Dialkylcarbamoyl chloride (DACC)-coated dressings in the management and prevention of wound infection: A systematic review

Totty, J.P.; Bua, N.; Smith, G.E.; Harwood, A.E.; Carradice, D.; Wallace, T.; Chetter, I.C.

Abstract

Objective: Dialkylcarbomoyl chloride (DACC)-coated dressings (Leukomed Sorbact and Cutimed Sorbact) irreversibly bind bacteria at the wound surface that are then removed when the dressing is changed. They are a recent addition to the wound care professional's armamentarium and have been used in a variety of acute and chronic wounds. This systematic review aims to assess the evidence supporting the use of DACC-coated dressings in the clinical environment. Method: We included all reports of the clinical use of DACC-coated dressings in relation to wound infection. Medline, Embase, CENTRAL and CINAHL databases were searched to September 2016 for studies evaluating the role of DACC-coated dressings in preventing or managing wound infections. Results: We identified 17 studies with a total of 3408 patients which were included in this review. The DACC-coating was suggested to reduce postoperative surgical site infection rates and result in chronic wounds that subjectively looked cleaner and had less bacterial load on microbiological assessments. Conclusion: Existing evidence for DACC-coated dressings in managing chronic wounds or as a surgical site infection (SSI) prophylaxis is limited but encouraging with evidence in support of DACC-coated dressings preventing and treating infection without adverse effects.

Citation

Totty, J., Bua, N., Smith, G., Harwood, A., Carradice, D., Wallace, T., & Chetter, I. (2017). Dialkylcarbamoyl chloride (DACC)-coated dressings in the management and prevention of wound infection: A systematic review. Journal of Wound Care, 26(3), 107-114. https://doi.org/10.12968/jowc.2017.26.3.107

• Journal Article Type: Article
• Acceptance Date: Feb 3, 2017
• Online Publication Date: Mar 9, 2017
• Publication Date: Mar 2, 2017
• Deposit Date: Mar 13, 2017
• Publicly Available Date: Mar 13, 2017
• Journal: Journal of wound care
• Print ISSN: 0969-0700
• Publisher: MA Healthcare
• Peer Reviewed: Peer Reviewed
• Volume: 26
• Issue: 3
• Pages: 107-114
• DOI: https://doi.org/10.12968/jowc.2017.26.3.107
• Keywords: Dialkylcarbamoyl chloride; DACC; Leukomed sorbact; Cutimed sorbact
• Public URL: https://hull-repository.worktribe.com/output/449486
• Publisher URL: http://www.magonlinelibrary.com/doi/10.12968/jowc.2017.26.3.107
• Additional Information: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of wound care, copyright © MA Healthcare, after peer review and technical editing by the publisher. To access the final edited and published work see: http://www.magonlinelibrary.com/doi/10.12968/jowc.2017.26.3.107
• Contract Date: Mar 13, 2017