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Risk factors for emergency presentation with lung and colorectal cancers: A systematic review (2015)
Journal Article
Mitchell, E. D., Pickwell-Smith, B., & Macleod, U. (2015). Risk factors for emergency presentation with lung and colorectal cancers: A systematic review. BMJ open, 5(4), Article e006965. https://doi.org/10.1136/bmjopen-2014-006965

© 2015, BMJ. All rights reserved. Objective: To identify patient and practitioner factors that influence cancer diagnosis via emergency presentation (EP). Design: Systematic review. Data sources: MEDLINE, EMBASE, CINAHL, EBM Reviews, Science and Soci... Read More about Risk factors for emergency presentation with lung and colorectal cancers: A systematic review.

Chronic kidney disease in Nigeria: an evaluation of the spatial accessibility to healthcare for diagnosed cases in Edo State (2015)
Journal Article
Oviasu, O., Rigby, J. E., & Ballas, D. (2015). Chronic kidney disease in Nigeria: an evaluation of the spatial accessibility to healthcare for diagnosed cases in Edo State. Journal of Public Health in Africa, 6(1), 40-44. https://doi.org/10.4081/jphia.2015.394

Chronic kidney disease (CKD) is a growing problem in Nigeria, presenting challenges to the nation’s health and economy. This study evaluates the accessibility to healthcare in Edo State of CKD patients diagnosed between 2006 and 2009. Using cost anal... Read More about Chronic kidney disease in Nigeria: an evaluation of the spatial accessibility to healthcare for diagnosed cases in Edo State.

A randomized clinical trial of endovenous laser ablation versus conventional surgery for small saphenous varicose veins (2015)
Journal Article
Nandhra, S., El-sheikha, J., Carradice, D., Wallace, T., Souroullas, P., Samuel, N., Smith, G., & Chetter, I. C. (2015). A randomized clinical trial of endovenous laser ablation versus conventional surgery for small saphenous varicose veins. Journal of vascular surgery, 61(3), 741-746. https://doi.org/10.1016/j.jvs.2014.09.037

Background: This randomized clinical trial compared endovenous laser ablation (EVLA) and surgical ligation with attempted stripping in the treatment of small saphenous vein (SSV) insufficiency. The early results demonstrated that EVLA was more likely... Read More about A randomized clinical trial of endovenous laser ablation versus conventional surgery for small saphenous varicose veins.

Central and Peripheral Fatigue in Male Cyclists after 4-, 20-, and 40-km Time Trials (2015)
Journal Article
Thomas, K., Goodall, S., Stone, M., Howatson, G., Gibson, A. S. C., & ANSLEY, L. (2015). Central and Peripheral Fatigue in Male Cyclists after 4-, 20-, and 40-km Time Trials. Medicine and Science in Sports and Exercise, 47(3), 537-546. https://doi.org/10.1249/mss.0000000000000448

Purpose
Few studies have assessed neuromuscular fatigue after self-paced locomotor exercise; moreover, none have assessed the degree of supraspinal fatigue. This study assessed central and peripheral fatigue after self-paced exercise of different d... Read More about Central and Peripheral Fatigue in Male Cyclists after 4-, 20-, and 40-km Time Trials.

Myocardial fibrosis in stroke survivors (2015)
Journal Article
Wong, K., Sze, S., Wong, S., McSwiggan, S., Allgar, V., MacWalter, R., & Struthers, A. D. (2015). Myocardial fibrosis in stroke survivors. International journal of cardiology, 187(1), 138-140. https://doi.org/10.1016/j.ijcard.2015.03.212

Stroke survivors are most likely to die of cardiac death, yet few undergo comprehensive cardiac assessment to look for reversible causes. Myocardial fibrosis (MF) is not only the hallmark of cardiomyopathy, but also a substrate for sudden cardiac dea... Read More about Myocardial fibrosis in stroke survivors.

Aspartame sensitivity? : a double blind randomised crossover study (2015)
Journal Article
Sathyapalan, T., Thatcher, N. J., Hammersley, R., Rigby, A. S., Pechlivanis, A., Gooderham, N. J., Holmes, E., Le Roux, C. W., Atkin, S. L., & Courts, F. (2015). Aspartame sensitivity? : a double blind randomised crossover study. PLoS ONE, 10(3), e0116212. https://doi.org/10.1371/journal.pone.0116212

Background Aspartame is a commonly used intense artificial sweetener, being approximately 200 times sweeter than sucrose. There have been concerns over aspartame since approval in the 1980s including a large anecdotal database reporting severe sympto... Read More about Aspartame sensitivity? : a double blind randomised crossover study.

