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Dialkylcarbamoyl chloride (DACC)-coated dressings in the management and prevention of wound infection: A systematic review

Totty, J.P.; Bua, N.; Smith, G.E.; Harwood, A.E.; Carradice, D.; Wallace, T.; Chetter, I.C.


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Mr Josh Totty
NIHR Clinical Lecturer in Plastic Surgery

N. Bua

G.E. Smith

A.E. Harwood

D. Carradice

T. Wallace

I.C. Chetter


Objective: Dialkylcarbomoyl chloride (DACC)-coated dressings (Leukomed Sorbact and Cutimed Sorbact) irreversibly bind bacteria at the wound surface that are then removed when the dressing is changed. They are a recent addition to the wound care professional's armamentarium and have been used in a variety of acute and chronic wounds. This systematic review aims to assess the evidence supporting the use of DACC-coated dressings in the clinical environment. Method: We included all reports of the clinical use of DACC-coated dressings in relation to wound infection. Medline, Embase, CENTRAL and CINAHL databases were searched to September 2016 for studies evaluating the role of DACC-coated dressings in preventing or managing wound infections. Results: We identified 17 studies with a total of 3408 patients which were included in this review. The DACC-coating was suggested to reduce postoperative surgical site infection rates and result in chronic wounds that subjectively looked cleaner and had less bacterial load on microbiological assessments. Conclusion: Existing evidence for DACC-coated dressings in managing chronic wounds or as a surgical site infection (SSI) prophylaxis is limited but encouraging with evidence in support of DACC-coated dressings preventing and treating infection without adverse effects.


Totty, J., Bua, N., Smith, G., Harwood, A., Carradice, D., Wallace, T., & Chetter, I. (2017). Dialkylcarbamoyl chloride (DACC)-coated dressings in the management and prevention of wound infection: A systematic review. Journal of Wound Care, 26(3), 107-114.

Journal Article Type Article
Acceptance Date Feb 3, 2017
Online Publication Date Mar 9, 2017
Publication Date Mar 2, 2017
Deposit Date Mar 13, 2017
Publicly Available Date Mar 13, 2017
Journal Journal of wound care
Print ISSN 0969-0700
Electronic ISSN 2052-2916
Publisher Mark Allen Healthcare
Peer Reviewed Peer Reviewed
Volume 26
Issue 3
Pages 107-114
Keywords Dialkylcarbamoyl chloride; DACC; Leukomed sorbact; Cutimed sorbact
Public URL
Publisher URL
Additional Information This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of wound care, copyright © MA Healthcare, after peer review and technical editing by the publisher. To access the final edited and published work see:


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