All Outputs (664)

In-hospital worsening heart failure: a clinically relevant endpoint? (2017)
Journal Article
Clark, A. L., Cherif, M., McDonagh, T. A., & Squire, I. B. (2018). In-hospital worsening heart failure: a clinically relevant endpoint?. ESC Heart Failure, 5(1), 9-18. https://doi.org/10.1002/ehf2.12195

Outcome measures used for the clinical evaluation of patients with acute heart failure differ between studies and may neither adequately address the characteristic presenting symptoms and signs nor reflect the pathophysiological processes involved. I... Read More about In-hospital worsening heart failure: a clinically relevant endpoint?.

cGMP signaling inhibits platelet shape change through regulation of the RhoA-Rho Kinase-MLC phosphatase signaling pathway (2017)
Journal Article
Aburima, A., Walladbegi, K., Wake, J. D., & Naseem, K. M. (2017). cGMP signaling inhibits platelet shape change through regulation of the RhoA-Rho Kinase-MLC phosphatase signaling pathway. Journal of thrombosis and haemostasis : JTH, 15(8), 1668-1678. https://doi.org/10.1111/jth.13738

Essentials Platelet shape change requires cytoskeletal rearrangement via myosin‐mediated actin contraction. We investigated whether nitric oxide (NO) affected thrombin‐induced platelet shape change. NO inhibits shape change, RhoA/ROCK signalling a... Read More about cGMP signaling inhibits platelet shape change through regulation of the RhoA-Rho Kinase-MLC phosphatase signaling pathway.

Deoxynivalenol biomarkers in the urine of UK vegetarians (2017)
Journal Article
Wells, L., Hardie, L., Williams, C., White, K., Liu, Y., De Santis, B., Debegnach, F., Moretti, G., Greetham, S., Brera, C., Papageorgiou, M., Thatcher, N. J., Rigby, A., Atkin, S. L., & Sathyapalan, T. (2017). Deoxynivalenol biomarkers in the urine of UK vegetarians. Toxins, 9(7), 196. https://doi.org/10.3390/toxins9070196

Deoxynivalenol (DON) is produced by Fusarium graminearum and is one of the most commonly occurring trichothecenes. Vegetarians are alleged to be a high-risk group for DON exposure due to high intakes of cereals susceptible to the growth of the mycoto... Read More about Deoxynivalenol biomarkers in the urine of UK vegetarians.

Heart rate and rhythm and the benefit of beta-blockers in patients with heart failure (2017)
Journal Article
Kotecha, D., Flather, M. D., Altman, D. G., Holmes, J., Rosano, G., Wikstrand, J., Packer, M., Coats, A. J., Manzano, L., Böhm, M., van Veldhuisen, D. J., Andersson, B., Wedel, H., von Lueder, T. G., Rigby, A. S., Hjalmarson, Å., Kjekshus, J., & Cleland, J. G. (2017). Heart rate and rhythm and the benefit of beta-blockers in patients with heart failure. Journal of the American College of Cardiology, 69(24), 2885-2896. https://doi.org/10.1016/j.jacc.2017.04.001

Background The relationship between mortality and heart rate remains unclear for patients with heart failure with reduced ejection fraction in either sinus rhythm or atrial fibrillation (AF). Objectives This analysis explored the prognostic importan... Read More about Heart rate and rhythm and the benefit of beta-blockers in patients with heart failure.

Genistein crosses the bioartificial oviduct and alters secretion composition (2017)
Journal Article
Simintiras, C. A., & Sturmey, R. G. (2017). Genistein crosses the bioartificial oviduct and alters secretion composition. Reproductive Toxicology, 71, 63-70. https://doi.org/10.1016/j.reprotox.2017.04.010

The dietary derived isoflavone and oestrogen analogue, genistein, is known to perturb fundamental reproductive events such as implantation and embryo cleavage. However the question of whether genistein is able to traverse the oviduct epithelial monol... Read More about Genistein crosses the bioartificial oviduct and alters secretion composition.

