All Outputs (28)

Cough hypersensitivity syndrome is an important clinical concept: A pro/con debate (2011)
Journal Article
Morice, A. H., McGarvey, L. P., & Dicpinigaitis, P. V. (2012). Cough hypersensitivity syndrome is an important clinical concept: A pro/con debate. Lung, 190(1), 3-9. https://doi.org/10.1007/s00408-011-9351-y

The major etiologies of chronic cough are generally accepted to consist of upper airway cough syndrome (formerly postnasal drip syndrome), eosinophilic airway inflammation (asthma, nonasthmatic eosinophilic bronchitis), and gastroesophageal reflux di... Read More about Cough hypersensitivity syndrome is an important clinical concept: A pro/con debate.

Angiotensin converting enzyme inhibitors effect on arterial stiffness and wave reflections: a meta-analysis and meta-regression of randomised controlled trials (2011)
Journal Article
Shahin, Y., Khan, J. A., & Chetter, I. (2012). Angiotensin converting enzyme inhibitors effect on arterial stiffness and wave reflections: a meta-analysis and meta-regression of randomised controlled trials. Atherosclerosis, 221(1), 18-33. https://doi.org/10.1016/j.atherosclerosis.2011.12.005

ObjectiveSeveral studies have assessed the effect of angiotensin converting enzyme inhibitors (ACEIs) on arterial stiffness and wave reflections as measured by pulse wave velocity (PWV) and augmentation index (AIx), respectively. We conducted a meta-... Read More about Angiotensin converting enzyme inhibitors effect on arterial stiffness and wave reflections: a meta-analysis and meta-regression of randomised controlled trials.

Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study (2011)
Journal Article
Faruqi, S., Molyneux, I. D., Fathi, H., Wright, C., Thompson, R., & Morice, A. H. (2011). Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study. Respirology : official journal of the Asian Pacific Society of Respirology, 16(7), 1150-1156. https://doi.org/10.1111/j.1440-1843.2011.02014.x

Background and objective: Gastro-oesophageal reflux has been implicated in the pathogenesis of chronic cough. Guidelines on management suggest a therapeutic trial of anti-reflux medication. Esomeprazole is a proton pump inhibitor licensed for the lon... Read More about Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study.

Bronchoconstriction and airway remodeling [2] (2011)
Journal Article
Morjaria, J., Hart, S., & Morice, A. H. (2011). Bronchoconstriction and airway remodeling [2]. New England Journal of Medicine, 365(12), 1156-1157. https://doi.org/10.1056/NEJMc1107353

Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis (2011)
Journal Article
Botham, A., Guo, X., Xiao, Y. P., Morice, A. H., Compton, S., & Sadofsky, L. R. (2011). Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis. Biochemical Journal, 438(2), 359-367. https://doi.org/10.1042/BJ20101958

hPAR2 (human proteinase-activated receptor-2) is a member of the novel family of proteolytically activated GPCRs (G-protein-coupled receptors) termed PARs (proteinase-activated receptors). Previous pharmacological studies have found that activation o... Read More about Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis.

Differential proteomics in the search for biomarkers of radiotherapy resistance (2011)
Journal Article
Scaife, L., Hodgkinson, V. C., Drew, P. J., Lind, M. J., & Cawkwell, L. (2011). Differential proteomics in the search for biomarkers of radiotherapy resistance. Expert Review of Proteomics, 8(4), 535-552. https://doi.org/10.1586/EPR.11.32

The individualization of radiotherapy treatment would be beneficial for cancer patients; however, there are no predictive biomarkers of radiotherapy resistance in routine clinical use. This article describes the body of work in this field where compa... Read More about Differential proteomics in the search for biomarkers of radiotherapy resistance.

Comparing the treatment response of great saphenous and small saphenous vein incompetence following surgery and endovenous laser ablation: a retrospective cohort study (2011)
Journal Article
Hatfield, J., Carradice, D., Mazari, F. A. K., Josie, H., Samuel, N., Chetter, I., & Wallace, T. (2012). Comparing the treatment response of great saphenous and small saphenous vein incompetence following surgery and endovenous laser ablation: a retrospective cohort study. Phlebology, 27(3), 128-134. https://doi.org/10.1258/phleb.2011.011014

ObjectiveMany venous trials mix patients with great saphenous vein (GSV) and small saphenous vein (SSV) diseases. There is no evidence that both respond similarly to treatment and our aim was to test this assumption.Method This cohort study compares... Read More about Comparing the treatment response of great saphenous and small saphenous vein incompetence following surgery and endovenous laser ablation: a retrospective cohort study.

