All Outputs (388)

Non-opioid medications for the relief of chronic breathlessness: current evidence (2017)
Journal Article
Barbetta, C., Currow, D. C., & Johnson, M. J. (2017). Non-opioid medications for the relief of chronic breathlessness: current evidence. Expert Review of Respiratory Medicine, 11(4), 333-341. https://doi.org/10.1080/17476348.2017.1305896

Introduction: To evaluate systematically randomised clinical trials investigating non-opioid medications for the management and treatment of chronic breathlessness. Areas covered: The evidence for the role of benzodiazepines, anxiolytics, selective s... Read More about Non-opioid medications for the relief of chronic breathlessness: current evidence.

Oral and topical antibiotics for clinically infected eczema in children: A pragmatic randomized controlled trial in ambulatory care (2017)
Journal Article
Francis, N. A., Ridd, M. J., Thomas-Jones, E., Butler, C. C., Hood, K., Shepherd, V., Marwick, C. A., Huang, C., Longo, M., Wootton, M., & Sullivan, F. (2017). Oral and topical antibiotics for clinically infected eczema in children: A pragmatic randomized controlled trial in ambulatory care. Annals of Family Medicine, 15(2), 124-130. https://doi.org/10.1370/afm.2038

PURPOSE Eczema may flare because of bacterial infection, but evidence supporting antibiotic treatment is of low quality. We aimed to determine the effect of oral and topical antibiotics in addition to topical emollient and corticosteroids in children... Read More about Oral and topical antibiotics for clinically infected eczema in children: A pragmatic randomized controlled trial in ambulatory care.

A calibration method for non-positive definite covariance matrix in multivariate data analysis (2017)
Journal Article
Huang, C., Farewell, D., & Pan, J. (2017). A calibration method for non-positive definite covariance matrix in multivariate data analysis. Journal of Multivariate Analysis, 157, 45-52. https://doi.org/10.1016/j.jmva.2017.03.001

Covariance matrices that fail to be positive definite arise often in covariance estimation. Approaches addressing this problem exist, but are not well supported theoretically. In this paper, we propose a unified statistical and numerical matrix calib... Read More about A calibration method for non-positive definite covariance matrix in multivariate data analysis.

Extracorporeal shockwave therapy for the treatment of lower limb intermittent claudication: Study protocol for a randomised controlled trial (the SHOCKWAVE 1 trial) (2017)
Journal Article
Harwood, A. E., Smith, G. E., Totty, J. P., Carradice, D., Chetter, I. C., Harwood, A., Totty, J., Cayton, T., & Smith, G. (2017). Extracorporeal shockwave therapy for the treatment of lower limb intermittent claudication: Study protocol for a randomised controlled trial (the SHOCKWAVE 1 trial). Trials, 18(1), https://doi.org/10.1186/s13063-017-1844-4

© 2017 The Author(s). Background: Peripheral arterial disease (PAD) has a population prevalence of 4.6% with intermittent claudication (IC) presenting as one of the earliest and most common symptoms. PAD has detrimental effects on patients' walking a... Read More about Extracorporeal shockwave therapy for the treatment of lower limb intermittent claudication: Study protocol for a randomised controlled trial (the SHOCKWAVE 1 trial).

Dialkylcarbamoyl chloride (DACC)-coated dressings in the management and prevention of wound infection: A systematic review (2017)
Journal Article
Totty, J., Bua, N., Smith, G., Harwood, A., Carradice, D., Wallace, T., & Chetter, I. (2017). Dialkylcarbamoyl chloride (DACC)-coated dressings in the management and prevention of wound infection: A systematic review. Journal of Wound Care, 26(3), 107-114. https://doi.org/10.12968/jowc.2017.26.3.107

Objective: Dialkylcarbomoyl chloride (DACC)-coated dressings (Leukomed Sorbact and Cutimed Sorbact) irreversibly bind bacteria at the wound surface that are then removed when the dressing is changed. They are a recent addition to the wound care profe... Read More about Dialkylcarbamoyl chloride (DACC)-coated dressings in the management and prevention of wound infection: A systematic review.