VDR gene methylation as a molecular adaption to light exposure: Historic, recent and genetic influences (2017)
Journal Article
Beckett, E., Jones, P., Veysey, M., Duesing, K., Martin, C., Furst, J., Yates, Z., Jablonski, N., Chaplin, G., & Lucock, M. (2017). VDR gene methylation as a molecular adaption to light exposure: Historic, recent and genetic influences. American Journal of Human Biology, 29(5), Article e23010. https://doi.org/10.1002/ajhb.23010

Objectives The vitamin D receptor (VDR) is a member of the nuclear receptor family of transcription factors. We examined whether degree of VDR gene methylation acts as a molecular adaptation to light exposure. We explored this in the context of phot... Read More about VDR gene methylation as a molecular adaption to light exposure: Historic, recent and genetic influences.

Non-invasive measurement of right atrial pressure by near-infrared spectroscopy: preliminary experience. A report from the SICA-HF study (2017)
Journal Article
Pellicori, P., Clark, A. L., Kallvikbacka-Bennett, A., Zhang, J., Urbinati, A., Monzo, L., …Cleland, J. G. (2017). Non-invasive measurement of right atrial pressure by near-infrared spectroscopy: preliminary experience. A report from the SICA-HF study. European journal of heart failure, 19(7), 883-892. https://doi.org/10.1002/ejhf.825

Background: Jugular venous distension, reflecting raised right atrial pressure (RAP), is a classical sign of congestive heart failure (CHF), but its clinical assessment can be difficult. Methods: RAP was measured non-invasively using near-infrared sp... Read More about Non-invasive measurement of right atrial pressure by near-infrared spectroscopy: preliminary experience. A report from the SICA-HF study.

Reduced plasma homocysteine levels in elderly Australians following mandatory folic acid fortification – A comparison of two cross-sectional cohorts (2017)
Journal Article
Beckett, E., Martin, C., Boyd, L., Porter, T., King, K., Niblett, S., Yates, Z., Veysey, M., & Lucock, M. (2017). Reduced plasma homocysteine levels in elderly Australians following mandatory folic acid fortification – A comparison of two cross-sectional cohorts. Journal of Nutrition and Intermediary Metabolism, 8, 14-20. https://doi.org/10.1016/j.jnim.2017.04.001

© 2017 Objective In 2009, Australia implemented mandatory folic acid fortification in wheat flour for bread-making. The primary aim was to improve folate status in reproductive-aged women to reduce neural tube defect incidence. However, folic acid co... Read More about Reduced plasma homocysteine levels in elderly Australians following mandatory folic acid fortification – A comparison of two cross-sectional cohorts.

Soy protein improves cardiovascular risk in subclinical hypothyroidism : a randomized double-blinded crossover study (2017)
Journal Article
Sathyapalan, T., Javed, Z., Rigby, A. S., Kilpatrick, E. S., & Atkin, S. L. (2017). Soy protein improves cardiovascular risk in subclinical hypothyroidism : a randomized double-blinded crossover study. Journal of the Endocrine Society, 1(5), 423-430. https://doi.org/10.1210/js.2016-1068

© 2017 Endocrine Society. Background: Soy protein with isoflavones appears to have an adverse effect on thyroid function, but it is not known whether it is the protein or isoflavone component that is deleterious. The effect of isoflavone-free soy on... Read More about Soy protein improves cardiovascular risk in subclinical hypothyroidism : a randomized double-blinded crossover study.

Attitudes of newly qualified doctors towards a career in general practice: A qualitative focus group study (2017)
Journal Article
Merrett, A., Jones, D., Sein, K., Green, T., & Macleod, U. (2017). Attitudes of newly qualified doctors towards a career in general practice: A qualitative focus group study. The British journal of general practice : the journal of the Royal College of General Practitioners, 67(657), e253-e259. https://doi.org/10.3399/bjgp17X690221

© British Journal of General Practice 2017. Background A key element of the NHS is universal access to a GP. Recently, UK general practice has been described as being in crisis, with training places unfilled and multiple practices reporting vacancies... Read More about Attitudes of newly qualified doctors towards a career in general practice: A qualitative focus group study.

