All Outputs (667)

Amyloid-related protein changes associated with dementia differ according to severity of hypoglycemia (2021)
Journal Article
Moin, A. S. M., Kahal, H., Al-Qaissi, A., Kumar, N., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2021). Amyloid-related protein changes associated with dementia differ according to severity of hypoglycemia. BMJ Open Diabetes Research and Care, 9(1), Article e002211. https://doi.org/10.1136/bmjdrc-2021-002211

Introduction Hypoglycemia in type 2 diabetes (T2D) may increase risk for Alzheimer’s disease (AD), but no data on changes in AD-related proteins with differing degrees of hypoglycemia exist. We hypothesized that milder prolonged hypoglycemia would ca... Read More about Amyloid-related protein changes associated with dementia differ according to severity of hypoglycemia.

Regulation of circulating CTRP-2/CTRP-9 and GDF-8/GDF-15 by intralipids and insulin in healthy control and polycystic ovary syndrome women following chronic exercise training (2021)
Journal Article
Jerobin, J., Ramanjaneya, M., Bettahi, I., Parammal, R., Siveen, K. S., Alkasem, M., …Abou-Samra, A. B. (2021). Regulation of circulating CTRP-2/CTRP-9 and GDF-8/GDF-15 by intralipids and insulin in healthy control and polycystic ovary syndrome women following chronic exercise training. Lipids in Health and Disease, 20(1), Article 34. https://doi.org/10.1186/s12944-021-01463-3

Background: Polycystic ovary syndrome (PCOS) is associated with obesity, diabetes, and insulin resistance. The circulating C1Q/TNF-related proteins (CTRP-2, CTRP-9) and growth differentiation factors (GDF-8, GDF-15) contribute to glucose and lipid ho... Read More about Regulation of circulating CTRP-2/CTRP-9 and GDF-8/GDF-15 by intralipids and insulin in healthy control and polycystic ovary syndrome women following chronic exercise training.

The role of diagnostic ultrasound imaging for patients with known prostate cancer within an active surveillance pathway: a systematic review (2021)
Journal Article
Simms, M., Parker, P., Rigby, A., Whybrow, P., & Twiddy, M. (in press). The role of diagnostic ultrasound imaging for patients with known prostate cancer within an active surveillance pathway: a systematic review. Ultrasound, https://doi.org/10.1177/1742271X21995212

Background: The use of multiparametric magnetic resonance imaging (mpMRI) within active surveillance of prostate cancer programmes is identified by the UK National Institute for Health and Care Excellence (NICE guideline NG 131 2019) as having a role... Read More about The role of diagnostic ultrasound imaging for patients with known prostate cancer within an active surveillance pathway: a systematic review.

BMJ Opinion 12 April 2021: Covid-19 and clinical reasoning - we all became novices once more (2021)
Digital Artefact
Hammond, A. (2021). BMJ Opinion 12 April 2021: Covid-19 and clinical reasoning - we all became novices once more

When Covid-19 emerged, all doctors were faced with a new disease about which they knew little. Anna Hammond describes how the experience has changed her consultations with patients and how she teaches medical students.

Published in BMJ Opinion 12... Read More about BMJ Opinion 12 April 2021: Covid-19 and clinical reasoning - we all became novices once more.

Inter-rater reliability of care home staff's proxy judgements with residents' assessments of their own health-related quality of life: an analysis of the PATCH trial EQ-5D data (2021)
Journal Article
Kelly, C., Hulme, C., Graham, L., Ellwood, A., Patel, I., Cundill, B., …Forster, A. (2021). Inter-rater reliability of care home staff's proxy judgements with residents' assessments of their own health-related quality of life: an analysis of the PATCH trial EQ-5D data. Age and ageing, 50(4), 1314-1320. https://doi.org/10.1093/ageing/afab053

OBJECTIVES: to compare care staff proxies with care home residents' self-assessment of their health-related quality of life (HRQoL). METHODS: we assessed the degree of inter-rater reliability between residents and care staff proxies for the EQ-5D-5L... Read More about Inter-rater reliability of care home staff's proxy judgements with residents' assessments of their own health-related quality of life: an analysis of the PATCH trial EQ-5D data.

Understanding the impact of professional motivation on the workforce crisis in medicine: a rapid review (2021)
Journal Article
Andah, E., Essang, B., Friend, C., Greenley, S., Harvey, K., Spears, M., & Reeve, J. (2021). Understanding the impact of professional motivation on the workforce crisis in medicine: a rapid review. BJGP Open, 5(2), 1-11. https://doi.org/10.3399/BJGPO.2021.0005

Background: The NHS is facing a workforce crisis. Responses to date have focused on improving recruitment of staff, but less attention has been paid to retention. Aim: To conduct a rapid review using Rosabeth Moss Kanter's three Ms model of workforce... Read More about Understanding the impact of professional motivation on the workforce crisis in medicine: a rapid review.

