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A randomized placebo controlled trial to evaluate the effects of butamirate and dextromethorphan on capsaicin induced cough in healthy volunteers (2014)
Journal Article
Faruqi, S., Wright, C., Thompson, R., & Morice, A. H. (2014). A randomized placebo controlled trial to evaluate the effects of butamirate and dextromethorphan on capsaicin induced cough in healthy volunteers. British Journal of Clinical Pharmacology, 78(6), 1272-1280. https://doi.org/10.1111/bcp.12458

AIMS The examination of cough reflex sensitivity through inhalational challenge can be utilized to demonstrate pharmacological end points. Here we compare the effect of butamirate, dextromethorphan and placebo on capsaicin-induced cough in healthy vo... Read More about A randomized placebo controlled trial to evaluate the effects of butamirate and dextromethorphan on capsaicin induced cough in healthy volunteers.

Human TRPM8 and TRPA1 pain channels, including a gene variant with increased sensitivity to agonists (TRPA1 R797T), exhibit differential regulation by SRC-tyrosine kinase inhibitor (2014)
Journal Article
Morgan, K., Sadofsky, L. R., Crow, C., & Morice, A. H. (2014). Human TRPM8 and TRPA1 pain channels, including a gene variant with increased sensitivity to agonists (TRPA1 R797T), exhibit differential regulation by SRC-tyrosine kinase inhibitor. Bioscience Reports, 34(4), 469-478. https://doi.org/10.1042/BSR20140061

TRPM8 (transient receptor potential M8) and TRPA1 (transient receptor potential A1) are cold-temperature-sensitive nociceptors expressed in sensory neurons but their behaviour in neuronal cells is poorly understood. Therefore DNA expression construct... Read More about Human TRPM8 and TRPA1 pain channels, including a gene variant with increased sensitivity to agonists (TRPA1 R797T), exhibit differential regulation by SRC-tyrosine kinase inhibitor.

Clinical outcomes and quality of life 5 years after a randomized trial of concomitant or sequential phlebectomy following endovenous laser ablation for varicose veins (2014)
Journal Article
El-Sheikha, J., Nandhra, S., Carradice, D., Wallace, T., Samuel, N., Smith, G., & Chetter, I. C. (2014). Clinical outcomes and quality of life 5 years after a randomized trial of concomitant or sequential phlebectomy following endovenous laser ablation for varicose veins. British journal of surgery, 101(9), 1093-1097. https://doi.org/10.1002/bjs.9565

BackgroundEndovenous laser ablation (EVLA) is a popular treatment for superficial venous insufficiency. Debate continues regarding the optimal management of symptomatic varicose tributaries following ablation of the main saphenous trunk. This randomi... Read More about Clinical outcomes and quality of life 5 years after a randomized trial of concomitant or sequential phlebectomy following endovenous laser ablation for varicose veins.

Unique responses are observed in transient receptor potential ankyrin 1 and vanilloid 1 (TRPA1 and TRPV1) co-expressing cells (2014)
Journal Article
Sadofsky, L. R., Sreekrishna, K. T., Lin, Y., Schinaman, R., Gorka, K., Mantri, Y., …Morice, A. H. (2014). Unique responses are observed in transient receptor potential ankyrin 1 and vanilloid 1 (TRPA1 and TRPV1) co-expressing cells. Cells, 3(2), 616-626. https://doi.org/10.3390/cells3020616

Transient receptor potential (TRP) ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) receptors are implicated in modulation of cough and nociception. In vivo, TRPA1 and TRPV1 are often co-expressed in neurons and TRPA1V1 hetero-tetramer formation is noted in... Read More about Unique responses are observed in transient receptor potential ankyrin 1 and vanilloid 1 (TRPA1 and TRPV1) co-expressing cells.

On the definition of chronic cough and current treatment pathways: An international qualitative study (2014)
Journal Article
Faruqi, S., Murdoch, R. D., Allum, F., & Morice, A. H. (2014). On the definition of chronic cough and current treatment pathways: An international qualitative study. Cough, 10(1), Article 5. https://doi.org/10.1186/1745-9974-10-5

Background: The pathogenesis of chronic cough is not well understood and treatment options are limited. In this study we sought to explore the current understanding and management of chronic cough across an international group of specialists.Methods:... Read More about On the definition of chronic cough and current treatment pathways: An international qualitative study.

