All Outputs (954)

Investigating the importance of CBX2’s structural motifs for its chromatin interactions and pro-oncogenic epigenetic regulatory function in triple negative breast cancer (2022)
Thesis
Dobrowinski, W. Investigating the importance of CBX2’s structural motifs for its chromatin interactions and pro-oncogenic epigenetic regulatory function in triple negative breast cancer. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4291232

Epigenetics is the study of the change in gene expression patterns that are not caused by direct alterations in the DNA nucleotide sequence but instead are as a result of the dynamic remodelling of the chromatin state. Regulation of the chromatin lan... Read More about Investigating the importance of CBX2’s structural motifs for its chromatin interactions and pro-oncogenic epigenetic regulatory function in triple negative breast cancer.

Investigating the role Of CBX2 to promote cell growth in triple negative breast cancer (2022)
Thesis
Bilton, L. Investigating the role Of CBX2 to promote cell growth in triple negative breast cancer. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4240594

Breast cancer is the uncontrolled proliferation of breast cells and is one of the most common cancers in the UK. It is a complex disease that can be divided into different subtypes based upon the presence or lack of hormone receptors, namely the oest... Read More about Investigating the role Of CBX2 to promote cell growth in triple negative breast cancer.

Investigating the impact of interstitial fluid flow on cancer biology (2022)
Thesis
Pyne, E. S. Investigating the impact of interstitial fluid flow on cancer biology. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4251436

Despite major advances in our understanding of cancer progression mechanisms, cancer remains a leading cause of death in the UK and globally. Solid tumours are complex, and heterogeneous, existing in a dynamic microenvironment subjected to a variety... Read More about Investigating the impact of interstitial fluid flow on cancer biology.

Airborne transmission of biological agents within the indoor built environment: a multidisciplinary review (2022)
Journal Article
Argyropoulos, C. D., Skoulou, V., Efthimiou, G., & Michopoulos, A. K. (2022). Airborne transmission of biological agents within the indoor built environment: a multidisciplinary review. Air Quality, Atmosphere and Health, https://doi.org/10.1007/s11869-022-01286-w

The nature and airborne dispersion of the underestimated biological agents, monitoring, analysis and transmission among the human occupants into building environment is a major challenge of today. Those agents play a crucial role in ensuring comforta... Read More about Airborne transmission of biological agents within the indoor built environment: a multidisciplinary review.

Microplastics in the surgical environment (2022)
Journal Article
Field, D. T., Green, J. L., Bennett, R., Jenner, L. C., Sadofsky, L., Chapman, E., Loubani, M., & Rotchell, J. M. (2022). Microplastics in the surgical environment. Environment International, 170, Article 107630. https://doi.org/10.1016/j.envint.2022.107630

Atmospheric microplastics (MPs) have been consistently detected within indoor and outdoor air samples. Locations with high human activity are reported to have high MP levels. The aim was to quantify and characterise the MPs present within the surgica... Read More about Microplastics in the surgical environment.

STIMULATE-ICP-Delphi (Symptoms, Trajectory, Inequalities and Management: Understanding Long-COVID to Address and Transform Existing Integrated Care Pathways Delphi): Study protocol (2022)
Journal Article
van der Feltz-Cornelis, C. M., Sweetman, J., Allsopp, G., Attree, E., Crooks, M. G., Cuthbertson, D. J., Forshaw, D., Gabbay, M., Green, A., Heightman, M., Hillman, T., Hishmeh, L., Khunti, K., Lip, G. Y., Lorgelly, P., Montgomery, H., Strain, W. D., Wall, E., Watkins, C., Williams, N., …McAuliffe, S. (2022). STIMULATE-ICP-Delphi (Symptoms, Trajectory, Inequalities and Management: Understanding Long-COVID to Address and Transform Existing Integrated Care Pathways Delphi): Study protocol. PLoS ONE, 17(11 November), Article e0277936. https://doi.org/10.1371/journal.pone.0277936

Introduction As mortality rates from COVID-19 disease fall, the high prevalence of long-term sequelae (Long COVID) is becoming increasingly widespread, challenging healthcare systems globally. Traditional pathways of care for Long Term Conditions (LT... Read More about STIMULATE-ICP-Delphi (Symptoms, Trajectory, Inequalities and Management: Understanding Long-COVID to Address and Transform Existing Integrated Care Pathways Delphi): Study protocol.