The patients’ experience of a bladder cancer diagnosis: a systematic review of the qualitative evidence (2017)
Journal Article
Edmondson, A. J., Birtwistle, J. C., Catto, J. W., & Twiddy, M. (2017). The patients’ experience of a bladder cancer diagnosis: a systematic review of the qualitative evidence. Journal of cancer survivorship : research and practice, 11(4), 453-461. https://doi.org/10.1007/s11764-017-0603-6

© 2017, The Author(s). Purpose: Bladder cancer (BC) is a common disease with disparate treatment options and variable outcomes. Despite the disease’s high prevalence, little is known of the lived experience of affected patients. National patient expe... Read More about The patients’ experience of a bladder cancer diagnosis: a systematic review of the qualitative evidence.

The Community IntraVenous Antibiotic Study (CIVAS): a mixed-methods evaluation of patient preferences for and cost-effectiveness of different service models for delivering outpatient parenteral antimicrobial therapy (2017)
Journal Article
Minton, J., Murray, C. C., Meads, D., Hess, S., Vargas-Palacios, A., Mitchell, E., Wright, J., Hulme, C., Raynor, D. K., Gregson, A., Stanley, P., McLintock, K., Vincent, R., & Twiddy, M. (2017). The Community IntraVenous Antibiotic Study (CIVAS): a mixed-methods evaluation of patient preferences for and cost-effectiveness of different service models for delivering outpatient parenteral antimicrobial therapy. Health Services and Delivery Research, 5(6), 1-272. https://doi.org/10.3310/hsdr05060

Background

Outpatient parenteral antimicrobial therapy (OPAT) is widely used in most developed countries, providing considerable opportunities for improved cost savings. However, it is implemented only partially in the UK, using a variety of servi... Read More about The Community IntraVenous Antibiotic Study (CIVAS): a mixed-methods evaluation of patient preferences for and cost-effectiveness of different service models for delivering outpatient parenteral antimicrobial therapy.

Predicting probable Alzheimer's disease using linguistic deficits and biomarkers (2017)
Journal Article
Orimaye, S. O., Wong, J. S.-M., Golden, K. J., Wong, C. P., & Soyiri, I. N. (2017). Predicting probable Alzheimer's disease using linguistic deficits and biomarkers. BMC Bioinformatics, 18(1), Article 34. https://doi.org/10.1186/s12859-016-1456-0

Background
The manual diagnosis of neurodegenerative disorders such as Alzheimer’s disease (AD) and related Dementias has been a challenge. Currently, these disorders are diagnosed using specific clinical diagnostic criteria and neuropsychological ex... Read More about Predicting probable Alzheimer's disease using linguistic deficits and biomarkers.

Efficacy of oral risperidone, haloperidol, or placebo for symptoms of delirium among patients in palliative care: A randomized clinical trial (2017)
Journal Article
Agar, M. R., Lawlor, P. G., Quinn, S., Draper, B., Caplan, G. A., Rowett, D., Sanderson, C., Hardy, J., Le, B., Eckermann, S., McCaffrey, N., Devilee, L., Fazekas, B., Hill, M., & Currow, D. C. (2017). Efficacy of oral risperidone, haloperidol, or placebo for symptoms of delirium among patients in palliative care: A randomized clinical trial. JAMA Internal Medicine, 177(1), 34-42. https://doi.org/10.1001/jamainternmed.2016.7491

IMPORTANCE Antipsychotics are widely used for distressing symptoms of delirium, but efficacy has not been established in placebo-controlled trials in palliative care. OBJECTIVE To determine efficacy of risperidone or haloperidol relative to placebo i... Read More about Efficacy of oral risperidone, haloperidol, or placebo for symptoms of delirium among patients in palliative care: A randomized clinical trial.

Oxygen for breathlessness in patients with chronic obstructive pulmonary disease who do not qualify for home oxygen therapy (2016)
Journal Article
Ekström, M., Ahmadi, Z., Bornefalk-Hermansson, A., Abernethy, A., & Currow, D. (2016). Oxygen for breathlessness in patients with chronic obstructive pulmonary disease who do not qualify for home oxygen therapy. The Cochrane database of systematic reviews, 2016(11), https://doi.org/10.1002/14651858.CD006429.pub3

© 2016 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. Background: Breathlessness is a cardinal symptom of chronic obstructive pulmonary disease (COPD). Long-term oxygen therapy (LTOT) is given to improve survival time in people wi... Read More about Oxygen for breathlessness in patients with chronic obstructive pulmonary disease who do not qualify for home oxygen therapy.

