All Outputs (163)

The effect of boundary constraints on finite element modelling of the human pelvis (2017)
Journal Article
Watson, P., Dostanpor, A., Fagan, M. J., & Dobson, C. A. (2017). The effect of boundary constraints on finite element modelling of the human pelvis. Medical engineering & physics, 43, 48-57. https://doi.org/10.1016/j.medengphy.2017.02.001

The use of finite element analysis (FEA) to investigate the biomechanics of anatomical systems critically relies on the specification of physiologically representative boundary conditions. The biomechanics of the pelvis has been the specific focus of... Read More about The effect of boundary constraints on finite element modelling of the human pelvis.

Computational biomechanics changes our view on insect head evolution (2017)
Journal Article
Blanke, A., Watson, P. J., Holbrey, R., & Fagan, M. J. (2017). Computational biomechanics changes our view on insect head evolution. Proceedings of the Royal Society B: Biological Sciences, 284(1848), Article 20162412. https://doi.org/10.1098/rspb.2016.2412

© 2017 The Author(s) Published by the Royal Society. All rights reserved. Despite large-scale molecular attempts, the relationships of the basal winged insect lineages dragonflies, mayflies and neopterans, are still unresolved. Other data sources, su... Read More about Computational biomechanics changes our view on insect head evolution.

Morphological evolution of the mammalian jaw adductor complex (2016)
Journal Article
Lautenschlager, S., Gill, P., Luo, Z.-X., Fagan, M. J., & Rayfield, E. J. (2017). Morphological evolution of the mammalian jaw adductor complex. Biological Reviews, 92(4), 1910-1940. https://doi.org/10.1111/brv.12314

The evolution of the mammalian jaw during the transition from non-mammalian synapsids to crown mammals is a key event in vertebrate history and characterised by the gradual reduction of its individual bones into a single element and the concomitant t... Read More about Morphological evolution of the mammalian jaw adductor complex.

Accuracy of pulse interval timing in ambulatory blood pressure measurement (2016)
Journal Article
Kane, S. A., Blake, J. R., McArdle, F. J., Langley, P., & Sims, A. J. (2016). Accuracy of pulse interval timing in ambulatory blood pressure measurement. Scientific reports, 6(1), Article 37472. https://doi.org/10.1038/srep37472

Blood pressure (BP) monitors rely on pulse detection. Some blood pressure monitors use pulse timings to analyse pulse interval variability for arrhythmia screening, but this assumes that the pulse interval timings detected from BP cuffs are accurate... Read More about Accuracy of pulse interval timing in ambulatory blood pressure measurement.

A study on stability analysis of atrial repolarization variability using ARX model in sinus rhythm and atrial tachycardia ECGs (2016)
Journal Article
Sivaraman, J., Uma, G., Langley, P., Umapathy, M., Venkatesan, S., & Palanikumar, G. (2016). A study on stability analysis of atrial repolarization variability using ARX model in sinus rhythm and atrial tachycardia ECGs. Computer Methods and Programs in Biomedicine, 137, 341-351. https://doi.org/10.1016/j.cmpb.2016.10.005

© 2016 Elsevier Ireland Ltd Background The interaction between the PTa and PP interval dynamics from the surface ECG is seldom explained. Mathematical modeling of these intervals is of interest in finding the relationship between the heart rate and r... Read More about A study on stability analysis of atrial repolarization variability using ARX model in sinus rhythm and atrial tachycardia ECGs.

The atrial T wave: The elusive electrocardiographic wave exposed by a case of shifting atrial pacemaker (2016)
Journal Article
Langley, P., & Caldwell, J. (2016). The atrial T wave: The elusive electrocardiographic wave exposed by a case of shifting atrial pacemaker. Journal of Electrocardiology, 49(4), 557-559. https://doi.org/10.1016/j.jelectrocard.2016.05.003

The atrial T wave (Ta wave) is the body surface manifestation of atrial repolarisation and, unlike the P wave (atrial depolarisation), is little recognised. We report the case of a patient with shifting pacemaker which clearly demonstrates the effect... Read More about The atrial T wave: The elusive electrocardiographic wave exposed by a case of shifting atrial pacemaker.

Opportunistic detection of atrial fibrillation using blood pressure monitors: a systematic review (2016)
Journal Article
Kane, S. A., Blake, J. R., McArdle, F. J., Langley, P., & Sims, A. J. (2016). Opportunistic detection of atrial fibrillation using blood pressure monitors: a systematic review. Open heart, 3(1), e000362. https://doi.org/10.1136/openhrt-2015-000362

Background: Atrial Fibrillation (AF) affects around 2% of the population and early detection is beneficial, allowing patients to begin potentially life-saving anticoagulant therapies. Blood pressure (BP) monitors may offer an opportunity to screen fo... Read More about Opportunistic detection of atrial fibrillation using blood pressure monitors: a systematic review.

