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Hypoxic pulmonary vasoconstriction in humans (2013)
Journal Article
Ariyaratnam, P., Loubani, M., & Morice, A. H. (2013). Hypoxic pulmonary vasoconstriction in humans. Biomed research international, 2013, Article 623684. https://doi.org/10.1155/2013/623684

Hypoxic pulmonary vasoconstriction is the elegant theory put forward more than six decades ago to explain regional variations in perfusion within the lung in certain animal species in response to localised restrictions in oxygenation. Although consid... Read More about Hypoxic pulmonary vasoconstriction in humans.

Percutaneous transluminal angioplasty results in improved physical function but not balance in patients with intermittent claudication (2013)
Journal Article
Gohil, R. A., Mockford, K. A., Mazari, F. A., Khan, J. A., Van Vanicek, N., Chetter, I. C., & Coughlin, P. A. (2013). Percutaneous transluminal angioplasty results in improved physical function but not balance in patients with intermittent claudication. Journal of vascular surgery, 58(6), 1533-1539. https://doi.org/10.1016/j.jvs.2013.05.106

Objective The aim of this study was to identify whether revascularization by percutaneous transluminal angioplasty (PTA) for patients with intermittent claudication improved measures of functional performance including balance. Methods A prospective... Read More about Percutaneous transluminal angioplasty results in improved physical function but not balance in patients with intermittent claudication.

Economic analysis of a randomized trial of percutaneous angioplasty, supervised exercise or combined treatment for intermittent claudication due to femoropopliteal arterial disease (2013)
Journal Article
Mazari, F. A. K., Khan, J. A., Carradice, D., Samuel, N., Gohil, R., McCollum, P. T., & Chetter, I. C. (2013). Economic analysis of a randomized trial of percutaneous angioplasty, supervised exercise or combined treatment for intermittent claudication due to femoropopliteal arterial disease. British journal of surgery, 100(9), 1172-1179. https://doi.org/10.1002/bjs.9200

BackgroundThe aim was to compare costs and utilities of percutaneous transluminal angioplasty (PTA), a supervised exercise programme (SEP) and combined treatment (PTA + SEP) in patients with intermittent claudication (IC) to establish the most cost-e... Read More about Economic analysis of a randomized trial of percutaneous angioplasty, supervised exercise or combined treatment for intermittent claudication due to femoropopliteal arterial disease.

Randomized clinical trial of angiotensin-converting enzyme inhibitor, ramipril, in patients with intermittent claudication (2013)
Journal Article
Shahin, Y., Cockcroft, J. R., & Chetter, I. C. (2013). Randomized clinical trial of angiotensin-converting enzyme inhibitor, ramipril, in patients with intermittent claudication. British journal of surgery, 100(9), 1154-1163. https://doi.org/10.1002/bjs.9198

BackgroundThe aim was to investigate the effect of ramipril on clinical parameters in patients with peripheral arterial disease.MethodsPatients with intermittent claudication were randomized to receive ramipril or placebo for 24 weeks in a double-bli... Read More about Randomized clinical trial of angiotensin-converting enzyme inhibitor, ramipril, in patients with intermittent claudication.

Airway reflux as a cause of respiratory disease (2013)
Journal Article
Morice, A. H. (2013). Airway reflux as a cause of respiratory disease. Breathe, 9(4), 257-266. https://doi.org/10.1183/20734735.000513

Reflux is the cause of much respiratory disease. More commonly still, it is the unrecognised agent provoking the symptoms of respiratory disease. That the reflux entering the airways from the gastrointestinal tract is central to the diagnosis, therap... Read More about Airway reflux as a cause of respiratory disease.

Symptoms of airway reflux predict exacerbations and quality of life in bronchiectasis (2013)
Journal Article
Mandal, P., Morice, A. H., Chalmers, J. D., & Hill, A. T. (2013). Symptoms of airway reflux predict exacerbations and quality of life in bronchiectasis. Respiratory medicine, 107(7), 1008-1013. https://doi.org/10.1016/j.rmed.2013.04.006

Aim We have explored the association of the upper airway symptoms related to cough with exacerbation frequency, sputum microbiology and inflammatory markers in patients with non cystic fibrosis bronchiectasis. Methods Patients with bronchiectasis com... Read More about Symptoms of airway reflux predict exacerbations and quality of life in bronchiectasis.