Chronicle: results of a randomised phase III trial in locally advanced rectal cancer after neoadjuvant chemoradiation randomising postoperative adjuvant capecitabine plus oxaliplatin (XELOX) versus control (2014)
Journal Article
Glynne-Jones, R., Counsell, N., Quirke, P., Mortensen, N., Maraveyas, A., Meadows, H. M., …Sebag-Montefiore, D. (2014). Chronicle: results of a randomised phase III trial in locally advanced rectal cancer after neoadjuvant chemoradiation randomising postoperative adjuvant capecitabine plus oxaliplatin (XELOX) versus control. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO, 25(7), 1356-1362. https://doi.org/10.1093/annonc/mdu147

Background: In stage III colon cancer, oxaliplatin/5-fluorouracil (5-FU)-based adjuvant chemotherapy (FOLFOX) improves disease-free survival (DFS) and overall survival (OS). In rectal adenocarcinoma following neoadjuvant chemoradiation (CRT), we exam... Read More about Chronicle: results of a randomised phase III trial in locally advanced rectal cancer after neoadjuvant chemoradiation randomising postoperative adjuvant capecitabine plus oxaliplatin (XELOX) versus control.

Antitussive drugs-past, present, and future (2014)
Journal Article
Dicpinigaitis, P. V., Morice, A. H., Birring, S. S., McGarvey, L., Smith, J. A., Canning, B. J., & Page, C. P. (2014). Antitussive drugs-past, present, and future. Pharmacological Reviews, 66(2), 468-512. https://doi.org/10.1124/pr.111.005116

Cough remains a serious unmet clinical problem, both as a symptom of a range of other conditions such as asthma, chronic obstructive pulmonary disease, gastroesophageal reflux, and as a problem in its own right in patients with chronic cough of unkno... Read More about Antitussive drugs-past, present, and future.

Electrical stimulation vs. standard care for chronic ulcer healing: a systematic review and meta-analysis of randomised controlled trials (2014)
Journal Article
Barnes, R., Shahin, Y., Gohil, R., & Chetter, I. (2014). Electrical stimulation vs. standard care for chronic ulcer healing: a systematic review and meta-analysis of randomised controlled trials. European Journal of Clinical Investigation, 44(4), 429-440. https://doi.org/10.1111/eci.12244

Background We conducted a systematic review to investigate the effect of electrical stimulation on ulcer healing compared to usual treatment and/or sham stimulation. This systematic review also aimed to investigate the effect of different types of... Read More about Electrical stimulation vs. standard care for chronic ulcer healing: a systematic review and meta-analysis of randomised controlled trials.

Randomized clinical trial of selective versus routine preoperative duplex ultrasound imaging before arteriovenous fistula surgery: Duplex imaging before arteriovenous fistula surgery (2014)
Journal Article
Barnes, R., Chetter, I. C., & Smith, G. E. (2014). Randomized clinical trial of selective versus routine preoperative duplex ultrasound imaging before arteriovenous fistula surgery: Duplex imaging before arteriovenous fistula surgery. British journal of surgery, 101(5), 469-474. https://doi.org/10.1002/bjs.9435

BackgroundAnatomical suitability for arteriovenous fistula (AVF) formation was formerly determined by clinical examination alone. There are potential benefits from imaging to assess anatomical suitability. Existing studies examined the role of routin... Read More about Randomized clinical trial of selective versus routine preoperative duplex ultrasound imaging before arteriovenous fistula surgery: Duplex imaging before arteriovenous fistula surgery.

Effect of supervised exercise on physical function and balance in patients with intermittent claudication (2014)
Journal Article
Mockford, K. A., Gohil, R. A., Mazari, F., Khan, J. A., Vanicek, N., Coughlin, P. A., & Chetter, I. C. (2014). Effect of supervised exercise on physical function and balance in patients with intermittent claudication. British journal of surgery, 101(4), 356-362. https://doi.org/10.1002/bjs.9402

Background The aim of the study was to identify whether a standard supervised exercise programme (SEP) for patients with intermittent claudication improved specific measures of functional performance including balance. Methods A prospective observati... Read More about Effect of supervised exercise on physical function and balance in patients with intermittent claudication.

Fear of falling in claudicants and its relationship to physical ability, balance, and quality of Life (2014)
Journal Article
Lane, R. A., Mazari, F., Mockford, K. A., Vanicek, N., Chetter, I. C., & Coughlin, P. A. (2014). Fear of falling in claudicants and its relationship to physical ability, balance, and quality of Life. Vascular and endovascular surgery, 48(4), 297-304. https://doi.org/10.1177/1538574413519711

Objectives: Intermittent claudication is associated with poor physical function, quality of life (QoL), and balance impairment. Fear of falling (FoF) is a recognized contributing factor to poor physical ability. Any link between claudication and FoF... Read More about Fear of falling in claudicants and its relationship to physical ability, balance, and quality of Life.

The effect of deep hypothermia on the human pulmonary circulation (2014)
Journal Article
Ariyaratnam, P., Loubani, M., Cale, A. R., Chaudhry, M., Cowen, M. E., Jarvis, M. A., …Morice, A. H. (2014). The effect of deep hypothermia on the human pulmonary circulation. Journal of Thermal Biology, 40(1), 20-24. https://doi.org/10.1016/j.jtherbio.2014.01.001

Objective: Acute rises in pulmonary artery pressures following complex cardiac surgery are associated with high morbidity and mortality. We hypothesised that periods of deep hypothermia predispose to elevated pulmonary pressures upon rewarming. We in... Read More about The effect of deep hypothermia on the human pulmonary circulation.

