All Outputs (17)

Socioeconomic status and older adult’s experiences of weight loss: a qualitative secondary analysis (2025)
Journal Article
Bullock, A., Newton-Clarke, A., Johnson, M. J., Murtagh, F. E., & Nwulu, U. (2025). Socioeconomic status and older adult’s experiences of weight loss: a qualitative secondary analysis. PLoS ONE, 20(4), Article e0321313. https://doi.org/10.1371/journal.pone.0321313

Objectives: Unintentional weight loss in older adults is common, with 15-20% of those aged >65 having clinically significant weight loss, associated with increased mortality and morbidity. People with socioeconomic disadvantage are more likely to be... Read More about Socioeconomic status and older adult’s experiences of weight loss: a qualitative secondary analysis.

Optimisation of the preparation phase for orthopaedic surgery: Study protocol for a student-led multimodal prehabilitation feasibility trial (BoneFit) (2025)
Journal Article
Ingle, L., Snook, J., Smith, L., Oliver, B., Bray, J., Wells, L., Moorhouse, J., Dixon, L., Simpson, P., Osman, S., Saxton, J., Rajendran, A., Gopalakrishnan, G., & Symes, T. (2025). Optimisation of the preparation phase for orthopaedic surgery: Study protocol for a student-led multimodal prehabilitation feasibility trial (BoneFit). PLoS ONE, 20(2 February), Article e0314680. https://doi.org/10.1371/journal.pone.0314680

Background Since the Covid-19 pandemic, a surgical backlog for total hip replacement (THR) and total knee replacement (TKR) surgery remains in the United Kingdom. Multimodal prehabilitation pathways (encompassing exercise, nutritional support and psy... Read More about Optimisation of the preparation phase for orthopaedic surgery: Study protocol for a student-led multimodal prehabilitation feasibility trial (BoneFit).

The Effect of a Very-Low-Calorie Diet (VLCD) vs. a Moderate Energy Deficit Diet in Obese Women with Polycystic Ovary Syndrome (PCOS)—A Randomised Controlled Trial (2023)
Journal Article
Deshmukh, H., Papageorgiou, M., Wells, L., Akbar, S., Strudwick, T., Deshmukh, K., Vitale, S. G., Rigby, A., Vince, R. V., Reid, M., & Sathyapalan, T. (2023). The Effect of a Very-Low-Calorie Diet (VLCD) vs. a Moderate Energy Deficit Diet in Obese Women with Polycystic Ovary Syndrome (PCOS)—A Randomised Controlled Trial. Nutrients, 15(18), Article 3872. https://doi.org/10.3390/nu15183872

We performed an open-label, randomised controlled trial to compare the effects of a very-low-calorie diet (VLCD) vs. moderate energy deficit approach on body weight, body composition, free androgen index (FAI), and metabolic markers in obese women wi... Read More about The Effect of a Very-Low-Calorie Diet (VLCD) vs. a Moderate Energy Deficit Diet in Obese Women with Polycystic Ovary Syndrome (PCOS)—A Randomised Controlled Trial.

Phase II, double blind, placebo controlled, multi-site study to evaluate the safety, feasibility and desirability of conducting a phase III study of anamorelin for anorexia in people with small cell lung cancer: A study protocol (LUANA trial) (2023)
Journal Article
Sousa, M. S., Martin, P., Johnson, M. J., Lind, M., Maddocks, M., Bullock, A., Agar, M., Chang, S., Kochovska, S., Kinchin, I., Morgan, D., Fazekas, B., Razmovski-Naumovski, V., Lee, J. T., Itchins, M., Bray, V., & Currow, D. C. (2023). Phase II, double blind, placebo controlled, multi-site study to evaluate the safety, feasibility and desirability of conducting a phase III study of anamorelin for anorexia in people with small cell lung cancer: A study protocol (LUANA trial). PLoS ONE, 18(5 May), Article e0285850. https://doi.org/10.1371/journal.pone.0285850

Anorexia is experienced by most people with lung cancer during the course of their disease and treatment. Anorexia reduces response to chemotherapy and the ability of patients to cope with, and complete their treatment leading to greater morbidity, p... Read More about Phase II, double blind, placebo controlled, multi-site study to evaluate the safety, feasibility and desirability of conducting a phase III study of anamorelin for anorexia in people with small cell lung cancer: A study protocol (LUANA trial).

Inoperable malignant bowel obstruction: palliative interventions outcomes-mixed-methods systematic review (2022)
Journal Article
Patterson, M., Greenley, S., Ma, Y., Bullock, A., Curry, J., Smithson, J., Lind, M., & Johnson, M. J. (2022). Inoperable malignant bowel obstruction: palliative interventions outcomes-mixed-methods systematic review. BMJ supportive & palliative care, Article 003492. https://doi.org/10.1136/bmjspcare-2021-003492

Background: Parenteral nutrition (PN) and palliative venting gastrostomies (PVG) are two interventions used clinically to manage inoperable malignant bowel obstruction (MBO); however, little is known about their role in clinical and quality-of-life o... Read More about Inoperable malignant bowel obstruction: palliative interventions outcomes-mixed-methods systematic review.

