All Outputs (388)

Molecular mechanisms of action of negative pressure wound therapy: A systematic review (2023)
Journal Article
Ravindhran, B., Schafer, N., Howitt, A., Carradice, D., Smith, G., & Chetter, I. (2023). Molecular mechanisms of action of negative pressure wound therapy: A systematic review. Expert Reviews in Molecular Medicine, 25, Article e29. https://doi.org/10.1017/erm.2023.24

Negative pressure wound therapy (NPWT) has significantly advanced wound care and continues to find new applications. Its effects at a molecular level however, remain a subject of debate. The aim of this systematic review is to summarize the current e... Read More about Molecular mechanisms of action of negative pressure wound therapy: A systematic review.

Associations between physical activity, sedentary behaviour, and alcohol consumption among UK adults: Findings from the Health Behaviours during the COVID-19 pandemic (HEBECO) study (2023)
Journal Article
Akwa, L. G., Smith, L., Twiddy, M., Abt, G., Garnett, C., Oldham, M., Shahab, L., & Herbec, A. (2023). Associations between physical activity, sedentary behaviour, and alcohol consumption among UK adults: Findings from the Health Behaviours during the COVID-19 pandemic (HEBECO) study. PLoS ONE, 18(10 October), Article e0287199. https://doi.org/10.1371/journal.pone.0287199

Introduction The COVID-19 pandemic and attendant lockdowns have had a substantial negative effect on alcohol consumption and physical activity globally. Pre-pandemic evidence in the adult population suggests that higher levels of physical activity we... Read More about Associations between physical activity, sedentary behaviour, and alcohol consumption among UK adults: Findings from the Health Behaviours during the COVID-19 pandemic (HEBECO) study.

Breathlessness limiting exertion in very old adults: findings from the Newcastle 85+ study (2023)
Journal Article
Johnson, M. J., Pitel, L., Currow, D. C., Forbes, C., Soyiri, I., & Robinson, L. (2023). Breathlessness limiting exertion in very old adults: findings from the Newcastle 85+ study. Age and ageing, 52(9), Article afad155. https://doi.org/10.1093/ageing/afad155

INTRODUCTION: Long-term breathlessness is more common with age. However, in the oldest old (>85years), little is known about the prevalence, or impact of breathlessness. We estimated breathlessness limiting exertion prevalence and explored (i) associ... Read More about Breathlessness limiting exertion in very old adults: findings from the Newcastle 85+ study.

A randomised phase 2a study to investigate the effects of blocking interleukin-33 with tozorakimab in patients hospitalised with COVID-19: ACCORD-2 (2023)
Journal Article
Wilkinson, T., De Soyza, A., Carroll, M., Chalmers, J. D., Crooks, M. G., Griffiths, G., Shankar-Hari, M., Ho, L. P., Horsley, A., Kell, C., Lara, B., Mishra, B., Moate, R., Page, C., Pandya, H., Raw, J., Reid, F., Saralaya, D., Scott, I. C., Siddiqui, S., …on behalf of The ACCORD Collaborative Group. (2023). A randomised phase 2a study to investigate the effects of blocking interleukin-33 with tozorakimab in patients hospitalised with COVID-19: ACCORD-2. ERJ Open Research, 9(5), Article 00249-2023. https://doi.org/10.1183/23120541.00249-2023

Background Increased serum interleukin (IL)-33 predicts poor outcomes in patients hospitalised with coronavirus disease 2019 (COVID-19). We examined the efficacy and safety of tozorakimab, a monoclonal antibody that neutralises IL-33, in improving ou... Read More about A randomised phase 2a study to investigate the effects of blocking interleukin-33 with tozorakimab in patients hospitalised with COVID-19: ACCORD-2.

Surgical and rehabilitation outcomes of patients undergoing through knee amputation compared with above knee amputation (2023)
Journal Article
Gordon, H., Hebenton, J., Davie-Smith, F., Twiddy, M., Smith, G., & Carradice, D. (2023). Surgical and rehabilitation outcomes of patients undergoing through knee amputation compared with above knee amputation. Journal of Vascular Societies Great Britain and Ireland, 2(4), 208-214. https://doi.org/10.54522/jvsgbi.2023.081

Background: Through knee amputation (TKA) may offer benefits over above knee amputation (AKA) in patients unsuitable for below knee amputation. This retrospective analysis compared surgical and rehabilitation outcomes post TKA and AKA.

Methods: Al... Read More about Surgical and rehabilitation outcomes of patients undergoing through knee amputation compared with above knee amputation.