What stops students working well in clinical environments? (2015)
Presentation / Conference Contribution
Hammond, A., & Henderson, J. (2015, March). What stops students working well in clinical environments?. Paper presented at UK Council for Clinical Communication National Conference, Manchester

Aims
* To discuss the challenges for Undergraduate Medical Students when moving from University Based to Full time clinical placements
* Discuss HYMS’ Year Three Induction Block
* To share ideas regarding how to address these challenges

Prevalence and correlates of strength exercise among breast, prostate, and colorectal cancer survivors (2015)
Journal Article
Forbes, C. C., Blanchard, C. M., Mummery, W. K., & Courneya, K. S. (2015). Prevalence and correlates of strength exercise among breast, prostate, and colorectal cancer survivors. Oncology Nursing Forum, 42(2), 118-127. https://doi.org/10.1188/15.ONF.42-02AP

Purpose/Objectives: To identify and compare the prevalence and correlates of strength exercise among breast, prostate, and colorectal cancer survivors.

Design: Cross-sectional, descriptive survey.

Setting: Nova Scotia, Canada.

Sample: 741 breast,... Read More about Prevalence and correlates of strength exercise among breast, prostate, and colorectal cancer survivors.

Oxidized LDL activates blood platelets through CD36/NOX2–mediated inhibition of the cGMP/protein kinase G signaling cascade (2015)
Journal Article
Magwenzi, S., Woodward, C., Wraith, K. S., Aburima, A., Raslan, Z., Jones, H., McNeil, C., Wheatcroft, S., Yuldasheva, N., Febbriao, M., Kearney, M., & Naseem, K. M. (2015). Oxidized LDL activates blood platelets through CD36/NOX2–mediated inhibition of the cGMP/protein kinase G signaling cascade. Blood, 125(17), 2693-2703. https://doi.org/10.1182/blood-2014-05-574491

Oxidized low-density lipoprotein (oxLDL) promotes unregulated platelet activation in dyslipidemic disorders. Although oxLDL stimulates activatory signaling, it is unclear how these events drive accelerated thrombosis. Here, we describe a mechanism fo... Read More about Oxidized LDL activates blood platelets through CD36/NOX2–mediated inhibition of the cGMP/protein kinase G signaling cascade.

QT peak prolongation predicts cardiac death following stroke (2015)
Journal Article
Wong, K. Y. K., MacWalter, R. S., Wong, S. Y. S., Suich, J., Douglas, D., Fraser, H. W., …Struthers, A. D. (2015). QT peak prolongation predicts cardiac death following stroke. Journal of cardiology and current research, 2(1), Article 00050. https://doi.org/10.15406/jccr.2015.02.00050

Cardiac death has been linked in many populations to prolongation of the QT interval (QTe). However, basic science research suggested that the best estimate of the time point when repolarisation begins is near the T-wave peak. We found QT peak (QTp)... Read More about QT peak prolongation predicts cardiac death following stroke.

Prescribing patterns to optimize heart rate. Analysis of 1,000 consecutive outpatient appointments toasingle heart failure clinic over a 6-month period. (2015)
Journal Article
Dierckx, R., Cleland, J. G., Parsons, S., Putzu, P., Pellicori, P., Dicken, B., Boyalla, V., & Clark, A. L. (2015). Prescribing patterns to optimize heart rate. Analysis of 1,000 consecutive outpatient appointments toasingle heart failure clinic over a 6-month period. JACC: Heart Failure, 3(3), 224-230. https://doi.org/10.1016/j.jchf.2014.11.003

Objectives: This study sought to characterize patients attending a community heart failure (HF) clinic and identified those who were eligible for optimization of beta-blockers (BB) or ivabradine. Background: Among patients with HF due to left ventric... Read More about Prescribing patterns to optimize heart rate. Analysis of 1,000 consecutive outpatient appointments toasingle heart failure clinic over a 6-month period..

Methylation diet and methyl group genetics in risk for adenomatous polyp occurrence (2015)
Journal Article
Lucock, M., Yates, Z., Martin, C., Choi, J.-H., Beckett, E., Boyd, L., LeGras, K., Ng, X., Skinner, V., Wai, R., Kho, J., Roach, P., & Veysey, M. (2015). Methylation diet and methyl group genetics in risk for adenomatous polyp occurrence. Bba Clinical, 3, 107-112. https://doi.org/10.1016/j.bbacli.2014.11.005

Purpose
The aim of this study is to explore whether a methylation diet influences risk for adenomatous polyps (AP) either independently, or interactively with one-carbon metabolism-dependent gene variants, and whether such a diet modifies blood homoc... Read More about Methylation diet and methyl group genetics in risk for adenomatous polyp occurrence.

