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Adrenomedullin and CGRP interact with endogenous calcitonin-receptor-like receptor in endothial cells and induce its desensitisation by different mechanism (2006)
Journal Article
Nikitenko, L. L., Blucher, N., Fox, S. B., Bicknell, R., Smith, D. M., & Rees, M. C. (2006). Adrenomedullin and CGRP interact with endogenous calcitonin-receptor-like receptor in endothial cells and induce its desensitisation by different mechanism. Journal of cell science, 119(5), 910-922. https://doi.org/10.1242/jcs.02783

Adrenomedullin (AM) and calcitonin gene-related peptide (CGRP) are related peptides with distinct pharmacological profiles. Calcitonin-receptor-like receptor (CRLR, now known as CL) can function as either an AM receptor or a CGRP receptor, when cotra... Read More about Adrenomedullin and CGRP interact with endogenous calcitonin-receptor-like receptor in endothial cells and induce its desensitisation by different mechanism.

Fission yeast Dss1 associates with the proteasome and is required for efficient ubiquitin-dependent proteolysis (2006)
Journal Article
Jossé, L., Harley, M. E., Monteiro dos Santos Pires, I., & Hughes, D. A. (2006). Fission yeast Dss1 associates with the proteasome and is required for efficient ubiquitin-dependent proteolysis. Biochemical Journal, 393(1), 303-309. https://doi.org/10.1042/BJ20051238

Human DSS1 associates with BRCA2, a tumour suppressor protein required for efficient recombinational DNA repair, but the biochemical function of DSS1 is not known. Orthologues of DSS1 are found in organisms such as budding yeast and fission yeast tha... Read More about Fission yeast Dss1 associates with the proteasome and is required for efficient ubiquitin-dependent proteolysis.

Pretreatment with hyperbaric oxygen and its effect on neuropsychometric dysfunction and systemic inflammatory response after cardiopulmonary bypass: a prospective randomized double-blind trial (2005)
Journal Article
Alex, J., Laden, G., Cale, A. R. J., Bennett, S., Flowers, K., Madden, L., Gardiner, E., McCollum, P. T., & Griffin, S. C. (2005). Pretreatment with hyperbaric oxygen and its effect on neuropsychometric dysfunction and systemic inflammatory response after cardiopulmonary bypass: a prospective randomized double-blind trial. Journal of thoracic and cardiovascular surgery, 130(6), 1623-1630. https://doi.org/10.1016/j.jtcvs.2005.08.018

Objective: Animal studies have shown that pretreatment with hyperbaric oxygen can induce central nervous system ischemic tolerance and also modulate the inflammatory response. We evaluated this therapy in patients undergoing cardiopulmonary bypass. M... Read More about Pretreatment with hyperbaric oxygen and its effect on neuropsychometric dysfunction and systemic inflammatory response after cardiopulmonary bypass: a prospective randomized double-blind trial.

Adrenomedullin and tumour angiogenesis (2005)
Journal Article
Nikitenko, L. L., Fox, S. B., Kehoe, S., Rees, M. C., & Bicknell, R. (2006). Adrenomedullin and tumour angiogenesis. The British Journal of Cancer, 94(1), 1-7. https://doi.org/10.1038/sj.bjc.6602832

The angiogenic activity of peptide adrenomedullin (AM) was first shown in 1998 . Since then, a number of reports have confirmed the ability of AM to induce the growth and migration of isolated vascular endothelial and smooth muscle cells in vitro and... Read More about Adrenomedullin and tumour angiogenesis.

Phenotype and homing of CD4 tumor-specific T cells is modulated by tumor bulk (2005)
Journal Article
Benigni, F., Zimmermann, V. S., Hugues, S., Caserta, S., Basso, V., Rivino, L., Ingulli, E., Malherbe, L., Glaichenhaus, N., & Mondino, A. (2005). Phenotype and homing of CD4 tumor-specific T cells is modulated by tumor bulk. Journal of Immunology, 175(2), 739-748. https://doi.org/10.4049/jimmunol.175.2.739

Technical difficulties in tracking endogenous CD4 T lymphocytes have limited the characterization of tumor-specific CD4 T cell responses. Using fluorescent MHC class II/peptide multimers, we defined the fate of endogenous Leishmania receptor for acti... Read More about Phenotype and homing of CD4 tumor-specific T cells is modulated by tumor bulk.

Heat shock proteins in vascular disease - a review (2005)
Journal Article
Mehta, T., Greenman, J., Ettelaie, C., Venkatasubramaniam, A., Chetter, I., & McCollum, P. (2005). Heat shock proteins in vascular disease - a review. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 29(4), 395-402. https://doi.org/10.1016/j.ejvs.2005.01.005

Introduction
There is growing evidence that heat shock proteins (HSPs), a family of stress-inducible proteins may be involved in the pathogenesis of atherosclerotic vascular diseases. Here, we systematically review the evidence behind this notion.... Read More about Heat shock proteins in vascular disease - a review.