Chronic cough hypersensitivity syndrome (2013)
Journal Article
Morice, A. H. (2013). Chronic cough hypersensitivity syndrome. Cough, 9(1), Article 14. https://doi.org/10.1186/1745-9974-9-14

Chronic cough has been suggested to be due to three conditions, asthma, post nasal drip, and reflux disease. A different paradigm has evolved in which cough is viewed as the primary condition characterised by afferent neuronal hypersensitivity and di... Read More about Chronic cough hypersensitivity syndrome.

Comparison of 12-W versus 14-W endovenous laser ablation in the treatment of great saphenous varicose veins: 5-year outcomes from a randomized controlled trial (2013)
Journal Article
Samuel, N., Wallace, T., Carradice, D., Mazari, F. A., & Chetter, I. C. (2013). Comparison of 12-W versus 14-W endovenous laser ablation in the treatment of great saphenous varicose veins: 5-year outcomes from a randomized controlled trial. Vascular and endovascular surgery, 47(5), 346-352. https://doi.org/10.1177/1538574413487265

Introduction: Endovenous laser ablation (EVLA) has been demonstrated to be an effective treatment for lower limb varicose veins in the short and midterm results. This study reports the 5-year outcomes of EVLA technique at different power settings. Me... Read More about Comparison of 12-W versus 14-W endovenous laser ablation in the treatment of great saphenous varicose veins: 5-year outcomes from a randomized controlled trial.

Randomized clinical trial of endovenous laser ablation versus conventional surgery for small saphenous varicose veins (2013)
Journal Article
Samuel, N., Carradice, D., Wallace, T., Mekako, A., Hatfield, J., & Chetter, I. (2013). Randomized clinical trial of endovenous laser ablation versus conventional surgery for small saphenous varicose veins. Annals of Surgery, 257(3), 419-426. https://doi.org/10.1097/SLA.0b013e318275f4e4

Introduction: No randomized clinical trial comparing treatment options for small saphenous vein (SSV) incompetence exists, and there is no clear evidence that this axis behaves the same as the great saphenous vein after treatment. This means that the... Read More about Randomized clinical trial of endovenous laser ablation versus conventional surgery for small saphenous varicose veins.

Role of pre-operative multiple gated acquisition scanning in predicting long-term outcome in patients undergoing elective abdominal aortic aneurysm repair (2013)
Journal Article
Barakat, H. M., Shahin, Y., Khan, J. A., McCollum, P. T., & Chetter, I. C. (2013). Role of pre-operative multiple gated acquisition scanning in predicting long-term outcome in patients undergoing elective abdominal aortic aneurysm repair. World Journal of Surgery, 37(5), 1169-1173. https://doi.org/10.1007/s00268-013-1939-3

ObjectiveTo determine whether resting pre-operative left ventricular ejection fraction (LVEF) estimated by multiple gated acquisition scanning (MUGA) predicts long-term survival in patients undergoing elective abdominal aortic aneurysm (AAA) repair.... Read More about Role of pre-operative multiple gated acquisition scanning in predicting long-term outcome in patients undergoing elective abdominal aortic aneurysm repair.

A "Christmas tree" band for the treatment of arteriovenous dialysis access-related steal syndrome (2013)
Journal Article
Smith, G., Barnes, R., Green, L., Kuhan, G., & Chetter, I. C. (2013). A "Christmas tree" band for the treatment of arteriovenous dialysis access-related steal syndrome. Annals of vascular surgery, 27(2), 239.e9 - 239.e12. https://doi.org/10.1016/j.avsg.2012.10.004

Background Dialysis access steal syndrome (DASS) is an uncommon but often debilitating complication of dialysis access formation. We present a technical description of a novel arteriovenous fistula (AVF) banding technique for the treatment of DASS a... Read More about A "Christmas tree" band for the treatment of arteriovenous dialysis access-related steal syndrome.