Long Covid active case finding study protocol: A co-produced community-based pilot within the STIMULATE-ICP study (Symptoms, Trajectory, Inequalities and Management: Understanding Long-COVID to Address and Transform Existing Integrated Care Pathways) (2023)
Journal Article
Alwan, N. A., Clutterbuck, D., Pantelic, M., Hayer, J., Fisher, L., Hishmeh, L., Heightman, M., Allsopp, G., Wootton, D., Khan, A., Hastie, C., Jackson, M., Rayner, C., Brown, D., Parrett, E., Jones, G., Smith, K., Clarke, R., McFarland, S., Gabbay, M., …Cleary, N. (2023). Long Covid active case finding study protocol: A co-produced community-based pilot within the STIMULATE-ICP study (Symptoms, Trajectory, Inequalities and Management: Understanding Long-COVID to Address and Transform Existing Integrated Care Pathways). PLoS ONE, 18(7 July), Article e0284297. https://doi.org/10.1371/journal.pone.0284297

Background and aim Long Covid is a significant public health concern with potentially negative implications for health inequalities. We know that those who are already socially disadvantaged in society are more exposed to COVID-19, experience the wor... Read More about Long Covid active case finding study protocol: A co-produced community-based pilot within the STIMULATE-ICP study (Symptoms, Trajectory, Inequalities and Management: Understanding Long-COVID to Address and Transform Existing Integrated Care Pathways).

Phase II, double blind, placebo controlled, multi-site study to evaluate the safety, feasibility and desirability of conducting a phase III study of anamorelin for anorexia in people with small cell lung cancer: A study protocol (LUANA trial) (2023)
Journal Article
Sousa, M. S., Martin, P., Johnson, M. J., Lind, M., Maddocks, M., Bullock, A., Agar, M., Chang, S., Kochovska, S., Kinchin, I., Morgan, D., Fazekas, B., Razmovski-Naumovski, V., Lee, J. T., Itchins, M., Bray, V., & Currow, D. C. (2023). Phase II, double blind, placebo controlled, multi-site study to evaluate the safety, feasibility and desirability of conducting a phase III study of anamorelin for anorexia in people with small cell lung cancer: A study protocol (LUANA trial). PLoS ONE, 18(5 May), Article e0285850. https://doi.org/10.1371/journal.pone.0285850

Anorexia is experienced by most people with lung cancer during the course of their disease and treatment. Anorexia reduces response to chemotherapy and the ability of patients to cope with, and complete their treatment leading to greater morbidity, p... Read More about Phase II, double blind, placebo controlled, multi-site study to evaluate the safety, feasibility and desirability of conducting a phase III study of anamorelin for anorexia in people with small cell lung cancer: A study protocol (LUANA trial).

Improving asthma care through implementation of the SENTINEL programme: findings from the pilot site (2023)
Journal Article
Crooks, M. G., Crowther, L., Cummings, H., Cohen, J., Huang, C., Pitel, L., Pearson, M., Morice, A., Turgoose, J., Faruqi, S., Watt, M., Morris, T., & Xu, Y. (2023). Improving asthma care through implementation of the SENTINEL programme: findings from the pilot site. ERJ Open Research, 9(3), Article 00685-2022. https://doi.org/10.1183/23120541.00685-2022

Aim: Short-acting β2-agonist (SABA) overuse adversely impacts asthma-related outcomes and the environment. The SABA rEductioN Through ImplemeNting Hull asthma guidELines (SENTINEL) programme aims to reduce SABA overuse through supported implementatio... Read More about Improving asthma care through implementation of the SENTINEL programme: findings from the pilot site.

Designing an intervention to help the quitters quit: A qualitative, intervention co-design study (2023)
Journal Article
Dyson, J., Skinner, J., Crick, J., & Crooks, M. G. (2023). Designing an intervention to help the quitters quit: A qualitative, intervention co-design study. PEC Innovation, 2, Article 100141. https://doi.org/10.1016/j.pecinn.2023.100141

Objective: E-cigarettes are increasingly being provided by publicly funded stop smoking services. Our objectives were to understand the challenges and establish the means by which services could best support the use and subsequent discontinuation of... Read More about Designing an intervention to help the quitters quit: A qualitative, intervention co-design study.

Telemedicine in addictions: Feasibility randomised controlled trial (2023)
Journal Article
Mayet, S., Gledhill, A., McCaw, I., Hashmani, Z., Drozdova, Z., Arshad, S., Shahbaz, S., Huang, C., & Phillips, T. (2023). Telemedicine in addictions: Feasibility randomised controlled trial. Heroin Addiction and Related Clinical Problems, 25(3), 27-36

Background. Opioid dependence is high risk. Opioid agonist treatment (OAT) improves outcomes and reduces deaths. Nonattendance at addiction specialist prescribers who monitor OAT worsens outcomes. Telemedicine has been shown to improve attendance wit... Read More about Telemedicine in addictions: Feasibility randomised controlled trial.