Complementary feeding and the early origins of obesity risk: a study protocol (2016)
Journal Article
Muniandy, N. D., Allotey, P. A., Soyiri, I. N., & Reidpath, D. D. (2016). Complementary feeding and the early origins of obesity risk: a study protocol. BMJ open, 6(11), Article e011635. https://doi.org/10.1136/bmjopen-2016-011635

Introduction The rise in the prevalence of childhood obesity worldwide calls for an intervention earlier in the life cycle. Studies show that nutrition during early infancy may contribute to later obesity. Hence, this study is designed to determine i... Read More about Complementary feeding and the early origins of obesity risk: a study protocol.

Bleomycin increases neutrophil adhesion to human vascular endothelial cells independently of upregulation of ICAM-1 and E-selectin (2016)
Journal Article
Williamson, J. D., Sadofsky, L. R., Crooks, M. G., Greenman, J., & Hart, S. P. (2016). Bleomycin increases neutrophil adhesion to human vascular endothelial cells independently of upregulation of ICAM-1 and E-selectin. Experimental Lung Research, 42(8-10), 397-407. https://doi.org/10.1080/01902148.2016.1243742

© 2016 Taylor & Francis. Aim of the Study: Bleomycin-induced lung disease is a serious complication of therapy characterized by alveolar injury, cytokine release, inflammatory cell recruitment, and eventually pulmonary fibrosis. The mechanisms unde... Read More about Bleomycin increases neutrophil adhesion to human vascular endothelial cells independently of upregulation of ICAM-1 and E-selectin.

A systematic review of management of inadvertent arterial injury during central venous catheterisation (2016)
Journal Article
Dixon, O. G. B., Smith, G. E., Carradice, D., & Chetter, I. C. (2017). A systematic review of management of inadvertent arterial injury during central venous catheterisation. The journal of vascular access, 18(2), 97-102. https://doi.org/10.5301/jva.5000611

© 2017 Wichtig Publishing. Introduction: Central venous catheterisation (CVC) is a technique commonly used to obtain vascular access and over five million CVCs are inserted annually. This systematic review of CVC-related arterial injury aims to compa... Read More about A systematic review of management of inadvertent arterial injury during central venous catheterisation.

Coming of age, becoming obese: A cross-sectional analysis of obesity among adolescents and young adults in Malaysia (2016)
Journal Article
Pell, C., Allotey, P., Evans, N., Hardon, A., Imelda, J. D., Soyiri, I., Reidpath, D. D., & The SEACO Team. (2016). Coming of age, becoming obese: A cross-sectional analysis of obesity among adolescents and young adults in Malaysia. BMC public health, 16(1), Article 1082. https://doi.org/10.1186/s12889-016-3746-x

© 2016 The Author(s). Background: Malaysians have become increasingly obese over recent years. The transition from adolescence to early adulthood is recognized as critical for the development of eating and activity habits. However, little obesity-rel... Read More about Coming of age, becoming obese: A cross-sectional analysis of obesity among adolescents and young adults in Malaysia.

Somatostatin analogues compared to placebo and other pharmacological agents in the management of symptoms of inoperable malignant bowel obstruction: a systematic review (2016)
Journal Article
Obita, G. P., Boland, E. G., Currow, D. C., Johnson, M. J., & Boland, J. W. (2016). Somatostatin analogues compared to placebo and other pharmacological agents in the management of symptoms of inoperable malignant bowel obstruction: a systematic review. Journal of pain and symptom management, 52(6), 901-919. https://doi.org/10.1016/j.jpainsymman.2016.05.032

Context Somatostatin analogues are commonly used to relieve symptoms in malignant bowel obstruction (MBO) but are more expensive than other antisecretory agents. Objectives To evaluate the evidence of effectiveness of somatostatin analogues compared... Read More about Somatostatin analogues compared to placebo and other pharmacological agents in the management of symptoms of inoperable malignant bowel obstruction: a systematic review.