Identification and prioritization of tumour-associated antigens for immunotherapeutic and diagnostic capacity in epithelial ovarian cancer: a systematic literature review (2022)
Journal Article
Wiseman, L., Cinti, N., & Guinn, B. A. (2022). Identification and prioritization of tumour-associated antigens for immunotherapeutic and diagnostic capacity in epithelial ovarian cancer: a systematic literature review. Carcinogenesis, 43(11), 1015-1029. https://doi.org/10.1093/carcin/bgac084

Epithelial ovarian cancer (EOC) is a prevalent carcinoma in the female population associated with poor prognostic outcomes, in part due to the late stage of the disease at diagnosis. Aiming to identify tumour-associated antigens (TAAs) with the poten... Read More about Identification and prioritization of tumour-associated antigens for immunotherapeutic and diagnostic capacity in epithelial ovarian cancer: a systematic literature review.

Should aspirin be replaced with ADP blockers or anti-GPVI to manage thrombosis? (2022)
Journal Article
Khan, H., Ghulam, T., Ahmed, N., Babar, M. R., Calaminus, S. D., & Yusuf, M. Z. (2022). Should aspirin be replaced with ADP blockers or anti-GPVI to manage thrombosis?. Vascular Biology, https://doi.org/10.1530/vb-22-0010

Platelets have a pivotal role in maintaining cardiovascular homeostasis. They are kept docile by endothelial derived mediators. Aberration in haemostatic balance predisposes an individual to an elevated risk of a pro-thrombotic environment. Anti-plat... Read More about Should aspirin be replaced with ADP blockers or anti-GPVI to manage thrombosis?.

Computational Studies on Selected Macrolides Active against Escherichia coli Combined with the NMR Study of Tylosin A in Deuterated Chloroform (2022)
Journal Article
Arsic, B., Barber, J., Cikos, A., Kadirvel, M., Kostic, E., McBain, A., Milicevic, J., Oates, A., & Regan, A. (2022). Computational Studies on Selected Macrolides Active against Escherichia coli Combined with the NMR Study of Tylosin A in Deuterated Chloroform. Molecules, 27(21), Article 7280. https://doi.org/10.3390/molecules27217280

Although many antibiotics are active against Gram-positive bacteria, fewer also show activity against Gram-negative bacteria. Here, we present a combination of in silico (electron ion-interaction potential, molecular docking, ADMET), NMR, and microbi... Read More about Computational Studies on Selected Macrolides Active against Escherichia coli Combined with the NMR Study of Tylosin A in Deuterated Chloroform.

Cancer patients’ experiences of the diagnosis and treatment of incidental pulmonary embolism (a qualitative study) (2022)
Journal Article
Benelhaj, N. E., Hutchinson, A., Maraveyas, A., & Johnson, M. (2022). Cancer patients’ experiences of the diagnosis and treatment of incidental pulmonary embolism (a qualitative study). PLoS ONE, 17(10), Article e0276754. https://doi.org/10.1371/journal.pone.0276754

Background: The diagnosis of symptomatic cancer-associated thrombosis often causes distress and alarm for patients, especially for those unaware of the risk, or the signs and symptoms to look out for. There are few data about cancer patients’ experie... Read More about Cancer patients’ experiences of the diagnosis and treatment of incidental pulmonary embolism (a qualitative study).