Examining public knowledge, attitudes and perceptions towards palliative care: a mixed method sequential study (2021)
Journal Article
McIlfatrick, S., Slater, P., Beck, E., Bamidele, O., McCloskey, S., Carr, K., …Hasson, F. (2021). Examining public knowledge, attitudes and perceptions towards palliative care: a mixed method sequential study. BMC Palliative Care, 20(1), Article 44. https://doi.org/10.1186/s12904-021-00730-5

Background: Palliative care is recognised as a public health issue with the need for earlier integration in the wider healthcare system. However, research indicates that it continues to be accessed late in the course of an illness, public understandi... Read More about Examining public knowledge, attitudes and perceptions towards palliative care: a mixed method sequential study.

The irrational health beliefs scale and health behaviors in a non-clinical population (2021)
Journal Article
Pitel, L., & Ballová Mikušková, E. (in press). The irrational health beliefs scale and health behaviors in a non-clinical population. European Journal of Health Psychology, https://doi.org/10.1027/2512-8442/a000075

To date, there has been inconclusive evidence on the predictive ability of health-related cognitive distortion, as measured by the Irrational Health Belief Scale (IHBS), regarding health behaviors (HBs). The aims of our study were to provide a valida... Read More about The irrational health beliefs scale and health behaviors in a non-clinical population.

The PEOPLE-HULL Study: improving help-seeking for lung symptoms in Hull. Trial registration. (2021)
Data
Mitchell, L., Macleod, U., & Walabyeki, J. (2021). The PEOPLE-HULL Study: improving help-seeking for lung symptoms in Hull. Trial registration. [Data]. https://doi.org/10.1186/ISRCTN28517662

Background and study aims:
More people are diagnosed with and die from lung cancer in Hull than any other place in Yorkshire. The main reason for this is related to lung cancers being diagnosed at a time when they are too advanced to be eligible for... Read More about The PEOPLE-HULL Study: improving help-seeking for lung symptoms in Hull. Trial registration..

Palliative medicine in the intensive care unit: needs, delivery, quality (2021)
Journal Article
Hill, S., Dawood, A., Boland, E., Leahy, H. E., & Murtagh, F. (in press). Palliative medicine in the intensive care unit: needs, delivery, quality. BMJ supportive & palliative care, Article 2795. https://doi.org/10.1136/bmjspcare-2020-002795

Background: 15%-20% of critical care patients die during their hospital admission. This service evaluation assesses quality of palliative care in intensive care units (ICUs) compared with national standards. Methods: Retrospective review of records f... Read More about Palliative medicine in the intensive care unit: needs, delivery, quality.

How physicians in South India recognize, assess, and manage people with chronic breathlessness syndrome: A thematic analysis (2021)
Journal Article
Barnes-Harris, M., Daniel, S., Venkateswaran, C., Hutchinson, A., & Johnson, M. (2021). How physicians in South India recognize, assess, and manage people with chronic breathlessness syndrome: A thematic analysis. Indian Journal of Palliative Care, 27(1), 54-61. https://doi.org/10.4103/IJPC.IJPC_139_20

Objectives: Chronic breathlessness syndrome has been defined to help clinicians actively seek, and patients legitimately present with, persistent breathlessness, and to drive services and research. However, views from low- to middle-income countries... Read More about How physicians in South India recognize, assess, and manage people with chronic breathlessness syndrome: A thematic analysis.

Electrochemically Induced Mesomorphism Switching in a Chlorpromazine Hydrochloride Lyotropic Liquid Crystal (2021)
Journal Article
Crapnell, R. D., Alhasan, H. S., Partington, L. I., Zhou, Y., Ahmed, Z., Altalhi, A. A., Varley, T. S., Alahmadi, N., Mehl, G. H., Kelly, S. M., Lawrence, N. S., Marken, F., & Wadhawan, J. D. (2021). Electrochemically Induced Mesomorphism Switching in a Chlorpromazine Hydrochloride Lyotropic Liquid Crystal. ACS Omega, 6(7), 4630-4640. https://doi.org/10.1021/acsomega.0c05284

The discovery of electrochemical switching of the Lα phase of chlorpromazine hydrochloride in water is reported. The phase is characterized using polarizing microscopy, X-ray scattering, rheological measurements, and microelectrode voltammetry. Fast,... Read More about Electrochemically Induced Mesomorphism Switching in a Chlorpromazine Hydrochloride Lyotropic Liquid Crystal.

Professional identity formation within longitudinal integrated clerkships: A scoping review (2021)
Journal Article
Brown, M. E. L., Whybrow, P., Kirwan, G., & Finn, G. M. (in press). Professional identity formation within longitudinal integrated clerkships: A scoping review. Medical Education, https://doi.org/10.1111/medu.14461

Context
Although the uptake of Longitudinal Integrated Clerkships (LICs) is increasing worldwide, and there are documented benefits to participation, there is a lack of conceptual evidence regarding how LICs exert many of their benefits, including t... Read More about Professional identity formation within longitudinal integrated clerkships: A scoping review.