Patients' perspective of functional outcome after elective abdominal aortic aneurysm repair: a questionnaire survey (2011)
Journal Article
Khan, J. A., Mazari, F. A., Abdul Rahman, M., Mockford, K., Chetter, I. C., & McCollum, P. T. (2011). Patients' perspective of functional outcome after elective abdominal aortic aneurysm repair: a questionnaire survey. Annals of vascular surgery, 25(7), 878-886. https://doi.org/10.1016/j.avsg.2011.05.013

BackgroundTo evaluate patients' awareness, functional outcome, and satisfaction after abdominal aortic aneurysm (AAA) repair.MethodsA study-specific questionnaire was developed with collaboration of a multidisciplinary team. Lists of patients who und... Read More about Patients' perspective of functional outcome after elective abdominal aortic aneurysm repair: a questionnaire survey.

Gastro-oesophageal reflux, eosinophilic airway inflammation and chronic cough (2011)
Journal Article
Pacheco, A., Faro, V., Cobeta, I., Royuela, A., Molyneux, I., & Morice, A. H. (2011). Gastro-oesophageal reflux, eosinophilic airway inflammation and chronic cough. Respirology : official journal of the Asian Pacific Society of Respirology, 16(6), 994-999. https://doi.org/10.1111/j.1440-1843.2011.02010.x

Background and objective: Patients with eosinophilic airway inflammation (EAI) often show a therapeutic response to corticosteroids. Non-invasive methods of diagnosing EAI are potentially useful in guiding therapy, particularly in conditions such as... Read More about Gastro-oesophageal reflux, eosinophilic airway inflammation and chronic cough.

Effect of bitter tastants on human bronchi (2011)
Journal Article
Morice, A. H., Bennett, R. T., Chaudhry, M. A., Cowen, M. E., Griffin, S. C., & Loubani, M. (2011). Effect of bitter tastants on human bronchi. Nature Medicine, 17(7), 775. https://doi.org/10.1038/nm0711-775

Targeted duplex ultrasound in a one-stop dialysis vascular access assessment clinic (2011)
Journal Article
Smith, G. E., Samuel, N., Khan, J., Johnson, B. F., & Chetter, I. C. (2011). Targeted duplex ultrasound in a one-stop dialysis vascular access assessment clinic. Annals of vascular surgery, 25(8), 1099-1103. https://doi.org/10.1016/j.avsg.2011.02.043

BackgroundMany duplex detectable factors have been shown to correlate with upper limb arteriovenous fistula (AVF) outcomes, and many practitioners now request preoperative duplex vessel mapping routinely before AVF surgery. We report outcomes from a... Read More about Targeted duplex ultrasound in a one-stop dialysis vascular access assessment clinic.

Serum LDH in chronic cough: A potential marker of airway inflammation (2011)
Journal Article
Faruqi, S., Wilmot, R., Wright, C., & Morice, A. H. (2012). Serum LDH in chronic cough: A potential marker of airway inflammation. Clinical Respiratory Journal, 6(2), 81-87. https://doi.org/10.1111/j.1752-699X.2011.00250.x

Introduction and Objectives: Lactate dehydrogenase (LDH) is found in almost all tissues of the body and five different isoenzymes are known (LDH-1 to LDH-5). LDH can be elevated in many pathological conditions. We have observed serum LDH to be increa... Read More about Serum LDH in chronic cough: A potential marker of airway inflammation.

Clinical and technical outcomes from a randomized clinical trial of endovenous laser ablation compared with conventional surgery for great saphenous varicose veins (2011)
Journal Article
Carradice, D., Mekako, A. I., Mazari, F. A. K., Samuel, N., Hatfield, J., & Chetter, I. C. (2011). Clinical and technical outcomes from a randomized clinical trial of endovenous laser ablation compared with conventional surgery for great saphenous varicose veins. British journal of surgery, 98(8), 1117-1123. https://doi.org/10.1002/bjs.7615

Background:This report describes the clinical effectiveness and recurrence rates from a randomized trial of endovenous laser ablation (EVLA) and surgery for varicose veins.Methods:Some 280 patients were randomized equally using sealed opaque envelope... Read More about Clinical and technical outcomes from a randomized clinical trial of endovenous laser ablation compared with conventional surgery for great saphenous varicose veins.

