrid models (MM + MUcp, MM + CDI, MUcp+CDI, MM + MUcp+CDI) performance were AUC_ROC = 0.94 ± 0.03, 0.85 ± 0.06, 0.89 ± 0.06, 0.91 ± 0.03, and r = 0.7, 0.5, 0.6, 0.7. The MP, MUcp, and CDI are suitable predictors for dose deliverability models implementing ML methods. Additionally, hybrid models are susceptible to improving their prediction performance, including two or more input predictors.

Citation

Quintero, P., Benoit, D., Cheng, Y., Moore, C., & Beavis, A. (2022). Machine learning-based predictions of gamma passing rates for virtual specific-plan verification based on modulation maps, monitor unit profiles, and composite dose images. Physics in Medicine and Biology, 67(24), Article 245001. https://doi.org/10.1088/1361-6560/aca38a

• Journal Article Type: Article
• Acceptance Date: Nov 16, 2022
• Online Publication Date: Dec 6, 2022
• Publication Date: Dec 21, 2022
• Deposit Date: Jun 13, 2024
• Publicly Available Date: Jun 17, 2024
• Journal: Physics in Medicine and Biology
• Print ISSN: 0031-9155
• Electronic ISSN: 1361-6560
• Publisher: IOP Publishing
• Peer Reviewed: Peer Reviewed
• Volume: 67
• Issue: 24
• Article Number: 245001
• DOI: https://doi.org/10.1088/1361-6560/aca38a
• Keywords: Machine-learning; Radiotherapy; CNN; Gamma-passing-rates
• Public URL: https://hull-repository.worktribe.com/output/4161343