Electrochemically Induced Mesomorphism Switching in a Chlorpromazine Hydrochloride Lyotropic Liquid Crystal

Crapnell, Robert D.; Alhasan, Huda S.; Partington, Lee I.; Zhou, Yan; Ahmed, Ziauddin; Altalhi, Amal A.; Varley, Thomas S.; Alahmadi, Nadiyah; Mehl, Georg H.; Kelly, Stephen M.; Lawrence, Nathan S.; Marken, Frank; Wadhawan, Jay D.

Abstract

The discovery of electrochemical switching of the Lα phase of chlorpromazine hydrochloride in water is reported. The phase is characterized using polarizing microscopy, X-ray scattering, rheological measurements, and microelectrode voltammetry. Fast, heterogeneous oxidation of the lyotropic liquid crystal is shown to cause a phase change resulting from the disordering of the structural order in a stepwise process. The underlying molecular dynamics is considered to be a cooperative effect of both increasing electrostatic interactions and an unfolding of the monomers from "butterfly"-shaped in the reduced form to planar in the oxidized form.

Citation

Crapnell, R. D., Alhasan, H. S., Partington, L. I., Zhou, Y., Ahmed, Z., Altalhi, A. A., Varley, T. S., Alahmadi, N., Mehl, G. H., Kelly, S. M., Lawrence, N. S., Marken, F., & Wadhawan, J. D. (2021). Electrochemically Induced Mesomorphism Switching in a Chlorpromazine Hydrochloride Lyotropic Liquid Crystal. ACS Omega, 6(7), 4630-4640. https://doi.org/10.1021/acsomega.0c05284

• Journal Article Type: Article
• Acceptance Date: Dec 18, 2020
• Online Publication Date: Feb 5, 2021
• Publication Date: Feb 23, 2021
• Deposit Date: Aug 5, 2021
• Publicly Available Date: Aug 5, 2021
• Journal: ACS Omega
• Print ISSN: 2470-1343
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 6
• Issue: 7
• Pages: 4630-4640
• DOI: https://doi.org/10.1021/acsomega.0c05284
• Public URL: https://hull-repository.worktribe.com/output/3718106