Meridians Under the Skin (2014)
Journal Article
Shaw, V., & Aland, R. C. (2014). Meridians Under the Skin. European Journal of Oriental Medicine, 7(6),

The physical nature of the acupuncture meridian system is currently the subject of enquiry. The original structural descriptions for the meridian system contained in the Huang Di Nei Jing, The Yellow Emperor's Canon of Internal Medicine, are detailed... Read More about Meridians Under the Skin.

c-MYC is a radiosensitive locus in human breast cells (2014)
Journal Article
Wade, M. A., Sunter, N. J., Fordham, S. E., Long, A., Masic, D., Russell, L. J., Harrison, C. J., Rand, V., Elstob, C., Bown, N., Rowe, D., Lowe, C., Cuthbert, G., Bennett, S., Crosier, S., Bacon, C. M., Onel, K., Scott, K., Scott, D., Travis, L. B., …Allan, J. M. (2015). c-MYC is a radiosensitive locus in human breast cells. Oncogene, 34(38), 4985-4994. https://doi.org/10.1038/onc.2014.427

Ionising radiation is a potent human carcinogen. Epidemiological studies have shown that adolescent and young women are at increased risk of developing breast cancer following exposure to ionising radiation compared with older women, and that risk is... Read More about c-MYC is a radiosensitive locus in human breast cells.

The Anatomical Accuracy of the Robber King Ou Xi Fan (and his 56 dissected gang members) (2014)
Presentation / Conference Contribution
Shaw, V. (2014, December). The Anatomical Accuracy of the Robber King Ou Xi Fan (and his 56 dissected gang members). Poster presented at Joint Meeting of the Anatomical Society and the Primate Society of Great Britain: Primate Ecomorpholgy, University of Birmingham, Birmingham, UK

Anatomical drawings have formed the cornerstone of anatomical education in the West for centuries before the arrival of photography, the internet and virtual resources. The images in Vesalius’ On the Fabric of the Human Body and later in Gray’s Anato... Read More about The Anatomical Accuracy of the Robber King Ou Xi Fan (and his 56 dissected gang members).

High glucose enhances store-operated calcium entry by upregulating ORAI/STIM via calcineurin-NFAT signalling (2014)
Journal Article
Daskoulidou, N., Xu, S. Z., Zeng, B., Gomez, M. F., Berglund, L. M., Atkin, S. L., Jiang, H., Griffin, S., Ayoola, J., Bhandari, S., Kotova, O., Chen, G. L., Griffin, S., Jiang, H., Berglund, L. M., Zeng, B., & Daskoulidou, N. (2015). High glucose enhances store-operated calcium entry by upregulating ORAI/STIM via calcineurin-NFAT signalling. Journal of Molecular Medicine, 93(5), 511-521. https://doi.org/10.1007/s00109-014-1234-2

© 2014, Springer-Verlag Berlin Heidelberg. Abstract: ORAI and stromal interaction molecule (STIM) are store-operated channel molecules that play essential roles in human physiology through a coupling mechanism of internal Ca 2+ store to Ca 2+ influx.... Read More about High glucose enhances store-operated calcium entry by upregulating ORAI/STIM via calcineurin-NFAT signalling.

Human embryos from overweight and obese women display phenotypic and metabolic abnormalities (2014)
Journal Article
Leary, C., Leese, H. J., & Sturmey, R. G. (2015). Human embryos from overweight and obese women display phenotypic and metabolic abnormalities. Human Reproduction, 30(1), 122-132. https://doi.org/10.1093/humrep/deu276

STUDY QUESTION Is the developmental timing and metabolic regulation disrupted in embryos from overweight or obese women? SUMMARY ANSWER Oocytes from overweight or obese women are smaller than those from women of healthy weight, yet post-fertilization... Read More about Human embryos from overweight and obese women display phenotypic and metabolic abnormalities.

Increased platelet reactivity in idiopathic pulmonary fibrosis is mediated by a plasma factor (2014)
Journal Article
Crooks, M. G., Fahim, A., Naseem, K. M., Morice, A. H., & Hart, S. P. (2014). Increased platelet reactivity in idiopathic pulmonary fibrosis is mediated by a plasma factor. PLoS ONE, 9(10), Article ARTN e111347. https://doi.org/10.1371/journal.pone.0111347

Introduction Idiopathic Pulmonary Fibrosis (IPF) is a progressive, incurable fibrotic interstitial lung disease with a prognosis worse than many cancers. Its pathogenesis is poorly understood. Activated platelets can release pro-fibrotic mediators th... Read More about Increased platelet reactivity in idiopathic pulmonary fibrosis is mediated by a plasma factor.