Bn2DT3A, a Chelator for 68Ga Positron Emission Tomography: Hydroxide Coordination Increases Biological Stability of [68Ga][Ga(Bn2DT3A)(OH)]− (2022)
Journal Article
Price, T. W., Renard, I., Prior, T. J., Kubíček, V., Benoit, D. M., Archibald, S. J., …Stasiuk, G. J. (2022). Bn2DT3A, a Chelator for 68Ga Positron Emission Tomography: Hydroxide Coordination Increases Biological Stability of [68Ga][Ga(Bn2DT3A)(OH)]−. Inorganic chemistry, 61(43), 17059–17067. https://doi.org/10.1021/acs.inorgchem.2c01992

The chelator Bn2DT3A was used to produce a novel 68Ga complex for positron emission tomography (PET). Unusually, this system is stabilized by a coordinated hydroxide in aqueous solutions above pH 5, which confers sufficient stability for it to be use... Read More about Bn2DT3A, a Chelator for 68Ga Positron Emission Tomography: Hydroxide Coordination Increases Biological Stability of [68Ga][Ga(Bn2DT3A)(OH)]−.

Establishing a novel 3-dimensional microfluidic model of bunyavirus Infection to characterise exosome release from tumour cells (2022)
Thesis
Marsh, D. Establishing a novel 3-dimensional microfluidic model of bunyavirus Infection to characterise exosome release from tumour cells. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4224638

The order Bunyavirales represents the largest and most diverse taxonomic grouping of negative-sense RNA viruses, some of which are associated with significant diseases in humans and livestock. The global emergence of these viruses is exacerbated by t... Read More about Establishing a novel 3-dimensional microfluidic model of bunyavirus Infection to characterise exosome release from tumour cells.

Corrigendum: MEF2 transcription factors are key regulators of sprouting angiogenesis (2022)
Journal Article
Sacilotto, N., Chouliaras, K. M., Nikitenko, L. L., Lu, Y. W., Fritzsche, M., Wallace, M. D., …De Val, S. (2022). Corrigendum: MEF2 transcription factors are key regulators of sprouting angiogenesis. Genes & development, 36(19-20), 1096. https://doi.org/10.1101/gad.350249.122

The above-mentioned article contained three errors in the Supplemental Figures. In Supplemental Figure 3D, both bar graphs are missing labels for the X-axes due to an oversight during figure preparation.

Nebivolol as a Potent TRPM8 Channel Blocker: A Drug-Screening Approach through Automated Patch Clamping and Ligand-Based Virtual Screening (2022)
Journal Article
Jahanfar, F., Sadofsky, L., Morice, A., & D’Amico, M. (2022). Nebivolol as a Potent TRPM8 Channel Blocker: A Drug-Screening Approach through Automated Patch Clamping and Ligand-Based Virtual Screening. Membranes, 12(10), Article 954. https://doi.org/10.3390/membranes12100954

Transient Receptor Potential Melastatin 8 (TRPM8) from the melastatin TRP channel subfamily is a non-selective Ca2+-permeable ion channel with multimodal gating which can be activated by low temperatures and cooling compounds, such as menthol and ici... Read More about Nebivolol as a Potent TRPM8 Channel Blocker: A Drug-Screening Approach through Automated Patch Clamping and Ligand-Based Virtual Screening.

Design, synthesis, and evaluation of a novel PET imaging agent targeting lipofuscin in senescent cells (2022)
Journal Article
Brickute, D., Chen, C., Braga, M., Barnes, C., Wang, N., Allott, L., & Aboagye, E. O. (2022). Design, synthesis, and evaluation of a novel PET imaging agent targeting lipofuscin in senescent cells. RSC advances, 12(40), 26372-26381. https://doi.org/10.1039/d2ra04535d

Promoting a senescent phenotype to suppress tumour progression may present an alternative strategy for treating cancer and encourages the development of positron emission tomography (PET) imaging biomarkers for assessing response to treatment. The ac... Read More about Design, synthesis, and evaluation of a novel PET imaging agent targeting lipofuscin in senescent cells.

