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All Outputs (388)

Factors Influencing the Implementation of Digital Advance Care Planning: Qualitative Interview Study (2024)
Journal Article
Bradshaw, A., Birtwistle, J., Evans, C. J., Sleeman, K. E., Richards, S., Foy, R., Martin, P. M., Carder, P., Allsop, M. J., & Twiddy, M. (2024). Factors Influencing the Implementation of Digital Advance Care Planning: Qualitative Interview Study. Journal of medical Internet research, 26, Article e50217. https://doi.org/10.2196/50217

BACKGROUND: Palliative care aims to improve the quality of life for people with life-limiting illnesses. Advance care planning conversations that establish a patient's wishes and preferences for care are part of a person-centered approach. Internatio... Read More about Factors Influencing the Implementation of Digital Advance Care Planning: Qualitative Interview Study.

"What influences how well householders living in previously flooded communities feel they are protected or could recover from future flooding?: Results of a survey" (2024)
Journal Article
Twiddy, M., & Ramsden, S. (2024). "What influences how well householders living in previously flooded communities feel they are protected or could recover from future flooding?: Results of a survey". PLoS ONE, 19(8 AUGUST), Article e0306593. https://doi.org/10.1371/journal.pone.0306593

In England, the Environment Agency (EA) estimates that over 3 million properties in England are at risk of surface water flooding. Heavy and prolonged rainfall that drives surface water flooding is projected to increase in the future due to climate c... Read More about "What influences how well householders living in previously flooded communities feel they are protected or could recover from future flooding?: Results of a survey".

The association between completion of supervised exercise therapy and long-term outcomes in patients with intermittent claudication, concomitant sarcopenia and cardiometabolic multimorbidity (2024)
Journal Article
Ravindhran, B., Igwe, C., Nazir, S., Prosser, J., Harwood, A., Lathan, R., Harwood, A. E., Carradice, D., Smith, G. E., Chetter, I. C., & Pymer, S. (online). The association between completion of supervised exercise therapy and long-term outcomes in patients with intermittent claudication, concomitant sarcopenia and cardiometabolic multimorbidity. Annals of vascular surgery, https://doi.org/10.1016/j.avsg.2024.04.032

Introduction: The combination of intermittent claudication (IC), cardiometabolic multimorbidity (CMM), and sarcopenia is associated with worse outcomes than IC alone. This study aimed to identify whether the completion of supervised exercise therapy... Read More about The association between completion of supervised exercise therapy and long-term outcomes in patients with intermittent claudication, concomitant sarcopenia and cardiometabolic multimorbidity.

Integrated care policy recommendations for complex multisystem long term conditions and long COVID (2024)
Journal Article
van der Feltz-Cornelis, C. M., Sweetman, J., Turk, F., Allsopp, G., Gabbay, M., Khunti, K., Williams, N., Montgomery, H., Heightman, M., Lip, G. Y., Crooks, M. G., Strain, W. D., Loveless, A., Hishmeh, L., Smith, N., & Banerjee, A. (2024). Integrated care policy recommendations for complex multisystem long term conditions and long COVID. Scientific reports, 14(1), Article 13634. https://doi.org/10.1038/s41598-024-64060-1

The importance of integrated care for complex, multiple long term conditions was acknowledged before the COVID pandemic but remained a challenge. The pandemic and consequent development of Long COVID required rapid adaptation of health services to ad... Read More about Integrated care policy recommendations for complex multisystem long term conditions and long COVID.

Nebulised interferon beta-1a (SNG001) in the treatment of viral exacerbations of COPD (2024)
Journal Article
Monk, P. D., Brookes, J. L., Tear, V. J., Batten, T. N., Newall, C., Mankowski, M., Crooks, M. G., Singh, D., Chaudhuri, R., Leaker, B., Lunn, K., Reynolds, S., Dudley, S., Gabbay, F. J., Holgate, S. T., Djukanovic, R., & Wilkinson, T. M. (2024). Nebulised interferon beta-1a (SNG001) in the treatment of viral exacerbations of COPD. Respiratory Research, 25(1), Article 228. https://doi.org/10.1186/s12931-024-02854-7

Background: Respiratory viral infections are major drivers of chronic obstructive pulmonary disease (COPD) exacerbations. Interferon-β is naturally produced in response to viral infection, limiting replication. This exploratory study aimed to demonst... Read More about Nebulised interferon beta-1a (SNG001) in the treatment of viral exacerbations of COPD.

The prognostic value of simple frailty and malnutrition screening tools for determining surgical risk in patients with chronic limb threatening ischaemia undergoing major vascular surgery: A retrospective cross-sectional study (2024)
Journal Article
Palmer, J., Pymer, S., Smith, G., Ingle, L., Harwood, A., & Chetter, I. (online). The prognostic value of simple frailty and malnutrition screening tools for determining surgical risk in patients with chronic limb threatening ischaemia undergoing major vascular surgery: A retrospective cross-sectional study. Journal of Vascular Societies Great Britain and Ireland, https://doi.org/10.54522/jvsgbi.2024.124

Background: This study aims to explore the prognostic value of simple frailty and malnutrition tools for determining postoperative outcomes at 30 days and 1 year in patients with CLTI undergoing major surgery.
Methods: This was a single-centre retr... Read More about The prognostic value of simple frailty and malnutrition screening tools for determining surgical risk in patients with chronic limb threatening ischaemia undergoing major vascular surgery: A retrospective cross-sectional study.

Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 (2024)
Journal Article
Brauer, M., Roth, G. A., & Soyiri, I. (2024). Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet, 403(10440), 2162-2203. https://doi.org/10.1016/S0140-6736%2824%2900933-4

Background: Understanding the health consequences associated with exposure to risk factors is necessary to inform public health policy and practice. To systematically quantify the contributions of risk factor exposures to specific health outcomes, th... Read More about Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021.

Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021 (2024)
Journal Article
Schumacher, A. E., Hmwe Kyu, H., & Soyiri, I. N. (2024). Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021. Lancet, 403(10440), 1989-2056. https://doi.org/10.1016/S0140-6736%2824%2900476-8

Background: Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this... Read More about Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021.

Home-based high intensity interval training in patients with intermittent claudication: a systematic review protocol (2024)
Journal Article
Prosser, J., Staniland, T., Harwood, A., Ravindhran, B., McGregor, G., Huang, C., Twiddy, M., Nicholls, A., Ingle, L., Long, J., Chetter, I., & Pymer, S. (2024). Home-based high intensity interval training in patients with intermittent claudication: a systematic review protocol. Journal of Vascular Societies Great Britain and Ireland, 3(3), 155-159. https://doi.org/10.54522/jvsgbi.2024.103

Introduction: The aim of this systematic review is to consider the evidence base for home-based high intensity interval training (HIIT) in patients with intermittent claudication (IC). Prior knowledge of the evidence base suggests that there may be l... Read More about Home-based high intensity interval training in patients with intermittent claudication: a systematic review protocol.

Outcomes in patients treated with loop diuretics without a diagnosis of heart failure: a retrospective cohort study (2024)
Journal Article
Cuthbert, J. J., Soyiri, I., Lomax, S. J., Turgoose, J., Fuat, A., Cohen, J., & Clark, A. L. (2024). Outcomes in patients treated with loop diuretics without a diagnosis of heart failure: a retrospective cohort study. Heart, 110(12), 854-862. https://doi.org/10.1136/heartjnl-2023-323577

Background Loop diuretics are commonly prescribed in the community, not always to patients with a recorded diagnosis of heart failure (HF). The rate of HF events in patients prescribed loop diuretics without a diagnosis of HF is unknown. Methods This... Read More about Outcomes in patients treated with loop diuretics without a diagnosis of heart failure: a retrospective cohort study.

Creating more comparable cohorts in observational palliative care studies: A proposed framework to improve applicability and replicability of research (2024)
Journal Article
Kochovska, S., Murtagh, F. E., Agar, M., Phillips, J. L., Dudgeon, D., Lujic, S., Johnson, M., & Currow, D. C. (2024). Creating more comparable cohorts in observational palliative care studies: A proposed framework to improve applicability and replicability of research. Palliative medicine, https://doi.org/10.1177/02692163241234227

Background: Palliative care is characterised by heterogeneous patient and caregiver populations who are provided care in different health systems and a research base including a large proportion of observational, mostly retrospective studies. The inh... Read More about Creating more comparable cohorts in observational palliative care studies: A proposed framework to improve applicability and replicability of research.

A feasibility survey to inform trial design investigating surgical site infection prevention in vascular surgery (2024)
Journal Article
Lathan, R., Hitchman, L., Long, J., Gwilym, B., Wall, M., Juszczak, M., Smith, G., Popplewell, M., Bosanquet, D., Hinchliffe, R., Pinkney, T., & Chetter, I. (2024). A feasibility survey to inform trial design investigating surgical site infection prevention in vascular surgery. Journal of Vascular Societies Great Britain and Ireland, 3(2), 76-83. https://doi.org/10.54522/jvsgbi.2024.116

Introduction: Current surgical site infection (SSI) prevention guidance indicates low-quality evidence supporting many of their recommendations. Subsequently, there is substantial variation in practice and often implementation of unsubstantiated inte... Read More about A feasibility survey to inform trial design investigating surgical site infection prevention in vascular surgery.

Tailored risk assessment and forecasting in intermittent claudication (2024)
Journal Article
Ravindhran, B., Prosser, J., Lim, A., Lathan, R., Mishra, B., Hitchman, L., Smith, G. E., Carradice, D., Thakker, D., Chetter, I. C., & Pymer, S. (2024). Tailored risk assessment and forecasting in intermittent claudication. BJS Open, 8(1), Article zrad166. https://doi.org/10.1093/bjsopen/zrad166

Background: Guidelines recommend cardiovascular risk reduction and supervised exercise therapy as the first line of treatment in intermittent claudication, but implementation challenges and poor patient compliance lead to significant variation in man... Read More about Tailored risk assessment and forecasting in intermittent claudication.