A non-invasive, home-based EEG hypoglycaemia warning system for personal monitoring using skin surface electrodes : a single-case feasibility study (2016)
Journal Article
Clewett, C. J., Langley, P., Bateson, A. D., Asghar, A., & Wilkinson, A. J. (2016). A non-invasive, home-based EEG hypoglycaemia warning system for personal monitoring using skin surface electrodes : a single-case feasibility study. Health Technology Letters, 3(1), 2-5. https://doi.org/10.1049/htl.2015.0037

Hypoglycaemia unawareness is a common condition associated with increased risk of severe hypoglycaemia. The purpose of the authors' study was to develop a simple to use, home-based and non-invasive hypoglycaemia warning system based on electroencepha... Read More about A non-invasive, home-based EEG hypoglycaemia warning system for personal monitoring using skin surface electrodes : a single-case feasibility study.

Abnormal heart sounds detected from short duration unsegmented phonocardiograms by wavelet entropy (2016)
Presentation / Conference Contribution
Langley, P., & Murray, A. Abnormal heart sounds detected from short duration unsegmented phonocardiograms by wavelet entropy

© 2016 CCAL. Segmentation of the characteristic heart sounds is thought to be an essential requirement for the automatic classification of phonocardiograms. The aim of this work was to test the feasibility of classification using short duration, unse... Read More about Abnormal heart sounds detected from short duration unsegmented phonocardiograms by wavelet entropy.

Application of Far Cortical Locking Technology in Periprosthetic Femoral Fracture Fixation: A Biomechanical Study (2016)
Journal Article
Moazen, M., Leonidou, A., Pagkalos, J., Marghoub, A., Fagan, M. J., & Tsiridis, E. (2016). Application of Far Cortical Locking Technology in Periprosthetic Femoral Fracture Fixation: A Biomechanical Study. Journal of Arthroplasty, 31(8), 1849-1856. https://doi.org/10.1016/j.arth.2016.02.013

© 2016 Elsevier Inc. Background Lack of fracture movement could be a potential cause of periprosthetic femoral fracture (PFF) fixation failures. This study aimed to test whether the use of distal far cortical locking screws reduces the overall stiffn... Read More about Application of Far Cortical Locking Technology in Periprosthetic Femoral Fracture Fixation: A Biomechanical Study.

The U wave in atrial fibrillation (2016)
Presentation / Conference Contribution
Langley, P., Bourke, J. P., & Murray, A. The U wave in atrial fibrillation. Presented at 2015 Computing in Cardiology Conference (CinC)

The U wave in ECGs of patients is difficult to observe because it is hidden under the atrial fibrillatory wave. Measurement and characteristics of the U wave in atrial fibrillation have not previously been described. Beat averaging was used to reveal... Read More about The U wave in atrial fibrillation.

The Impact of Vein Mechanical Compliance on Arteriovenous Fistula Outcomes (2016)
Journal Article
Smith, G. E., Barnes, R., Chetter, I. C., Barnes, R., & Fagan, M. (2016). The Impact of Vein Mechanical Compliance on Arteriovenous Fistula Outcomes. Annals of vascular surgery, 32, 9-14. https://doi.org/10.1016/j.avsg.2015.11.002

© 2016 Elsevier Inc. Background Arteriovenous fistulae (AVFs) are the preferred access for hemodialysis but suffer a high early failure rate. The aim of this study was to determine how venous distensibility, as measured in vitro, relates to early out... Read More about The Impact of Vein Mechanical Compliance on Arteriovenous Fistula Outcomes.

Skeletal immaturity, rostral sparing, and disparate hip morphologies as biomechanical causes for Legg-Calvé-Perthes’ disease (2016)
Journal Article
Berthaume, M. A., Perry, D. C., Dobson, C. A., Witzel, U., Clarke, N. M., & Fagan, M. J. (2016). Skeletal immaturity, rostral sparing, and disparate hip morphologies as biomechanical causes for Legg-Calvé-Perthes’ disease. Clinical Anatomy, 29(6), 759-772. https://doi.org/10.1002/ca.22690

Legg-Calvé-Perthes' (Perthes') disease is a developmental disease of the hip joint that may result in numerous short and long term problems. The etiology of the disease remains largely unknown, but the mechanism is believed to be vascular and/or biom... Read More about Skeletal immaturity, rostral sparing, and disparate hip morphologies as biomechanical causes for Legg-Calvé-Perthes’ disease.