Antiangiogenic activity of a domain deletion mutant of tissue plasminogen activator containing kringle 2 (2005)
Journal Article
Carroll, V. A., Nikitenko, L. L., Bicknell, R., & Harris, A. L. (2005). Antiangiogenic activity of a domain deletion mutant of tissue plasminogen activator containing kringle 2. Arteriosclerosis, Thrombosis, and Vascular Biology, 25(4), 736-741. https://doi.org/10.1161/01.ATV.0000157980.15710.2b

Objective - The thrombolytic therapy drug, Reteplase, is a domain deletion mutant of tissue plasminogen activator (tPA), comprising the kringle 2 and protease (K2P) domains. Some kringle domains of hemostatic proteins are antiangiogenic and promote a... Read More about Antiangiogenic activity of a domain deletion mutant of tissue plasminogen activator containing kringle 2.

Adrenomedullin: Multiple functions in human pregnancy (2004)
Journal Article
Wilson, C., Nikitenko, L. L., Sargent, I. L., & Rees, M. C. (2004). Adrenomedullin: Multiple functions in human pregnancy. Angiogenesis, 7(3), 203-212. https://doi.org/10.1007/s10456-004-4183-5

Adrenomedullin is a 52 amino acid peptide originally isolated from human phaeochromocytoma in 1993. It was initially demonstrated to have profound effects on the vasculature including vasodilatation and subsequently promotion of angiogenesis. Since t... Read More about Adrenomedullin: Multiple functions in human pregnancy.

IL-10-Conditioned Dendritic Cells, Decommissioned for Recruitment of Adaptive Immunity, Elicit Innate Inflammatory Gene Products in Response to Danger Signals (2004)
Journal Article
Nolan, K. F., Croxton, R., Strong, V., Soler, D., Fairchild, P. J., Cobbold, S. P., …Waldmann, H. (2004). IL-10-Conditioned Dendritic Cells, Decommissioned for Recruitment of Adaptive Immunity, Elicit Innate Inflammatory Gene Products in Response to Danger Signals. Journal of Immunology, 172(4), 2201-2209. https://doi.org/10.4049/jimmunol.172.4.2201

Dendritic cells (DCs) are the professional APCs of the immune system, enabling T cells to perceive and respond appropriately to potentially dangerous microbes, while also being able to maintain T cell tolerance toward self. In part, such tolerance ca... Read More about IL-10-Conditioned Dendritic Cells, Decommissioned for Recruitment of Adaptive Immunity, Elicit Innate Inflammatory Gene Products in Response to Danger Signals.

GPI-anchored uPAR requires Endo180 for rapid directional sensing during chemotaxis (2003)
Journal Article
Sturge, J., Wienke, D., East, L., Jones, G. E., & Isacke, C. M. (2003). GPI-anchored uPAR requires Endo180 for rapid directional sensing during chemotaxis. Journal of Cell Biology, 162(5), 789-794. https://doi.org/10.1083/jcb.200302124

Urokinase-type plasminogen activator (uPA) and its receptor (uPAR) play an important role in cell guidance and chemotaxis during normal and pathological events. uPAR is GPI-anchored and the mechanism by which it transmits intracellular polarity cues... Read More about GPI-anchored uPAR requires Endo180 for rapid directional sensing during chemotaxis.

Transcriptional regulation of the CRLR gene in human microvascular endothelial cells by hypoxia. (2003)
Journal Article
Nikitenko, L. L., Smith, D. M., Bicknell, R., & Rees, M. C. (2003). Transcriptional regulation of the CRLR gene in human microvascular endothelial cells by hypoxia. FASEB Journal, 17(11), 1499-1501. https://doi.org/10.1096/fj.02-0993fje

Adrenomedullin is a 52 amino acid peptide that shows a remarkable range of effects on the vasculature that include inter alia, vasodilatation, regulation of permeability, inhibition of endothelial cell apoptosis, and promotion of angiogenesis. Recent... Read More about Transcriptional regulation of the CRLR gene in human microvascular endothelial cells by hypoxia..

A targeted deletion in the endocytic receptor gene Endo 180 results in a defect in collagen uptake (2003)
Journal Article
East, L., McCarthy, A., Wienke, D., Sturge, J., Ashworth, A., & Isacke, C. M. (2003). A targeted deletion in the endocytic receptor gene Endo 180 results in a defect in collagen uptake. EMBO Reports, 4(7), 710-716. https://doi.org/10.1038/sj.embor.embor882

The four members of the mannose receptor family (the mannose receptor, the M-type phospholipase A2 receptor, DEC-205 and Endo180) share a common extracellular arrangement of an amino-terminal cysteine-rich domain followed by a fibronectin type II (FN... Read More about A targeted deletion in the endocytic receptor gene Endo 180 results in a defect in collagen uptake.

Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-Kinase p110δ (2003)
Journal Article
Sawyer, C., Sturge, J., Bennett, D. C., O'Hare, M. J., Allen, W. E., Bain, J., Jones, G. E., & Vanhaesebroeck, B. (2003). Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-Kinase p110δ. Cancer Research, 63(7), 1667-1675

Class IA phosphoinositide 3′-kinases (PI3Ks) regulate many cellular processes downstream of tyrosine kinases and Ras. Despite a clear implication of PI3K in cancer, little is known about the distribution of the different PI3K isoforms in malignant ce... Read More about Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-Kinase p110δ.