All Outputs (667)

Inhaled corticosteriod use and the risk of pneumonia and COPD exacerbations in the UPLIFT study (2017)
Journal Article
Morjaria, J. B., Morice, A. H., Morice, A., Rigby, A., & Morjaria, J. (2017). Inhaled corticosteriod use and the risk of pneumonia and COPD exacerbations in the UPLIFT study. Lung, 195(3), 281-288. https://doi.org/10.1007/s00408-017-9990-8

Rationale Unlike many other COPD studies, the 4-year UPLIFT trial permitted inhaled corticosteroid (ICS) use during run-in and treatment phases. This provided the opportunity to prospectively observe the continuing effects of ICS on respiratory event... Read More about Inhaled corticosteriod use and the risk of pneumonia and COPD exacerbations in the UPLIFT study.

What proportion of patients with chronic heart failure are eligible for sacubitril-valsartan? (2017)
Journal Article
Pellicori, P., Urbinati, A., Shah, P., MacNamara, A., Kazmi, S., Dierckx, R., …Clark, A. L. (2017). What proportion of patients with chronic heart failure are eligible for sacubitril-valsartan?. European journal of heart failure, 19(6), 768-778. https://doi.org/10.1002/ejhf.788

Aims The PARADIGM-HF trial showed that sacubitril–valsartan, an ARB–neprilysin inhibitor, is more effective than enalapril for some patients with heart failure (HF). It is uncertain what proportion of patients with HF would be eligible for sacubitril... Read More about What proportion of patients with chronic heart failure are eligible for sacubitril-valsartan?.

Prognostic value of simple frailty and malnutrition screening tools in patients with acute heart failure due to left ventricular systolic dysfunction (2017)
Journal Article
Sze, S., Zhang, J., Pellicori, P., Morgan, D., Hoye, A., & Clark, A. L. (2017). Prognostic value of simple frailty and malnutrition screening tools in patients with acute heart failure due to left ventricular systolic dysfunction. Clinical Research in Cardiology, 106(7), 533-541. https://doi.org/10.1007/s00392-017-1082-5

© 2017, Springer-Verlag Berlin Heidelberg. Background: Frailty and malnutrition are common in patients with heart failure (HF), and are associated with adverse outcomes. We studied the prognostic value of three malnutrition and three frailty indices... Read More about Prognostic value of simple frailty and malnutrition screening tools in patients with acute heart failure due to left ventricular systolic dysfunction.

Tussive challenge with ATP and AMP: does it reveal cough hypersensitivity? (2017)
Journal Article
Fowles, H. E., Rowland, T., Wright, C., & Morice, A. (2017). Tussive challenge with ATP and AMP: does it reveal cough hypersensitivity?. European respiratory journal, 49(2), Article ARTN 1601452. https://doi.org/10.1183/13993003.01452-2016

Recent studies have demonstrated that blockade of P2X3 adenosine triphosphate (ATP) receptors may profoundly inhibit chronic cough. We have considered whether inhaled ATP produces a tussive response and whether chronic cough patients are hypersensiti... Read More about Tussive challenge with ATP and AMP: does it reveal cough hypersensitivity?.

Dual-modal SERS/fluorescence AuNP probe for mitochondrial imaging (2017)
Journal Article
Eling, C. J., Price, T. W., Marshall, A. R. L., Narda Viscomi, F., Robinson, P., Firth, G., Adawi, A. M., Bouillard, J.-S. G., & Stasiuk, G. J. (2017). Dual-modal SERS/fluorescence AuNP probe for mitochondrial imaging. ChemPlusChem, 82(5), 674-680. https://doi.org/10.1002/cplu.201600593

A novel SERS/fluorescent multimodal imaging probe for mitochondria has been synthesised using 12 nm diameter gold nanoparticles (AuNP) surface functionalised with a rhodamine thiol derivative ligand. The normal pH dependant acidic fluorescence of the... Read More about Dual-modal SERS/fluorescence AuNP probe for mitochondrial imaging.