High INtensity Interval Training in pATiEnts with Intermittent Claudication: A Qualitative Acceptability Study (2024)
Journal Article
Pymer, S., Harwood, A., Ibeggazene, S., McGregor, G., Huang, C., Nicholls, A., Ingle, L., Long, J., Rooms, M., Chetter, I. C., & Twiddy, M. (2024). High INtensity Interval Training in pATiEnts with Intermittent Claudication: A Qualitative Acceptability Study. Annals of vascular surgery, 102, 17-24. https://doi.org/10.1016/j.avsg.2023.11.043

Background: A novel high-intensity interval training (HIIT) program has demonstrated feasibility for patients with intermittent claudication (IC). The aim of this study was to explore patient perspectives of the HIIT program to inform refinement and... Read More about High INtensity Interval Training in pATiEnts with Intermittent Claudication: A Qualitative Acceptability Study.

Views of patients with progressive illness and carers about the role of digital advance care planning systems to record and share information: a qualitative study (2024)
Journal Article
Birtwistle, J., Allsop, M. J., Bradshaw, A., Millares Martin, P., Sleeman, K. E., Twiddy, M., & Evans, C. J. (2024). Views of patients with progressive illness and carers about the role of digital advance care planning systems to record and share information: a qualitative study. Palliative medicine, 38(7), 711-724. https://doi.org/10.1177/02692163241255511

Background: Digital approaches are being explored internationally to support the elicitation, documentation and sharing of advance care planning information. However, the views and experiences of patients and carers are little understood, impeding th... Read More about Views of patients with progressive illness and carers about the role of digital advance care planning systems to record and share information: a qualitative study.

Evaluating the Role of Ultrasound in Prostate Cancer trial – phase 1: Early experience of micro-ultrasound in the United Kingdom (2024)
Journal Article
Parker, P., Twiddy, M., Rigby, A., Whybrow, P., & Simms, M. (2024). Evaluating the Role of Ultrasound in Prostate Cancer trial – phase 1: Early experience of micro-ultrasound in the United Kingdom. Ultrasound, https://doi.org/10.1177/1742271X231226302

Purpose: The purpose of this study was to evaluate if the use of micro-ultrasound can detect clinically significant prostate pathology when compared to histology obtained during a transperineal prostate biopsy. Methods: Patients suspected of having p... Read More about Evaluating the Role of Ultrasound in Prostate Cancer trial – phase 1: Early experience of micro-ultrasound in the United Kingdom.

Patient influence on general practice service improvement decision making: a participatory research mixed-methods intervention study (2023)
Journal Article
Drinkwater, J., MacFarlane, A., Twiddy, M., Meads, D., Chadwick, R. H., Donnelly, A., Gleeson, P., Hayward, N., Kelly, M., Mir, R., Prestwich, G., Rathfelder, M., & Foy, R. (2024). Patient influence on general practice service improvement decision making: a participatory research mixed-methods intervention study. The British journal of general practice : the journal of the Royal College of General Practitioners, 74(745), e552-e559. https://doi.org/10.3399/BJGP.2023.0263

BACKGROUND: Health policy promotes patient participation in decision making about service organisation. In English general practice this happens through contractually required patient participation groups (PPGs). However, there are problems with the... Read More about Patient influence on general practice service improvement decision making: a participatory research mixed-methods intervention study.

Pathways to care for Long COVID and for long-term conditions from patients' and clinicians' perspective (2023)
Journal Article
Turk, F., Sweetman, J., Allsopp, G., Crooks, M., Cuthbertson, D. J., Gabbay, M., Hishmeh, L., Lip, G. Y., Strain, W. D., Williams, N., Wootton, D., Banerjee, A., & van der Feltz-Cornelis, C. (2023). Pathways to care for Long COVID and for long-term conditions from patients' and clinicians' perspective. Journal of Evidence-Based Medicine, 16(4), 435-437. https://doi.org/10.1111/jebm.12563

Supervised Exercise Therapy for Intermittent Claudication: A Propensity Score Matched Analysis of Retrospective Data on Long Term Cardiovascular Outcomes (2023)
Journal Article
Ravindhran, B., Lim, A. J., Kurian, T., Walshaw, J., Hitchman, L. H., Lathan, R., Smith, G. E., Carradice, D., Chetter, I. C., & Pymer, S. (in press). Supervised Exercise Therapy for Intermittent Claudication: A Propensity Score Matched Analysis of Retrospective Data on Long Term Cardiovascular Outcomes. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, https://doi.org/10.1016/j.ejvs.2023.11.040

Objective: This study aimed to explore the long term outcomes of patients with intermittent claudication (IC) who completed supervised exercise therapy (SET) vs. those who declined or prematurely discontinued SET, focusing on the incidence of chronic... Read More about Supervised Exercise Therapy for Intermittent Claudication: A Propensity Score Matched Analysis of Retrospective Data on Long Term Cardiovascular Outcomes.