Patient, family and carer experiences of nutritional screening: a systematic review (2020)
Journal Article
Bullock, A., Greenley, S. L., Patterson, M. J., McKenzie, G. A. G., & Johnson, M. J. (2021). Patient, family and carer experiences of nutritional screening: a systematic review. Journal of Human Nutrition and Dietetics, 34(3), 595-603. https://doi.org/10.1111/jhn.12849

Background: Despite recommendations for nutritional risk screening of all inpatients, outpatients and care home residents, as well as work to assess clinician's experiences and the validity of tools, little attention has been paid to the experiences... Read More about Patient, family and carer experiences of nutritional screening: a systematic review.

Implementation of geriatric assessment in oncology settings: A systematic realist review (2020)
Journal Article
McKenzie, G. A., Bullock, A. F., Greenley, S. L., Lind, M. J., Johnson, M. J., & Pearson, M. (2021). Implementation of geriatric assessment in oncology settings: A systematic realist review. Journal of Geriatric Oncology, 12(1), 22-33. https://doi.org/10.1016/j.jgo.2020.07.003

Older adults with cancer are more likely to have worse clinical outcomes than their younger counterparts, and shared decision-making can be difficult, due to both complexity from adverse ageing and under-representation in clinical trials. Geriatric a... Read More about Implementation of geriatric assessment in oncology settings: A systematic realist review.

Relationship between markers of malnutrition and clinical outcomes in older adults with cancer: systematic review, narrative synthesis and meta-analysis (2020)
Journal Article
Bullock, A. F., Greenley, S. L., McKenzie, G. A., Paton, L. W., & Johnson, M. J. (2020). Relationship between markers of malnutrition and clinical outcomes in older adults with cancer: systematic review, narrative synthesis and meta-analysis. European journal of clinical nutrition, 74, 1519–1535. https://doi.org/10.1038/s41430-020-0629-0

© 2020, The Author(s). Malnutrition predicts poorer clinical outcomes for people with cancer. Older adults with cancer are a complex, growing population at high risk of weight-losing conditions. A number of malnutrition screening tools exist, however... Read More about Relationship between markers of malnutrition and clinical outcomes in older adults with cancer: systematic review, narrative synthesis and meta-analysis.

Physiologically relevant screening of polyphenol-rich commercial preparations for bioactivity in vascular endothelial cells and application to healthy volunteers: a viable workflow and a cautionary tale (2019)
Journal Article
Jones, H., Papageorgiou, M., Gordon, A., Ehtesham, Javed, Z., Wells, L. K., Greetham, S., Doyle, B., Hayes, N., Rigby, A., Atkin, S. L., Courts, F. L., & Sathyapalan, T. (2020). Physiologically relevant screening of polyphenol-rich commercial preparations for bioactivity in vascular endothelial cells and application to healthy volunteers: a viable workflow and a cautionary tale. Biochemical Pharmacology, 173, Article 113754. https://doi.org/10.1016/j.bcp.2019.113754

© 2019 Elsevier Inc. This study describes the screening of 13 commercially-available plant extracts for pharmacological activity modulating vascular function using an endothelial cell model. A French maritime pine bark extract (FMPBE) was found to ha... Read More about Physiologically relevant screening of polyphenol-rich commercial preparations for bioactivity in vascular endothelial cells and application to healthy volunteers: a viable workflow and a cautionary tale.

Validated screening tools for the assessment of cachexia, sarcopenia, and malnutrition: a systematic review (2018)
Journal Article
Miller, J., Wells, L., Nwulu, U., Currow, D., Johnson, M. J., & Skipworth, R. J. (2018). Validated screening tools for the assessment of cachexia, sarcopenia, and malnutrition: a systematic review. American Journal of Clinical Nutrition, 108(6), 1196-1208. https://doi.org/10.1093/ajcn/nqy244

Background: There is great overlap between the presentation of cachexia, sarcopenia, and malnutrition. Distinguishing between these conditions would allow for better targeted treatment for patients. Objectives: The aim was to systematically review va... Read More about Validated screening tools for the assessment of cachexia, sarcopenia, and malnutrition: a systematic review.

Occurrence of deoxynivalenol in an elderly cohort in the UK: a biomonitoring approach (2018)
Journal Article
Papageorgiou, M., Wells, L., Williams, C., White, K. L., De Santis, B., Liu, Y., Debegnach, F., Miano, B., Moretti, G., Greetham, S., Brera, C., Atkin, S. L., Hardie, L. J., & Sathyapalan, T. (2018). Occurrence of deoxynivalenol in an elderly cohort in the UK: a biomonitoring approach. Food Additives and Contaminants: Part A: Chemistry, Analysis, Control, Exposure and Risk Assessment, 35(10), 2032-2044. https://doi.org/10.1080/19440049.2018.1508890

Deoxynivalenol (DON) is a Fusarium toxin, to which humans are frequently exposed via diet. Although the elderly are speculated to be sensitive to the toxic effects of DON as a result of age-related conditions, disease and altered DON metabolism, ther... Read More about Occurrence of deoxynivalenol in an elderly cohort in the UK: a biomonitoring approach.