The potential role of incretin-based therapies for polycystic ovary syndrome: a narrative review of the current evidence (2021)
Journal Article
Abdalla, M. A., Deshmukh, H., Atkin, S., & Sathyapalan, T. (2021). The potential role of incretin-based therapies for polycystic ovary syndrome: a narrative review of the current evidence. Therapeutic Advances in Endocrinology and Metabolism, 12, https://doi.org/10.1177/2042018821989238

© The Author(s), 2021. Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women of reproductive age. Metabolic consequences associated with PCOS include, but are not limited to, insulin resistance (IR), type 2... Read More about The potential role of incretin-based therapies for polycystic ovary syndrome: a narrative review of the current evidence.

Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations (Protocol) (2021)
Journal Article
Crane, H., Boam, G., Carradice, D., Vanicek, N., Twiddy, M., & Smith, G. E. (2021). Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations (Protocol). Cochrane Database of Systematic Reviews, 2021(1), Article CD013839. https://doi.org/10.1002/14651858.CD013839

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the effects of through-knee amputation compared to above-knee amputation on clinical and rehabilitation outcomes and complication rates in... Read More about Through-knee versus above-knee amputation for vascular and non-vascular major lower limb amputations (Protocol).

Platelet releasate normalises the compromised muscle regeneration in a mouse model of hyperlipidaemia (2021)
Journal Article
Barlow, J., Sfyri, P. P., Mitchell, R., Verpoorten, S., Scully, D., Andreou, C., Papadopoulos, P., Patel, K., & Matsakas, A. (2021). Platelet releasate normalises the compromised muscle regeneration in a mouse model of hyperlipidaemia. Experimental Physiology, 106(3), 700-713. https://doi.org/10.1113/ep088937

Muscle satellite cells are important stem cells for skeletal muscle regeneration and repair after injury. ApoE‐deficient mice, an established mouse model of hyperlipidaemia and atherosclerosis, show evidence of oxidative stress‐induced lesions and fa... Read More about Platelet releasate normalises the compromised muscle regeneration in a mouse model of hyperlipidaemia.

Radiological anatomy of the abdomen (2021)
Journal Article
Fang, C., Kane, P., Bazira, P. J., & Ben Cresswell, A. (2021). Radiological anatomy of the abdomen. Surgery (Oxford), 39(2), 61-74. https://doi.org/10.1016/j.mpsur.2020.12.001

Advances in technology have led to significant developments in techniques for imaging the abdominal and pelvic organs, in both the elective and emergency surgical settings. Improvements in the quality and availability of imaging has had a profound ef... Read More about Radiological anatomy of the abdomen.

Fetal alcohol spectrum disorders: An overview of current evidence and activities in the UK (2021)
Journal Article
Schölin, L., Mukherjee, R. A., Aiton, N., Blackburn, C., Brown, S., Flemming, K. M., …Cook, P. A. (2021). Fetal alcohol spectrum disorders: An overview of current evidence and activities in the UK. Archives of Disease in Childhood, 106(7), 636-640. https://doi.org/10.1136/archdischild-2020-320435

Estimates for the UK suggest that alcohol consumption during pregnancy and prevalence of fetal alcohol spectrum disorder (FASD) - the most common neurodevelopmental condition - are high. Considering the significant health and social impacts of FASD,... Read More about Fetal alcohol spectrum disorders: An overview of current evidence and activities in the UK.

The Virtual Dissection Room: Live-streamed Demonstrations to Complement Recorded Lectures (2021)
Presentation / Conference Contribution
Shaw, V., & Winder, I. C. (2021, January). The Virtual Dissection Room: Live-streamed Demonstrations to Complement Recorded Lectures. Presented at Anatomical Society Virtual Winter Meeting: Vision and Visualisation, Newcastle

Complying with the constraints on class size created by social distancing meant that in Bangor, it was not possible to have in-person cadaveric teaching this year. This had the biggest impact on the second-year Medical Sciences students, and the firs... Read More about The Virtual Dissection Room: Live-streamed Demonstrations to Complement Recorded Lectures.

Optimising planned medical education strategies to develop learners' person-centredness: A realist review (2021)
Journal Article
Bansal, A., Greenley, S., Mitchell, C., Park, S., Shearn, K., & Reeve, J. (2021). Optimising planned medical education strategies to develop learners' person-centredness: A realist review. Medical Education, https://doi.org/10.1111/medu.14707

Context: Person-centeredness is a stated aim for medical education; however, studies suggest this is not being achieved. There is a gap in our understanding of how, why and in what circumstances medical education interventions that aim to develop per... Read More about Optimising planned medical education strategies to develop learners' person-centredness: A realist review.