Altruism or obligation? The motivations and experience of women who donate oocytes to known recipients in assisted conception treatment: An Interpretative Phenomenological Analysis study. (2016)
Journal Article
Arharya, S., Bryant, L. B., & Twiddy, M. (2017). Altruism or obligation? The motivations and experience of women who donate oocytes to known recipients in assisted conception treatment: An Interpretative Phenomenological Analysis study. Journal of Psychosomatic Obstetrics and Gynecology, 38(1), 4 - 11. https://doi.org/10.1080/0167482X.2016.1233171

Introduction: This qualitative study was conducted to explore the motivations and experience of oocyte donors donating to women known to them.

Methods: Three women who donated oocytes to a close relative were interviewed and data were analysed usi... Read More about Altruism or obligation? The motivations and experience of women who donate oocytes to known recipients in assisted conception treatment: An Interpretative Phenomenological Analysis study..

Altruism or obligation? The motivations and experience of women who donate oocytes to known recipients in assisted conception treatment: an interpretative phenomenological analysis study (2016)
Journal Article
Acharya, S., Bryant, L., & Twiddy, M. (2016). Altruism or obligation? The motivations and experience of women who donate oocytes to known recipients in assisted conception treatment: an interpretative phenomenological analysis study. Journal of Psychosomatic Obstetrics and Gynecology, 38(1), 4-11. https://doi.org/10.1080/0167482X.2016.1233171

© 2016 Informa UK Limited, trading as Taylor & Francis Group. Introduction: This qualitative study was conducted to explore the motivations and experience of oocyte donors donating to women known to them. Methods: Three women who donated oocytes to... Read More about Altruism or obligation? The motivations and experience of women who donate oocytes to known recipients in assisted conception treatment: an interpretative phenomenological analysis study.

Patient-reported outcome measures for allergy and asthma in children (2016)
Journal Article
Soyiri, I. N., Nwaru, B. I., & Sheikh, A. (2016). Patient-reported outcome measures for allergy and asthma in children. Pediatric Allergy and Immunology, 27(8), 779-783. https://doi.org/10.1111/pai.12603

There is increasing recognition of the importance of patient's perceptions of disease and their assessments of heathcare processes. Patient‐reported outcome measures (PROMs) are therefore now regarded as at least as important as the traditional objec... Read More about Patient-reported outcome measures for allergy and asthma in children.

Missing data in randomized controlled trials testing palliative interventions pose a significant risk of bias and loss of power: a systematic review and meta-analyses (2016)
Journal Article
Hussain, J. A., White, I. R., Langan, D., Johnson, M. J., Currow, D. C., Torgerson, D. J., & Bland, M. (2016). Missing data in randomized controlled trials testing palliative interventions pose a significant risk of bias and loss of power: a systematic review and meta-analyses. Journal of clinical epidemiology, 74, 57-65. https://doi.org/10.1016/j.jclinepi.2015.12.003

Objectives To assess the risk posed by missing data (MD) to the power and validity of trials evaluating palliative interventions. Study Design and Setting A systematic review of MD in published randomized controlled trials (RCTs) of palliative interv... Read More about Missing data in randomized controlled trials testing palliative interventions pose a significant risk of bias and loss of power: a systematic review and meta-analyses.

Exploratory trial of a school-based alcohol prevention intervention with a family component: Implications for implementation (2016)
Journal Article
Segrott, J., Rothwell, H., Pignatelli, I., Playle, R., Hewitt, G., Huang, C., Murphy, S., Hickman, M., Reed, H., & Moore, L. (2016). Exploratory trial of a school-based alcohol prevention intervention with a family component: Implications for implementation. Health Education, 116(4), 410-431. https://doi.org/10.1108/HE-01-2015-0005

Purpose – Involvement of parents/carers may increase effectiveness of primary school-based alcohol-misuse prevention projects through strengthening family-based protective factors, but rates of parental engagement are typically low. This paper report... Read More about Exploratory trial of a school-based alcohol prevention intervention with a family component: Implications for implementation.