Exploring the relation between changes in NT-proBNP and renal function in patients with suspected heart failure using structural equation modelling (2017)
Journal Article
Zhang, J., Wong, K., Clark, A. L., & Cleland, J. G. (2017). Exploring the relation between changes in NT-proBNP and renal function in patients with suspected heart failure using structural equation modelling. International journal of cardiology, 233, 67-72. https://doi.org/10.1016/j.ijcard.2017.01.127

Background The relation between changes in NT-proBNP and renal function has commonly been studied using multiple regressions, which may ignore the complexity of relations between related variables. Methods and results Data were collected from patient... Read More about Exploring the relation between changes in NT-proBNP and renal function in patients with suspected heart failure using structural equation modelling.

A potential sex dimorphism in the relationship between bitter taste and alcohol consumption (2017)
Journal Article
Beckett, E., Duesing, K., Boyd, L., Yates, Z., Veysey, M., & Lucock, M. (2017). A potential sex dimorphism in the relationship between bitter taste and alcohol consumption. Food and Function, 8(3), 1116-1123. https://doi.org/10.1039/c6fo01759b

© The Royal Society of Chemistry. Background: Bitterness is an innate aversive taste important in detecting potentially toxic substances, including alcohol. However, bitter compounds exist in many foods and beverages, and can be desirable, such as in... Read More about A potential sex dimorphism in the relationship between bitter taste and alcohol consumption.

Regulation of IL-12p40 by HIF controls Th1/Th17 responses to prevent mucosal inflammation (2017)
Journal Article
Marks, E., Naudin, C., Nolan, G., Goggins, B. J., Burns, G., Mateer, S. W., Latimore, J. K., Minahan, K., Plank, M., Foster, P. S., Callister, R., Veysey, M., Walker, M. M., Talley, N. J., Radford-Smith, G., & Keely, S. (2017). Regulation of IL-12p40 by HIF controls Th1/Th17 responses to prevent mucosal inflammation. Mucosal Immunology, 10(5), 1224-1236. https://doi.org/10.1038/mi.2016.135

Intestinal inflammatory lesions are inherently hypoxic, due to increased metabolic demands created by cellular infiltration and proliferation, and reduced oxygen supply due to vascular damage. Hypoxia stabilizes the transcription factor hypoxia-induc... Read More about Regulation of IL-12p40 by HIF controls Th1/Th17 responses to prevent mucosal inflammation.

Influence of case definition on incidence and outcome of acute coronary syndromes (2016)
Journal Article
Torabi, A., Cleland, J. G. F., Sherwi, N., Atkin, P., Panahi, H., Kilpatrick, E., Thackray, S., Hoye, A., Alamgir, F., Goode, K., Clark, A. L., & Rigby, A. (2016). Influence of case definition on incidence and outcome of acute coronary syndromes. Open heart, 3(2), e000487. https://doi.org/10.1136/openhrt-2016-000487

© 2016, BMJ Publishing Group. All rights reserved. Objective: Acute coronary syndromes (ACS) are common, but their incidence and outcome might depend greatly on how data are collected. We compared case ascertainment rates for ACS and myocardial infar... Read More about Influence of case definition on incidence and outcome of acute coronary syndromes.

Effect of ivacaftor on objective and subjective measures of cough in patients with cystic fibrosis (2016)
Journal Article
Faruqi, S., Shiferaw, D., & Morice, A. H. (2016). Effect of ivacaftor on objective and subjective measures of cough in patients with cystic fibrosis. Open Respiratory Medicine Journal, 10, 105-108. https://doi.org/10.2174/1874306401610010105

© Faruqi et al. Background and Objectives: Cough is a major symptom in cystic fibrosis. Ivacaftor is a novel drug which targets the G551D mutation and has been demonstrated to improve lung function and weight in the long term. It also improves sympto... Read More about Effect of ivacaftor on objective and subjective measures of cough in patients with cystic fibrosis.