Pseudotumor cerebri syndrome in childhood : incidence, clinical profile and risk factors in a national prospective population-based cohort study (2017)
Journal Article
Matthews, Y.-Y., Dean, F., Lim, M. J., Mclachlan, K., Rigby, A. S., Solanki, G. A., White, C. P., Whitehouse, W. P., & Kennedy, C. R. (2017). Pseudotumor cerebri syndrome in childhood : incidence, clinical profile and risk factors in a national prospective population-based cohort study. Archives of Disease in Childhood, 102(8), 715-721. https://doi.org/10.1136/archdischild-2016-312238

Aim To investigate the epidemiology, clinical profile and risk factors of pseudotumor cerebri syndrome (PTCS) in children aged 1-16 years. Methods A national prospective population-based cohort study over 25 months. Newly diagnosed PTCS cases notifie... Read More about Pseudotumor cerebri syndrome in childhood : incidence, clinical profile and risk factors in a national prospective population-based cohort study.

Continuous cough monitoring using ambient sound recording during convalescence from a COPD exacerbation (2017)
Journal Article
Crooks, M. G., den Brinker, A., Hayman, Y., Williamson, J. D., Innes, A., Wright, C. E., Hill, P., & Morice, A. H. (2017). Continuous cough monitoring using ambient sound recording during convalescence from a COPD exacerbation. Lung, 195(3), 289-294. https://doi.org/10.1007/s00408-017-9996-2

Purpose Cough is common in chronic obstructive pulmonary disease (COPD) and is associated with frequent exacerbations and increased mortality. Cough increases during acute exacerbations (AE-COPD), representing a possible metric of clinical deteriorat... Read More about Continuous cough monitoring using ambient sound recording during convalescence from a COPD exacerbation.

The effects of exogenous lipid on THP-1 cells : an in vitro model of airway aspiration? (2017)
Journal Article
Hayman, Y. A., Sadofsky, L. R., Williamson, J. D., Hart, S. P., & Morice, A. H. (2017). The effects of exogenous lipid on THP-1 cells : an in vitro model of airway aspiration?. Ers Monograph, 3(1), 00026-2016. https://doi.org/10.1183/23120541.00026-2016

Chronic inflammatory diseases of the airways are associated with gastro-oesophageal reflux (GOR) and aspiration events. The observation of lipid laden macrophages (LLM) within the airway may indicate aspiration secondary to GOR. The proposed mechanis... Read More about The effects of exogenous lipid on THP-1 cells : an in vitro model of airway aspiration?.

The effects of short-term omission of daily medication on the pathophysiology of heart failure (2017)
Journal Article
Dovancescu, S., Pellicori, P., Mabote, T., Torabi, A., Clark, A. L., & Cleland, J. G. (2017). The effects of short-term omission of daily medication on the pathophysiology of heart failure. European journal of heart failure, 19(5), 643-649. https://doi.org/10.1002/ejhf.748

Aims Pharmacological therapies for heart failure (HF) aim to improve congestion, symptoms, and prognosis. Failing to take medication is a potential cause of worsening HF. Characterizing the effects of short-term medication omission could inform the d... Read More about The effects of short-term omission of daily medication on the pathophysiology of heart failure.

Exploring the performance reserve: Effect of different magnitudes of power output deception on 4,000 m cycling time-trial performance (2017)
Journal Article
Stone, M. R., Thomas, K., Wilkinson, M., Stevenson, E., St. Clair Gibson, A., Jones, A. M., & Thompson, K. G. (in press). Exploring the performance reserve: Effect of different magnitudes of power output deception on 4,000 m cycling time-trial performance. PLoS ONE, 12(3), Article e0173120. https://doi.org/10.1371/journal.pone.0173120

Purpose The aim of the present study was to investigate whether a magnitude of deception of 5% in power output would lead to a greater reduction in the amount of time taken for participants to complete a 4000 m cycling TT than a magnitude of deceptio... Read More about Exploring the performance reserve: Effect of different magnitudes of power output deception on 4,000 m cycling time-trial performance.