Telerehabilitation for patients who have been hospitalised with covid-19: a qualitative study (2023)
Journal Article
Killingback, C., Thompson, M., Nettleton, M., Hyde, L., Marshall, P., Shepherdson, J., …Simpson, A. J. (2023). Telerehabilitation for patients who have been hospitalised with covid-19: a qualitative study. Disability and Rehabilitation, https://doi.org/10.1080/09638288.2022.2159075

Purpose: The aim of this qualitative study was to explore the views of participants of a group-based, supervised, telerehabilitation programme, following discharge from hospital with Covid-19. This study was part of a single-centre, fast-track (wait-... Read More about Telerehabilitation for patients who have been hospitalised with covid-19: a qualitative study.

Multi-organ impairment and long COVID: a 1-year prospective, longitudinal cohort study (2023)
Journal Article
Dennis, A., Cuthbertson, D. J., Wootton, D., Crooks, M., Gabbay, M., Eichert, N., Mouchti, S., Pansini, M., Roca-Fernandez, A., Thomaides-Brears, H., Kelly, M., Robson, M., Hishmeh, L., Attree, E., Heightman, M., Banerjee, R., & Banerjee, A. (2023). Multi-organ impairment and long COVID: a 1-year prospective, longitudinal cohort study. Journal of the Royal Society of Medicine, 116(3), 97-112. https://doi.org/10.1177/01410768231154703

Objectives: To determine the prevalence of organ impairment in long COVID patients at 6 and 12 months after initial symptoms and to explore links to clinical presentation. Design: Prospective cohort study. Participants: Individuals. Methods: In indiv... Read More about Multi-organ impairment and long COVID: a 1-year prospective, longitudinal cohort study.

STIMULATE-ICP: A pragmatic, multi-centre, cluster randomised trial of an integrated care pathway with a nested, Phase III, open label, adaptive platform randomised drug trial in individuals with Long COVID: A structured protocol (2023)
Journal Article
Forshaw, D., Wall, E. C., Prescott, G., Dehbi, H. M., Green, A., Attree, E., Hismeh, L., Strain, W. D., Crooks, M. G., Watkins, C., Robson, C., Banerjee, R., Lorgelly, P., Heightman, M., & Banerjee, A. (2023). STIMULATE-ICP: A pragmatic, multi-centre, cluster randomised trial of an integrated care pathway with a nested, Phase III, open label, adaptive platform randomised drug trial in individuals with Long COVID: A structured protocol. PLoS ONE, 18(2), Article e0272472. https://doi.org/10.1371/journal.pone.0272472

INTRODUCTION: Long COVID (LC), the persistent symptoms ≥12 weeks following acute COVID-19, presents major threats to individual and public health across countries, affecting over 1.5 million people in the UK alone. Evidence-based interventions are ur... Read More about STIMULATE-ICP: A pragmatic, multi-centre, cluster randomised trial of an integrated care pathway with a nested, Phase III, open label, adaptive platform randomised drug trial in individuals with Long COVID: A structured protocol.

Nebulised interferon-β1a (SNG001) in hospitalised COVID-19: SPRINTER phase III study (2022)
Journal Article
Monk, P. D., Brookes, J. L., Tear, V. J., Batten, T. N., Mankowski, M., Adzic-Vukicevic, T., Crooks, M. G., Dosanjh, D. P., Kraft, M., Brightling, C. E., Gabbay, F. J., Holgate, S. T., Djukanovic, R., & Wilkinson, T. M. (2023). Nebulised interferon-β1a (SNG001) in hospitalised COVID-19: SPRINTER phase III study. ERJ Open Research, 9(2), Article 00605-2022. https://doi.org/10.1183/23120541.00605-2022

Background Despite the availability of vaccines and therapies, patients are being hospitalised with coronavirus disease 2019 (COVID-19). Interferon (IFN)-β is a naturally occurring protein that stimulates host immune responses against most viruses, i... Read More about Nebulised interferon-β1a (SNG001) in hospitalised COVID-19: SPRINTER phase III study.

Long term outcomes of ‘Christmas Tree’ banding for haemodialysis access induced distal ischemia: A 13-year experience (2022)
Journal Article
Ravindhran, B., Totty, J. P., Sidapra, M., Lathan, R., Carradice, D., Chetter, I. C., & Smith, G. E. (in press). Long term outcomes of ‘Christmas Tree’ banding for haemodialysis access induced distal ischemia: A 13-year experience. The journal of vascular access, https://doi.org/10.1177/11297298221141497

Background: The reduction in distal arterial flow following arteriovenous fistula (AVF) creation can cause a perfusion deficit known as haemodialysis access induced distal ischemia (HAIDI). Various techniques have been advocated to treat this difficu... Read More about Long term outcomes of ‘Christmas Tree’ banding for haemodialysis access induced distal ischemia: A 13-year experience.