Integrating user-centred design in the development of a silent speech interface based on permanent magnetic articulography (2015)
Book Chapter
Cheah, L. A., Gilbert, J. M., Gonzalez, J. A., Bai, J., Ell, S. R., Fagan, M. J., Moore, R. K., Green, P. D., & Rychenko, S. I. (2015). Integrating user-centred design in the development of a silent speech interface based on permanent magnetic articulography. In Biomedical Engineering Systems and Technologies; Communications in Computer and Information Science (324-337). Springer Verlag. https://doi.org/10.1007/978-3-319-27707-3_20

Abstract: A new wearable silent speech interface (SSI) based on Permanent Magnetic Articulography (PMA) was developed with the involvement of end users in the design process. Hence, desirable features such as appearance, port-ability, ease of use and... Read More about Integrating user-centred design in the development of a silent speech interface based on permanent magnetic articulography.

Intracranial pressure changes during mouse development (2015)
Journal Article
Moazen, M., Alazmani, A., Rafferty, K., Liu, Z.-J., Gustafson, J., Cunningham, M. L., Fagan, M. J., & Herring, S. W. (2016). Intracranial pressure changes during mouse development. Journal of biomechanics, 49(1), 123-126. https://doi.org/10.1016/j.jbiomech.2015.11.012

During early stages of postnatal development, pressure from the growing brain as well as cerebrospinal fluid, i.e. intracranial pressure (ICP), load the calvarial bones. It is likely that such loading contributes to the peripheral bone formation at t... Read More about Intracranial pressure changes during mouse development.

Validity and sensitivity of a human cranial finite element model: Implications for comparative studies of biting performance (2015)
Journal Article
Toro-Ibacache, V., Fitton, L. C., Fagan, M. J., & O'Higgins, P. (2016). Validity and sensitivity of a human cranial finite element model: Implications for comparative studies of biting performance. Journal of anatomy, 228(1), 70-84. https://doi.org/10.1111/joa.12384

Finite element analysis (FEA) is a modelling technique increasingly used in anatomical studies investigating skeletal form and function. In the case of the cranium this approach has been applied to both living and fossil taxa to (for example) investi... Read More about Validity and sensitivity of a human cranial finite element model: Implications for comparative studies of biting performance.

Wavelet entropy as a measure of ventricular beat suppression from the electrocardiogram in atrial fibrillation (2015)
Journal Article
Langley, P. (2015). Wavelet entropy as a measure of ventricular beat suppression from the electrocardiogram in atrial fibrillation. Entropy, 17(9), 6397-6411. https://doi.org/10.3390/e17096397

A novel method of quantifying the effectiveness of the suppression of ventricular activity from electrocardiograms (ECGs) in atrial fibrillation is proposed. The temporal distribution of the energy of wavelet coefficients is quantified by wavelet ent... Read More about Wavelet entropy as a measure of ventricular beat suppression from the electrocardiogram in atrial fibrillation.

Effect of catheter ablation on quality of life in patients with atrial fibrillation and its correlation with arrhythmia outcome (2015)
Journal Article
Raine, D., Langley, P., Shepherd, E., Lord, S., Murray, S., Murray, A., & Bourke, J. P. (2015). Effect of catheter ablation on quality of life in patients with atrial fibrillation and its correlation with arrhythmia outcome. Open heart, 2(1), e000302. https://doi.org/10.1136/openhrt-2015-000302

Objective To assess the effect of catheter ablation on atrial fibrillation (AF) symptoms and quality of life (QoL). Methods Patients with AF scheduled for ablation were recruited. Pulmonary vein isolation (PVI) was performed and complex fractionated... Read More about Effect of catheter ablation on quality of life in patients with atrial fibrillation and its correlation with arrhythmia outcome.

A virtual approach to evaluate therapies for management of multiple myeloma induced bone disease: Modelling Therapies for Multiple Myeloma Induced Bone Disease (2015)
Journal Article
Ji, B., Genever, P. G., & Fagan, M. J. (2016). A virtual approach to evaluate therapies for management of multiple myeloma induced bone disease: Modelling Therapies for Multiple Myeloma Induced Bone Disease. International journal for numerical methods in biomedical engineering, 32(3), e02735. https://doi.org/10.1002/cnm.2735

Multiple myeloma bone disease is devastating for patients and a major cause of morbidity. The disease leads to bone destruction by inhibiting osteoblast activity while stimulating osteoclast activity. Recent advances in multiple myeloma research have... Read More about A virtual approach to evaluate therapies for management of multiple myeloma induced bone disease: Modelling Therapies for Multiple Myeloma Induced Bone Disease.

Mechanical properties of calvarial bones in a mouse model for craniosynostosis (2015)
Journal Article
Moazen, M., Peskett, E., Babbs, C., Pauws, E., & Fagan, M. J. (2015). Mechanical properties of calvarial bones in a mouse model for craniosynostosis. PLoS ONE, 10(5), e0125757. https://doi.org/10.1371/journal.pone.0125757

The mammalian cranial vault largely consists of five flat bones that are joined together along their edges by soft fibrous tissues called sutures. Premature closure of the cranial sutures, craniosynostosis, can lead to serious clinical pathology unle... Read More about Mechanical properties of calvarial bones in a mouse model for craniosynostosis.