The sternalis – more common than we believe? A cadaveric study (2016)
Presentation / Conference Contribution
Krishnan, J. V., Brittain, J., Gabriel, J., Murphy, T., Reid, M. D., Shaw, V., & Smith, C. F. (2016, December). The sternalis – more common than we believe? A cadaveric study. Presented at Anatomical Society Winter meeting. King's College London, 2016. Understanding Anatomy Through Embryology, London, UK

Introduction
The sternalis is a normal anatomical variant that is typically poorly understood and not taught at undergraduate level. It is a thin, para‐sternal strap muscle that originates from the upper sternum and infra‐clavicular region with vari... Read More about The sternalis – more common than we believe? A cadaveric study.

Neuromuscular changes and the rapid adaptation following a bout of damaging eccentric exercise (2016)
Journal Article
Goodall, S., Thomas, K., Barwood, M., Keane, K., Gonzalez, J. T., St Clair Gibson, A., & Howatson, G. (2017). Neuromuscular changes and the rapid adaptation following a bout of damaging eccentric exercise. Acta Physiologica, 220(4), 486-500. https://doi.org/10.1111/apha.12844

Introduction
An initial bout of eccentric exercise is known to protect against muscle damage following a repeated bout of the same exercise; however, the neuromuscular adaptations owing to this phenomenon are unknown.

Aim
To determine whether ne... Read More about Neuromuscular changes and the rapid adaptation following a bout of damaging eccentric exercise.

Dog ownership and physical activity among breast, prostate, and colorectal cancer survivors (2016)
Journal Article
Forbes, C. C., Blanchard, C. M., Mummery, W. K., & Courneya, K. S. (2017). Dog ownership and physical activity among breast, prostate, and colorectal cancer survivors. Psycho-oncology, 26(12), 2186-2193. https://doi.org/10.1002/pon.4324

Background
Dog ownership has been associated with higher rates of physical activity (PA) in several populations but no study to date has focused on cancer survivors. The purpose of this study was to examine the associations between dog ownership and... Read More about Dog ownership and physical activity among breast, prostate, and colorectal cancer survivors.

A pilot study on the motivational effects of an internet-delivered physical activity behaviour change programme in Nova Scotian cancer survivors (2016)
Journal Article
Forbes, C. C., Blanchard, C. M., Mummery, W. K., & Courneya, K. S. (2017). A pilot study on the motivational effects of an internet-delivered physical activity behaviour change programme in Nova Scotian cancer survivors. Psychology & health, 32(2), 234-252. https://doi.org/10.1080/08870446.2016.1260725

© 2016 Informa UK Limited, trading as Taylor & Francis Group. Objective: To examine the effects of an internet-delivered, distance-based physical activity (PA) behaviour change programme on motivation to perform PA in cancer survivors. Design: Brea... Read More about A pilot study on the motivational effects of an internet-delivered physical activity behaviour change programme in Nova Scotian cancer survivors.

Is the long case dead? ‘Uh, I don't think so’: the Uh/Um Index (2016)
Journal Article
Duvivier, R., & Veysey, M. (2016). Is the long case dead? ‘Uh, I don't think so’: the Uh/Um Index. Medical Education, 50(12), 1245-1248. https://doi.org/10.1111/medu.13091

© 2016 John Wiley & Sons Ltd and The Association for the Study of Medical Education Current tools for clinical assessment are tedious and time-consuming, particularly the dreadful long case. There is a need for novel instruments that incorporate ot... Read More about Is the long case dead? ‘Uh, I don't think so’: the Uh/Um Index.