Thrombotic and bleeding complications in patients with chronic lymphocytic leukemia and severe COVID-19: a study of ERIC, the European Research Initiative on CLL (2022)
Journal Article
Antic, D., Milic, N., Chatzikonstantinou, T., Scarfò, L., Otasevic, V., Rajovic, N., Allsup, D., Alonso Cabrero, A., Andres, M., Baile Gonzales, M., Capasso, A., Collado, R., Cordoba, R., Cuéllar-García, C., Correa, J. G., De Paoli, L., De Paolis, M. R., Del Poeta, G., Dimou, M., Doubek, M., …Stamatopoulos, K. (2022). Thrombotic and bleeding complications in patients with chronic lymphocytic leukemia and severe COVID-19: a study of ERIC, the European Research Initiative on CLL. Journal of Hematology & Oncology, 15(1), Article 116. https://doi.org/10.1186/s13045-022-01333-0

BACKGROUND: Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to COVID-19 related poor outcomes, including thrombosis and death, due to the advanced age, the presence of comorbidities, and the disease and treatment-related immu... Read More about Thrombotic and bleeding complications in patients with chronic lymphocytic leukemia and severe COVID-19: a study of ERIC, the European Research Initiative on CLL.

Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release (2022)
Journal Article
Diego-Taboada, A., Sathyapalan, T., Courts, F., Lorch, M., Almutairi, F., Burke, B. P., …Mackenzie, G. (2022). Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release. Journal of controlled release : official journal of the Controlled Release Society, 350, 244-255. https://doi.org/10.1016/j.jconrel.2022.08.017

Sporopollenin exine capsules (SpECs) are microcapsules derived from the outer shells (exines) of plant spore and pollen grains. This work reports the first clinical study on healthy volunteers to show enhanced bioavailability of vitamin D encapsulate... Read More about Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release.

A guide to pedagogical research for scientists from a biological sciences background (2022)
Journal Article
Lacey, M. M., & Efthimiou, G. (2022). A guide to pedagogical research for scientists from a biological sciences background. Access Microbiology, 4(8), Article 416. https://doi.org/10.1099/acmi.0.000416

How we teach science and engage with the public, particularly in fast moving subjects such as microbiology, are constantly being reflected upon, improved and innovated. This has led to a significant increase of pedagogy publications by microbiology e... Read More about A guide to pedagogical research for scientists from a biological sciences background.

Epithelial arginase-1 is a key mediator of age-associated delayed healing in vaginal injury (2022)
Journal Article
Wilkinson, H. N., Reubinoff, B., Shveiky, D., Hardman, M. J., & Menachem-Zidon, O. B. (2022). Epithelial arginase-1 is a key mediator of age-associated delayed healing in vaginal injury. Frontiers in endocrinology, 13, Article 927224. https://doi.org/10.3389/fendo.2022.927224

Pelvic organ prolapse is a disorder that substantially affects the quality of life of millions of women worldwide. The greatest risk factors for prolapse are increased parity and older age, with the largest group requiring surgical intervention being... Read More about Epithelial arginase-1 is a key mediator of age-associated delayed healing in vaginal injury.

Multi-omic analysis of two common p53 mutations: Proteins regulated by mutated p53 as potential targets for immunotherapy (2022)
Journal Article
Vadakekolathu, J., Boocock, D. J., Pandey, K., Guinn, B. A., Legrand, A., Miles, A. K., …McArdle, S. E. (2022). Multi-omic analysis of two common p53 mutations: Proteins regulated by mutated p53 as potential targets for immunotherapy. Cancers, 14(16), Article 3975. https://doi.org/10.3390/cancers14163975

The p53 protein is mutated in more than 50% of human cancers. Mutated p53 proteins not only lose their normal function but often acquire novel oncogenic functions, a phenomenon termed mutant p53 gain-of-function. Mutant p53 has been shown to affect t... Read More about Multi-omic analysis of two common p53 mutations: Proteins regulated by mutated p53 as potential targets for immunotherapy.