Increased platelet binding to circulating monocytes in idiopathic pulmonary fibrosis. (2014)
Journal Article
Fahim, A., Crooks, M. G., Morice, A. H., & Hart, S. P. (2014). Increased platelet binding to circulating monocytes in idiopathic pulmonary fibrosis. Lung, 192(2), 277-284. https://doi.org/10.1007/s00408-013-9546-5

Purpose Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pneumonia and its prognosis is poor. Epidemiological evidence suggests an association of IPF with vascular disease and thrombotic tendency, which may be related to... Read More about Increased platelet binding to circulating monocytes in idiopathic pulmonary fibrosis..

Characterization of physical properties of tissue factor-containing microvesicles and a comparison of ultracentrifuge-based recovery procedures (2014)
Journal Article
Ettelaie, C., Collier, M., Maraveyas, A., & Ettelaie, R. (2014). Characterization of physical properties of tissue factor-containing microvesicles and a comparison of ultracentrifuge-based recovery procedures. Journal of Extracellular Vesicles, 3(1), 1-14. https://doi.org/10.3402/jev.v3.23592

© 2014 Camille Ettelaie et al. Microvesicles were isolated from the conditioned media of 3 cell lines (MDA-MB-231, AsPC-1 and A375) by ultracentrifugation at a range of relative centrifugal forces, and the tissue factor (TF) protein and activity, mic... Read More about Characterization of physical properties of tissue factor-containing microvesicles and a comparison of ultracentrifuge-based recovery procedures.

Dietary intervention in the treatment of patients with cough and symptoms suggestive of airways reflux as determined by Hull airways Reflux Questionnaire (2013)
Journal Article
Smith, J. E., Morjaria, J. B., & Morice, A. H. (2013). Dietary intervention in the treatment of patients with cough and symptoms suggestive of airways reflux as determined by Hull airways Reflux Questionnaire. Cough, 9(1), Article 27. https://doi.org/10.1186/1745-9974-9-27

Background: Chronic cough is a common and distressing symptom. Gastro-oesophageal reflux is a common cause of chronic cough however the symptom complex in cough is not confined to classic peptic symptoms. Dyspeptic symptoms have previously been shown... Read More about Dietary intervention in the treatment of patients with cough and symptoms suggestive of airways reflux as determined by Hull airways Reflux Questionnaire.

The Impact of Previous Surgery and Revisions on Outcome after Major Lower Limb Amputation (2013)
Journal Article
Souroullas, P., Barnes, R., Lane, R. A., & Chetter, I. (2014). The Impact of Previous Surgery and Revisions on Outcome after Major Lower Limb Amputation. Annals of vascular surgery, 28(5), 1166-1171. https://doi.org/10.1016/j.avsg.2013.10.017

IntroductionMorbidity and mortality after lower limb amputation (LLA) remain disappointingly high. This study aimed to assess the impact of previous ipsilateral vascular intervention on outcomes after major LLA.MethodsProspective data were collected... Read More about The Impact of Previous Surgery and Revisions on Outcome after Major Lower Limb Amputation.

Supervised exercise program improves aerobic fitness in patients awaiting abdominal aortic aneurysm repair (2013)
Journal Article
Barakat, H. M., Shahin, Y., Barnes, R., Gohil, R., Souroullas, P., Khan, J., …Chetter, I. C. (2014). Supervised exercise program improves aerobic fitness in patients awaiting abdominal aortic aneurysm repair. Annals of vascular surgery, 28(1), 74-79. https://doi.org/10.1016/j.avsg.2013.09.001

Background Aerobic fitness is an important predictor of postoperative outcome in major surgery. In this study, we assess the effects of a period of preoperative exercise on aerobic fitness as measured by cardiopulmonary exercise testing (CPET) in pa... Read More about Supervised exercise program improves aerobic fitness in patients awaiting abdominal aortic aneurysm repair.

Computerized dynamic posturography for postural control assessment in patients with intermittent claudication. (2013)
Journal Article
Vanicek, N., King, S. A., Gohil, R., Chetter, I. C., & Coughlin, P. A. (2013). Computerized dynamic posturography for postural control assessment in patients with intermittent claudication. Journal of Visualized Experiments, Article e51077. https://doi.org/10.3791/51077

Computerized dynamic posturography with the EquiTest is an objective technique for measuring postural strategies under challenging static and dynamic conditions. As part of a diagnostic assessment, the early detection of postural deficits is importan... Read More about Computerized dynamic posturography for postural control assessment in patients with intermittent claudication..