Balance impairment, physical ability, and its link with disease severity in patients with intermittent claudication (2013)
Journal Article
Gohil, R. A., Mockford, K. A., Mazari, F., Khan, J., Vanicek, N., Chetter, I. C., & Coughlin, P. A. (2013). Balance impairment, physical ability, and its link with disease severity in patients with intermittent claudication. Annals of vascular surgery, 27(1), 68-74. https://doi.org/10.1016/j.avsg.2012.05.005

BackgroundTo determine whether increasing claudication severity is associated with impaired balance and physical functional ability.MethodsA prospective observational study in claudicants was performed. Disease severity was determined according to Ru... Read More about Balance impairment, physical ability, and its link with disease severity in patients with intermittent claudication.

Management of patients with chronic cough using a clinical protocol: A prospective observational study (2013)
Journal Article
Ojoo, O. C., Everett, C. F., Mulrennan, S. A., Faruqi, S., Kastelik, J. A., & Morice, A. H. (2013). Management of patients with chronic cough using a clinical protocol: A prospective observational study. Cough, 9(1), Article 2. https://doi.org/10.1186/1745-9974-9-2

Background and aims: Chronic cough is a common symptom the aetiology of which can be challenging to diagnose. Diagnostic protocols for chronic cough have required the use of specialist investigations which are not always easily available. We wanted t... Read More about Management of patients with chronic cough using a clinical protocol: A prospective observational study.

Proteomic (antibody microarray) exploration of the molecular mechanism of action of the specific COX-2 inhibitor DuP 697 (2013)
Journal Article
Agarwal, V., Hodgkinson, V. C., Eagle, G. L., Scaife, L., Lind, M. J., & Cawkwell, L. (2013). Proteomic (antibody microarray) exploration of the molecular mechanism of action of the specific COX-2 inhibitor DuP 697. International Journal of Oncology, 42(3), 1088-1092. https://doi.org/10.3892/ijo.2013.1784

We have previously shown that specific COX-2 inhibitors, including DuP 697, have anti-proliferative effects on mesothelioma cells and potentiate the cytotoxicity of pemetrexed. Here, we used a novel proteomic approach to explore the mechanism of acti... Read More about Proteomic (antibody microarray) exploration of the molecular mechanism of action of the specific COX-2 inhibitor DuP 697.

PTEN protein expression in malignant pleural mesothelioma (2012)
Journal Article
Agarwal, V., Campbell, A., Beaumont, K. L., Cawkwell, L., & Lind, M. J. (2013). PTEN protein expression in malignant pleural mesothelioma. Tumor Biology, 34(2), 847-851. https://doi.org/10.1007/s13277-012-0615-9

Malignant pleural mesothelioma is associated with poor prognosis and despite recent advances in chemotherapy, the median survival is still approximately 12 months. Loss of phosphatase and tensin homolog (PTEN) protein expression may lead to constitut... Read More about PTEN protein expression in malignant pleural mesothelioma.

Atorvastatin reduces malondialdehyde concentrations in patients with polycystic ovary syndrome (2012)
Journal Article
Sathyapalan, T., Shepherd, J., Coady, A.-M., Kilpatrick, E. S., & Atkin, S. L. (2012). Atorvastatin reduces malondialdehyde concentrations in patients with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 97(11), 3951-3955. https://doi.org/10.1210/jc.2012-2279

Background: It has been shown that there is an increase in oxidative stress in polycystic ovary syndrome (PCOS). Statins are considered to have a pleiotropic effect other than their lipid-lowering effect. These effects may be mediated in part by redu... Read More about Atorvastatin reduces malondialdehyde concentrations in patients with polycystic ovary syndrome.

Novel antitussive strategies (2012)
Journal Article
Morjaria, J. B., Dickinson, R. S., & Morice, A. H. (2013). Novel antitussive strategies. Drug Discovery Today, 18(7-8), 380-388. https://doi.org/10.1016/j.drudis.2012.11.004

Acute and chronic cough represent one of the most common symptoms of medical importance but effective pharmacotherapy is, to all intents and purposes, absent. Numerous initiatives targeting the recently discovered tussive pathways are in progress. He... Read More about Novel antitussive strategies.