Extracorporeal shockwave therapy for the treatment of lower limb intermittent claudication: Study protocol for a randomised controlled trial (the SHOCKWAVE 1 trial) (2017)
Journal Article
Harwood, A. E., Smith, G. E., Totty, J. P., Carradice, D., Chetter, I. C., Harwood, A., Totty, J., Cayton, T., & Smith, G. (2017). Extracorporeal shockwave therapy for the treatment of lower limb intermittent claudication: Study protocol for a randomised controlled trial (the SHOCKWAVE 1 trial). Trials, 18(1), https://doi.org/10.1186/s13063-017-1844-4

© 2017 The Author(s). Background: Peripheral arterial disease (PAD) has a population prevalence of 4.6% with intermittent claudication (IC) presenting as one of the earliest and most common symptoms. PAD has detrimental effects on patients' walking a... Read More about Extracorporeal shockwave therapy for the treatment of lower limb intermittent claudication: Study protocol for a randomised controlled trial (the SHOCKWAVE 1 trial).

A systematic review examining reducing unplanned hospital admissions in adults with cancer (2017)
Preprint / Working Paper
Walabyeki, J., Macleod, U., Johnson, M., Dyson, J., Oliver, S., Allgar, V., Oviasu, O., Chen, H., Smith, S., & Hammond, T. A systematic review examining reducing unplanned hospital admissions in adults with cancer

Review question: 1. What interventions have been tested and have successfully reduced unplanned hospital admissions in adults with cancer? 2. What are the factors associated with unplanned hospital admissions in adults with cancer?

Inhaled corticosteriod use and the risk of pneumonia and COPD exacerbations in the UPLIFT study (2017)
Journal Article
Morjaria, J. B., Morice, A. H., Morice, A., Rigby, A., & Morjaria, J. (2017). Inhaled corticosteriod use and the risk of pneumonia and COPD exacerbations in the UPLIFT study. Lung, 195(3), 281-288. https://doi.org/10.1007/s00408-017-9990-8

Rationale Unlike many other COPD studies, the 4-year UPLIFT trial permitted inhaled corticosteroid (ICS) use during run-in and treatment phases. This provided the opportunity to prospectively observe the continuing effects of ICS on respiratory event... Read More about Inhaled corticosteriod use and the risk of pneumonia and COPD exacerbations in the UPLIFT study.

What proportion of patients with chronic heart failure are eligible for sacubitril-valsartan? (2017)
Journal Article
Pellicori, P., Urbinati, A., Shah, P., MacNamara, A., Kazmi, S., Dierckx, R., …Clark, A. L. (2017). What proportion of patients with chronic heart failure are eligible for sacubitril-valsartan?. European journal of heart failure, 19(6), 768-778. https://doi.org/10.1002/ejhf.788

Aims The PARADIGM-HF trial showed that sacubitril–valsartan, an ARB–neprilysin inhibitor, is more effective than enalapril for some patients with heart failure (HF). It is uncertain what proportion of patients with HF would be eligible for sacubitril... Read More about What proportion of patients with chronic heart failure are eligible for sacubitril-valsartan?.

Prognostic value of simple frailty and malnutrition screening tools in patients with acute heart failure due to left ventricular systolic dysfunction (2017)
Journal Article
Sze, S., Zhang, J., Pellicori, P., Morgan, D., Hoye, A., & Clark, A. L. (2017). Prognostic value of simple frailty and malnutrition screening tools in patients with acute heart failure due to left ventricular systolic dysfunction. Clinical Research in Cardiology, 106(7), 533-541. https://doi.org/10.1007/s00392-017-1082-5

© 2017, Springer-Verlag Berlin Heidelberg. Background: Frailty and malnutrition are common in patients with heart failure (HF), and are associated with adverse outcomes. We studied the prognostic value of three malnutrition and three frailty indices... Read More about Prognostic value of simple frailty and malnutrition screening tools in patients with acute heart failure due to left ventricular systolic dysfunction.