Assessment of urinary deoxynivalenol biomarkers in UK children and adolescents (2018)
Journal Article
Papageorgiou, M., Wells, L., Williams, C., White, K., De Santis, B., Liu, Y., Debegnach, F., Miano, B., Moretti, G., Greetham, S., Brera, C., Atkin, S. L., Hardie, L. J., & Sathyapalan, T. (2018). Assessment of urinary deoxynivalenol biomarkers in UK children and adolescents. Toxins, 10(2), 50. https://doi.org/10.3390/toxins10020050

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Deoxynivalenol (DON), the mycotoxin produced mainly by Fusarium graminearum and found in contaminated cereal-based foodstuff, has been consistently detected in body fluids in adults. Available... Read More about Assessment of urinary deoxynivalenol biomarkers in UK children and adolescents.

Deoxynivalenol biomarkers in the urine of UK vegetarians (2017)
Journal Article
Wells, L., Hardie, L., Williams, C., White, K., Liu, Y., De Santis, B., Debegnach, F., Moretti, G., Greetham, S., Brera, C., Papageorgiou, M., Thatcher, N. J., Rigby, A., Atkin, S. L., & Sathyapalan, T. (2017). Deoxynivalenol biomarkers in the urine of UK vegetarians. Toxins, 9(7), 196. https://doi.org/10.3390/toxins9070196

Deoxynivalenol (DON) is produced by Fusarium graminearum and is one of the most commonly occurring trichothecenes. Vegetarians are alleged to be a high-risk group for DON exposure due to high intakes of cereals susceptible to the growth of the mycoto... Read More about Deoxynivalenol biomarkers in the urine of UK vegetarians.

Determination of deoxynivalenol in the urine of pregnant women in the UK (2016)
Journal Article
Rigby, A., Sathyapalan, T., Wells, L., Atkin, S., Brera, C., De Santis, B., Debegnach, F., Greetham, S., Hardie, L., Liu, Y., Moretti, G., White, K., & Williams, C. (2016). Determination of deoxynivalenol in the urine of pregnant women in the UK. Toxins, 8(11), 306. https://doi.org/10.3390/toxins8110306

Deoxynivalenol (DON) is one of the most commonly occurring trichothecenes, produced mainly by Fusarium graminearum. Little is known about the effect of DON exposure or the levels of DON exposure that occur during pregnancy. The project aimed to provi... Read More about Determination of deoxynivalenol in the urine of pregnant women in the UK.

Pilot investigation of a virtual gastric band hypnotherapy intervention (2016)
Journal Article
Greetham, S., Goodwin, S., Wells, L., Whitham, C., Jones, H., Rigby, A., Sathyapalan, T., Reid, M., & Atkin, S. (2016). Pilot investigation of a virtual gastric band hypnotherapy intervention. International Journal of Clinical and Experimental Hypnosis, 64(4), 419-433. https://doi.org/10.1080/00207144.2016.1209037

This was a pilot investigation of 30 men and women with a BMI > 27kg/m² over a 24 week period. It aimed to determine whether virtual gastric band (VGB) hypnotherapy has an effect on weight loss in overweight adults, compared to relaxation hypnotherap... Read More about Pilot investigation of a virtual gastric band hypnotherapy intervention.

Investigating strength and range of motion of the hip complex in ice hockey athletes (2015)
Journal Article
Wilcox, C. R. J., Osgood, C. T., White, H. S. F., & Vince, R. V. (2015). Investigating strength and range of motion of the hip complex in ice hockey athletes. Journal of sport rehabilitation, 24(3), 300-306. https://doi.org/10.1123/jsr.2014-0175

CONTEXT: Ice hockey athletes frequently injure the hip complex via a non-contact mechanism. We investigated patterns of strength and range of motion (ROM) to establish major differences compared to soccer athletes. Soccer athletes were compared to ic... Read More about Investigating strength and range of motion of the hip complex in ice hockey athletes.

Genetic factors associated with exercise performance in atmospheric hypoxia (2015)
Journal Article
Hennis, P. J., Grocott, M. P. W., Levett, D. Z. H., Montgomery, H. M., & O'Doherty, A. F. (2015). Genetic factors associated with exercise performance in atmospheric hypoxia. Sports medicine, 45(5), 745-761. https://doi.org/10.1007/s40279-015-0309-8

Background and Objective ‘Natural selection’ has been shown to have enriched the genomes of high-altitude native populations with genetic variants of advantage in this hostile hypoxic environment. In lowlanders who ascend to altitude, genetic factors... Read More about Genetic factors associated with exercise performance in atmospheric hypoxia.