Exposure to traffic-related air pollution and risk of development of childhood asthma: A systematic review and meta-analysis (2016)
Journal Article
Khreis, H., Kelly, C., Tate, J., Parslow, R., Lucas, K., & Nieuwenhuijsen, M. (2017). Exposure to traffic-related air pollution and risk of development of childhood asthma: A systematic review and meta-analysis. Environment International, 100, 1-31. https://doi.org/10.1016/j.envint.2016.11.012

Background and objective The question of whether children's exposure to traffic-related air pollution (TRAP) contributes to their development of asthma is unresolved. We conducted a systematic review and performed meta-analyses to analyze the associa... Read More about Exposure to traffic-related air pollution and risk of development of childhood asthma: A systematic review and meta-analysis.

STAAR: a randomised controlled trial of electronic adherence monitoring with reminder alarms and feedback to improve clinical outcomes for children with asthma (2016)
Journal Article
Morton, R. W., Elphick, H. E., Rigby, A. S., Daw, W. J., King, D. A., Smith, L. J., & Everard, M. L. (2017). STAAR: a randomised controlled trial of electronic adherence monitoring with reminder alarms and feedback to improve clinical outcomes for children with asthma. Thorax, 72(4), 347-354. https://doi.org/10.1136/thoraxjnl-2015-208171

Background Suboptimal adherence to inhaled steroids is common in children with asthma and is associated with poor disease control, reduced quality of life and even death. Previous studies using feedback of electronically monitored adherence data have... Read More about STAAR: a randomised controlled trial of electronic adherence monitoring with reminder alarms and feedback to improve clinical outcomes for children with asthma.

Bleomycin increases neutrophil adhesion to human vascular endothelial cells independently of upregulation of ICAM-1 and E-selectin (2016)
Journal Article
Williamson, J. D., Sadofsky, L. R., Crooks, M. G., Greenman, J., & Hart, S. P. (2016). Bleomycin increases neutrophil adhesion to human vascular endothelial cells independently of upregulation of ICAM-1 and E-selectin. Experimental Lung Research, 42(8-10), 397-407. https://doi.org/10.1080/01902148.2016.1243742

© 2016 Taylor & Francis. Aim of the Study: Bleomycin-induced lung disease is a serious complication of therapy characterized by alveolar injury, cytokine release, inflammatory cell recruitment, and eventually pulmonary fibrosis. The mechanisms unde... Read More about Bleomycin increases neutrophil adhesion to human vascular endothelial cells independently of upregulation of ICAM-1 and E-selectin.

Effect of soy in men with type 2 diabetes mellitus and subclinical hypogonadism: a randomised controlled study (2016)
Journal Article
Sathyapalan, T., Rigby, A. S., Bhasin, S., Thatcher, N. J., Kilpatrick, E. S., & Atkin, S. L. (2017). Effect of soy in men with type 2 diabetes mellitus and subclinical hypogonadism: a randomised controlled study. Journal of Clinical Endocrinology and Metabolism, 102(2), 425-433. https://doi.org/10.1210/jc.2016-2875

Context: Isoflavones found in soy products have a chemical structure similar to estrogen, leading to concerns of an adverse estrogenic effect in men, particularly in those with type 2 diabetes mellitus (T2DM) who have low testosterone levels due to h... Read More about Effect of soy in men with type 2 diabetes mellitus and subclinical hypogonadism: a randomised controlled study.

Determination of deoxynivalenol in the urine of pregnant women in the UK (2016)
Journal Article
Rigby, A., Sathyapalan, T., Wells, L., Atkin, S., Brera, C., De Santis, B., Debegnach, F., Greetham, S., Hardie, L., Liu, Y., Moretti, G., White, K., & Williams, C. (2016). Determination of deoxynivalenol in the urine of pregnant women in the UK. Toxins, 8(11), 306. https://doi.org/10.3390/toxins8110306

Deoxynivalenol (DON) is one of the most commonly occurring trichothecenes, produced mainly by Fusarium graminearum. Little is known about the effect of DON exposure or the levels of DON exposure that occur during pregnancy. The project aimed to provi... Read More about Determination of deoxynivalenol in the urine of pregnant women in the UK.