The relationship between serum levels of C-reactive protein and the Framingham coronary risk score in patients newly diagnosed with intermittent claudication (2011)
Presentation / Conference Contribution
Shahin, Y., Hatfield, J., & Chetter, I. C. The relationship between serum levels of C-reactive protein and the Framingham coronary risk score in patients newly diagnosed with intermittent claudication

Does anaerobic threshold in cardiopulmonary exercise testing predicts outcome in patients undergoing abdominal aortic aneurysm (AAA) repair? (2011)
Presentation / Conference Contribution
Mazari, F., Khan, J., McCollum, P., Gohil, R., & Chetter, I. Does anaerobic threshold in cardiopulmonary exercise testing predicts outcome in patients undergoing abdominal aortic aneurysm (AAA) repair?

Junction jump sign: a useful adjunct to the precise positioning of the catheter tip during endovenous thermal ablation (2011)
Journal Article
Samuel, N., Wallace, T., Smith, G. E., Shahin, Y., & Chetter, I. C. (2011). Junction jump sign: a useful adjunct to the precise positioning of the catheter tip during endovenous thermal ablation. Ultrasound, 19(2), 97-98. https://doi.org/10.1258/ult.2011.011006

Duplex ultrasound imaging plays a key role in the increasingly popular, minimally invasive endothermal treatment of varicose veins. Accurate placement of the echodense tip of endovenous catheter distal to the site of junctional incompetence is by far... Read More about Junction jump sign: a useful adjunct to the precise positioning of the catheter tip during endovenous thermal ablation.

Airway reflux, cough and respiratory disease (2011)
Journal Article
Molyneux, I. D., & Morice, A. H. (2011). Airway reflux, cough and respiratory disease. Therapeutic Advances in Chronic Disease, 2(4), 237-248. https://doi.org/10.1177/2040622311406464

It is increasingly accepted that the effects of gastro-oesophageal reflux are not limited to the gastrointestinal tract. The adjacent respiratory structures are also at risk from material ejected from the proximal oesophagus as a result of the failur... Read More about Airway reflux, cough and respiratory disease.

N-linked glycosylation regulates human proteinase-activated receptor-1 cell surface expression and disarming via neutrophil proteinases and thermolysin (2011)
Journal Article
Xiao, Y. P., Morice, A. H., Compton, S. J., & Sadofsky, L. (2011). N-linked glycosylation regulates human proteinase-activated receptor-1 cell surface expression and disarming via neutrophil proteinases and thermolysin. Journal of Biological Chemistry, 286(26), 22991-23002. https://doi.org/10.1074/jbc.M110.204271

Proteinase-activated receptor 1 (PAR1) induces activation of platelet and vascular cells after proteolytic cleavage of its extracellular N terminus by thrombin. In pathological situations, other proteinases may be generated in the circulation and mig... Read More about N-linked glycosylation regulates human proteinase-activated receptor-1 cell surface expression and disarming via neutrophil proteinases and thermolysin.

The effect of soy phytoestrogen supplementation on thyroid status and cardiovascular risk markers in patients with subclinical hypothyroidism: A randomized, double-blind, crossover study (2011)
Journal Article
Sathyapalan, T., Manuchehri, A. M., Thatcher, N. J., Rigby, A. S., Chapman, T., Kilpatrick, E. S., & Atkin, S. L. (2011). The effect of soy phytoestrogen supplementation on thyroid status and cardiovascular risk markers in patients with subclinical hypothyroidism: A randomized, double-blind, crossover study. Journal of Clinical Endocrinology and Metabolism, 96(5), 1442-1449. https://doi.org/10.1210/jc.2010-2255

Context: There is concern whether soy phytoestrogens may affect thyroid function. If true, soy phytoestrogens may be expected to have a greater impact in subjects with subclinical hypothyroidism. Objective: The primary aim was to determine the effect... Read More about The effect of soy phytoestrogen supplementation on thyroid status and cardiovascular risk markers in patients with subclinical hypothyroidism: A randomized, double-blind, crossover study.

Gastroesophageal reflux and idiopathic pulmonary fibrosis: A prospective study (2011)
Journal Article
Fahim, A., Dettmar, P. W., Morice, A. H., & Hart, S. P. (2011). Gastroesophageal reflux and idiopathic pulmonary fibrosis: A prospective study. 00 Journal not listed, 47(4), 200-205. https://doi.org/10.3390/medicina47040028

Background and Objective: Idiopathic pulmonary fibrosis (IPF) is the most common of the idiopathic interstitial pneumonias. There is evidence of the increased prevalence of gastroesophageal reflux disease in patients with IPF. The aim of this prospec... Read More about Gastroesophageal reflux and idiopathic pulmonary fibrosis: A prospective study.