Extracorporeal shockwave therapy compared with standard care for diabetic foot ulcer healing: An updated systematic review (2022)
Journal Article
Hitchman, L., Totty, J., Smith, G. E., Carradice, D., Twiddy, M., Iglesias, C., Russell, D., & Chetter, I. C. (2022). Extracorporeal shockwave therapy compared with standard care for diabetic foot ulcer healing: An updated systematic review. International wound journal, https://doi.org/10.1111/iwj.14035

Emerging evidence suggests that extracorporeal shockwave therapy (ESWT) may improve time to DFU healing. The aim of this review was to appraise the evidence on role of ESWT in DFU healing and impact of different ESWT doses. Databases were searched fo... Read More about Extracorporeal shockwave therapy compared with standard care for diabetic foot ulcer healing: An updated systematic review.

Provision of NICE-recommended varicose vein treatment in the NHS (2022)
Journal Article
Hitchman, L., Mohamed, A., Smith, G. E., Pymer, S., Chetter, I. C., Forsyth, J., & Carradice, D. (2023). Provision of NICE-recommended varicose vein treatment in the NHS. British journal of surgery, 110(2), 225-232. https://doi.org/10.1093/bjs/znac392

BACKGROUND: Standardization of access to treatment and compliance with clinical guidelines are important to ensure the delivery of high-quality care to people with varicose veins. In the National Health Service (NHS) in England, commissioning of care... Read More about Provision of NICE-recommended varicose vein treatment in the NHS.

Group-based pulmonary telerehabilitation is feasible, safe, beneficial and well-received in patients who have been hospitalised with COVID-19 (2022)
Journal Article
Simpson, A. J., Green, A., Nettleton, M., Hyde, L., Shepherdson, J., Killingback, C., …Crooks, M. G. (2023). Group-based pulmonary telerehabilitation is feasible, safe, beneficial and well-received in patients who have been hospitalised with COVID-19. ERJ Open Research, 9(2), Article 00373-2022. https://doi.org/10.1183/23120541.00373-2022

Introduction Coronavirus disease 2019 (COVID-19) has caused worldwide mass hospitalisation. The need for multidisciplinary post-hospitalisation rehabilitation is becoming increasingly apparent, and telerehabilitation has been endorsed. The aim of stu... Read More about Group-based pulmonary telerehabilitation is feasible, safe, beneficial and well-received in patients who have been hospitalised with COVID-19.

Recruiting to surgical trials in the emergency setting: using a mixed methods study to understand clinician and patient perspectives (2022)
Journal Article
Twiddy, M., Birtwistle, J., Edmondson, A., Croft, J., Gordon, K., Meads, D., Burke, D., Griffiths, B., Rose, A., Sagar, P., Stocken, D., Brown, J. M. B., & Harji, D. (2022). Recruiting to surgical trials in the emergency setting: using a mixed methods study to understand clinician and patient perspectives. BJS Open, 6(6), Article zrac137. https://doi.org/10.1093/bjsopen/zrac137

Background: Undertaking randomized clinical trials (RCTs) in emergency surgical settings is associated with methodological and practical challenges. This study explored patients' and clinicians' perspectives associated with the conduct of an RCT comp... Read More about Recruiting to surgical trials in the emergency setting: using a mixed methods study to understand clinician and patient perspectives.

Assessment of the diagnostic accuracy of automated ankle brachial pressure index devices in patients with diagnosed or suspected peripheral arterial disease: protocol for a systematic review and meta-analysis (2022)
Journal Article
Walshaw, J., Lathan, R., Huang, C., Staniland, T., Chetter, I., & Pymer, S. (2023). Assessment of the diagnostic accuracy of automated ankle brachial pressure index devices in patients with diagnosed or suspected peripheral arterial disease: protocol for a systematic review and meta-analysis. Journal of Vascular Societies Great Britain and Ireland, 2(2), 91-96. https://doi.org/10.54522/jvsgbi.2022.053

Background: The ankle brachial pressure index (ABPI) is a common diagnostic tool used in the assessment of peripheral arterial disease (PAD). The Doppler ultrasound technique is regarded as the gold-standard method for ABPI measurement; however, time... Read More about Assessment of the diagnostic accuracy of automated ankle brachial pressure index devices in patients with diagnosed or suspected peripheral arterial disease: protocol for a systematic review and meta-analysis.